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Laboratory Study

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

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Pages 411-423 | Received 26 Aug 2015, Accepted 21 Dec 2015, Published online: 22 Jan 2016

References

  • Gosavi T, Kandhare A, Raygude K, Ghosh P, Bodhankar S. A comparative study on the efficacy, safety and cost effectiveness of Viscum album and Rauwolfia serpentina mother tincture in hypertensive patients. Deccan J Nat Prod. 2011;2:29–35.
  • Ghosh P, Kandhare AD, Raygude KS, et al. Determination of the long term diabetes related complications and cardiovascular events using UKPDS risk engine and UKPDS outcomes model in a representative western Indian population. Asian Pac J Trop Dis. 2012;2:S642–S650.
  • Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013;380:2224–2260.
  • Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: Analysis of worldwide data. Lancet. 2005;365:217–223.
  • Patel V, Chatterji S, Chisholm D, et al. Chronic diseases and injuries in India. Lancet. 2011;377:413–428.
  • Badole SL, Chaudhari SM, Jangam GB, Kandhare AD, Bodhankar SL. Cardioprotective activity of Pongamia pinnata in streptozotocin-nicotinamide induced diabetic rats. BioMed Res Int. 2015;2015:1–8.
  • Visnagri A, Kandhare AD, Ghosh P, Bodhankar SL. Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats. Cardiovasc Endocrinol. 2013;2:85–97.
  • Mohan S, Reddy KS, Prabhakaran D. Chronic Non-communicable Diseases in India – Reversing the Tide. New Delhi: Public Health Foundation of India; 2011.
  • Lee DH, Kim JH, Park JS, Choi YJ, Lee JS. Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides. 2004;25:621–627.
  • de Champlain J, van Ameringen MR. Regulation of blood pressure by sympathetic nerve fibers and adrenal medulla in normotensive and hypertensive rats. Circ Res. 1972;31:617–628.
  • Mulrow PJ, Forman BH. The tissue effects of mineralocorticoids. Am J Med. 1972;53:561–572.
  • Brown L, Duce B, Miric G, Sernia C. Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. J Am Soc Nephrol. 1999;10:S143–S148.
  • Zhou M-S, Adam AG, Jaimes EA, Raij L. In salt-sensitive hypertension, increased superoxide production is linked to functional upregulation of angiotensin II. Hypertension. 2003;42:945–951.
  • Callera GE, Touyz RM, Teixeira SA, et al. ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension. 2003;42:811–817.
  • Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y. Aldosterone induces superoxide generation via Rac1 activation in endothelial cells. Endocrinology. 2008;149:1009–1014.
  • Kandhare AD, Raygude KS, Ghosh P, Gosavi TP, Bodhankar SL. Patentability of Animal Models: India and the Globe. Int J Pharm Biol Arch. 2011;2:1024–1032.
  • Shivakumar V, Kandhare A, Rajmane A, et al. Estimation of the long-term cardiovascular events using ukpds risk engine in metabolic syndrome patients. Indian J Pharm Sci. 2014;76:174–178.
  • Westcott ND, Muir AD. Process for extracting lignans from flaxseed. Google Patents; 1998.
  • Prasad K. Secoisolariciresinol diglucoside (SDG) isolated from flaxseed, an alternative to ACE inhibitors in the treatment of hypertension. Int J Angiol. 2013;22:235.
  • Zanwar AA, Hegde M, Bodhankar S. In vitro antioxidant activity of ethanolic extract of Linum usitatissimum. Pharmacol Online. 2010;1:683–696.
  • Zanwar A, Hegde M, Bodhankar S. Cardioprotective activity of flax lignan concentrate extracted from seeds of Linum usitatissimum in isoprenalin induced myocardial necrosis in rats. Interdiscip Toxicol. 2011;4:90–97.
  • Zanwar AA, Hegde MV, Bodhankar SL. Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity. Food Sci Hum Wellness. 2013;2:29–38.
  • Ghule AE, Jadhav SS, Bodhankar SL. Renoprotective effect of Linum usitatissimum seeds through hemodynamic changes and conservation of antioxidant enzymes in renal ischemia-reperfusion injury in rats. Arab J Urol. 2011;9:215–221.
  • Lemay A, Dodin S, Kadri N, Jacques H, Forest J-C. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol. 2002;100:495–504.
  • Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis. 1997;132:69–76.
  • Prasad K, Mantha S, Muir A, Westcott N. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Atherosclerosis. 1998;136:367–375.
  • Chen J, Stavro PM, Thompson LU. Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. Nutr Cancer. 2002;43:187–192.
  • Collins TF, Sprando RL, Black TN, et al. Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats. Food Chem Toxicol. 2003;41:819–834.
  • Kinniry P, Amrani Y, Vachani A, et al. Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr. 2006;136:1545–1551.
  • Rajesha J, Murthy KNC, Kumar MK, Madhusudhan B, Ravishankar GA. Antioxidant potentials of flaxseed by in vivo model. J Agric Food Chem. 2006;54:3794–3799.
  • Ghule AE, Kandhare AD, Jadhav SS, Zanwar AA, Bodhankar SL. Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis. Int Immunopharmacol. 2015;28:751–763.
  • Fenning A, Harrison G, Rose’meyer R, Hoey A, Brown L. LArginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol. 2005;289:H1408–H1416.
  • Adil M, Kandhare A, Visnagri A, Bodhankar S. Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β and TNF-α. Ren Fail. 2015;37:1396–1407.
  • Kandhare AD, Patil MVK, Bodhankar SL. L-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs. Ren Fail. 2015;37:709–721.
  • Visnagri A, Kandhare AD, Bodhankar SL. Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation. Ren Fail. 2015;37:482–493.
  • Kumar VS, Rajmane AR, Adil M, Kandhare AD, Ghosh P, Bodhankar SL. Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 2014;28:132–145.
  • Patil MVK, Kandhare AD, Ghosh P, Bhise SD. Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals. Orient Pharm Exp Med. 2012;12:255–264.
  • Raygude KS, Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology. 2012;20:331–341.
  • Saraswathi KY, Muthal A, Kandhare A, Rojatkar S, Bodhankar S. Study of methanolic extract of Artemisia pallens wall on endurance of laboratory animals. Pharmacologia. 2014;5:298–309.
  • Sarkar A, Sengupta A, Mukhrjee A, et al. Antiulcer potential of morin in acetic acid-induced gastric ulcer via modulation of endogenous biomarkers in laboratory animals. Pharmacologia. 2015;6:273–281.
  • Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol. 2014;52:814–828.
  • Visnagri A, Kandhare AD, Shiva Kumar V, et al. Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol. 2012;2:157–172.
  • Prasad K. Antihypertensive activity of secoisolariciresinol diglucoside (SDG) isolated from flaxseed: role of guanylate cyclase. Int J Angiol. 2004;13:7–14.
  • Hayakawa H, Hirata Y, Suzuki E, et al. Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats. Hypertension. 1994;23:752–756.
  • Frohlich ED, Apstein C, Chobanian AV, et al. The heart in hypertension. N Engl J Med. 1992;327:998–1008.
  • Chan V, Hoey A, Brown L. Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats . Br J Pharmacol. 2006;148:902–908.
  • Leiba A, Vald A, Peleg E, Shamiss A, Grossman E. Does dietary recall adequately assess sodium, potassium, and calcium intake in hypertensive patients? Nutrition. 2005;21:462–466.
  • Schenk J, McNeill JH. The pathogenesis of DOCA-salt hypertension. J Pharmacol Toxicol Methods. 1992;27:161–170.
  • Iyer A, Chan V, Brown L. The DOCA-salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress. Curr Cardiol Rev. 2010;6:291.
  • Kojda G, Harrison D. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res. 1999;43:652–671.
  • Goswami S, Kandhare A, Zanwar AA, et al. Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. Int Wound J. 2016;13:116–124.
  • Kamble H, Kandhare AD, Bodhankar S, Mohan V, Thakurdesai P. Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol. 2013;3:145–151.
  • Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA. Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice. Regul Toxicol Pharmacol. 2015;72:323–334.
  • Kandhare AD, Bodhankar SL, Singh V, Mohan V, Thakurdesai PA. Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals. Biomed Aging Pathol. 2013;3:23–30.
  • Kandhare AD, Ghosh P, Bodhankar SL. Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chem Biol Interact. 2014;219:101–112.
  • Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol induced neuropathic pain. Fundam Clin Pharmacol. 2013;27:603–622.
  • Kandhare AD, Ghosh P, Ghule AE, Zambare GN, Bodhankar SL. Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin. Apollo Med. 2013;10:87–97.
  • Kandhare AD, Kumar VS, Adil M, Rajmane AR, Ghosh P, Bodhankar SL. Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker. Orient Pharm Exp Med. 2012;12:287–299.
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia. 2012;83:650–659.
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett. 2012;511:18–22.
  • Kandhare AD, Raygude KS, Shiva Kumar V, et al. Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol. 2012;2:173–186.
  • Kandhare AD, Shivakumar V, Rajmane A, Ghosh P, Bodhankar SL. Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury. J Nat Med. 2014;68:586–603.
  • Ketkar S, Rathore A, Kandhare A, et al. Alleviating exercise induced muscular stress using neat and processed bee pollen: Oxidative markers, mitochondrial enzymes and myostatin expression in rats. Integr Med Res. 2015;4:147–160
  • Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL. Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr. 2012;2:215–222.
  • Kidd PM. Glutathione: Systemic protectant against oxidative and free radical damage. Altern Med Rev. 1997;2:155–176.
  • Aswar UM, Kandhare AD, Mohan V, Thakurdesai PA. Anti-allergic effect of intranasal administration of type-A procyanidin polyphenols based standardized extract of cinnamon bark in ovalbumin sensitized BALB/c mice. Phytother Res. 2015;29:423–433.
  • Gosavi TP, Ghosh P, Kandhare AD, et al. Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals. Asian Pac J Trop Dis. 2012;2:S603–S611.
  • Armas-Padilla MC, Armas-Hernández MJ, Sosa-Canache B, et al. Nitric oxide and malondialdehyde in human hypertension. Am J Ther. 2007;14:172–176.
  • Matusiewicz M, Kosieradzka I, Zuk M, Szopa J. Effect of dose and administration period of seed cake of genetically modified and non-modified flax on selected antioxidative activities in rats. Int J Mol Sci. 2015;16:14259–14275.
  • Sarkar D, Latif S, Uddin M, et al. Studies on serum lipid profile in hypertensive patient. Mymensingh Med J. 2007;16:70–76.
  • Dimitrova A, Strashimirov D, Betova T, Russeva A, Alexandrova M. Zinc content in the diet affects the activity of Cu/ZnSOD, lipid peroxidation and lipid profile of spontaneously hypertensive rats. Acta Biol Hung. 2008;59:305–314.
  • Ameijeiras AH, Paz JL, Seijo MP, et al. Lipid profile in hypertensive patients treated with lipid lowering therapy: PP.23.446. J Hypertens. 2010;28:e378–e379.
  • Veeramani C, Al-Numair KS, Chandramohan G, Alsaif MA, Pugalendi KV. Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats. Asian Pac J Trop Med. 2012;5:434–439.
  • Girard A, Madani S, El Boustani ES, Belleville J, Prost J. Changes in lipid metabolism and antioxidant defense status in spontaneously hypertensive rats and Wistar rats fed a diet enriched with fructose and saturated fatty acids. Nutrition. 2005;21:240–248.
  • Bernard L, Kathy K. Reactive oxygen species in hypertension. Am J Hypertens. 2004;17:852–860.
  • Honmore V, Kandhare A, Zanwar AA, Rojatkar S, Bodhankar S, Natu A. Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers. Pharm Biol. 2015;53:571–581.
  • Kandhare A, Raygude K, Ghosh P, Bodhankar S. The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Int J Green Pharm. 2011;5:236–243.
  • Kandhare AD, Alam J, Patil MVK, Sinha A, Bodhankar SL. Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats. Pharm Biol. 2015;54:419–432.
  • Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA. Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem Biol Interact. 2015;237:151–165.
  • Hoetzel A, Welle A, Schmidt R, et al. Nitric oxide-deficiency regulates hepatic heme oxygenase-1. Nitric Oxide. 2008;18:61–69.
  • Hemalatha G, Pugalendi KV, Saravanan R. Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats. Mol Cell Biochem. 2013;379:255–265.
  • Navarro MC, Montialla M, Martín A, Jiménez J, Utrilla MP. Free radical scavenger and antihepatotoxic activity of Rosmarinus tomentosus. Planta Med. 1993;59:312–314.
  • Bhattacharjee N, Pathak S, Khuda-Bukhsh AR. Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum Sulphuricum 200. Evid Based Complement Alternat Med. 2009;6:65–75.
  • Mohring J, Mohring B, Naumann H, et al. Salt and water balance and renin activity in renal hypertension of rats. Am J Physiol Legacy Content. 1975;228:1847–1855.
  • Prahalathan P, Kumar S, Raja B. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: A dose dependent study. Asian Pac J Trop Biomed. 2012;2:443–448.
  • Mair J, Wagner I, Jakob G, et al. Different time courses of cardiac contractile proteins after acute myocardial infarction. Clin Chim Acta. 1994;231:47–60.

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