Neurotensin, a Novel Messenger to Cross-Link Inflammation and Tumor Invasion via Epithelial-Mesenchymal Transition Pathway

REFERENCES

• Alizadeh D, Larmonier N. Chemotherapeutic targeting of cancer-induced immunosuppressive cells[J]. Cancer Res 2014;74(10):2663–2668.
   PubMed Web of Science ®Google Scholar
• Hoyer D, Bartfai T. Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach[J]. Chem Biodivers 2012;9(11):2367–2387.
   PubMed Web of Science ®Google Scholar
• Lango MN, Dyer KF, Lui VW, Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck[J]. J Natl Cancer Inst 2002;94(5):375–383.
   PubMed Web of Science ®Google Scholar
• Kobayashi N, Seto K, Orikawa Y, Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gene in human pancreatic cancer cells[J]. Biol Pharm Bull 2010;33(2):216–222.
   PubMed Web of Science ®Google Scholar
• Hori H, Nakata H, Iguchi G, Oncogenic ras induces gastrin/CCKB receptor gene expression in human colon cancer cell lines LoVo and Colo320HSR[J]. J Lab Clin Med 2003;141(5):335–341.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhu S, Yi L, Neurotensin receptor1 antagonist SR48692 reduces proliferation by inducing apoptosis and cell cycle arrest in melanoma cells[J]. Mol Cell Biochem 2014;389(1–2):1–8.
   PubMed Web of Science ®Google Scholar
• DEAD JM, Lopes AG, Capella MA. Effects of Angiotensin, vasopressin and aldosterone on proliferation of mcf-7 cells and their sensitivity to Doxorubicin[J]. Anticancer Res 2014;34(4):1843–1848.
   PubMed Web of Science ®Google Scholar
• Bendinelli P, Maroni P, Matteucci E, Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer[J]. Biochim Biophys Acta 2014;1843(4):815–826.
   PubMed Web of Science ®Google Scholar
• Carraway R, Leeman SE. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami[J]. J Biol Chem 1973;248(19):6854–6861.
   PubMed Web of Science ®Google Scholar
• Pelaprat D. Interactions between neurotensin receptors and G proteins[J]. Peptides 2006;27(10):2476–2487.
   PubMed Web of Science ®Google Scholar
• Dal Farra C, Sarret P, Navarro V, Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines[J]. Int J Cancer 2001;92(4):503–509.
   PubMed Web of Science ®Google Scholar
• Martin S, Vincent JP, Mazella J. Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia[J]. J Neurosci 2003;23(4):1198–1205.
   PubMed Web of Science ®Google Scholar
• Nielsen MS, Jacobsen C, Olivecrona G, Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase[J]. J Biol Chem 1999;274(13):8832–8836.
   PubMed Web of Science ®Google Scholar
• Kitabgi P. Neurotensin modulates dopamine neurotransmission at several levels along brain dopaminergic pathways[J]. Neurochem Int 1989;14(2):111–119.
   PubMed Web of Science ®Google Scholar
• Dobner PR. Neurotensin and pain modulation[J]. Peptides 2006;27(10):2405–2414.
   PubMed Web of Science ®Google Scholar
• Popp E, Schneider A, Vogel P, Time course of the hypothermic response to continuously administered neurotensin[J]. Neuropeptides 2007;41(5):349–354.
   PubMed Web of Science ®Google Scholar
• Andersson S, Chang D, Folkers K, Rosell S. Inhibition of gastric acid secretion in dogs by neurotensin[J]. Life Sci 1976;19(3):367–370.
   PubMed Web of Science ®Google Scholar
• Andersson S, Rosell S, Hjelmquist U, Inhibition of gastric and intestinal motor activity in dogs by (Gln4) neurotensin[J]. Acta Physiol Scand 1977;100(2):231–235.
   PubMedGoogle Scholar
• Armstrong MJ, Parker MC, Ferris CF, Leeman SE. Neurotensin stimulates [3H]oleic acid translocation across rat small intestine[J]. Am J Physiol 1986;251(6 Pt 1):G823–G829.
   PubMed Web of Science ®Google Scholar
• Baca I, Feurle GE, Schwab A, Effect of neurotensin on exocrine pancreatic secretion in dogs[J]. Digestion 1982;23(3):174–183.
   PubMed Web of Science ®Google Scholar
• Evers BM. Neurotensin and growth of normal and neoplastic tissues[J]. Peptides 2006;27(10):2424–2433.
   PubMed Web of Science ®Google Scholar
• Souaze F, Dupouy S, Viardot-Foucault V, Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression[J]. Cancer Res 2006;66(12):6243–6249.
   PubMed Web of Science ®Google Scholar
• Yoshinaga K, Evers BM, Izukura M, Neurotensin stimulates growth of colon cancer[J]. Surg Oncol 1992;1(2):127–134.
   PubMedGoogle Scholar
• Vias M, Burtt G, Culig Z, A role for neurotensin in bicalutamide resistant prostate cancer cells[J]. Prostate 2007;67(2):190–202.
   PubMed Web of Science ®Google Scholar
• Reubi JC, Waser B, Friess H, Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma[J]. Gut 1998;42(4):546–550.
   PubMed Web of Science ®Google Scholar
• Ocejo-Garcia M, Ahmed SI, Coulson JM, Woll PJ. Use of RT-PCR to detect co-expression of neuropeptides and their receptors in lung cancer[J]. Lung Cancer 2001;33(1):1–9.
   PubMed Web of Science ®Google Scholar
• Yu J, Ren X, Chen Y, Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients[J]. PLoS One 2013;8(2):e56069.
   PubMed Web of Science ®Google Scholar
• Myers RM, Shearman JW, Kitching MO, Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors[J]. ACS Chem Biol 2009;4(7):503–525.
   PubMed Web of Science ®Google Scholar
• Cross AS, Azzopardi JG, Krausz T, A morphological and immunocytochemical study of a distinctive variant of ductal carcinoma in-situ of the breast[J]. Histopathology 1985;9(1):21–37.
   PubMed Web of Science ®Google Scholar
• Maoret JJ, Anini Y, Rouyer-Fessard C, Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice[J]. Int J Cancer 1999;80(3):448–454.
   PubMed Web of Science ®Google Scholar
• Moody TW, Chiles J, Casibang M, SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells[J]. Peptides 2001;22(1):109–115.
   PubMed Web of Science ®Google Scholar
• Somai S, Gompel A, Rostene W, Forgez P. Neurotensin counteracts apoptosis in breast cancer cells[J]. Biochem Biophys Res Commun 2002;295(2):482–488.
   PubMed Web of Science ®Google Scholar
• Gui X, Guzman G, Dobner PR, Kadkol SS. Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma[J]. Peptides 2008;29(9):1609–1615.
   PubMed Web of Science ®Google Scholar
• Alifano M, Souaze F, Dupouy S, Neurotensin receptor 1 determines the outcome of non-small cell lung cancer[J]. Clin Cancer Res 2010;16(17):4401–4410.
   PubMed Web of Science ®Google Scholar
• Mijatovic T, Gailly P, Mathieu V, Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (PDAC) migration[J]. Cell Oncol 2007;29(4):315–326.
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease[J]. Cell 2009;139(5):871–890.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA, The basics of epithelial-mesenchymal transition[J]. J Clin Invest 2009;119(6):1420–1428.
   PubMed Web of Science ®Google Scholar
• Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links[J]. Semin Cancer Biol 2012;22(5–6):396–403.
   PubMed Web of Science ®Google Scholar
• Mani SA, Guo W, Liao MJ, The epithelial-mesenchymal transition generates cells with properties of stem cells[J]. Cell 2008;133(4):704–715.
   PubMed Web of Science ®Google Scholar
• Brabletz T, Hlubek F, Spaderna S, Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin[J]. Cells Tissues Organs 2005;179(1–2):56–65.
   PubMed Web of Science ®Google Scholar
• Zhao D, Pothoulakis C. Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation[J]. Peptides 2006;27(10):2434–2444.
   PubMed Web of Science ®Google Scholar
• Robbins RA, Nelson KJ, Gossman GL, Rubinstein I. Neurotensin stimulates neutrophil adherence to bronchial epithelial cells in vitro[J]. Life Sci 1995;56(16):1353–1359.
   PubMed Web of Science ®Google Scholar
• Garrido JJ, Arahuetes RM, Hernanz A, De la Fuente M. Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes[J]. Regul Pept 1992;41(1):27–37.
   PubMed Web of Science ®Google Scholar
• Olszewski U, Hamilton G. Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells[J]. Mol Oncol 2009;3(3):204–213.
   PubMed Web of Science ®Google Scholar
• Tang KH, Ma S, Lee TK, CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling[J]. Hepatology 2012;55(3):807–820.
   PubMed Web of Science ®Google Scholar
• Zhao D, Keates AC, Kuhnt-Moore S, Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes[J]. J Biol Chem 2001;276(48):44464–44471.
   PubMed Web of Science ®Google Scholar
• Warny M, Keates AC, Keates S, p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis[J]. J Clin Invest 2000;105(8):1147–1156.
   PubMed Web of Science ®Google Scholar
• Bliss CM, Jr., Golenbock DT, Keates S, Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes[J]. Infect Immun 1998;66(11):5357–5363.
   PubMed Web of Science ®Google Scholar
• Fraser CC. G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer[J]. Int Rev Immunol 2008;27(5):320–350.
   PubMed Web of Science ®Google Scholar
• Krakauer T. Nuclear factor-kappaB: fine-tuning a central integrator of diverse biologic stimuli[J]. Int Rev Immunol 2008;27(5):286–292.
   PubMed Web of Science ®Google Scholar
• Zhao D, Zhan Y, Zeng H, Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha[J]. Mol Pharmacol 2005;67(6):2025–2031.
   PubMed Web of Science ®Google Scholar
• Carraway RE, Hassan S, Dobner PR. Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells[J]. Regul Pept 2008;147(1–3):96–109.
   PubMed Web of Science ®Google Scholar
• Zhao D, Kuhnt-Moore S, Zeng H, Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways[J]. Am J Physiol Cell Physiol 2003;284(6):C1397–C1404.
   PubMed Web of Science ®Google Scholar
• Etienne-Manneville S, Hall A. Rho GTPases in cell biology[J]. Nature 2002;420(6916):629–635.
   PubMed Web of Science ®Google Scholar
• Bishop AL, Hall A. Rho GTPases and their effector proteins[J]. Biochem J 2000;348 Pt 2:241–255.
   PubMed Web of Science ®Google Scholar
• Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation[J]. Biochim Biophys Acta 1991;1072(2–3):129–157.
   PubMed Web of Science ®Google Scholar
• Brzozowski AM, Derewenda U, Derewenda ZS, A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex[J]. Nature 1991;351(6326):491–494.
   PubMed Web of Science ®Google Scholar
• Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK[J]. Nature 1994;371(6493):171–175.
   PubMed Web of Science ®Google Scholar
• Hipskind RA, Rao VN, Mueller CG, Reddy ES. A Nordheim, Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF[J]. Nature 1991;354(6354):531–534.
   PubMed Web of Science ®Google Scholar
• Kunsch C, Rosen CA. NF-kappa B subunit-specific regulation of the interleukin-8 promoter[J]. Mol Cell Biol 1993;13(10):6137–6146.
   PubMed Web of Science ®Google Scholar
• Waugh DJ, Wilson C. The interleukin-8 pathway in cancer[J]. Clin Cancer Res 2008;14(21):6735–6741.
   PubMed Web of Science ®Google Scholar
• Gabellini C, Trisciuoglio D, Desideri M, Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression[J]. Eur J Cancer 2009;45(14):2618–2627.
   PubMed Web of Science ®Google Scholar
• Li XJ, Peng LX, Shao JY, As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling[J]. Carcinogenesis 2012;33(7):1302–1309.
   PubMed Web of Science ®Google Scholar
• Grille SJ, Bellacosa A, Upson J, The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines[J]. Cancer Res 2003;63(9):2172–2178.
   PubMed Web of Science ®Google Scholar
• Wu J, Ru NY, Zhang Y, HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug[J]. Oncogene 2011;30(43):4410–4427.
   PubMed Web of Science ®Google Scholar
• Zhou BP, Deng J, Xia W, Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition[J]. Nat Cell Biol 2004;6(10):931–940.
   PubMed Web of Science ®Google Scholar
• Kim JY, Kim YM, Yang CH, Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation[J]. FEBS J 2012;279(16):2929–2939.
   PubMed Web of Science ®Google Scholar
• Knall C, Young S, Nick JA, Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils[J]. J Biol Chem 1996;271(5):2832–2838.
   PubMed Web of Science ®Google Scholar
• Venkatakrishnan G, Salgia R, Groopman JE. Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells[J]. J Biol Chem 2000;275(10):6868–6875.
   PubMed Web of Science ®Google Scholar
• Nagarajan D, Melo T, Deng Z, ERK/GSK3beta/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition[J]. Free Radic Biol Med 2012;52(6):983–992.
   PubMed Web of Science ®Google Scholar
• Weiss MB, Abel EV, Mayberry MM, TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells[J]. Cancer Res 2012;72(24):6382–6392.
   PubMed Web of Science ®Google Scholar
• Fernando RI, Litzinger M, Trono P, The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells[J]. J Clin Invest 2010;120(2):533–544.
   PubMed Web of Science ®Google Scholar
• Fernando RI, Castillo MD, Litzinger M, IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells[J]. Cancer Res 2011;71(15):5296–5306.
   PubMed Web of Science ®Google Scholar
• Hwang WL, Yang MH, Tsai ML, SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells[J]. Gastroenterology 2011;141(1):279–291;291 e1–5.
   PubMed Web of Science ®Google Scholar
• Grosse-Steffen T, Giese T, Giese N, Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase[J]. Clin Dev Immunol 2012;2012:720768.
   PubMedGoogle Scholar
• Bonde AK, Tischler V, Kumar S, Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors[J]. BMC Cancer 2012;12:35.
   PubMed Web of Science ®Google Scholar
• Chicaybam L, Sodre AL, Bonamino M. Chimeric antigen receptors in cancer immuno-gene therapy: current status and future directions[J]. Int Rev Immunol 2011;30(5–6):294–311.
   PubMed Web of Science ®Google Scholar
• Dupouy S, Viardot-Foucault V, Alifano M, The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression[J]. PLoS One 2009;4(1):e4223.
   PubMed Web of Science ®Google Scholar
• Shimizu S, Tsukada J, Sugimoto T, Identification of a novel therapeutic target for head and neck squamous cell carcinomas: a role for the neurotensin-neurotensin receptor 1 oncogenic signaling pathway[J]. Int J Cancer 2008;123(8):1816–1823.
   PubMed Web of Science ®Google Scholar
• Garcia-Garayoa E, Blauenstein P, Blanc A, A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours[J]. Eur J Nucl Med Mol Imaging 2009;36(1):37–47.
   PubMed Web of Science ®Google Scholar
• Valerie NC, Casarez EV, Dasilva JO, Inhibition of neurotensin receptor 1 selectively sensitizes prostate cancer to ionizing radiation[J]. Cancer Res 2011;71(21):6817–6826.
   PubMed Web of Science ®Google Scholar
• Wang X, Jackson LN, Johnson SM, Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers[J]. Mol Cancer Ther 2010;9(8):2389–2398.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang Q, Ives KL, Evers BM. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells[J]. Clin Cancer Res 2006;12(18):5346–5355.
   PubMed Web of Science ®Google Scholar
• Huang S, Mills L, Mian B, Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma[J]. Am J Pathol 2002;161(1):125–134.
   PubMed Web of Science ®Google Scholar
• Mian BM, Dinney CP, Bermejo CE, Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB[J]. Clin Cancer Res 2003;9(8):3167–3175.
   PubMed Web of Science ®Google Scholar
• Merritt WM, Lin YG, Spannuth WA, Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth[J]. J Natl Cancer Inst 2008;100(5):359–372.
   PubMed Web of Science ®Google Scholar
• Singh S, Sadanandam A, Nannuru KC, Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis[J]. Clin Cancer Res 2009;15(7):2380–2386.
   PubMed Web of Science ®Google Scholar
• Singh JK, Farnie G, Bundred NJ, Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms[J]. Clin Cancer Res 2013;19(3):643–656.
   PubMed Web of Science ®Google Scholar