Changed gene expression in brains of mice exposed to traffic in a highway tunnel

References

• Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T. 2007. Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85:525–535.
   PubMed Web of Science ®Google Scholar
• Bos I, Jacobs L, Nawrot TS, de Geus B, Torfs R, Int Panis L, Degraeuwe B, Meeusen R. 2011. No exercise-induced increase in serum BDNF after cycling near a major traffic road. Neurosci Lett 500:129–132.
   PubMed Web of Science ®Google Scholar
• Block ML, Calderón-Garcidueñas L. 2009. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 32:506–516.
   PubMed Web of Science ®Google Scholar
• Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD; American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. 2010. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121:2331–2378.
   PubMed Web of Science ®Google Scholar
• Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M. 2005. Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology 26:133–140.
   PubMed Web of Science ®Google Scholar
• Campbell A, Araujo JA, Li H, Sioutas C, Kleinman M. 2009. Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. J Nanosci Nanotechnol 9:5099–5104.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas L, Reed W, Maronpot RR, Henríquez-Roldán C, Delgado-Chavez R, Calderón-Garcidueñas A, Dragustinovis I, Franco-Lira M, Aragón-Flores M, Solt AC, Altenburg M, Torres-Jardón R, Swenberg JA. 2004. Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution. Toxicol Pathol 32:650–658.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas L, Franco-Lira M, Torres-Jardón R, Henriquez-Roldán C, Barragán-Mejía G, Valencia-Salazar G, González-Maciel A, Reynoso-Robles R, Villarreal-Calderón R, Reed W. 2007. Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Toxicol Pathol 35:154–162.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas L, Solt AC, Henríquez-Roldán C, Torres-Jardón R, Nuse B, Herritt L, Villarreal-Calderón R, Osnaya N, Stone I, García R, Brooks DM, González-Maciel A, Reynoso-Robles R, Delgado-Chávez R, Reed W. 2008a. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol Pathol 36:289–310.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas L, Mora-Tiscareño A, Ontiveros E, Gómez-Garza G, Barragán-Mejía G, Broadway J, Chapman S, Valencia-Salazar G, Jewells V, Maronpot RR, Henríquez-Roldán C, Pérez-Guillé B, Torres-Jardón R, Herrit L, Brooks D, Osnaya-Brizuela N, Monroy ME, González-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Solt AC, Engle RW. 2008b. Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn 68:117–127.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, Jewells V, Torres-Jardón R, Romero L, Monroy-Acosta ME, Bryant C, González-González LO, Medina-Cortina H, D’Angiulli A. 2011. Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain Cogn 77:345–355.
   PubMed Web of Science ®Google Scholar
• Chen JC, Schwartz J. 2009. Neurobehavioral effects of ambient air pollution on cognitive performance in US adults. Neurotoxicology 30:231–239.
   PubMed Web of Science ®Google Scholar
• Clougherty JE, Rossi CA, Lawrence J, Long MS, Diaz EA, Lim RH, McEwen B, Koutrakis P, Godleski JJ. 2010. Chronic social stress and susceptibility to concentrated ambient fine particles in rats. Environ Health Perspect 118:769–775.
   PubMed Web of Science ®Google Scholar
• Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55:24–35.
   PubMed Web of Science ®Google Scholar
• Ferris LT, Williams JS, Shen CL. 2007. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc 39:728–734.
   PubMed Web of Science ®Google Scholar
• Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A. 2010. Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7:12.
   PubMed Web of Science ®Google Scholar
• Gertler AW, Abu-Allaban M, Coulombe W, Gillies JA, Pierson WP, Rogers FC, Sagebiel JC, Tarnay L, Cahill TA. 2001. Measurements of mobile source particulate emissions in a highway tunnel. Int J Vehicle Des 27:86–93.
   Google Scholar
• Goekint M, Roelands B, Heyman E, Njemini R, Meeusen R. 2011. Influence of citalopram and environmental temperature on exercise-induced changes in BDNF. Neurosci Lett 494:150–154.
   PubMed Web of Science ®Google Scholar
• Griffin ÉW, Mullally S, Foley C, Warmington SA, O’Mara SM, Kelly AM. 2011. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 104:934–941.
   PubMed Web of Science ®Google Scholar
• Happo MS, Salonen RO, Hälinen AI, Jalava PI, Pennanen AS, Dormans JA, Gerlofs-Nijland ME, Cassee FR, Kosma VM, Sillanpää M, Hillamo R, Hirvonen MR. 2010. Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities. Inhal Toxicol 22:402–416.
   PubMed Web of Science ®Google Scholar
• Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023–16029.
   PubMed Web of Science ®Google Scholar
• Jacobs L, Emmerechts J, Mathieu C, Hoylaerts MF, Fierens F, Hoet PH, Nemery B, Nawrot TS. 2010a. Air pollution related prothrombotic changes in persons with diabetes. Environ Health Perspect 118:191–196.
   PubMed Web of Science ®Google Scholar
• Jacobs L, Nawrot TS, de Geus B, Meeusen R, Degraeuwe B, Bernard A, Sughis M, Nemery B, Panis LI. 2010b. Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study. Environ Health 9:64.
   PubMed Web of Science ®Google Scholar
• Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC. 2008. Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicol Lett 178:127–130.
   PubMed Web of Science ®Google Scholar
• MohanKumar SM, Campbell A, Block M, Veronesi B. 2008. Particulate matter, oxidative stress and neurotoxicity. Neurotoxicology 29:479–488.
   PubMed Web of Science ®Google Scholar
• Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB. 2003. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem 278:4536–4541.
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437–445.
   PubMed Web of Science ®Google Scholar
• Peterson MR, Richards MH. 2002. Thermal-optical-transmittance analysis for organic, elemental, carbonate, total carbon, and OCX2 in PM2.5 by the EPA/NIOSH method. In: Winegar ED, Tropp RJ, ed. Proceedings, Symposium on Air Quality Measurement Methods and Technology. Pittsburgh, PA: Air & Waste Management Association, 83-1–83-19.
   Google Scholar
• Pfaffl MW, Horgan GW, Dempfle L. 2002. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36.
   PubMed Web of Science ®Google Scholar
• Phuleria HC, Geller MD, Fine PM, Sioutas C. 2006. Size-resolved emissions of organic tracers from light- and heavy-duty vehicles measured in a California roadway tunnel. Environ Sci Technol 40:4109–4118.
   PubMed Web of Science ®Google Scholar
• Pope CA 3rd, Ezzati M, Dockery DW. 2009. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360:376–386.
   PubMed Web of Science ®Google Scholar
• Ranft U, Schikowski T, Sugiri D, Krutmann J, Krämer U. 2009. Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res 109:1004–1011.
   PubMed Web of Science ®Google Scholar
• Rasmussen R. 2001. Quantification on the LightCycler. In: Meuer S, Wittwer C, Nakagawara K, eds. Rapid cycle real-time PCR methods and applications. Heidelberg: Springer Press, 21–34.
   Google Scholar
• Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. 2009. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 94:1062–1069.
   PubMed Web of Science ®Google Scholar
• Rojas Vega S, Strüder HK, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W. 2006. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res 1121:59–65.
   PubMed Web of Science ®Google Scholar
• Stewart D, Killeen E, Naquin R, Alam S, Alam J. 2003. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 278:2396–2402.
   PubMed Web of Science ®Google Scholar
• Sturm PJ, Rodler J, Lechner B, Almbauer RA. 2001. Validation of emission factors for road vehicles based on street tunnel measurements. Int J Vehicle Des 27:65–75.
   Web of Science ®Google Scholar
• Suglia SF, Gryparis A, Wright RO, Schwartz J, Wright RJ. 2008. Association of black carbon with cognition among children in a prospective birth cohort study. Am J Epidemiol 167:280–286.
   PubMed Web of Science ®Google Scholar
• Tellabati A, Fernandes VE, Teichert F, Singh R, Rylance J, Gordon S, Andrew PW, Grigg J. 2010. Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia. Part Fibre Toxicol 7:30.
   PubMed Web of Science ®Google Scholar
• Tin-Tin-Win-Shwe, Yamamoto S, Ahmed S, Kakeyama M, Kobayashi T, Fujimaki H. 2006. Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black. Toxicol Lett 163:153–160.
   PubMed Web of Science ®Google Scholar
• van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RP. 2010. Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84:553–562.
   PubMed Web of Science ®Google Scholar
• Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034.
   PubMed Web of Science ®Google Scholar
• Vaynman S, Ying Z, Gomez-Pinilla F. 2004. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20:2580–2590.
   PubMed Web of Science ®Google Scholar
• Vercauteren J, Matheeussen C, Wauters E, Roekens E, van Grieken R, Krata A, Makarovska Y, Maenhaut W, Chi X, Geypens B. 2011. Chemkar PM10: An extensive look at the local differences in chemical composition of PM10 in Flanders Belgium. Atmospheric Env 45:108–116.
   Web of Science ®Google Scholar
• Weingartner E, Keller C, Stahel WA, Burtscher H, Baltensperger U. 1997. Aerosol emission in a road tunnel. Atmospheric Env 31:451–462.
   Web of Science ®Google Scholar
• Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. 2012. Exposure to particulate air pollution and cognitive decline in older women. Arch Intern Med 172:219–227.
   PubMed Web of Science ®Google Scholar