226
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells

, &
Pages 473-479 | Received 18 Sep 2010, Accepted 06 Nov 2010, Published online: 13 Dec 2010

References

  • Tong, X., Van Dross, R.T., Abu-Yousif, A., Morrison, A.R., Pelling, J.C. Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. Mol. Cell. Biol. 2007, 27, 283–296.
  • Zhu, Z., Homer, R.J., Wang, Z., Chen, Q., Geba, G.P., Wang, J., Zhang, Y., Elias, J.A. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999, 103, 779–788.
  • Royer, B., Varadaradjalou, S., Saas, P., Gabiot, A.C., Kantelip, B., Féger, F., Guillosson, J.J., Kantelip, J.P., Arock, M. Autocrine regulation of cord blood-derived human mast cell activation by IL-10. J. Allergy Clin. Immunol. 2001, 108, 80–86.
  • Stassen, M., Müller, C., Arnold, M., Hültner, L., Klein-Hessling, S., Neudörfl, C., Reineke, T., Serfling, E., Schmitt, E. IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9. J. Immunol. 2000, 166, 4391–4398.
  • Barnes, P.J., Adcock, I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 1993, 14, 436–441.
  • Arend, W.P., Dayer, J.M. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 1995, 38, 151–160.
  • Butler, D.M., Maini, R.N., Feldmann, M., Brennan, F.M. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytokine Netw. 1995, 6, 225–230.
  • Rasmussen, H., Goodman, D.B. Relationships between calcium and cyclic nucleotides in cell activation. Physiol. Rev. 1977, 57, 421–509.
  • White, J.R., Pluznik, D.H., Ishizaka, K., Ishizaka, T. Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells. Proc. Natl. Acad. Sci. U.S.A. 1985, 82, 8193–8197.
  • Kim, M.S., Lim, W.K., Park, R.K., Shin, T., Yoo, Y.H., Hong, S.H., An, N.H., Kim, H.M. Involvement of mitogen-activated protein kinase and NF-kappaB activation in Ca2+-induced IL-8 production in human mast cells. Cytokine 2005, 32, 226–233.
  • Jeong, H.J., Hong, S.H., Lee, D.J., Park, J.H., Kim, K.S., Kim, H.M. Role of Ca(2+) on TNF-alpha and IL-6 secretion from RBL-2H3 mast cells. Cell. Signal. 2002, 14, 633–639.
  • Pastore, S., Fanales-Belasio, E., Albanesi, C., Chinni, L.M., Giannetti, A., Girolomoni, G. Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin. J. Clin. Invest. 1997, 99, 3009–3017.
  • Newton, R., Kuitert, L.M., Bergmann, M., Adcock, I.M., Barnes, P.J. Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem. Biophys. Res. Commun. 1997, 237, 28–32.
  • Kang, O.H., Lee, G.H., Choi, H.J., Park, P.S., Chae, H.S., Jeong, S.I., Kim, Y.C., Sohn, D.H., Park, H., Lee, J.H., Kwon, D.Y. Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha via mitogen-activated protein kinases and nuclear factor-kappaB in macrophages. Pharmacol. Res. 2007, 55, 263–270.
  • Salgame, P., Abrams, J.S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R.L., Bloom, B.R. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991, 254, 279–282.
  • Grynkiewicz, G., Poenie, M., Tsien, R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260, 3440–3450.
  • Kim, S.J., Jeong, H.J., Choi, I.Y., Lee, K.M., Park, R.K., Hong, S.H., Kim, H.M. Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells. J. Pharmacol. Exp. Ther. 2005, 314, 27–34.
  • Azzolina, A., Bongiovanni, A., Lampiasi, N. Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim. Biophys. Acta 2003, 1643, 75–83.
  • Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Wewers, M.D., Guttridge, D.C., Grotewold, E., Doseff, A.I. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J. Immunol. 2007, 179, 7121–7127.
  • Baeuerle, P.A., Baichwal, V.R. NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv. Immunol. 1997, 65, 111–137.
  • Pan, M.H., Lin-Shiau, S.Y., Ho, C.T., Lin, J.H., Lin, J.K. Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem. Pharmacol. 2000, 59, 357–367.
  • Hide, I., Toriu, N., Nuibe, T., Inoue, A., Hide, M., Yamamoto, S., Nakata, Y. Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription, and degranulation. J. Immunol. 1997, 159, 2932–2940.
  • Beaven, M.A., Moore, J.P., Smith, G.A., Hesketh, T.R., Metcalfe, J.C. The calcium signal and phosphatidylinositol breakdown in 2H3 cells. J. Biol. Chem. 1984, 259, 7137–7142.
  • Blackwell, T.S., Blackwell, T.R., Christman, J.W. Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J. Immunol. 1997, 158, 5934–5940.
  • Jeong, H.J., Na, H.J., Hong, S.H., Kim, H.M. Inhibition of the stem cell factor-induced migration of mast cells by dexamethasone. Endocrinology 2003, 144, 4080–4086.
  • Bochenek, G., Nizankowska, E., Gielicz, A., Swierczynska, M., Szczeklik, A. Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. Thorax 2004, 59, 459–464.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.