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Original Article

Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities

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Pages 191-200 | Received 18 Oct 1993, Published online: 11 Jul 2009

References

  • Allison C, McFarlan C, MacFarlane GT. Studies on mixed populations of human intestinal bacteria grown in single-stage and multi-stage continuous culture system. Applied and Environmental Microbiology 1989; 55: 672–678
  • Berg JO, Nord CE, Wadstrom T. Formation of glycosidases in batch and continuous cultures of Bacteroides fragilis. Applied and Environmental Microbiology 1978; 35: 269–273
  • Bol J. Influences of food on microflora of the large intestine in man. Low Digestibility Carbohydrates., VJ Feron, RJJ Hermus. Leegwater, DC 1987; 103–113
  • Bradford M. Analytical and sensitive methods for the quantitation of microgram quantitive of protein utilizing the principal of protein dye binding. Analytical Biochemistry 1976; 72: 248–254
  • Callant D. Synthese en evaluatie van macromoleculaire prodrugs van 5–aminosalicylzuur. Proefschrift voorgedragen tot het behalen van de graad van doctor in de wetenschappen. Faculteit Wetenschappen, Universiteit Gent 1991; 205
  • Das KM, Dubin R. Clinical pharmacokinetics of sulfasalazine. Clinical Pharmacokinetics 1976; 1: 406–425
  • Dore J, Morvan B, Pochart P, Goderel I, Rieu-Lesme F, Fonty G, Rambaud J-C, Gouet P. Enumeration of bacteria forming acetate from H2 and CO2 and other H2-utilizing microorganisms from the digestive tract of animals and man. Proceedings of the Nutrition Society 1993; 52: 117A
  • Englyst HN, Hay S, MacFarlane GT. Polysaccharide breakdown by mixed populations of human faecal bacteria. FEMS Microbiology Ecology 1987; 95: 163–171
  • Finegold SM, Sutter VL, Mathisen GE. Normal indigenous intestinal flora. Human Intestinal Microflora in Health and Disease, DJ Hentges. Academic Press, London 1983; 3–31
  • Gibson GR, Cummings JH, MacFarlane GT. Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria. Applied and Environmental Microbiology 1988; 54: 2750–2755
  • Holdeman LV, Good IJ, Moore WEC. Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress. Applied and Environmental Microbiology 1976; 31: 359–375
  • Johansson M-L, Molin G, Jeppsson B, Nobaek S, Ahrne S, Bengmark S. Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora. Applied and Environmental Microbiology 1993; 59: 15–20
  • Miller TL, Wolin MJ. Fermentation by the human large intestinal microbial community in an in vitro semi-continuous culture system. Applied and Environmental Microbiology 1981; 42: 400–407
  • Molly K, Vande Woestyne M, Verstraete W. Development of a 5–step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Applied Microbiology and Biotechnology 1993; 39: 254–258
  • Peppercorn and Goldman. The role of intestinal bacteria in the metabolism of salicyl azo-sulphapyridine. Journal of Pharmacology and Experimental Therapeutics 1972; 181: 555–562
  • Van Assche P. Taxonomische studie van de Bacteroidaceae en de dominante species bij de big. Proefschrift voorgedragen tot het behalen van de graad van Doctor in de landbouwwetenschappen, Faculteit Landbouwwetenschappen. Universiteit Gent. 1978; 236
  • Veilleux B, Rowland IR. Simulation of the rat intestinal ecosystem using a two-stage continuous culture system. Journal of General Microbiology 1981; 123: 103–115
  • Wilkins TD, Chalgren S. Medium for use in antibiotic susceptibility testing of anaerobic bacteria. Antimicrobial Agents and Chemotherapy 1976; 10: 926–928