Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 27, 2015 - Issue 1
427
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Nitrogen dioxide exposure and airway responsiveness in individuals with asthma

Pages 1-14 | Received 24 Jul 2014, Accepted 17 Oct 2014, Published online: 28 Nov 2014

References

  • Ahmed T, Dougherty R, Sackner MA. (1983a). Effect of 0.1 ppm NO2 on pulmonary functions and non-specific bronchial reactivity of normals and asthmatics [final report]. (CR-83/11/BI). Warren, MI: General Motors Research Laboratories
  • Ahmed T, Dougherty R, Sackner MA. (1983b). Effect of NO2 exposure on specific bronchial reactivity in subjects with allergic bronchial asthma [final report]. (CR-83/07/BI). Warren, MI: General Motors Research Laboratories
  • Avol EL, Linn WS, Peng RC, et al. (1988). Laboratory study of asthmatic volunteers exposed to nitrogen dioxide and to ambient air pollution. Am Ind Hyg Assoc J 49:143–9
  • Avol EL, Linn WS, Peng RC, et al. (1989). Experimental exposures of young asthmatic volunteers to 0.3 ppm nitrogen dioxide and to ambient air pollution. Toxicol Ind Health 5:1025–34
  • Barck C, Sandstrom T, Lundahl J, et al. (2002). Ambient level of NO2 augments the inflammatory response to inhaled allergen in asthmatics. Respir Med 96:907–17
  • Bauer MA, Utell MJ, Morrow PE, et al. (1986). Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis 134:1203–8
  • Beaupré A, Orehek J. (1982). Factors influencing the bronchodilator effect of a deep inspiration in asthmatic patients with provoked bronchoconstriction. Thorax 37:124–8
  • Bylin G. (1993). Health risk evaluation of nitrogen oxide: controlled studies on humans. Scand J Work Environ Health 19:37–43
  • Bylin G, Hedenstierna G, Lindvall T, Sundin B. (1988). Ambient nitrogen dioxide concentrations increase bronchial responsiveness in subjects with mild asthma. Eur Respir J 1:606–12
  • Bylin G, Lindvall T, Rehn T, Sundin B. (1985). Effects of short-term exposure to ambient nitrogen dioxide concentrations on human bronchial reactivity and lung function. Eur Respir J 66:205–17
  • Casset A, Purohit A, Birba E, et al. (2007). Bronchial challenge test in asthmatics sensitized to mites: role of particle size in bronchial response. J Aerosol Med 20:509–18
  • Cockcroft DW. (2010). Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance [Review]. Chest 138:18S–24S
  • Cockcroft DW, Berscheid BA, Murdock KY. (1983). Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest 83:751–4
  • Cockcroft DW, Davis BE. (2006a). Airway hyperresponsiveness as a determinant of the early asthmatic response to inhaled allergen. J Asthma 43:175–8
  • Cockcroft DW, Davis BE. (2006b). Mechanisms of airway hyperresponsiveness [Review]. J Allergy Clin Immunol 118:551–9
  • Cockcroft DW, Davis BE. (2006c). The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result [Review]. J Allergy Clin Immunol 117:1244–8
  • Cockcroft DW, Davis BE, Todd DC, Smycniuk AJ. (2005). Methacholine challenge: comparison of two methods. Chest 127:839–44
  • Currell G, Dowman AA. (2014). Sign test (Web). Available from: http://calcscience.uwe.ac.uk/w2/am/Ch12/12_6_SignTest.pdf [Last accessed 30 June 2014]
  • Dawson SV, Schenker MB. (1979). Health effects of inhalation of ambient concentrations of nitrogen dioxide [Editorial]. Am Rev Respir Dis 120:281–92
  • Delfino RJ, Gone H, Linn WS, et al. (2003). Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environ Health Perspect 111:647–56
  • Delfino RJ, Zeiger RS, Seltzer JM, et al. (2002). Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use. Environ Health Perspect 110:A607–17
  • Downie SR, Salome CM, Verbanck S, et al. (2007). Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax 62:684–9
  • Dryden DM, Spooner CH, Stickland MK, et al. (2010). Exercise-induced bronchoconstriction and asthma. (AHRQ Publication No. 10-E001). Rockville, MD: Agency for Healthcare Research and Quality
  • Ezratty V, Guillossou G, Neukirch C, et al. (2014). Repeated nitrogen dioxide exposures and eosinophilic airway inflammation in asthmatics: a randomized crossover study. Environ Health Perspect 122:850–5
  • Folinsbee LJ. (1992). Does nitrogen dioxide exposure increase airways responsiveness? Toxicol Ind Health 8:273–83
  • Freedman S, Lane R, Gillett MK, Guz A. (1988). Abolition of methacholine induced bronchoconstriction by the hyperventilation of exercise or volition. Thorax 43:631–6
  • Goodman JE, Chandalia JK, Thakali S, Seeley M. (2009). Meta-analysis of nitrogen dioxide exposure and airway hyper-responsiveness in asthmatics. Crit Rev Toxicol 39:719–42
  • Hazucha MJ, Ginsberg JF, McDonnell WF, et al. (1983). Effects of 0.1 ppm nitrogen dioxide on airways of normal and asthmatic subjects. J Appl Physiol 54:730–9
  • Inman MD, Watson RM, Killian KJ, O'Byrne PM. (1990). Methacholine airway responsiveness decreases during exercise in asthmatic subjects. Am Rev Respir Dis 141:1414–17
  • Iskandar A, Andersen ZJ, Bønnelykke K, et al. (2012). Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children. Thorax 67:252–7
  • Jackson AC, Murphy MM, Rassulo J, et al. (2004). Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects. J Appl Physiol 96:137–42
  • Jalaludin B, Khalaj B, Sheppeard V, Morgan G. (2008). Air pollution and ED visits for asthma in Australian children: a case-crossover analysis. Int Arch Occup Environ Health 81:967–74
  • Jenkins HS, Devalia JL, Mister RL, et al. (1999). The effect of exposure to ozone and nitrogen dioxide on the airway response of atopic asthmatics to inhaled allergen: dose- and time-dependent effects. Am J Respir Crit Care Med 160:33–9
  • Jörres R, Magnussen H. (1990). Airways response of asthmatics after a 30 min exposure, at resting ventilation, to 0.25 ppm NO2 or 0.5 ppm SO2. Eur Respir J 3:132–7
  • Jörres R, Magnussen H. (1991). Effect of 0.25 ppm nitrogen dioxide on the airway response to methacholine in asymptomatic asthmatic patients. Lung 169:77–85
  • Kjaergaard SK, Rasmussen TR. (1996). Clinical studies of effects of nitrogen oxides in healthy and asthmatic subjects. Cent Eur J Public Health 4:23–6
  • Kleinman MT, Bailey RM, Linn WS, et al. (1983). Effects of 0.2 ppm nitrogen dioxide on pulmonary function and response to bronchoprovocation in asthmatics. J Toxicol Environ Health 12:815–26
  • Kudo M, Melton AC, Chen C, et al. (2012). IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med 18:547–54
  • Laube BL, Norman PS, Adams GK. (1992). The effect of aerosol distribution on airway responsiveness to inhaled methacholine in patients with asthma. J Allergy Clin Immunol 89:510–18
  • Magnussen H, Reuss G, Jörres R. (1986). Airway response to methacholine during exercise induced refractoriness in asthma. Thorax 41:667–70
  • Mann JK, Balmes JR, Bruckner TA, et al. (2010). Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environ Health Perspect 118:1497–502
  • Mohsenin V. (1987a). Effect of vitamin C on NO2-induced airway hyperresponsiveness in normal subjects: a randomized double-blind experiment. Am Rev Respir Dis 136:1408–11
  • Mohsenin V. (1987b). Airway responses to nitrogen dioxide in asthmatic subjects. J Toxicol Environ Health 22:371–80
  • Morrow PE, Utell MJ. (1989a). Responses of susceptible subpopulations to nitrogen dioxide [HEI]. (ISSN 1041–5505 Research Report 23). Cambridge, MA: Health Effects Institute
  • Morrow PE, Utell MJ. (1989b). Responses of susceptible subpopulations to nitrogen dioxide: appendix H. Selected raw data [HEI]. (Research Report 23). Cambridge, MA: Health Effects Institute
  • Moss OR, Oldham MJ. (2006). Dosimetry counts: molecular hypersensitivity may not drive pulmonary hyperresponsiveness. J Aerosol Med 19:555–64
  • O'Byrne PM, Gauvreau GM, Brannan JD. (2009). Provoked models of asthma: what have we learnt? [Review]. Clin Exp Allergy 39:181–92
  • Orehek J, Massari JP, Gayrard P, et al. (1976). Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients. J Clin Invest 57:301–7
  • Orehek J, Nicoli MM, Delpierre S, Beaupre A. (1981). Influence of the previous deep inspiration on the spirometric measurement of provoked bronchoconstriction in asthma. Am Rev Respir Dis 123:269–72
  • Postma DS, Boezen HM. (2004). Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD [Review]. Chest 126:96S–104S; discussion 159S–161S
  • Reddel HK, Taylor DR, Bateman ED, et al.; Exacerbations, ATSERSTFoACa. (2009). An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 180:59–99
  • Riedl MA, Diaz-Sanchez D, Linn WS, et al. (2012). Allergic inflammation in the human lower respiratory tract affected by exposure to diesel exhaust [HEI] (pp. 5–43; discussion 45–64). (ISSN 1041–5505 Research Report 165). Boston, MA: Health Effects Institute
  • Roger LJ, Horstman DH, Mcdonnell W, et al. (1990). Pulmonary function, airway responsiveness, and respiratory symptoms in asthmatics following exercise in NO2. Toxicol Ind Health 6:155–71
  • Rubinstein I, Bigby BG, Reiss TF, Boushey Jr, HA. (1990). Short-term exposure to 0.3 ppm nitrogen dioxide does not potentiate airway responsiveness to sulfur dioxide in asthmatic subjects. Am Rev Respir Dis 141:381–5
  • Sandström T, Andersson MC, Kolmodin-Hedman B, et al. (1990). Bronchoalveolar mastocytosis and lymphocytosis after nitrogen dioxide exposure in man: a time-kinetic study. Eur Respir J 3:138–43
  • Sandström T, Stjernberg N, Eklund A, et al. (1991). Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study. Eur Respir J 3:332–9
  • Silbaugh SA, Mauderly JL, Macken CA. (1981). Effects of sulfuric acid and nitrogen dioxide on airway responsiveness of the guinea pig. J Toxicol Environ Health 8:31–45
  • Son JY, Lee JT, Park YH, Bell ML. (2013). Short-term effects of air pollution on hospital admissions in Korea. Epidemiology 24:545–54
  • Strand V, Rak S, Svartengren M, Bylin G. (1997). Nitrogen dioxide exposure enhances asthmatic reaction to inhaled allergen in subjects with asthma. Am J Respir Crit Care Med 155:881–7
  • Strand V, Salomonsson P, Lundahl J, Bylin G. (1996). Immediate and delayed effects of nitrogen dioxide exposure at an ambient level on bronchial responsiveness to histamine in subjects with asthma. Eur Respir J 9:733–40
  • Strand V, Svartengren M, Rak S, et al. (1998). Repeated exposure to an ambient level of NO2 enhances asthmatic response to a nonsymptomatic allergen dose. Eur Respir J 12:6–12
  • Strickland MJ, Darrow LA, Klein M, et al. (2010). Short-term associations between ambient air pollutants and pediatric asthma emergency department visits. Am J Respir Crit Care Med 182:307–16
  • Tunnicliffe WS, Burge PS, Ayres JG. (1994). Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients. Lancet 344:1733–6
  • U.S. EPA (U.S. Environmental Protection Agency). (2008). Integrated science assessment for oxides of nitrogen Health criteria [EPA Report]. (EPA/600/R-08/071). Research Triangle Park, NC
  • Verbanck S, Schuermans D, Noppen M, et al. (2001). Methacholine versus histamine: paradoxical response of spirometry and ventilation distribution. J Appl Physiol 91:2587–94
  • Villeneuve PJ, Chen L, Rowe BH, Coates F. (2007). Outdoor air pollution and emergency department visits for asthma among children and adults: a case-crossover study in northern Alberta, Canada. Environ Health Global Access Sci Source 6:40
  • Wanner A, Brodnan JM, Perez J, et al. (1985). Variability of airway responsiveness to histamine aerosol in normal subjects. Role of deposition. Am Rev Respir Dis 131:3–7
  • Witten A, Solomon C, Abbritti E, et al. (2005). Effects of nitrogen dioxide on allergic airway responses in subjects with asthma. J Occup Environ Med 47:1250–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.