2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats

References

• American Conference of Governmental Industrial Hygienists. Threshold Limit Values and Biological Exposure Studies for 1988–89. ACGIH., Cincinnati 1989
   Google Scholar
• Birnboim H. C. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can. J. Physiol. Pharmacol. 1982; 60: 1359–1366
   PubMed Web of Science ®Google Scholar
• Bradley M. O., Erickson L. C. Comparison of the effects of hydrogen peroxide and x-ray irradiation on the toxicity, mutation, and DNA damagehepair in mammalian cells (V-79). Biochim. Biophys. Acta 1981; 654: 135–141
   PubMed Web of Science ®Google Scholar
• Buckley L. A., Jiang X. Z., James R. A., Morgan K. T., Barrow C. S. Respiratory tract lesions induced by sensory irritants at the RD50 concentration. Toxicol. Appl. Pharmacol. 1984; 74: 417–429
   PubMed Web of Science ®Google Scholar
• Burger G. T., Renne R. A., Sagartz J. W., Ayres P. H., Coggins C. R.E., Mosberg A. T., Hayes A. W. Histologic changes in the respiratory tract induced by inhalation of xenobiotics: Physiologic adaptation or toxicity?. Toxicol. Appl. Pharmacol. 1989; 101: 521–542
   PubMed Web of Science ®Google Scholar
• Cannon W. C., Blanton E. F., McDonald K. E. The flow-past chamber: An improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 1983; 44: 923–928
   PubMed Web of Science ®Google Scholar
• Code of Federal Regulations. 21CFR 182.1320, April, 1990. Office of the Federal Register, National Archives and Records Administration, Washington, D.C. 1990
   Google Scholar
• Deichmann W. Glycerol—Behavior in the animal organism—A review of the literature. Ind. Med. 1940; 9: 60–67
   Google Scholar
• Dixon W. J. BMDP: Biomedical Computer Programs. UCLA Press., Los Angeles, Calif 1975; 259–305
   Google Scholar
• Doolittle D. J., Lee D. A., Lee C. K. The genotoxic activity of glycerol in an in vitro test battery. Food Chem. Toxicol. 1988; 26(7)631–635
   Google Scholar
• Gopinath C., Prentice D. E., Lewis D. J. Atlas of Experimental Toxicologic Pathology, vol. 13 of Current Histopathology (Series). MTP Press., LancasterUK 1987; 25–28
   Google Scholar
• Hill M. A., Watson C. R., Moss O. R. NEWCAS: An Interactive Computer Program for Particle Size Analysis. PNL-2405, Battelle, Pacific Northwest Laboratories, Richland, Wash 1977
   Google Scholar
• Hine C. H., Anderson H. H., Moon H. D., Dunlap M. K., Morse M. S. Comparative toxicity of synthetic and natural glycerin. Arch. Ind. Hyg. Occup. Med. 1953; 7: 282–291
   Google Scholar
• Inayama Y. Promoting action of glycerol in pulmonary tumorigenesis model using a single administration of Cnitroquinoline 1-oxide in mice. GANN 1986; 77: 345–350
   Google Scholar
• Inayama Y., Kitamura H., Ito T., Kanisawa M. Effects of glycerol on Cnitroquinoline 1-oxide induced pulmonary tumorigenesis in ddY mice. GANN 1986; 77: 103–105
   Google Scholar
• Jiang X. Z., Morgan K. T., Beauchamp R. O., Jr. Histopathology of acute and subacute nasal toxicity. Toxicology of the Nasal Passages, C. S. Barrow. Hemisphere Publishing., Washington, D.C. 1986; 51–66
   Google Scholar
• Johnson V., Carlson A., Johnson A. The physiological action of glycerol on the animal organism. Am. J. Physiol. 1933; 103: 517–534
   Google Scholar
• Kern J. C. Glycerol. Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed., H. F. Mark, H. Othmer, C. D. Overberger, G. T. Seaborg. Wiley, New York 1980; vol. 11: 921–932
   Google Scholar
• Kitamura H., Inayama Y., Ito T., Yabana M., Piegorsch W., Kanisawa M. Morphologic of mouse Clara cells induced by glycerol: Ultrastructural and morphometric studies. Exp. Lung Res. 1987; 12: 281–302
   PubMed Web of Science ®Google Scholar
• Mayes P. A. Cluconeogenesis and the pentose phosphate pathway. Harper's Biochemistry, 21st ed., R. K. Murray, D. K. Cranner, P. A. Mayes, V. W. Rodwell. Appleton and Lange., Norwalk, Conn 1988a; 172–179
   Google Scholar
• Mayes P. A. Metabolism of acylglycerols and sphingolipids. Harper's Biochemistry, 21st ed., R. K. Murray, D. K. Cranner, P. A. Mayes, V. W. Rodwell. Appleton and Lange., Norwalk, Conn 1988b; 218–225
   Google Scholar
• McDowell E. M., Trump B. F. Histologic fixatives suitable to light and electron microscopy. Arch. Pathol. 1976; 100: 405–414
   Google Scholar
• Mercer T. T., lillery M. I., Newton C. J. A multi-stage, low flow rate cascade impactor. J. Aerosol Sci. 1970; 1: 9–15
   Google Scholar
• Moss O. R. 1980a, United States Patent 4,216,741, August 12
   Google Scholar
• Moss O. R. A chamber providing uniform concentration of particulates for exposure of animals on tiers separated by catchpans. Workshop in Inhalation Chamber Technology, R. Drew. BNL-51318, Brookhaven National Laboratory, Upton, Long island, NY., Associated Universities, Upton, NY 1980b
   Google Scholar
• Moss O. R., Decker J. R., Cannon W. C. Aerosol concentration in an animal exposure chamber having three levels of caging with excreta pans. Am. Ind. Hyg. Assoc. J. 1982; 43: 244–249
   Web of Science ®Google Scholar
• Nelson C. O. Controlled Test Atmospheres: Principles and Techniques. Ann Arbor Science., Ann Arbor, Mich. 1971; 16–17
   Google Scholar
• Peak J. C., Peak M. J. Similar ultraviolet action spectra for the protection by glycerol of transforming DNA against single-strand breaks and inactivation of biological activity. Radiat. Res. 1984; 97: 570–575
   Google Scholar
• Sasaki M. S., Matsubara S. Free radical scavenging in protection of human lymphocytes against chromosome aberration formation by gamma-ray irradiation. Int. J. Radiat. Biol. 1977; 32: 439–445
   Web of Science ®Google Scholar
• Sloviter H. A. Effects of the intravenous administration of glycerol solutions to animals and man. J. Clin. Invest. 1958; 37: 619–626
   PubMed Web of Science ®Google Scholar
• Smyth H., Seaton J., Fischer L. The single dose toxicity of some glycols and derivatives. J. Ind. Hyg. Toxicol. 1941; 23: 259–268
   Google Scholar
• Snedecor C. W., Cochran W. C. Statistical Methods, 7th ed. Iowa State University Press, Ames 1980
   Google Scholar
• Swinyard E. A., Pathak M. A. Surface-acting drugs. The Pharmacological Basis of Therapeutics, 7th ed., A. C. Cilman, L. S. Goodman, T. W. Rall, F. Murad. Macmillan, New York 1985; 946–958
   Google Scholar
• Szmigiero L., Erickson L. C., Ewig R. A., Kohn K. W. DNA strand scission and cross-linking by diaziridinylbenzoquinone (diaziquone) in human cells and relation to cell killing. Cancer Res. 1984; 44: 447–4452
   Google Scholar
• Wiebe J. P., Dinsdale C. J. Inhibition of cell proliferation by glycerol. Life Sci. 1991; 48: 1511–1517
   PubMed Web of Science ®Google Scholar
• Witschi H., Malkinson A. M., Peraino C., Russell J. J., Staffeldt E. F. Effects of glycerol on lung and liver tumor development. Fundam. Appl. Toxicol. 1989; 13: 174–180
   Google Scholar
• Young J. T. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1981; 1: 309–312
   PubMedGoogle Scholar