287
Views
21
CrossRef citations to date
0
Altmetric
Research Article

The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages

, , , , &
Pages 504-510 | Received 29 Mar 2010, Accepted 14 Dec 2010, Published online: 09 Feb 2011

References

  • Anderson MS, Bluestone JA. The NOD mouse: A model of immune dysregulation. Annu Rev Immunol. 2005; 23:447–485.
  • Bach JF, Chatenoud L. Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol. 2001; 19:131–161.
  • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004; 22:531–562.
  • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003; 299:1057–1061.
  • Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med. 2004; 199:1401–1408.
  • Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzwei MC, von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol. 2005; 6:1219–1227.
  • Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, Carlson MR, Li SH, Simpson PM, Chatila TA, Williams CBA. central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009; 182:3461–3468.
  • Curotto de Lafaille MA, Lino AC, Kutchukhidze N, Lafaille JJ. CD25− T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion. J Immunol. 2004; 173:7259–7268.
  • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med. 2003; 198:1875–1886.
  • Zheng SG, Wang J, Wang P, Gray JD. IL-2 Is Essential for TGF-β to convert naive CD4+CD25− cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007; 178:2018–2027.
  • Waid DM, Vaitaitis GM, Pennock NDJr, Wagner DH. Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol. 2008; 84:431–439.
  • Wu AJ, Hong H, Munson SH, McDevitt HO. Tumor necrosis factor-α regulation of CD4+C25+ T cell levels in NOD mice. Proc Natl Acad Sci USA. 2002; 99:12287–12292.
  • Berzins SP, Venanzi ES, Benoist C, Mathis D. T-cell compartments of prediabetic NOD mice. Diabetes. 2003; 52:327–334.
  • Mellanby RJ, Thomas D, Phillips JM, Cooke A. Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells. Immunology. 2007; 121:15–28.
  • Pop SM, Carmen PW, Donna AC, Stephen HC, Roland T. Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med. 2005; 201:1333–1346.
  • Gregori S, Nadia G, Simona S, Luciano A. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol. 2003; 171:4040–4047.
  • D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci USA. 2008; 105:19857–19862.
  • Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegle SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001; 27:68–73.
  • Schorle H, Holtschke T, Hünig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 1991; 352:621–624.
  • Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Proc Natl Acad Sci USA. 2000; 12:431–440.
  • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995; 155:1151–1164.
  • Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005; 201:723–735.
  • Chen Z, Benoist C, Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci USA. 2005; 102:14735–14740.
  • Fukushima K, Kobayashi M, Nagayama Y, Satoh T, Nakahara M, Kawasaki E, Yamasaki H, Ueha S, Matsushima K, Liu E, Eisenbarth GS, Eguchi K, Abiru N. Combined activation of innate and adaptive immunity with polyinosinic-polycytidylic acid and insulin B:9-23 self-peptide in the genetically susceptible NOD mouse: Differential effects on insulitis and diabetes progression. Biochem Biophys Res Commun. 2008; 367:719–724.
  • Kobayashi M, Abiru N, Arakawa T, Fukushima K, Zhou H, Kawasaki E, Yamasaki H, Liu E, Miao D, Wong FS, Eisenbarth GS, Eguchi K. Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes. J Immunol. 2007; 179:2082–2088.
  • Nakahara M, Nagayama Y, Sogawa R, Saitoh O, Tone S, Abiru N. Expression of immuno-regulatory molecules on the thyrocytes protects NOD-H2h4 mice from developing autoimmune thyroiditis. Endocrinology. 2009; 150:1545–1551.
  • Ansari MA, Dhar M, Spieker S, Bakht N, Rahman AM, Moore WV, Jacobson JD. Modulation of diabetes with gonadotropin-releasing hormone antagonists in the nonobese mouse model of autoimmune diabetes. Endocrinology. 2004; 145:337–342.
  • Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endor Rev. 1994; 15:516–535.
  • McHugh RS, Shevach EM. Depletion of CD4+CD25+ Regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol. 2002; 168:5979–5983.
  • Alyanakian MA, You S, Damotte D, Gouarin C, Esling A, Garcia C, Havouis S, Chatenoud L, Bach JF. Diversity of regulatory CD4+ T cells controlling distinct organ-specific autoimmune diseases. Proc Natl Acad Sci USA. 2003; 100:15806–15811.
  • Abiru N, Yu L, Miao D, Maniatis AK, Liu E, Moriyama H, Eisenbarth GS. Transient insulin autoantibody expression independent of development of diabetes: Comparison of NOD and NOR strains. J Autoimmun. 2001; 17:1–6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.