Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats

References

• Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28:41–50.
   PubMedGoogle Scholar
• Bihari P, Vippola M, Schultes S, Praetner M, Khandoga AG, Reichel CA, Coester C, Tuomi T, Rehberg M, Krombach F. 2008. Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol 5:14.
   PubMed Web of Science ®Google Scholar
• Card JW, Zeldin DC, Bonner JC, Nestmann ER. 2008. Pulmonary applications and toxicity of engineered nanoparticles. Am J Physiol Lung Cell Mol Physiol 295:L400–L411.
   PubMed Web of Science ®Google Scholar
• Churg A. 1996. The uptake of mineral particles by pulmonary epithelial cells. Am J Respir Crit Care Med 154:1124–1140.
   PubMed Web of Science ®Google Scholar
• Creutzenberg O, Pohlmann G, Hansen T, Rittinghausen S, Ziemann C. 2009. Nano- and microscaled titanium dioxide: comparative study on the inflammatory and genotoxic effects after a 3-week inhalation in rats. Poster presentation at the 46th Congress of the European Societies of Toxicology (EUROTOX), Dresden, Germany, September 13–16, 2009.
   Google Scholar
• Creutzenberg O. 2012. Biological interactions and toxicity of nanomaterials in the respiratory tract and various approaches of aerosol generation for toxicity testing. Arch Toxicol 86:1117–1122.
   Google Scholar
• CRP. 1994. Human respiratory tract model for radiological protection. ICRP Publication 66. Ann ICRP 24:1–3.
   Google Scholar
• Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55:24–35.
   PubMed Web of Science ®Google Scholar
• Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. 2005. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci 88:614–629.
   PubMed Web of Science ®Google Scholar
• Eydner M, Schaudien D, Creutzenberg O, Ernst H, Hansen T, Baumgärtner W, Rittinghausen S. 2012. Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes, translocation within the rat lung, and evaluation of particle deposition using the relative deposition index. Inhal Toxicol 24:557–569.
   PubMed Web of Science ®Google Scholar
• Goebbert C, Hardinghaus F, Kampmann KH, Kroell M, Lehr C-M, Schäfer U, Schultze-Isfort C, Schultze C, Voetz M, Wohlleben W. 2009. Particle synthesis and characterisation. In: Kuhlbusch TAJ, Krug HF, Nau K, editors. NanoCare: health related aspects of nanomaterials - final scientific report, DECHEMA e.V., 9–21.
   Google Scholar
• Henderson RF, Mauderly JL, Pickrell JA, Hahn FF, Muhle H, Rebar AH. 1987. Comparative study of bronchoalveolar lavage fluid: effect of species, age, and method of lavage. Exp Lung Res 13:329–342.
   PubMed Web of Science ®Google Scholar
• Ji Z, Jin X, George S, Xia T, Meng H, Wang X, Suarez E, Zhang H, Hoek EM, Godwin H, Nel AE, Zink JI. 2010. Dispersion and stability optimization of TiO2 nanoparticles in cell culture media. Environ Sci Technol 44:7309–7314.
   PubMed Web of Science ®Google Scholar
• Koch W. 1998. Application of aerosols. In: Uhlig S, Taylor AE, editors. Methods in pulmonary research. Basel-Boston-Berlin: Birkhäuser.
   Google Scholar
• Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, Gunther D, Stark WJ. 2005. Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 39:9370–9376.
   PubMed Web of Science ®Google Scholar
• Maier M, Hannebauer B, Holldorff H, Albers P. 2006. Does lung surfactant promote disaggregation of nanostructured titanium dioxide? J Occup Environ Med 48:1314–1320.
   PubMed Web of Science ®Google Scholar
• Meissner T, Potthoff A, Richter V. 2009. Physico-chemical characterization in the light of toxicological effects. Inhal Toxicol 21 Suppl 1:35–39.
   Google Scholar
• Mühlfeld C, Geiser M, Kapp N, Gehr P, Rothen-Rutishauser B. 2007. Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the “relative deposition index”: Evidence for clearance through microvasculature. Part Fibre Toxicol 4:7.
   PubMedGoogle Scholar
• OECD. 2010. Environment, Health and Safety Publications, Series on the Safety of Manufactured Nanomaterials No. 27, List of Manufactured Nanomaterials and List of Endpoints for Phase One of the Sponsorship Programme for the Testing of Manufactured Nanomaterials: Revision. Environment Directorate, ENV/JM/MONO(2010)46.
   Google Scholar
• Porter DW, Sriram K, Wolfarth M, Jefferson A, Schwegler-Berry D, Andrew M, Castranova V. 2008. A biocompatible medium for nanoparticle dispersion. Nanotox 2:144–154.
   Web of Science ®Google Scholar
• Rehn B, Seiler F, Rehn S, Bruch J, Maier M. 2003. Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: untreated and surface treated. Toxicol Appl Pharmacol 189:84–95.
   PubMed Web of Science ®Google Scholar
• Sager TM, Porter DW, Robinson VA, Lindsley WG, Schwegler-Berry DE, Castranova V. 2007. Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1:118–129.
   Web of Science ®Google Scholar
• Schaudien D, Knebel JW, Mangelsdorf I, Voss J-U, Koch W, Creutzenberg O. 2011. Dispersion and retention of dusts consisting of ultrafine primary particles in lungs. Available at: http://www.baua.de/de/Publikationen/Fachbeitraege/F2133.pdf;jsessionid=993A7E89D 5992C327276FCD75842DCF2.1_cid246?__blob=publicationFile&v=11.
   Google Scholar
• Schaudien D, Knebel J, Creutzenberg O. 2012. In vitro study revealed different size behavior of different nanoparticles. J Nanoparticle Res 14:1039.
   Google Scholar
• Schulze C, Kroll A, Lehr C-M, Schäfer UF, Becker K, Schnekenburger J, Schulze Isfort C, Landsiedel R, Wohlleben W. 2008. Not ready to use - overcoming pitfalls when dispersing nanoparticles in physiological media. Nanotoxicology 2:51–61.
   Web of Science ®Google Scholar
• Schulze C, Schaefer UF, Ruge CA, Wohlleben W, Lehr CM. 2011. Interaction of metal oxide nanoparticles with lung surfactant protein A. Eur J Pharm Biopharm 77:376–383.
   PubMed Web of Science ®Google Scholar
• Semmler-Behnke M, Takenaka S, Fertsch S, Wenk A, Seitz J, Mayer P, Oberdörster G, Kreyling WG. 2007. Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium. Environ Health Perspect 115:728–733.
   PubMed Web of Science ®Google Scholar
• US-EPA. 2010. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen. EPA/6700/R-09/057F, November 2010.
   Google Scholar
• Wong BA, Nash DG, Moss OR. 2009. Generation of nanoparticle agglomerates and their dispersion in lung serum simulant or water. Inhaled particles X (23–25 September 2008, Manchester). J Phys Conference Series 151:012036. doi:10.1088/1742-6596/151/1/012036.
   Google Scholar