CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells

References

• Neefjes, J., M. L. Jongsma, P. Paul, and O. Bakke. 2011. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 11: 823–836
   PubMed Web of Science ®Google Scholar
• Kurts, C., B. W. Robinson, and P. A. Knolle. 2010. Cross-priming in health and disease. Nat Rev Immunol. 10: 403–414
   PubMed Web of Science ®Google Scholar
• Medzhitov, R., and C. A. Janeway. Jr2002. Decoding the patterns of self and nonself by the innate immune system. Science. 296: 298–300
   PubMed Web of Science ®Google Scholar
• Matzinger, P. 2002. The danger model: a renewed sense of self. Science. 296: 301–305
   PubMed Web of Science ®Google Scholar
• Groettrup, M., C. J. Kirk, and M. Basler. 2010. Proteasomes in immune cells: more than peptide producers? Nat Rev Immunol. 10: 73–78
   PubMed Web of Science ®Google Scholar
• Macagno, A., M. Gilliet, F. Sallusto, A. Lanzavecchia, F. O. Nestle, and M. Groettrup. 1999. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation. Eur J Immunol. 29: 4037–4042
   PubMed Web of Science ®Google Scholar
• Li, J., B. Schuler-Thurner, G. Schuler, C. Huber, and B. Seliger. 2001. Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation. Int Immunol. 13: 1515–1523
   PubMed Web of Science ®Google Scholar
• Gaczynska, M., K. L. Rock, and A. L. Goldberg. 1993. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 365: 264–267
   PubMed Web of Science ®Google Scholar
• Driscoll, J., M. G. Brown, D. Finley, and J. J. Monaco. 1993. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature. 365: 262–264
   PubMed Web of Science ®Google Scholar
• Kuckelkorn, U., S. Frentzel, R. Kraft, S. Kostka, M. Groettrup, and P. M. Kloetzel. 1995. Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma. Eur J Immunol. 25: 2605–2611
   PubMed Web of Science ®Google Scholar
• Groettrup, M., C. J. Kirk, and M. Basler. 2010. Proteasomes in immune cells: more than peptide producers? Nat Rev Immunol. 10: 73–78
   PubMed Web of Science ®Google Scholar
• Klein, L., M. Hinterberger, G. Wirnsberger, and B. Kyewski. 2009. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol. 9: 833–844
   PubMed Web of Science ®Google Scholar
• Chen, W., C. C. Norbury, Y. Cho, J. W. Yewdell, and J. R. Bennink. 2001. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med. 193: 1319–1326
   PubMed Web of Science ®Google Scholar
• Nil, A., E. Firat, V. Sobek, K. Eichmann, and G. Niedermann. 2004. Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets. Eur J Immunol. 34: 2681–2689
   PubMed Web of Science ®Google Scholar
• Osterloh, P., K. Linkemann, S. Tenzer, H. G. Rammensee, M. P. Radsak, D. H. Busch, and H. Schild. 2006. Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci USA. 103: 5042–5047
   PubMed Web of Science ®Google Scholar
• Basler, M., J. Moebius, L. Elenich, M. Groettrup, and J. J. Monaco. 2006. An altered T cell repertoire in MECL-1-deficient mice. J Immunol. 176: 6665–6672
   PubMed Web of Science ®Google Scholar
• Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity. 13: 829–840
   PubMed Web of Science ®Google Scholar
• Eleftheriadis, T., S. Voyatzi, G. Antoniadi, C. Kartsios, V. Liakopoulos, P. Paraskevopoulos, and G. Galaktidou. 2006. Major histocompatibility complex class I restricted T-cell autoreactivity in human peripheral blood mononuclear cells. Cell Immunol. 240: 62–67
   PubMed Web of Science ®Google Scholar
• Leblond, J., A. Hubert-Buron, C. Bole-Feysot, P. Ducrotte, P. Dechelotte, and M. Coeffier. 2006. Regulation of proteolysis by cytokines in the human intestinal epithelial cell line HCT-8: role of IFNgamma. Biochimie. 88: 759–765
   PubMed Web of Science ®Google Scholar
• Hallermalm, K., K. Seki, C. Wei, C. Castelli, L. Rivoltini, R. Kiessling, and J. Levitskaya. 2001. Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface. Blood. 98: 1108–1115
   PubMed Web of Science ®Google Scholar
• Shin, E. C., U. Seifert, T. Kato, C. M. Rice, S. M. Feinstone, P. M. Kloetzel, and B. Rehermann. 2006. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest. 116: 3006–3014
   PubMed Web of Science ®Google Scholar
• Khan, S., M. van den Broek, K. Schwarz, R. de Giuli, P. A. Diener, and M. Groettrup. 2001. Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol. 167: 6859–6868
   PubMed Web of Science ®Google Scholar
• Barton, L. F., M. Cruz, R. Rangwala, G. S. Deepe, Jr.and J. J. Monaco. 2002. Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. J Immunol. 169: 3046–3052
   PubMed Web of Science ®Google Scholar
• Kesmir, C., V. van Noort, R. J. de Boer, and P. Hogeweg. 2003. Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome. Immunogenetics. 55: 437–449
   PubMed Web of Science ®Google Scholar
• Chapiro, J., S. Claverol, F. Piette, W. Ma, V. Stroobant, B. Guillaume, J. E. Gairin, et al. 2006. Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation. J Immunol. 176: 1053–1061
   Google Scholar
• Robek, M. D., M. L. Garcia, B. S. Boyd, and F. V. Chisari. 2007. Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus. J Virol. 81: 483–491
   PubMed Web of Science ®Google Scholar
• Dannull, J., D. T. Lesher, R. Holzknecht, W. Qi, G. Hanna, H. Seigler, D. S. Tyler, and S. K. Pruitt. 2007. Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. Blood. 110: 4341–4350
   PubMed Web of Science ®Google Scholar
• Dalet, A., V. Stroobant, N. Vigneron, and B. J. Van den Eynde. 2011. Differences in the production of spliced antigenic peptides by the standard proteasome and the immunoproteasome. Eur J Immunol. 41: 39–46
   PubMed Web of Science ®Google Scholar
• Hutchinson, S., S. Sims, G. O'Hara, J. Silk, U. Gileadi, V. Cerundolo, and P. Klenerman. 2011. A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus. PLoS One. 6: e14646
   Web of Science ®Google Scholar
• Eleftheriadis, T. 2012. The existence of two types of proteasome, the constitutive proteasome and the immunoproteasome, may serve as another layer of protection against autoimmunity. Med Hypotheses. 78: 138–141
   PubMed Web of Science ®Google Scholar
• Nelson, J. E., A. Loukissa, C. Altschuller-Felberg, J. J. Monaco, J. T. Fallon, and C. Cardozo. 2000. Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats. J Lab Clin Med. 135: 324–331
   PubMed Web of Science ®Google Scholar
• Bijuklic, K., D. H. Sturn, P. Jennings, J. Kountchev, W. Pfaller, C. J. Wiedermann, J. R. Patsch, and M. Joannidis. 2006. Mechanisms of neutrophil transmigration across renal proximal tubular HK-2 cells. Cell Physiol Biochem. 17: 233–244
   PubMed Web of Science ®Google Scholar
• Anikeeva, N., K. Somersalo, T. N. Sims, V. K. Thomas, M. L. Dustin, and Y. Sykulev. 2005. Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci USA. 102: 6437–6442
   PubMed Web of Science ®Google Scholar
• Kincaid, E. Z., J. W. Che, I. York, H. Escobar, E. Reyes-Vargas, J. C. Delgado, R. M. Welsh, et al. 2012. Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol. 13: 129–135
   Web of Science ®Google Scholar
• Muchamuel, T., M. Basler, M. A. Aujay, E. Suzuki, K. W. Kalim, C. Lauer, C. Sylvain, et al. 2009. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med. 15: 781–787
   PubMed Web of Science ®Google Scholar
• Basler, M., M. Dajee, C. Moll, M. Groettrup, and C. J. Kirk. 2010. Prevention of experimental colitis by a selective inhibitor of the immunoproteasome. J Immunol. 185: 634–641
   PubMed Web of Science ®Google Scholar
• Nagayama, Y., M. Nakahara, M. Shimamura, I. Horie, K. Arima, and N. Abiru. 2012. Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice. Clin Exp Immunol. 168: 268–273
   PubMed Web of Science ®Google Scholar
• Zinkernagel, R. M., and P. C. Doherty. 1974. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature. 248: 701–702
   PubMed Web of Science ®Google Scholar
• Anikeeva, N., and Y. Sykulev. 2011. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes. Immunol Res. 51: 183–194
   PubMed Web of Science ®Google Scholar
• La Cava, A. 2011. Regulatory immune cell subsets in autoimmunity. Autoimmunity. 44: 1–2
   PubMed Web of Science ®Google Scholar
• Hampe, C. S. 2012. Protective role of anti-idiotypic antibodies in autoimmunity—lessons for type 1 diabetes. Autoimmunity. 45: 320–331
   PubMed Web of Science ®Google Scholar
• Munoz, L. E., and M. Herrmann. 2012. When autologous chromatin becomes a foe. Autoimmunity. 45: 565–567
   PubMed Web of Science ®Google Scholar