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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 14
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Research Article

Estimating safe human exposure levels for lunar dust using benchmark dose modeling of data from inhalation studies in rats

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Pages 785-793 | Received 02 Aug 2013, Accepted 24 Sep 2013, Published online: 04 Dec 2013

References

  • Allen BC, Strong PL, Price CJ, et al. (1996). Benchmark dose analysis of developmental toxicity in rats exposed to boric acid. Fundam Appl Toxicol 32:194–204
  • Batsura YD, Kruglikov GG, Arutyunov VD. (1981). Morphology of experimental pneumoconiosis following inhalation of lunar soil. Bull Exp Biol Med 92:1294–7
  • Cassee FR. (2007). Foreword. In: Donaldson K, Borm P. (eds.) Particle toxicology. Boca Raton, FL: CRC Press Taylor and Francis Group
  • Castranova V, Pailes WH, Dalal ND, et al. (1996). Enhanced pulmonary response to the inhalation of freshly fractured silica as compared with aged dust exposure. Appl Occup Environ Hyg 11:937–41
  • Cooper BL, McKay DS, Riofrio LM, et al. (2010). Sub-10-micron and respirable particles in lunar soils. 41st Lunar and Planetary Science Conference; 2010 Mar 1–5; The Woodlands, TX
  • Crump KS. (1984). A new method for determining allowable daily intakes. Fundam Appl Toxicol 4:854–71
  • Crump K. (2002). Critical issues in benchmark calculations from continuous data. Crit Rev Toxicol 32:133–53
  • Donaldson K, Borm P. (1998). The quartz hazard: a variable entity. Ann Occup Hyg 42:287–94
  • Donaldson K, Stone V, Duffin R, et al. (2001). The quartz hazard: effects of surface and matrix on inflammogenic activity. J Environ Pathol Toxicol Oncol 20:109–18
  • DPR MT-2. (2004). Guidance for Benchmark Dose (BMD) Approach – Continuous Data. Medical Toxicology Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA
  • Drent M, Cobben NA, Henderson RF, et al. (1996). Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. Eur Respir J 9:1736–42
  • Fenoglio I, Martra G, Prandi L, et al. (2000). The role of mechanochemistry in the pulmonary toxicity caused by particulate minerals. J Mater Syn Proc 8:145–53
  • Fubini B. (1998). Surface chemistry and quartz hazard. Ann Occup Hyg 42:521–30
  • Fubini B. (2002). V. Chemical reactivity of the quartz surface in relation to its toxicity and genotoxicity. In: Schneider WD. (ed.) 2002 Quarz. Einstufung, Dosis-Wirkungs-Beziehungen. Workshop vom 07./08. März 2002 in Berlin. Dortmund/Berlin/Dresden. Available from: http://www.baua.de/cae/servlet/contentblob/697144/publicationFile/46888/
  • Ghiazza M, Polimeni M, Fenoglio I, et al. (2010). Does vitreous silica contradict the toxicity of the crystalline silica paradigm? Chem Res Toxicol 23:620–9
  • Henderson RF, Scott GG, Waide JJ. (1995). Source of alkaline phosphatase activity in epithelial lining fluid of normal and injured F344 rat lungs. Toxicol Appl Pharmacol 134:170–4
  • Holland JW, Simmonds RC. (1973). The mammalian response to lunar particulates. Space Life Sci 4:97–109
  • James JT, Lam C-W, Santana P, Scully RR. (2013). Estimate of safe human exposure levels for lunar dust based on comparative benchmark dose modeling. Inhal Toxicol 25:243–56
  • Jones T, BéruBé K. (2007). Chapter 2. Mineralogy and structure of pathogenic particles. In: Donaldson K, Borm P. (eds.) Particle toxicology. Boca Raton, FL: CRC Press Taylor and Francis Group, 13–45
  • Kajiwara T, Ogami A, Yamato H, et al. (2007). Effect of particle size of intratrachaeally instilled crystalline silica on pulmonary inflammation. J Occup Health 49:88–94
  • Klotz I. (2013). NASA Open to Hitching Ride to the Moon, Agency Chief Says. Space News (June 3). Available from: http://www.space.com/21418-nasa-hitch-ride-moon.html [Last accessed: 26 Jun 2013]
  • Kustov VV, Belkin VI, Kruglikov GG. (1989). Biological effects of lunar soil. Probl Space Biol 61:1–146
  • Kustov VV, Ostapvenko OF, Petrukhin VG. (1974). Research on the biological effect of a fine fraction of lunar soil sent to Earth by the unmanned station Luna-16. In: Vinogradov AP. (ed.) Lunar soil from the sea of fertility. Moscow: M. Nauka, 592
  • Lam C-W, Scully RR, Zhang Y, et al. (2013). Toxicity of lunar dust assessed in inhalation-exposed rats. Inhalation Toxicol 25:661--78
  • Liu Y, Park J, Schnare D, et al. (2008). Characterization of lunar dust for toxicological studies. II: texture and shape characteristics. J Aerosp Eng 21:272–9
  • Lunar and Planetary Institute. Available from http://www.lpi.usra.edu/lunar/missions/apollo/apollo_11/surface_opp/; http://www.lpi.usra.edu/lunar/missions/apollo/apollo_17/surface_opp/. [Last accessed: 23 Jul 2013]
  • Mauderly J. (1997). Relevance of particle-induced rat lung tumors for assessing lung carcinogenic hazard and human lung cancer risk. Environ Health Perspect 105:1337–46
  • Murata K, Budtz-Jørgensen E, Grandjean P. (2002). Benchmark dose calculations for methyl mercury-associated delays on evoked potential latencies in two cohorts of children. Risk Anal 22:465–74
  • Napierska D, Thomassen LCJ, Lison D, et al. (2010). The nanosilica hazard: another variable entity. Particle Fibre Toxicol 7:39--70
  • Occupational Safety & Health Administration. Permissible exposure limits. Available from: https://www.osha.gov/dsg/topics/pel/ [Last accessed: 23 Jul 2013]
  • Øvrevik J, Myran T, Refsnes M, et al. (2005). Mineral particles of varying composition induce differential chemokine release from epithelial lung cells: importance of physico-chemical characteristics. Ann Occup Hyg 49:219–31
  • Parent RA. (1992). Treatise on pulmonary toxicology, Volume I: comparative biology of the normal lung. Vol. 1. Boca Raton, FL: CRC Press
  • Park J, Liu Y, Kihm KD, Taylor LA. (2008). Characterization of lunar dust for toxicological studies. I: Particle size distribution. J Aerosp Eng 21:266–71
  • Pauluhn J. (2011). Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Toxicology 279:176–88
  • Pauluhn J. (2012). Subchronic inhalation toxicity of iron oxide (magnetite, Fe3O4) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles. J Appl Toxicol 32:488–504
  • Sager TM, Kommineni C, Castranova V. (2008). Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol 5:17 . doi:10.1186/1743-8977-5-17
  • Scheuring RA, Jones JA, Novak JD, et al. (2008). The Apollo Medical Operations Project: recommendations to improve crew health and performance for future exploration missions and lunar surface operations. Acta Astronaut 63:980–7
  • Schoonen MA, Cohn CA, Roemer E, et al. (2006). Mineral-induced formation of reactive oxygen species. Rev Minerol Geochem 64:179–221
  • Schwarze PE, Øvrevik J, Hetland RB, et al. (2007). Importance of size and composition of particles for effects on cells in vitro. Inhal Toxicol 19:17–22
  • Snyder WS, Cook MJ, Karhausen LR, et al. (1975). International Commission of Radiological Protection (ICRP) No. 23: Report of the Task Group on Reference Man. New York: Pergamon Press
  • Sokal RR, Rohlf FJ. (1981). 13. Assumptions of analysis of variance. In: Biometry the principles and practices of statistics in biological research. 2nd ed. New York: WH Freeman Co., 400–52
  • Taylor LA, Pieters CM, Keller LP, et al. (2001). Lunar mare soils: space weathering and the major effects of surface-correlated nanophase Fe. J Geophys Res 106:27985–99
  • US EPA. (2012). Benchmark Dose Technical Guidance EPA/100/R-12/001. Available from: http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf. [Last accessed: 23 Jul 2013]
  • Wagner SA. (2006). The Apollo Experience: Lessons Learned for Constellation Lunar Dust Management. NASA Technical Publication TP-2006-213726. Washington, DC: National Aeronautics and Space Administration
  • Warheit DB, Webb TR, Colvin VL, et al. (2007). Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci 95:270–80
  • Warheit DB, Webb TR, Sayes CM, et al. (2006). Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci 91:227–36
  • Wikipedia. (2013). List of proposed missions to the Moon. Available from: http://en.wikipedia.org/wiki/List_of_current_and_future_lunar_missions. [Last accessed: 26 Jun 2013]

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