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Original Article

Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1

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Pages 532-541 | Received 21 Jul 2014, Accepted 19 Jul 2015, Published online: 20 Aug 2015

References

  • Aaltonen, J., P. Björses, J. Perheentupa, et al. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17: 399–403
  • Nagamine, K., P. Peterson, H. S. Scott, et al. 1997. Positional cloning of the APECED gene. Nat. Genet. 17: 393–398
  • Gardner, J. M., J. J. Devoss, R. S. Friedman, et al. 2008. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 321: 843–847
  • Pitkänen, J., P. Vähämurto, K. Krohn, and P. Peterson. 2001. Subcellular localization of the autoimmune regulator protein. Characterization of nuclear targeting and transcriptional activation domain. J. Biol. Chem. 276: 19597–19602
  • Anderson, M. S., E. S. Venanzi, L. Klein, et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298: 1395–1401
  • Ramsey, C., O. Winqvist, L. Puhakka, et al. 2002. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11: 397–409
  • Gavanescu, I., B. Kessler, H. Ploegh, et al. 2007. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc. Natl. Acad. Sci. U.S.A. 104: 4583–4587
  • Suzuki, E., Y. Kobayashi, O. Kawano, et al. 2008. Expression of AIRE in thymocytes and peripheral lymphocytes. Autoimmunity 41: 133–139
  • Ahonen, P., S. Myllärniemi, I. Sipilä, and J. Perheentupa. 1990. Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N. Engl. J. Med. 322: 1829–1836
  • Perniola, R., A. Falorni, M. G. Clemente, et al. 2000. Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Eur. J. Endocrinol. 143: 497–503
  • Laakso, S. M., E. Kekäläinen, N. Heikkilä, et al. 2014. In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy provides evidence in support of an IL-22 defect. Autoimmunity 47: 556–562
  • Kemp, E. H., M. Habibullah, N. Kluger, et al. 2014. Prevalence and clinical associations of calcium-sensing receptor and NALP5 autoantibodies in Finnish APECED patients. J. Clin. Endocrinol. Metab. 99: 1064–1071
  • Lefranc, D., L. Almeras, S. Dubucquoi, et al. 2004. Distortion of the self-reactive IgG antibody repertoire in multiple sclerosis as a new diagnostic tool. J. Immunol. 172: 669–678
  • Almeras, L., D. Lefranc, H. Drobecq, et al. 2004. New antigenic candidates in multiple sclerosis: identification by serological proteome analysis. Proteomics. 4: 2184–2194
  • Lefranc, D., D. Launay, S. Dubucquoi, et al. 2007. Characterization of discriminant human brain antigenic targets in neuropsychiatric systemic lupus erythematosus using an immunoproteomic approach. Arthritis Rheum. 56: 3420–3432
  • Mouthon, L., M. Haury, S. Lacroix-Desmazes, et al. 1995. Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J. Immunol. 154: 5769–5778
  • Neufeld, M., N. Maclaren, and R. Blizzard. 1980. Autoimmune polyglandular syndromes. Pediatr. Ann. 9: 154–162
  • Saugier-Veber, P., N. Drouot, L. M. Wolf, et al. 2001. Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Eur. J. Endocrinol. 144: 347–351
  • Maurice, P., A. M. Daulat, C. Broussard, et al. 2008. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Mol. Cell Proteomics. 7: 1556–1569
  • Popler, J., M. Alimohammadi, O. Kämpe, et al. 2012. Autoimmune polyendocrine syndrome type 1: utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab. Pediatr. Pulmonol. 47: 84–87
  • Avrameas, S., and T. Ternynck. 1995. Natural autoantibodies: the other side of the immune system. Res. Immunol. 146: 235–248
  • Taylor, J. J., M. K. Jenkins, and K. A. Pape. 2012. Heterogeneity in the differentiation and function of memory B cells. Trends Immunol. 33: 590–597
  • Pillai, S., A. Cariappa, and S. T. Moran. 2005. Marginal zone B cells. Annu. Rev. Immunol. 23: 161–196
  • Weill, J.-C., S. Weller, and C.-A. Reynaud. 2009. Human marginal zone B cells. Annu. Rev. Immunol. 27: 267–285
  • Niki, S., K. Oshikawa, Y. Mouri, et al. 2006. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116: 1292–1301
  • Martin, F., and J. F. Kearney. 2000. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity. 12: 39–49
  • Ramsey, C., S. Hässler, P. Marits, et al. 2006. Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator. Eur. J. Immunol. 36: 305–317
  • Lindh, E., S. M. Lind, E. Lindmark, et al. 2008. AIRE regulates T-cell-independent B-cell responses through BAFF. Proc. Natl. Acad. Sci. U.S.A. 105: 18466–18471
  • Perheentupa, J. 2006. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Clin. Endocrinol. Metab. 91: 2843–2850
  • Proust-Lemoine, E., P. Saugier-Veber, H. Lefebvre, et al. 2010. Autoimmune polyendocrine syndrome type 1. Arch. Pediatr. 17: 597–598
  • Ekwall, O., H. Hedstrand, L. Grimelius, et al. 1998. Identification of tryptophan hydroxylase as an intestinal autoantigen. Lancet. 352: 279–283
  • Sköldberg, F., G. M. Portela-Gomes, L. Grimelius, et al. 2003. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. J. Clin. Endocrinol. Metab. 88: 1445–1452
  • Ward, L., J. Paquette, E. Seidman, et al. 1999. Severe autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: response to immunosuppressive therapy. J. Clin. Endocrinol. Metab. 84: 844–852
  • Högenauer, C., R. L. Meyer, G. J. Netto, et al. 2001. Malabsorption due to cholecystokinin deficiency in a patient with autoimmune polyglandular syndrome type I. N. Engl. J. Med. 344: 270–274
  • Scirè, G., F. M. Magliocca, S. Cianfarani, et al. 1991. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency. J. Pediatr. Gastroenterol. Nutr. 13: 224–227
  • Jiang, W., M. S. Anderson, R. Bronson, D. Mathis, and C. Benoist. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202: 805–815
  • Grimshaw, C. E., and E. J. Mathur. 1989. Immunoquantitation of aldose reductase in human tissues. Anal. Biochem. 176: 66–71
  • Karasawa, R., S. Ozaki, K. Nishioka, and T. Kato. 2005. Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. Microbiol. Immunol. 49: 57–65
  • Iwata, Y., F. Ogawa, K. Komura, et al. 2007. Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress. Rheumatology (Oxford). 46: 790–795
  • Iizuka, N., K. Okamoto, R. Matsushita, et al. 2010. Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement. Lupus. 19: 717–726

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