444
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells

, , , , , , , , , , & show all
Pages 215-224 | Received 19 Jun 2012, Accepted 23 Oct 2012, Published online: 21 Nov 2012

References

  • McCuskey RS, Urbaschek R, Urbaschek B. The microcirculation during endotoxemia. Cardiovasc Res 1996;32:752–63
  • Cheong MH, Lee SR, Yoo HS, et al. Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappaB activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol 2011;137:1402–8
  • De Boever S, Beyaert R, Vandemaele F, et al. The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens. Avian Pathol 2008;37:39–44
  • Lorenzoni AG, Wideman RF Jr. Intratracheal administration of bacterial lipopolysaccharide elicits pulmonary hypertension in broilers with primed airways. Poult Sci 2008;87:645–54
  • Shih MF, Chen LY, Tsai PJ, Cherng JY. In vitro and in vivo therapeutics of beta-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice. Int J Immunopathol Pharmacol 2012;25:39–48
  • Dixon B. The role of microvascular thrombosis in sepsis. Anaesth Intensive Care 2004;32:619–29
  • Santiago-Delpin EA. The endothelium and early immune activation: new perspective and interactions. Transplant Proc 2004;36:1709–13
  • Kumar P, Shen Q, Pivetti CD, et al. Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev Mol Med 2009;11:e19
  • Danese S, Dejana E, Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 2007;178:6017–22
  • Davies MG, Hagen PO. The vascular endothelium. A new horizon. Ann Surg 1993;218:593–609
  • Han XH, Liu P, Zhang YY, et al. Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes. J Tradit Chin Med 2011;31:321–6
  • Zhang Y, Hu G, Li S, et al. Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo. Mol Med Report 2012;5:805–11
  • Gu X, Jiang D, Wang Y, et al. Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen. Mol Med Report 2012;6:115–20
  • Li M, Qu YZ, Zhao ZW, et al. Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules. Neurochem Int 2012;60:458–65
  • Zhu HL, Huang CL, Wang WJ, et al. Effects of andrographolide on the concentration of cytokines in BALF and the expressions of type I and III collagen mRNA in lung tissue in bleomycin-induced rat pulmonary fibrosis. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011;27:725–9
  • Chen HW, Lin AH, Chu HC, et al. Inhibition of TNF-alpha-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway. J Nat Prod 2011;74:2408–13
  • Lee KC, Chang HH, Chung YH, Lee TY. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-kappaB pathway. J Ethnopharmacol 2011;135:678–84
  • Shao ZJ, Zheng XW, Feng T, et al. Andrographolide exerted its antimicrobial effects by upregulation of human beta-defensin-2 induced through p38 MAPK and NF-kappaB pathway in human lung epithelial cells. Can J Physiol Pharmacol 2012;90:647–53
  • Wang B, Tang C, Han Y, et al. Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives. Med Chem 2012;8:293–8
  • Gunn EJ, Williams JT, Huynh DT, et al. The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leuk Lymphoma 2011;52:1085–97
  • Kilani S, Ben Sghaier M, Limem I, et al. In vitro evaluation of antibacterial, antioxidant, cytotoxic and apoptotic activities of the tubers infusion and extracts of Cyperus rotundus. Bioresour Technol 2008;99:9004–8
  • Yu HH, Lee DH, Seo SJ, You YO. Anticariogenic properties of the extract of Cyperus rotundus. Am J Chin Med 2007;35:497–505
  • Kilani S, Ben Ammar R, Bouhlel I, et al. Investigation of extracts from (Tunisian) Cyperus rotundus as antimutagens and radical scavengers. Environ Toxicol Pharmacol 2005;20:478–84
  • He CL, Fu BD, Shen HQ, et al. Xiang-qi-tang increases avian pathogenic Escherichia coli-induced survival rate and regulates serum levels of tumor necrosis factor alpha, interleukin-1 and soluble endothelial protein C receptor in chicken. Biol Pharm Bull 2011;34:379–82
  • Zhang TTKD, Tian QC, Tian LF, Mu X. The culture of myocardial microvascular endothelial cells of suckling rats in vitro. Acta Anatomica Sinica 2008;39:3
  • Pennica D, Nedwin GE, Hayflick JS, et al. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature 1984;312:724–9
  • Ranta V, Orpana A, Carpen O, et al. Human vascular endothelial cells produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation. Crit Care Med 1999;27:2184–7
  • Morita M, Yano S, Yamaguchi T, et al. Phenylacetic acid stimulates reactive oxygen species generation and tumor necrosis factor-alpha secretion in vascular endothelial cells. Ther Apher Dial 2011;15:147–50
  • Cendan JC, Moldawer LL, Souba WW, et al. Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines. Arch Surg 1994;129:1296–300
  • Hu Y, Chen X, Lin H, et al. Study on the antiendotoxin action of Pulsatillae Decoction using an Affymetrix rat genome array. Cell Immunol 2009;257:32–7
  • Grellner W. Time-dependent immunohistochemical detection of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci Int 2002;130:90–6
  • Liao XX, Li X, Ma ZF, et al. Preventive effect of Ginkgo biloba extract on endothelial cells in rat models with atherosclerosis. Chin J TCM WM Crit Care 2008;15:4
  • Zhou HCGLY, Fan GL, Liu ZJ, Mu X. Effects of hyperoside on the secretions of NO,ET-1,P-selectin,sICAM-1 and TNF-α from rat intestinal microvascular endothelial cells induced by SLT-IIe. Chin Vet Sci 2009;39:6
  • Xiang MWJM, Zhou CH, Zhang YQ, Wu PP. Inhibition of crocetin on AGEs-induced hyperpermeability in vascular endothelial cells. Chinese Pharmacological Bulletin 2011;27:6
  • Zhang WJ, Hufnagl P, Binder BR, Wojta J. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thromb Haemost 2003;90:904–14
  • Liu X, Wang Y, Li G. Advances in pharmacological study of andrographolide and its derivatives. Zhong Yao Cai 2003;26:135–8
  • Colwell J. Pathogenesis of vascular disease. Diabetes Obes Metab 2000;2 Suppl 2:S19–24
  • Yang RB, Ng CK, Wasserman SM, et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem 2002;277:46364–73
  • Wong D, Dorovini-Zis K. Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide. J Neuroimmunol 1992;39:11–21
  • Dianzani C, Brucato L, Gallicchio M, et al. Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression. Br J Pharmacol 2008;153:1153–61
  • Chang YL, Chen CL, Kuo CL, et al. Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells. Acta Pharmacol Sin 2010;31:546–53
  • Branger J, van den Blink B, Weijer S, et al. Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. Blood 2003;101:4446–8
  • Yan W, Zhao K, Jiang Y, et al. Role of p38 MAPK in ICAM-1 expression of vascular endothelial cells induced by lipopolysaccharide. Shock 2002;17:433–8
  • Zhan J, Zhang ZZ, Chen C, et al. Penehyclidine hydrochloride attenuates LPS-induced iNOS production by inhibiting p38 MAPK activation in endothelial cells. Mol Biol Rep 2012;39:1261–5
  • Bi WY, Fu BD, Shen HQ, et al. Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. Inflammation 2012, in press
  • Dellinger RP. Inflammation and coagulation: implications for the septic patient. Clin Infect Dis 2003;36:1259–65
  • Aiuto LT, Barone SR, Cohen PS, Boxer RA. Recombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans. Crit Care Med 1997;25:1079–82
  • Veltrop MH, Beekhuizen H, Thompson J. Bacterial species- and strain-dependent induction of tissue factor in human vascular endothelial cells. Infect Immun 1999;67:6130–8
  • Shi RJ, Simpson-Haidaris PJ, Lerner NB, et al. Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB. Infect Immun 1998;66:1070–5
  • Zhang WJ, Wojta J, Binder BR. Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: astragaloside IV downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression. J Vasc Res 1997;34:273–80
  • Zheng Y, Liu X, Guo SW. Therapeutic potential of andrographolide for treating endometriosis. Hum Reprod 2012;27:1300–13
  • Lin Z, Kumar A, SenBanerjee S, et al. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res 2005;96:e48–57
  • Lin Z, Hamik A, Jain R, et al. Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation. Arterioscler Thromb Vasc Biol 2006;26:1185–9
  • Atkins GB, Jain MK. Role of Krüppel-like transcription factors in endothelial biology. Circ Res 2007;100:1686–95

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.