89
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Aliphatic alcohol contaminants of illegally produced spirits inhibit phagocytosis by human granulocytes

, , , , , , & show all
Pages 251-256 | Received 12 Oct 2012, Accepted 14 Dec 2012, Published online: 28 Jan 2013

References

  • World Health Organization (WHO). Global status report on alcohol. Geneva: WHO; 2011
  • Lachenmeier DW, Taylor BJ, Rehm J. Alcohol under the radar: do we have policy options regarding unrecorded alcohol? Int J Drug Policy 2011;22:153–60
  • Szűcs S, Sárváry A, McKee M, Ádány R. Could the high level of cirrhosis in central and eastern Europe be due partly to the quality of alcohol consumed? An exploratory investigation. Addiction 2005;100:536–42
  • McKee M, Szűcs S, Sárváry A, et al. The composition of surrogate alcohols consumed in Russia. Alcohol Clin Exp Res 2005;29:1884–8
  • Lang K, Väli M, Szűcs S, et al. The composition of surrogate and illegal alcohol products in Estonia. Alcohol Alcohol 2006;41:446–50
  • Lachenmeier DW, Schoeberl K, Kanteres F, et al. Is contaminated unrecorded alcohol a health problem in the European Union? A review of existing and methodological outline for future studies. Addiction 2011;106:20–30
  • Rehm J, Kanteres F, Lachenmeier DW. Unrecorded consumption, quality of alcohol and health consequences. Drug Alcohol Rev 2010;29:426–36
  • Lachenmeier DW, Haupt S, Schulz K. Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products. Regul Toxicol Pharmacol 2008;50:313–21
  • Strubelt O, Deters M, Pentz R, et al. The toxic and metabolic effects of 23 aliphatic alcohols in the isolated perfused rat liver. Toxicol Sci 1999;49:133–42
  • World Health Organization (WHO). Global Information System on Alcohol and Health. [online] Age-standardized death rates of liver cirrhosis. Available from: http://apps.who.int/ghodata/?theme=GISAH [last accessed 11 Dec 2012]
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA). 10th Special Report to the U.S. Congress on Alcohol and Health: highlights from Current Research. Bethesda: NIAAA; 2000
  • Goral J, Kovacs EJ. In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J Immunol 2005;174:456–63
  • Karavitis J, Kovacs EJ. Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factors. J Leukoc Biol 2011;90:1065–78
  • Lau AH, Szabo G, Thomson AW. Antigen-presenting cells under the influence of alcohol. Trends Immunol 2009;1:13–22
  • Molina PE, Happel KI, Zhang P, et al. Focus on: alcohol and the immune system. Alcohol Res Health 2010;33:97–108
  • Nelson S, Kolls JK. Alcohol, host defence and society. Nat Rev Immunol 2002;2:205–9
  • Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcohol 1999;34:830–41
  • Szabo G, Mandrekar P. Human monocytes, macrophages, and dendritic cells: alcohol treatment methods. Methods Mol Biol 2008;447:113–24
  • Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res 2009;33:220–32
  • Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol 2009;86:1097–104
  • Szabo G, Wands JR, Eken A, et al. Alcohol and hepatitis C virus–interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res 2010;34:1675–86
  • Désy O, Carignan D, de Campos-Lima PO. Short-term immunological effects of non-ethanolic short-chain alcohols. Toxicol Lett 2012;210:44–52
  • Carignan D, Désy O, de Campos-Lima PO. The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors. Toxicol Sci 2012;125:144–56
  • Désy O, Carignan D, Caruso M, de Campos-Lima PO. Immunosuppressive effect of isopropanol: down-regulation of cytokine production results from the alteration of discrete transcriptional pathways in activated lymphocytes. J Immunol 2008;181:2348–55
  • Désy O, Carignan D, Caruso M, de Campos-Lima PO. Methanol induces a discrete transcriptional dysregulation that leads to cytokine overproduction in activated lymphocytes. Toxicol Sci 2010;117:303–13
  • Árnyas EM, Pál L, Kovács C, et al. Aliphatic alcohols of illegally produced spirits can act synergistically on superoxide-anion production by human granulocytes. Immunopharmacol Immunotoxicol 2012; 34:844--51
  • Böyum A. Separation of leukocytes from blood and bone marrow. Introduction. Scand J Clin Lab Invest Suppl 1968;97:7.77–89
  • English D, Andersen BR. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods 1974;5:249–52
  • Hed J, Hallden G, Johansson SG, Larsson P. The use of fluorescence quenching in flow cytofluorometry to measure the attachment and ingestion phases in phagocytosis in peripheral blood without prior cell separation. J Immunol Methods 1987;101:119–25
  • Forslid J, Hed J. In vitro effect of hydrocortisone on the attachment and ingestion phases of immunoglobulin G- and complement component 3b-mediated phagocytosis by human neutrophils. Infect Immun 1982;38:811–16
  • Vrsalovic M, Vrsalovic MM, Presecki AV, Lukac J. Modulating role of alcohol and acetaldehyde on neutrophil and monocyte functions in vitro. J Cardiovasc Pharmacol 2007;50:462–5
  • Amulic B, Cazalet C, Hayes GL, et al. Neutrophil function: from mechanisms to disease. Annu Rev Immunol 2012;30:459–89
  • Ehrig T, Bohren KM, Wermuth B, von Wartburg JP. Degradation of aliphatic alcohols by human liver alcohol dehydrogenase: effect of ethanol and pharmacokinetic implications. Alcohol Clin Exp Res 1988;12:789–94
  • Haffner HT, Batra A, Wehner HD, et al. Methanol level and methanol elimination in alcoholic patients. Blutalkohol 1993;30:52–62
  • Zuba D, Piekoszewski W, Pach J, et al. Concentration of ethanol and other volatile compounds in the blood of acutely poisoned alcoholics. Alcohol 2002;26:17–22
  • Bilzer N, Schmutte P, Jehs M, Penners BM. Kinetics of aliphatic alcohols (methanol, propanol-1 and isobutanol) in the presence of alcohol in the human body. Blutalkohol 1990;27:385–409
  • Haffner HT, Wehner HD, Scheytt KD, Besserer K. The elimination kinetics of methanol and the influence of ethanol. Int J Legal Med 1992;105:111–14
  • Haffner HT, Besserer K, Graw M, Voges S. Methanol elimination in non-alcoholics: inter- and intraindividual variation. Forensic Sci Int 1997;86:69–76
  • Karavitis J, Murdoch EL, Deburghgraeve C, et al. Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis. Cell Immunol 2012;274:61–71
  • Blander JM. Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation. Trends Immunol 2007;28:19–25
  • Swanson JA, Hoppe AD. The coordination of signaling during Fc receptor-mediated phagocytosis. J Leukoc Biol 2004;76:1093–103
  • Underhill DM, Gantner B. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect 2004;6:1368–73
  • García-García E, Rosales C. Signal transduction during Fc receptor-mediated phagocytosis. J Leukocyte Biol 2002;72:1092–108
  • Rajendran L, Simons KJ. Lipid rafts and membrane dynamics. Cell Sci 2005;118:1099–102
  • Rollet-Labelle E, Marois S, Barbeau K, et al. Recruitment of the cross-linked opsonic receptor CD32A (FcgammaRIIA) to high-density detergent-resistant membrane domains in human neutrophils. Biochem J 2004;381:919–28
  • Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31–9
  • May RC, Machesky LM. Phagocytosis and the actin cytoskeleton. J Cell Sci 2001;114:1061–77
  • Dolganiuc A, Bakis G, Kodys K, et al. Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts. Alcohol Clin Exp Res 2006;30:76–85
  • McKarns SC, Hansch C, Caldwell WS, et al. Correlation between hydrophobicity of short-chain aliphatic alcohols and their ability to alter plasma membrane integrity. Fundam Appl Toxicol 1997;36:62–70
  • Goral J, Karavitis J, Kovacs EJ. Exposure-dependent effects of ethanol on the innate immune system. Alcohol 2008;42:237–47
  • Szabo G, Dolganiuc A, Dai Q, Pruett SB. TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects. J Immunol 2007;178:1243–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.