1,007
Views
31
CrossRef citations to date
0
Altmetric
Laboratory Study

Beneficial Effects of N-Acetylcysteine and Ebselen on Renal Ischemia/Reperfusion Injury

, , , , , , , , , , , , , & show all
Pages 512-517 | Received 28 Dec 2010, Accepted 15 Mar 2011, Published online: 06 May 2011

REFERENCES

  • Sheridan AM, Bonventre JV. Pathophysiology of ischemic acute renal failure. Contrib Nephrol. 2001;132:7–21.
  • Chatterjee PK. Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: A comprehensive review. Naunyn Schmiedebergs Arch Pharmacol. 2007;376:1–43.
  • Nath KA, Norby SM. Reactive oxygen species and acute renal failure. Am J Med. 2000;109:665–678.
  • Guven A, Uysal B, Akgul O, . Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury. Ren Fail. 2008;30:747–754.
  • Yanarates O, Guven A, Sizlan A, . Ameliorative effects of proanthocyanidin on renal ischemia/reperfusion injury. Ren Fail. 2008;30:931–938.
  • Guven A, Tunc T, Topal T, . Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine. Surg Today. 2008;38:1029–1035.
  • Greene EL, Paller MS. Oxygen free radicals in acute renal failure. Miner Electrolyte Metab. 1991;17:124–132.
  • Noiri E, Nakao A, Uchida K, . Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol Renal Physiol. 2001;281:F948–F957.
  • Chatterjee PK, Patel NS, Kvale EO, . Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int. 2002;61:862–871.
  • Di Giorno C, Pinheiro HS, Heinke T, . Beneficial effect of N-acetyl-cysteine on renal injury triggered by ischemia and reperfusion. Transplant Proc. 2006;38:2774–2776.
  • Ersoz N, Guven A, Cayci T, . Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: A role for inhibiting iNOS. Ren Fail. 2009;31:704–710.
  • Zafarullah M, Li WQ, Sylvester J, . Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003;60:6–20.
  • Klotz LO, Sies H. Defenses against peroxynitrite: Selenocompounds and flavonoids. Toxicol Lett. 2003;140–141:125–132.
  • Daiber A, Zou MH, Bachschmid M, . Ebselen as a peroxynitrite scavenger in vitro and ex vivo. Biochem Pharmacol. 2000;59:153–160.
  • Rabb H, Ramirez G, Saba SR, . Renal ischemic-reperfusion injury in L-selectin-deficient mice. Am J Physiol. 1996;271:F408–F413.
  • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol. 1996;271:C1424–C1437.
  • Nose K. Role of reactive oxygen species in the regulation of physiological functions. Biol Pharm Bull. 2000;23:897–903.
  • Williams P, Lopez H, Britt D, . Characterization of renal ischemia-reperfusion injury in rats. J Pharmacol Toxicol Methods. 1997;37:1–7.
  • Yaman H, Cayci T, Seyrek M, . Effects of vitamin A and C and melatonin on 3-nitrotyrosine formation in guinea pig heart under lipopolysaccharide-induced stress. Turk J Med Sci. 2010;40:715–721.
  • Scaldaferri F, Fiocchi C. Inflammatory bowel disease: Progress and current concepts of etiopathogenesis. J Dig Dis. 2007;8:171–178.
  • Oztas E, Guven A, Turk E, 3-Aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury. Ren Fail. 2009;31:393–399.
  • Aruoma OI, Halliwell B, Hoey BM, . The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med. 1989;6:593–597.
  • Grinberg L, Fibach E, Amer J, . N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic Biol Med. 2005;38:136–145.
  • Tunc T, Oter S, Guven A, . Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine. J Gastroenterol Hepatol. 2009;24:681–687.
  • Dodd S, Dean O, Copolov DL, . N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility. Expert Opin Biol Ther. 2008;8:1955–1962.
  • Briguori C, Colombo A, Violante A, . Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity. Eur Heart J. 2004;25:206–211.
  • Muller A, Gabriel H, Sies H, . A novel biologically active selenooorganic compound–VII. Biotransformation of ebselen in perfused rat liver. Biochem Pharmacol. 1988;37:1103–1109.
  • Zhao R, Masayasu H, Holmgren A. Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A. 2002;99:8579–8584.
  • Ozaki M, Nakamura M, Teraoka S, . Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. Transpl Int. 1997;10:96–102.
  • Seo JY, Lee CH, Cho JH, . Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes. J Neurol Sci. 2009;285:88–94.
  • Tunc T, Uysal B, Atabek C, . Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. J Surg Res. 2009;155:210–216.
  • Baljinnyam E, Hasebe N, Morihira M, . Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size. Hypertens Res. 2006;29:905–913.
  • Meotti FC, Borges VC, Zeni G, . Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice. Toxicol Lett. 2003;143(1):9–16.
  • Rodríguez F, Nieto-Cerón S, Fenoy FJ, . Sex differences in nitrosative stress during renal ischemia. Am J Physiol Regul Integr Comp Physiol. 2010;299(5):R1387–R1395.
  • Guven A, Gundogdu G, Vurucu S, . Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats. J Pediatr Surg. 2009;44:1730–1735.
  • Guven A, Gundogdu G, Uysal B, . Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model. J Pediatr Surg. 2009;44:534–540.
  • Briviba K, Tamler R, Klotz LO, . Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions. Biochem Pharmacol. 1998;55:817–823.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.