Diet in the treatment of ADHD in children—A systematic review of the literature

References

• Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, et al. ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 2011;128:1007–22.
   PubMed Web of Science ®Google Scholar
• Huang Y-S, Tsai M-H. Long-term outcomes with medications for attention-deficit hyperactivity disorder: Current status of knowledge. CNS Drugs 2011;25:539–54.
   PubMed Web of Science ®Google Scholar
• Hurt EA, Arnold LE, Lofthouse N. Dietary and nutritional treatments for attention-deficit/hyperactivity disorder: Current research support and recommendations for practitioners. Curr Psychiatry Rep 2011;13:323–32.
   PubMed Web of Science ®Google Scholar
• Feingold BF. Hyperkinesis and learning disabilities linked to artificial food flavors and colors. Am J Nurs 1975;75: 797–803.
   PubMedGoogle Scholar
• Lien L, Lien N, Heyerdahl S, Thoresen M, Bjertness E. Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway. Am J Public Health 2006;96:1815–20.
   PubMed Web of Science ®Google Scholar
• Kim Y, Chang H. Correlation between attention deficit hyperactivity disorder and sugar consumption, quality of diet, and dietary behavior in school children. Nutr Res Pract 2011;5:236–45.
   PubMed Web of Science ®Google Scholar
• Pelsser LMJ, Buitelaar JK, Savelkoul HFJ. ADHD as a (non) allergic hypersensitivity disorder: A hypothesis. Pediatr Allergy Immunol 2009;20:107–12.
   PubMed Web of Science ®Google Scholar
• Carter CM, Urbanowicz M, Hemsley R, Mantilla L, Strobel S, Graham PJ, et al. Effects of a few food diet in attention deficit disorder. Arch Dis Child 1993;69:564–8.
   PubMed Web of Science ®Google Scholar
• Arnsten AFT. Fundamentals of attention-deficit/hyperactivity disorder: Circuits and pathways. J Clin Psychiatry 2006; 67 Suppl 8:7–12.
   PubMed Web of Science ®Google Scholar
• Shaywitz BA, Sullivan CM, Anderson GM, Gillespie SM, Sullivan B, Shaywitz SE. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994;93:70–5.
   PubMed Web of Science ®Google Scholar
• Colquhoun I, Bunday S. A lack of essential fatty acids as a possible cause of hyperactivity in children. Med Hypotheses 1981;7:673–9.
   PubMed Web of Science ®Google Scholar
• Lauritzen L, Hansen HS, Jørgensen MH, Michaelsen KF. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001; 40:1–94.
   PubMed Web of Science ®Google Scholar
• Transler C, Mitchell S, Eilander A. Could polyunsaturated fatty acids deficiency explain some dysfunctions found in ADHD?Hypotheses from animal research. J Atten Disord 2013;17:20–8.
   PubMed Web of Science ®Google Scholar
• Antalis CJ, Stevens LJ, Campbell M, Pazdro R, Ericson K, Burgess JR. Omega-3 fatty acid status in attention-deficit/ hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2006;75:299–308.
   PubMed Web of Science ®Google Scholar
• Colter AL, Cutler C, Meckling KA. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: A case–control study. Nutr J 2008;7:8.
   PubMed Web of Science ®Google Scholar
• Delgado-Noguera MF, Calvache JA, Bonfill Cosp X. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst Rev 2010;CD007901.
   Google Scholar
• Asserhøj M, Nehammer S, Matthiessen J, Michaelsen KF, Lauritzen L. Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J Nutr 2009;139:298–304.
   PubMed Web of Science ®Google Scholar
• Kennedy DO, Haskell CF. Vitamins and cognition: What is the evidence?Drugs 2011;71:1957–71.
   PubMed Web of Science ®Google Scholar
• Torrioli MG, Vernacotola S, Peruzzi L, Tabolacci E, Mila M, Militerni R, et al. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Am J Med Genet A 2008;146:803–12.
   Google Scholar
• Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 2006;64:S34–43; discussion S72–91.
   PubMed Web of Science ®Google Scholar
• DiGirolamo AM, Ramirez-Zea M. Role of zinc in maternal and child mental health. Am J Clin Nutr 2009;89:940S–945S.
   Google Scholar
• Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 1997;10:143–8.
   PubMed Web of Science ®Google Scholar
• Arnold LE, Bozzolo H, Hollway J, Cook A, DiSilvestro RA, Bozzolo DR, et al. Serum zinc correlates with parent- and teacher-rated inattention in children with attention-deficit/ hyperactivity disorder. J Child Adolesc Psychopharmacol 2005;15:628–36.
   PubMed Web of Science ®Google Scholar
• Juneja M, Jain R, Singh V, Mallika V. Iron deficiency in Indian children with attention deficit hyperactivity disorder. Indian Pediatrics 2010;47:955–8.
   PubMed Web of Science ®Google Scholar
• Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005;15:619–27.
   PubMed Web of Science ®Google Scholar
• Cortese S, Lecendreux M, Bernardina BD, Mouren MC, Sbarbati A, Konofal E. Attention-deficit/hyperactivity disorder, Tourette's syndrome, and restless legs syndrome: The iron hypothesis. Med Hypotheses 2008;70:1128–32.
   PubMed Web of Science ®Google Scholar
• Smuts CM, Tichelaar HY, van Jaarsveld PJ, Badenhorst CJ, Kruger M, Laubscher R, et al. The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. Prostaglandins Leukot Essent Fatty Acids 1995;52:59–67.
   PubMed Web of Science ®Google Scholar
• Nigg JT, Lewis K, Edinger T, Falk M. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry 2012;51: 86–97.e8.
   PubMed Web of Science ®Google Scholar
• Sonuga-Barke EJS, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, et al. Nonpharmacological interventions for ADHD: Systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiatry 2013;170:275–89.
   PubMed Web of Science ®Google Scholar
• Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: Systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2011;50:991–1000.
   PubMed Web of Science ®Google Scholar
• Gillies D, Sinn JK, Lad SS, Leach MJ, Ross MJ. Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev 2012;7:CD007986.
   Google Scholar
• Levy F, Dumbrell S, Hobbes G, Ryan M, Wilton N, Woodhill JM. Hyperkinesis and diet: A double-blind crossover trial with a tartrazine challenge. Med J Aust 1978;1:61–4.
   PubMed Web of Science ®Google Scholar
• Goyette GH, Connors CK, Petti TA, Curtis LE. Effects of artificial colors on hyperkinetic children: A double-blind challenge study [proceedings]. Psychopharmacol Bull 1978;14:39–40.
   PubMedGoogle Scholar
• Conners CK, Goyette CH, Southwick DA, Lees JM, Andrulonis PA. Food additives and hyperkinesis: A controlled double-blind experiment. Pediatrics 1976;58:154–66.
   PubMed Web of Science ®Google Scholar
• Harley JP, Ray RS, Tomasi L, Eichman PL, Matthews CG, Chun R, et al. Hyperkinesis and food additives: Testing the Feingold hypothesis. Pediatrics 1978;61:818–28.
   PubMed Web of Science ®Google Scholar
• Eich WF, Thim EB, Crowder JE. Effect of the Feingold Kaiser Permanente diet in minimal brain dysfunction. J Med Assoc State Ala 1979;49:16–8
   PubMedGoogle Scholar
• Kaplan BJ, McNicol J, Conte RA, Moghadam HK. Dietary replacement in preschool-aged hyperactive boys. Pediatrics 1989;83:7–17.
   PubMed Web of Science ®Google Scholar
• Williams JI, Cram DM, Tausig FT, Webster E. Relative effects of drugs and diet on hyperactive behaviors: An experimental study. Pediatrics 1978;61:811–7.
   PubMed Web of Science ®Google Scholar
• Adams W. Lack of behavioral effects from Feingold diet violations. Percept Mot Skills 1981;52:307–13.
   PubMed Web of Science ®Google Scholar
• Swanson JM, Kinsbourne M. Food dyes impair performance of hyperactive children on a laboratory learning test. Science 1980;207:1485–7.
   PubMed Web of Science ®Google Scholar
• Bateman B, Warner JO, Hutchinson E, Dean T, Rowlandson P, Gant C, et al. The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children. Arch Dis Child 2004;89:506–11.
   PubMed Web of Science ®Google Scholar
• McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, et al. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: A randomised, double-blinded, placebo-controlled trial. Lancet 2007;370:1560–7.
   PubMed Web of Science ®Google Scholar
• Stevenson J, Sonuga-Barke E, McCann D, Grimshaw K, Parker KM, Rose-Zerilli MJ, et al. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. Am J Psychiatry 2010;167:1108–15.
   PubMed Web of Science ®Google Scholar
• Food Standards Agency. Food Standards Agency—Compulsory warnings on colours in food and drink [Internet]2010: http://www.food.gov.uk/news-updates/news/2010/jul/eucolourswarn#.UT4-EqAid6A
   Google Scholar
• Kavale KA, Forness SR. Hyperactivity and diet treatment: A meta-analysis of the Feingold hypothesis. J Learn Disabil 1983;16:324–30.
   PubMed Web of Science ®Google Scholar
• Schab DW, Trinh N-HT. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Devel Behav Pediatr 2004;25:423–34.
   PubMed Web of Science ®Google Scholar
• Gross MD. Effect of sucrose on hyperkinetic children. Pediatrics 1984;74:876–8.
   PubMed Web of Science ®Google Scholar
• Wolraich M, Milich R, Stumbo P, Schultz F. Effects of sucrose ingestion on the behavior of hyperactive boys. J Pediatr 1985;106:675–82.
   PubMed Web of Science ®Google Scholar
• Milich R, Pelham WE. Effects of sugar ingestion on the classroom and playground behavior of attention deficit disordered boys. J Consult Clin Psychol 1986;54:714–8.
   PubMed Web of Science ®Google Scholar
• Wender EH, Solanto MV. Effects of sugar on aggressive and inattentive behavior in children with attention deficit disorder with hyperactivity and normal children. Pediatrics 1991;88:960–6.
   PubMed Web of Science ®Google Scholar
• Schmidt MH, Möcks P, Lay B, Eisert HG, Fojkar R, Fritz-Sigmund D, et al. Does oligoantigenic diet influence hyperactive/conduct-disordered children—A controlled trial. Eur Child Adolesc Psychiatry 1997;6:88–95.
   PubMed Web of Science ®Google Scholar
• Pelsser LMJ, Frankena K, Toorman J, Savelkoul HFJ, Pereira RR, Buitelaar JK. A randomised controlled trial into the effects of food on ADHD. Eur Child Adolesc Psychiatry 2009;18:12–9.
   PubMed Web of Science ®Google Scholar
• Pelsser LM, Frankena K, Toorman J, Savelkoul HF, Dubois AE, Pereira RR, et al. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): A randomised controlled trial. Lancet 2011;377: 494–503.
   PubMed Web of Science ®Google Scholar
• Rapp DJ. Does diet affect hyperactivity?J Learn Disabil 1978;11:383–9.
   PubMed Web of Science ®Google Scholar
• Egger J, Carter CM, Graham PJ, Gumley D, Soothill JF. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet 1985;1:540–5.
   PubMed Web of Science ®Google Scholar
• Boris M, Mandel FS. Foods and additives are common causes of the attention deficit hyperactive disorder in children. Ann Allergy 1994;72:462–8.
   PubMedGoogle Scholar
• Jadresin O, Misak Z, Sanja K, Sonicki Z, Zizić V. Compliance with gluten-free diet in children with coeliac disease. J Pediatr Gastroenterol Nutr 2008;47:344–8.
   PubMed Web of Science ®Google Scholar
• Nemzer ED, Arnold LE, Votolato NA, McConnell H. Amino acid supplementation as therapy for attention deficit disorder. J Am Acad Child Psychiatry 1986;25:509–13.
   PubMedGoogle Scholar
• Zametkin AJ, Karoum F, Rapoport JL. Treatment of hyperactive children with D-phenylalanine. Am J Psychiatry 1987;144: 792–4.
   PubMed Web of Science ®Google Scholar
• Voigt RG, Llorente AM, Jensen CL, Fraley JK, Berretta MC, Heird WC. A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. J Pediatr 2001;139: 189–96.
   PubMed Web of Science ®Google Scholar
• Harding KL, Judah RD, Gant C. Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD. Altern Med Rev 2003;8:319–30.
   PubMedGoogle Scholar
• Stevens L, Zhang W, Peck L, Kuczek T, Grevstad N, Mahon A, et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 2003;38:1007–21.
   PubMed Web of Science ®Google Scholar
• Hirayama S, Hamazaki T, Terasawa K. Effect of docosahexaenoic acid-containing food administration on symptoms of attention- deficit/hyperactivity disorder—A placebo-controlled double-blind study. Eur J Clin Nutr 2004;58:467–73.
   PubMed Web of Science ®Google Scholar
• Germano M, Meleleo D, Montorfano G, Adorni L, Negroni M, Berra B, et al. Plasma, red blood cells phospholipids and clinical evaluation after long chain omega-3 supplementation in children with attention deficit hyperactivity disorder (ADHD). Nutr Neurosci 2007;10:1–9.
   PubMed Web of Science ®Google Scholar
• Vaisman N, Kaysar N, Zaruk-Adasha Y, Pelled D, Brichon G, Zwingelstein G, et al. Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: Effect of dietary n-3 fatty acids containing phospholipids. Am J Clin Nutr 2008;87:1170–80.
   PubMed Web of Science ®Google Scholar
• Bélanger SA, Vanasse M, Spahis S, Sylvestre M-P, Lippé S, L'heureux F, et al. Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study. Paediatr Child Health 2009;14:89–98.
   PubMed Web of Science ®Google Scholar
• Johnson M, Ostlund S, Fransson G, Kadesjö B, Gillberg C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: A randomized placebo-controlled trial in children and adolescents. J Atten Disord 2009;12:394–401.
   PubMed Web of Science ®Google Scholar
• Gustafsson PA, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H, et al. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD. Acta Paediatr 2010;99:1540–9.
   PubMed Web of Science ®Google Scholar
• Manor I, Magen A, Keidar D, Rosen S, Tasker H, Cohen T, et al. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: A double-blind placebo-controlled trial, followed by an open-label extension. Eur Psychiatry 2012;27:335–42.
   PubMed Web of Science ®Google Scholar
• Milte CM, Parletta N, Buckley JD, Coates AM, Young RM, Howe PRC. Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: A randomized controlled trial. Nutrition 2012;28:670–7.
   PubMed Web of Science ®Google Scholar
• Assareh M, Davari Ashtiani R, Khademi M, Jazayeri S, Rai A, Nikoo M. Efficacy of polyunsaturated fatty acids (PUFA) in the treatment of attention deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled clinical trial. J Atten Disord 2012 Nov 15. Epub ahead of print.
   Google Scholar
• Perera H, Jeewandara KC, Seneviratne S, Guruge C. Combined ω3 and ω6 supplementation in children with attention-deficit hyperactivity disorder (ADHD) refractory to methylphenidate treatment: A double-blind, placebo-controlled study. J Child Neurol 2012;27:747–53.
   PubMed Web of Science ®Google Scholar
• Arnold LE, Kleykamp D, Votolato NA, Taylor WA, Kontras SB, Tobin K. Gamma-linolenic acid for attention-deficit hyperactivity disorder: Placebo-controlled comparison to D-amphetamine. Biol Psychiatry 1989;25:222–8.
   PubMed Web of Science ®Google Scholar
• Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006;74:17–21.
   PubMed Web of Science ®Google Scholar
• Raz R, Carasso RL, Yehuda S. The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: A double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 2009;19:167–77.
   PubMed Web of Science ®Google Scholar
• Kromhout D, Yasuda S, Geleijnse JM, Shimokawa H. Fish oil and omega-3 fatty acids in cardiovascular disease: Do they really work?Eur Heart J 2012;33:436–43.
   PubMed Web of Science ®Google Scholar
• Arnold LE, Christopher J, Huestis RD, Smeltzer DJ. Megavitamins for minimal brain dysfunction. A placebo-controlled study. JAMA 1978;240:2642–3.
   PubMed Web of Science ®Google Scholar
• Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: Controlled studies with long-term follow-up. J Learn Disabil 1982;15:258–64.
   PubMed Web of Science ®Google Scholar
• Haslam RH, Dalby JT, Rademaker AW. Effects of megavitamin therapy on children with attention deficit disorders. Pediatrics 1984;74:103–11.
   PubMed Web of Science ®Google Scholar
• Van Oudheusden LJ, Scholte HR. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2002;67:33–8.
   PubMed Web of Science ®Google Scholar
• Arnold LE, Amato A, Bozzolo H, Hollway J, Cook A, Ramadan Y, et al. Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: A multi-site, placebo-controlled pilot trial. J Child Adolesc Psychopharmacol 2007;17:791–802.
   PubMed Web of Science ®Google Scholar
• Abbasi S-H, Heidari S, Mohammadi M-R, Tabrizi M, Ghaleiha A, Akhondzadeh S. Acetyl-L-carnitine as an adjunctive therapy in the treatment of attention-deficit/hyperactivity disorder in children and adolescents: A placebo-controlled trial. Child Psychiatry Human Devel 2011;42:367–75.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh S, Mohammadi M-R, Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry 2004;4:9.
   PubMed Web of Science ®Google Scholar
• Bilici M, Yildirim F, Kandil S, Bekaroğlu M, Yildirmiş S, Değer O, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181–90.
   PubMed Web of Science ®Google Scholar
• Arnold LE, Disilvestro RA, Bozzolo D, Bozzolo H, Crowl L, Fernandez S, et al. Zinc for attention-deficit/hyperactivity disorder: Placebo-controlled double-blind pilot trial alone and combined with amphetamine. J Child Adolesc Psychopharmacol 2011;21:1–19.
   PubMed Web of Science ®Google Scholar
• Sever Y, Ashkenazi A, Tyano S, Weizman A. Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report. Neuropsychobiology 1997;35:178–80.
   PubMed Web of Science ®Google Scholar
• Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaïm M, et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 2008;38:20–6.
   PubMed Web of Science ®Google Scholar
• Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997;10:149–56.
   Google Scholar
• Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res 2006;19:46–52.
   Google Scholar