106
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Pentoxifylline decreases soluble CD40 ligand concentration and CD40 gene expression in coronary artery disease patients

, , , &
Pages 523-529 | Received 20 Jun 2011, Accepted 05 Sep 2011, Published online: 15 Oct 2011

References

  • Corrado, E., Rizzo, M., Coppola, G., Fattouch, K., Novo, G., Marturana, I., Ferrara, F., Novo, S. An update on the role of markers of inflammation in atherosclerosis. J Atheroscler Thromb 2010, 17, 1–11.
  • Patel, S., Celermajer, D.S., Bao, S. Atherosclerosis-underlying inflammatory mechanisms and clinical implications. Int J Biochem Cell Biol 2008, 40, 576–580.
  • Wibaut-Berlaimont, V., Randi, A.M., Mandryko, V., Lunnon, M.W., Haskard, D.O., Naoumova, R.P. Atorvastatin affects leukocyte gene expression in dyslipidemia patients: In vivo regulation of hemostasis, inflammation and apoptosis. J Thromb Haemost 2005, 3, 677–685.
  • Blanco-Colio, L.M., Martín-Ventura, J.L., de Teresa, E., Farsang, C., Gaw, A., Gensini, G., Leiter, L.A., Langer, A., Martineau, P., Egido, J.; ACTFAST investigators. Atorvastatin decreases elevated soluble CD40L in subjects at high cardiovascular risk. Atorvastatin on inflammatory markers study: A substudy of ACTFAST. Kidney Int Suppl 2008, 74, S60–S63.
  • Kinlay, S., Schwartz, G.G., Olsson, A.G., Rifai, N., Sasiela, W.J., Szarek, M., Ganz, P., Libby, P.; Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study. Circulation 2004, 110, 386–391.
  • Hu, W.L., Qiao, S.B., Qian, S.B., Li, J.J. Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. Cytokine 2007, 40, 201–206.
  • Serrano, C.V. Jr, Pesaro, A.E., de Lemos, J.A., Rached, F., Segre, C.A., Gomes, F., Ribeiro, A.F., Nicolau, J.C., Yoshida, V.M., Monteiro, H.P. Native LDL-cholesterol mediated monocyte adhesion molecule overexpression is blocked by simvastatin. Cardiovasc Drugs Ther 2009, 23, 215–220.
  • Gómez-Garre, D., Muñoz-Pacheco, P., González-Rubio, M.L., Aragoncillo, P., Granados, R., Fernández-Cruz, A. Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect. Br J Pharmacol 2009, 156, 1218–1227.
  • Schönbeck, U., Libby, P. CD40 signaling and plaque instability. Circ Res 2001, 89, 1092–1103.
  • Davì, G., Tuttolomondo, A., Santilli, F., Basili, S., Ferrante, E., Di Raimondo, D., Pinto, A., Licata, G. CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke. J Atheroscler Thromb 2009, 16, 707–713.
  • Monaco, C., Andreakos, E., Kiriakidis, S., Mauri, C., Bicknell, C., Foxwell, B., Cheshire, N., Paleolog, E., Feldmann, M. Canonical pathway of nuclear factor κ B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci USA 2004, 101, 5634–5639.
  • Fuchs, D., Piller, R., Linseisen, J., Daniel, H., Wenzel, U. The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis. Proteomics 2007, 7, 3278–3288.
  • Fuchs, D., Vafeiadou, K., Hall, W.L., Daniel, H., Williams, C.M., Schroot, J.H., Wenzel, U. Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones. Am J Clin Nutr 2007, 86, 1369–1375.
  • Devaraj, S., Jialal, I. Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: Biomediator activity. Arch Pathol Lab Med 2008, 132, 1432–1435.
  • Zhang, M., Xu, Y.J., Mengi, S.A., Arneja, A.S., Dhalla, N.S. Therapeutic potentials of pentoxifylline for treatment of cardiovascular diseases. Exp Clin Cardiol 2004, 9, 103–111.
  • Vukanic, Z.S., Colic, M., Dimitrijevic, M. Effect of pentoxifylline on differentiation and maturation of human monocyte-derived dendritic cells in vitro. Int Immunopharmacol 2007, 7, 167–174.
  • Maiti, R., Agrawal, N.K., Dash, D., Pandey, B.L. Effect of Pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients. Vascul Pharmacol 2007, 47, 118–124.
  • Fernandes, J.L., de Oliveira, R.T., Mamoni, R.L., Coelho, O.R., Nicolau, J.C., Blotta, M.H., Serrano, C.V.Jr..Pentoxifylline reduces pro-inflammatory and increases anti-inflammatory activity in patients with coronary artery disease–a randomized placebo-controlled study. Atherosclerosis 2008, 196, 434–442.
  • Prasad, K., Lee, P. Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. Atherosclerosis 2007, 192, 313–322.
  • Zhang, M., Xu, Y.J., Saini, H.K., Turan, B., Liu, P.P., Dhalla, N.S. Pentoxifylline attenuates cardiac dysfunction and reduces TNF-α level in ischemic-reperfused heart. Am J Physiol Heart Circ Physiol 2005, 289, H832–H839.
  • Chen, Y.M., Tu, C.J., Hung, K.Y., Wu, K.D., Tsai, T.J., Hsieh, B.S. Inhibition by pentoxifylline of TNF-α-stimulated fractalkine production in vascular smooth muscle cells: Evidence for mediation by NF-κB down-regulation. Br J Pharmacol 2003, 138, 950–958.
  • Lutgens, E., Lievens, D., Beckers, L., Donners, M., Daemen, M. CD40 and its ligand in atherosclerosis. Trends Cardiovasc Med 2007, 17, 118–123.
  • Rizvi, M., Pathak, D., Freedman, J.E., Chakrabarti, S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med 2008, 14, 530–538.
  • Santilli, F., Basili, S., Ferroni, P., Davì, G. CD40/CD40L system and vascular disease. Intern Emerg Med 2007, 2, 256–268.
  • Lutgens, E., Daemen, M.J. CD40-CD40L interactions in atherosclerosis. Trends Cardiovasc Med 2002, 12, 27–32.
  • Fouad, H.H., Al-Dera, H., Bakhoum, S.W., Rashed, L.A., Sayed, R.H., Rateb, M.A., Haidara, M.A., Soskic, S., Isenovic, E.R. Levels of sCD40 ligand in chronic and acute coronary syndromes and its relation to angiographic extent of coronary arterial narrowing. Angiology 2010, 61, 567–573.
  • Danese, S., Sans, M., Scaldaferri, F., Sgambato, A., Rutella, S., Cittadini, A., Piqué, J.M., Panes, J., Katz, J.A., Gasbarrini, A., Fiocchi, C. TNF-α blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: A novel anti-inflammatory mechanism of infliximab in Crohn’s disease. J Immunol 2006, 176, 2617–2624.
  • Lu, L.F., Cook, W.J., Lin, L.L., Noelle, R.J. CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site. J Biol Chem 2003, 278, 45414–45418.
  • Fotin-Mleczek, M., Henkler, F., Hausser, A., Glauner, H., Samel, D., Graness, A., Scheurich, P., Mauri, D., Wajant, H. Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-κB activation. J Biol Chem 2004, 279, 677–685.
  • Vircheva, S., Alexandrova, A., Georgieva, A., Mateeva, P., Zamfirova, R., Kubera, M., Kirkova, M. In vivo effects of pentoxifylline on enzyme and non-enzyme antioxidant levels in rat liver after carrageenan-induced paw inflammation. Cell Biochem Funct 2010, 28, 668–672.
  • Cominacini, L., Anselmi, M., Garbin, U., Fratta Pasini, A., Stranieri, C., Fusaro, M., Nava, C., Agostoni, P., Keta, D., Zardini, P., Sawamura, T., Lo Cascio, V. Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-κB activation in patients with unstable angina. J Am Coll Cardiol 2005, 46, 799–806.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.