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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 44, 2015 - Issue 7
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Original Articles

Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis

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Pages 694-712 | Received 31 Mar 2015, Accepted 29 Jul 2015, Published online: 05 Oct 2015

References

  • Abtahi Froushani SM, Delirezh N, Hobbenaghi R, Mosayebi G. (2014). Synergistic effects of atorvastatin and all-trans retinoic acid in ameliorating animal model of multiple sclerosis. Immunol Invest, 43, 54–68
  • Bai S, Li Y, Wang J, et al. (2011). Modeled microgravity suppressed expansion of the MBP-specific T lymphocytes of rats with EAE. Immunol Invest, 40, 535–51
  • Bayless KJ, Meininger GA, Scholtz JM, Davis GE. (1998). Osteopontin is a ligand for the αβ1 integrin. J Cell Sci, 111, 1165–74
  • Bittner S. (2012). The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis. Exp Neurol, 238, 149–55
  • Bittner S, Afzali AM, Wiendl H, Meuth SG. (2014). Myelin oligodendrocyte glycoprotein (MOG35–55) induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. J Vis Exp, 86, e51275
  • Chames P, Regenmortel MV, Weiss E, Baty D. (2009). Therapeutic antibodies: Successes, limitations and hopes for the future. Br J Pharmacol, 157, 220–33
  • Chigaev A, Sklar LA. (2012). Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion. Front Immunol, 3, 242
  • Coisne C, Mao W, Engelhardt B. (2009). Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the BBB in vivo in an animal model of multiple sclerosis. J Immunol, 182, 5909–13
  • Cox D, Brennan M, Moran N. (2010). Integrins as therapeutic targets: Lessons and opportunities. Nat Rev Drug Discov, 9, 804–20
  • Davenport RJ, Munday JR. (2007). Alpha4-integrin antagonism-an effective approach for the treatment of inflammatory diseases? Drug Dis Today, 12, 569–76
  • de Andres C, Teijeiro R, Alonso B, et al. (2012). Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis. PLoS One, 7, e34103
  • Dong XW, Du XG, Zhang SJ, et al. (2008). Inhibitory effects of BIO-1211 on bronchoconstriction and neutrophil adhesion in rats. Zhejiang Da Xue Xue Bao Yi Xue Ban, 37, 340–4
  • Engelhardt B, Ransohoff RM. (2005). The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms. Trends Immunol, 26, 485–95
  • Evans R, Patzak I, Svensson L. (2009). Integrins in immunity. J Cell Sci, 122, 215–25
  • Frohman EM, Racke MK, Raine CS. (2006). Medical progress: Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med, 354, 942–55
  • Girolamo F, Ferrara G, Strippoli M, et al. (2011). Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Neurobiol Dis, 43, 678–89
  • Gold R, Linington C, Lassmann H. (2006). Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in EAE research. Brain, 129, 1953–71
  • Handel AE, Lincoln MR, Ramagopalan SV. (2011). Of mice and men: Experimental autoimmune encephalitis and multiple sclerosis. Eur J Clin Invest, 41, 1254–8
  • He YX, Du M, Gao Y, et al. (2013). Astragaloside IV attenuates EAE of mice by counteracting oxidative stress at multiple levels. PLoS One, 8, e76495
  • Heidary M, Rakhshi N, Pahlevan Kakhki M, et al. (2014). The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients. J Neuro Sci, 343, 41–5
  • Imai Y, Shimaoka M, Kurokawa M. (2010). Essential roles of VLA-4 in the hematopoietic system. Int J Hematol, 91, 569–75
  • Jackson DY. (2002). Alpha 4 integrin antagonists. Curr Pharma Design, 8, 1229–53
  • Karanam BV, Javrai A, Rabe M, et al. (2007). Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA4 antagonist. Xenobiotica, 37, 487–502
  • Kawamoto E, Nakahashi S, Okamoto T, et al. (2012). Anti-integrin therapy for multiple sclerosis. J Autoimmune Dis, 2012, 357101
  • Kent SJ, Karlik SJ, Cannon C, et al. (1995). A monoclonal antibody to alpha 4 integrin suppresses and reverses active EAE. J Neuroimmunol, 58, 1–10
  • Kenyon NJ, Liu R, Roark EM, et al. (2009). An alpha 4 beta 1 integrin antagonist decreases airway inflammation in ovalbumin exposed mice. Eur J Pharmacol, 603, 138–46
  • Kim C, Ye F, Ginsberg MH. (2011). Regulation of integrin activation. Annu Rev Cell Dev Biol, 27, 321–45
  • Krumbholz M, Meinl I, Kumpfel T, et al. (2008). Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology, 71, 1350–4
  • Kuerten S, Kostova-Bales DA, Frenzel LP, et al. (2007). MP4- and MOG:35–55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum. J Neuroimmunol, 189, 31–40
  • Lucchinetti CF, Popescu BF, Bunyan RF, et al. (2011). Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med, 365, 2188–97
  • Mangiardi M, Crawford DK, Xia X, et al. (2011). An animal model of cortical and callosal pathology in multiple sclerosis. Brain Pathol, 21, 263–78
  • Merkler D, Ernsting T, Kerschensteiner M, et al. (2006). A new focal EAE model of cortical demyelination: Multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination. Brain, 129, 1972–83
  • Miller SD, Karpus WJ, Davidson TS. (2007). Experimental autoimmune encephalomyelitis in the mouse. Current Protocols in Immunology, Chapter 15, Unit 15.1
  • Mindur JE, Ito N, Dhib-Jalbut S, Ito K. (2014). Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE. PLoS One, 9, e99068
  • Moon C, Ahn M, Jeong C, et al. (2011). Immunohistochemical study of netrin-1 in the spinal cord with rat experimental autoimmune encephalomyelitis. Immunol Invest, 40, 160–71
  • Muller DM, Pender MP, Greer JM. (2000). A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction. Acta Neuropathol, 100, 174–82
  • Muro F, Iimura S, Sugimoto Y, et al. (2009a). Discovery of Trans-4-[1-[[2, 5-Dichloro-4-(1-methyl-3-indolylcarboxamido) phenyl] acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy] cyclohexanecarboxylic acid: An orally active, selective very late antigen-4 antagonist. J Med Chem, 52, 79–4
  • Muro F, Iimura S, Yoneda Y, et al. (2008). Identification of 4-[1-[3-chloro-4-[N’-(5-fluoro-2-methylphenyl) ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy] benzoic acid as a potent, orally active VLA-4 antagonist. Bioorg Med Chem, 16, 9991–10000
  • Muro F, Iimura S, Yoneda Y, et al. (2009b). A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid. Bioorg Med Chem, 17, 1232–43
  • Niino M, Bodner C, Simard ML, et al. (2006). Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol, 59, 748–54
  • Paskowitz DM, Nguyen QD, Gehlbach P, et al. (2012). Safety, tolerability, and bioavailability of topical SAR (1118), a novel antagonist of lymphocyte function-associated antigen-1: A phase1b study. Eye, 26, 944–9
  • Peiris M, Monteith GR, Roberts-Thomson SJ, Cabot PJ. (2007). A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies. J Neurosci Meth, 163, 245–54
  • Polman CH, O’Connor PW, Havrdová E, et al. (2006). A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med, 354, 899–910
  • Pomeroy IM, Matthews PM, Frank JA, et al. (2005). Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis. Brain, 128, 2713–21
  • Putzki N, Baranwal MK, Tettenborn B, et al. (2010). Effects of natalizumab on circulating B cells, T regulatory cells and natural killer cells. Eur Neurol, 63, 311–17
  • Radue EW, Stuart WH, Calabresi PA, et al. (2010). Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis. J Neurol Sci, 292, 28–35
  • Ramroodi N, Niazi AA, Sanadgol N, et al. (2013). Evaluation of reactive Epstein–Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis. Braz J Infect Dis, 17, 156–63
  • Ransohoff RM. (2007). Natalizumab for multiple sclerosis. N Engl J Med, 356, 2622–9
  • Rasmussen S, Wang Y, Kivisäkk P, et al. (2007). Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing–remitting experimental autoimmune encephalomyelitis. Brain, 130, 2816–29
  • Reich M, Liefeld T, Gould J, et al. (2006). GenePattern 2.0. Nat Genet, 38, 500–1
  • Rudick RA, Sandrock A. (2004). Natalizumab: Alpha 4-integrin antagonist selective adhesion molecule inhibitors for MS. Expert Rev Neurother, 4, 571–80
  • Sanadgol N, Mostafaie A, Bahrami G, et al. (2010). Elaidic acid sustains LPS and TNF-alpha induced ICAM-1 and VCAM-I expression on human bone marrow endothelial cells (HBMEC). Clin Biochem, 43, 968–72
  • Sanadgol N, Mostafaie A, Mansouri K, Bahrami GH. (2012). Effect of palmitic acid and linoleic acid on expression of ICAM-1 and VCAM-1 in human bone marrow endothelial cells. Arch Med Sci, 8, 192–8
  • Sanadgol N, Ramroodi N, Ahmadi GA, et al. (2011). Prevalence of cytomegalovirus infection and its role in total immunoglobulin pattern in Iranian patients with different subtypes of multiple sclerosis. New Microbiol, 34, 263–74
  • Sanchooli J, Ramroodi N, Sanadgol N, et al. (2014). Relationship between metalloproteinase 2 and 9 concentrations and soluble CD154 expression in Iranian patients with multiple sclerosis. Kaohsiung J Med Sci, 30, 235–42
  • Setoguchi M, Iimura S, Sugimoto Y, et al. (2013). A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: Trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl] acetyl]-(5S)-[methoxy (methyl) amino] methyl-(2S)-pyrrolidinylmethoxy] cyclohexanecarboxylic acid. Bio Med Chem, 21, 42–61
  • Shin T, Kim S, Moon C. (2000). Aminoguanidine-induced amelioration of autoimmune encephalomyelitis is mediated by reduced expression of inducible nitric oxide synthase in the spinal cord. Immunol Invest, 29, 233–41
  • Shin T, Matsumoto Y. (2001). A quantitative analysis of CD45Rlow CD4+ T cells in the subarachnoid space of Lewis rats with autoimmune encephalomyelitis. Immunol Invest, 30, 57–64
  • Solati Sarvandi S, Joghataei MT, Parivar K, et al. (2015). In vitro differentiation of rat mesenchymal stem cells to hepatocyte lineage. Iran J Basic Med Sci, 18, 89–97
  • Stasiolek M, Bayas A, Kruse N, et al. (2006). Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis. Brain, 129, 1293–305
  • Stephen DM, William JK, Todd SD. (2007). Experimental autoimmune encephalomyelitis in the mouse. In: Current Protocol Immunology
  • Storch MK, Bauer J, Linington C, et al. (2006). Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatability complex (MHC) haplotype-related. J Neuropathol Exp Neurol, 65, 1137–42
  • Takayama G, Matsumoto K, Taira T, et al. (2013). Improvement of pulmonary function by oral treatment with a VLA-4 antagonist in a mouse asthmatic model. J Pharmacol Sci, 121, 172–5
  • Tambalo S, Peruzzotti-Jametti L, Rigolio R, et al. (2015). Functional magnetic resonance imaging of rats with EAE reveals brain cortex remodeling. J Neurosci, 35, 10088–100
  • Theien BE, Vanderlugt CL, Nickerson-Nutter C, et al. (2003). Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE. Blood, 15, 4464–71
  • Trapp BD, Nave KA. (2008). Multiple sclerosis: An immune or neurodegenerative disorder. Annu Rev Neurosci, 31, 247–69
  • Vajkoczy P, Laschinger M, Engelhardt B. (2001). Alpha4-integrein-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest, 108, 557–65
  • Vanderslice P, Woodside DG, Caivano AR, et al. (2010). Potent in vivo suppression of inflammation by selectively targeting the high affinity conformation of integrin alpha 4 beta1. Biochem Biophys Res Commun, 400, 619–24
  • Wang D, Lu Z, Hu L, et al. (2009). Macrolide antibiotics aggravate experimental autoimmune encephalomyelitis and inhibit inducible nitric oxide synthase. Immunol Invest, 38, 602–12
  • Wolf C, Sidhu J, Otoul C, et al. (2013). Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: A randomized, double-blind phase 1/2 Study. PLoS One, 8, e58438
  • Woodside DG, Vanderslice P. (2008). Cell adhesion antagonists: Therapeutic potential in asthma and chronic obstructive pulmonary disease. Bio Drugs, 22, 85–100
  • Yaldizli O, Putzki N. (2009). Natalizumab in the treatment of MS. Ther Adv Neurol Disord, 2, 115–28
  • Yednock TA, Cannon C, Fritz LC. (1992). Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature, 356, 63–6
  • Yonekawa K, Harlan JM. (2005). Targeting leukocyte integrins in human diseases. J Leukoc Biol, 77, 129–40
  • Zoghi S, Amirghofran Z, Nikseresht A, et al. (2011). Cytokine secretion pattern in treatment of lymphocytes of multiple sclerosis patients with fumaric acid esters. Immunol Invest, 40, 581–96

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