Honey and a Mixture of Honey, Beeswax, and Olive Oil–Propolis Extract in Treatment of Chemotherapy-Induced Oral Mucositis: A Randomized Controlled Pilot Study

REFERENCES

• Wojtaszek C. Management of chemotherapy-induced stomatitis. Clin J Oncol Nurs. 2000;4:263–270.
   PubMedGoogle Scholar
• Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Oncology. 2003;17:1767–1776.
   PubMedGoogle Scholar
• Rose-Ped AM, Bellm LA, Epstein JB, Complications of radiation therapy for head and neck cancers: the patient's perspective. Cancer Nurs. 2002;25:461– 467.
   PubMed Web of Science ®Google Scholar
• Eilers J. Nursing interventions and supportive care for the prevention and treatment of oral mucositis associated with cancer treatment. Oncol Nurs Forum. 2004;31(4 Suppl):13–23.
   PubMedGoogle Scholar
• White JW Jr. Composition of American Honeys. Washington, DC: Agricultural, Research Service, USDA; 1962. Technical Bulletin. 1261.
   Google Scholar
• White JW Jr. Detection of honey adulteration by carbohydrate analysis. J AOAC. 1980;63:11–18.
   Google Scholar
• Al Waili NS, Boni NS. Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food. 2003;6:129–33.
   PubMedGoogle Scholar
• Frankel S, Robinson GE, Berenbaum MR. Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Apic Res. 1998;37:27–31.
   Web of Science ®Google Scholar
• Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem. 2002;50:3050–3055.
   PubMed Web of Science ®Google Scholar
• Molan PC. The antibacterial activity of honey. 1. The nature of the antibacterial activity. Bee World. 1992;73:5–28. [Author]. xxx. 2. Variation in the potency of the antibacterial activity. Bee World. 1992;73:59–76.
   Web of Science ®Google Scholar
• Steinberg D, Kaine G, Gedalia I. Antibacterial effect of propolis and honey on oral bacteria. Am J Dent. 1996;9:236–239.
   PubMed Web of Science ®Google Scholar
• Molan PC. Honey as an antimicrobial agent. In: Mizrahi A, Lensky Y, eds. Bee Products: Properties, Applications and Apitherapy. London: Plenum; 1997:27–37.
   Google Scholar
• Theunissen F, Grobler S, Gedalia I. The antifungal action of three South, African honeys on Candida albicans. Apidologie. 2001;32:371–379.
   Web of Science ®Google Scholar
• Bardy J, Slevin NJ, Mais KL, Molassiotis A. A systematic review of honey uses and its potential value within oncology care. J Clin Nurs. 2008;17:2604–2623.
   PubMed Web of Science ®Google Scholar
• Molan PC. The potential of honey to promote oral wellness. Gen Dent. 2001;49:584–589.
   PubMedGoogle Scholar
• Khalil ML. Biological activity of bee propolis in health and disease. Asian, Pac J Cancer Prev. 2006;7:22–31.
   PubMedGoogle Scholar
• Golder W. [Propolis. The bee glue as presented by the Graeco-Roman literature]. Wurzbg Medizinhist Mitt. 2004;23:133–145. [in German]
   PubMedGoogle Scholar
• Ichihashi M, Ahmed NU, Budiyanto A, Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J Dermatol Sci. 2000;23(Suppl 1):S45–S50.
   Google Scholar
• Smith PP, Leith JT. Effects of topically-applied olive oil on the response of hamster skin to single or multiple doses of 230kV X-rays. Int J Radiat, Biol Relat Stud Phys Chem Med. 1977;31:467–475.
   PubMed Web of Science ®Google Scholar
• Harris DJ, Eilers J, Harriman A, Putting evidence into practice: evidence-based interventions for the management of oral mucositis. Clin J Oncol Nurs. 2008;12:141–152.
   PubMed Web of Science ®Google Scholar
• Elter JR, Champagne CME, Offenbacher S, Beck JD. Relationship of periodontal disease and tooth loss to prevalence of coronary heart disease. J Periodontol. 2004;75:782–790.
   PubMed Web of Science ®Google Scholar
• Hujoel PP, Drangsholt MT, Spiekerman C, Derouen TA. Periodontitis-systemic disease associations in the presence of smoking: causal or coincidental? J Periodontol. 2002;30:51–60.
   Google Scholar
• Schrappe M, Reiter A, Ludwig WD, Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood. 2000;95:3310–3322.
   PubMed Web of Science ®Google Scholar
• Volpato LE, Silva TC, Oliveira TM, Radiation therapy and chemotherapy-induced oral mucositis. Braz J Otorhinolaryngol. 2007;73:562–568.
   PubMedGoogle Scholar
• Turhal NS, Erdal S, Karacay S. Efficacy of treatment to relieve mucositis- induced discomfort. Support Care Cancer. 2000;8:55–58.
   PubMed Web of Science ®Google Scholar
• Migliorati CA, Oberle-Edwards L, Schubert M. The role of alternative natural agents, cryotherapy, and/or laser for management of alimentary mucositis. Support Care Cancer. 2006;14:533–540.
   PubMed Web of Science ®Google Scholar
• Arora H, Pai KM, Maiya A, Efficacy of He-12. Ne Laser in the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:180–186.
   PubMedGoogle Scholar
• Jaguar GC, Prado JD, Nishimoto IN, Low-energy laser therapy for prevention of oral mucositis in hematopoietic stem cell transplantation. Oral Dis. 2007;13:538–543.
   PubMedGoogle Scholar
• Bergman A, Yanai J, Weiss J, Acceleration of wound healing by topical application of honey. Am J Surg. 1983;145:374–376.
   PubMed Web of Science ®Google Scholar
• Molan PC. Honey as a topical antibacterial agent for the treatment of infected wounds. World Wide Wounds. 2001. Available at: http://www.worldwidewounds.com/2001/november/molan/honey-as-topical-agent.html. Accessed xxx.
   Google Scholar
• Stephen-Haynes J. Evaluation of a honey-impregnated tulle dressing in primary care. Br J Community Nurs Suppl. 2004;9:S21–S27.
   Google Scholar
• Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs. 2002;29:295–300.
   PubMedGoogle Scholar
• Anderson I. Honey dressings in wound care. Nurs Times. 2006;102:40–42.
   PubMedGoogle Scholar
• Hyslop PA, Hinshaw DB, Scraufstatter IU, Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med. 1995;19:31–37.
   PubMed Web of Science ®Google Scholar
• Chiba M, Idobata K, Kobayashi N, [Use of honey to ease the pain of stomatitis during radiotherapy]. Kangogaku Zasshi. 1985;49:171– 176.
   PubMedGoogle Scholar
• Smirnova II, Filatova EI, Suvorov AN, Bylinskaia EN. [The use of therapeutic/prophylactic dragee ‘honey laminolact’ in radiotherapy of uterine tumors]. Voprosy Onkologii. 2000;46:748–750.
   PubMedGoogle Scholar
• Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer. 2003;11:242– 248.
   PubMed Web of Science ®Google Scholar
• English HK, Pack AR, Molan PC. The effects of manuka honey on plaque and gingivitis: a pilot study. J Int Acad Periodontol. 2004;6:63–67.
   PubMedGoogle Scholar
• Moolenaar M, Poorter RL, Van, Der Toorn PP, The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients. Acta Oncol. 2006;45:623–624.
   PubMed Web of Science ®Google Scholar
• Simon A, Sofka K, Wiszniewsky G, Wound care with antibacterial honey (Medihoney) in pediatric hematology-oncology. Support Care Cancer. 2006;14:91–97.
   PubMed Web of Science ®Google Scholar
• Benderli Cihan Y, Deniz K. [Effect of propolis against radiation-induced oral mucositis in rats]. Kulak Burun Bogaz Ihtis Derg. 2011;21:32–41. [in Turkish]
   PubMedGoogle Scholar
• Bogdanov S. Beeswax: uses and trade. In: Bogdanov S, ed. The Beeswax Book. xx: Bee, Product Science; 2009:11–12. Available at: www.bee-hexagon.net. Accessed xxx.
   Google Scholar