Gastrocnemius-derived BDNF promotes motor function recovery in spinal cord transected rats

References

• Alderson RF, Alterman AL, Barde YA, Lindsay RM. 1990. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron. 5 3: 297–306.
   PubMedGoogle Scholar
• Barnabé-Heider F, Miller FD. 2003. Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci. 23 12: 5149–5160.
   PubMed Web of Science ®Google Scholar
• Blesch A, Tuszynski MH. 2007. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci. 27 39: 10535–10545.
   PubMed Web of Science ®Google Scholar
• Cai LL, Courtine G, Fong AJ, Burdick JW, Roy RR, Edgerton VR. 2006. Plasticity of functional connectivity in the adult spinal cord. Philos Trans R Soc Lond B Biol Sci. 361 1473: 1635–1646.
   Google Scholar
• Carvalho AL, Caldeira MV, Santos SD, Duarte CB. 2008. Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br J Pharmacol. 153 Suppl 1: S310–S324.
   PubMedGoogle Scholar
• Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y. 2010. Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury. Neuropathology. 30 3: 241–250.
   PubMed Web of Science ®Google Scholar
• Côté MP, Azzam GA, Lemay MA, Zhukareva V, Houlé JD. 2011. Activity-dependent increase in neurotrophic factors is associated with an enhanced modulation of spinal reflexes after spinal cord injury. J Neurotrauma. 28 2: 299–309.
   Google Scholar
• Ding Y, Kastin AJ, Pan W. 2005. Neural plasticity after spinal cord injury. Curr Pharm Des. 11 11: 1441–1450.
   PubMed Web of Science ®Google Scholar
• Fan J, Xiao Z, Zhang H, Chen B, Tang G, Hou X, Ding W, Wang B, Zhang P, Dai J, Xu R. 2010. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promote axonal regeneration and partial functional recovery after complete spinal cord transection. J Neurotrauma. 27 9: 1671–1683.
   PubMed Web of Science ®Google Scholar
• Genovese T, Mazzon E, Crisafulli C, Esposito E, Di Paola R, Muià C, Di Bella P, Bramanti P, Cuzzocrea S. 2007. Effects of combination of melatonin and dexamethasone on secondary injury in an experimental mice model of spinal cord trauma. J Pineal Res. 43 2: 140–153.
   PubMed Web of Science ®Google Scholar
• Genovese T, Menegazzi M, Mazzon E, Crisafulli C, Di Paola R, Dal Bosco M, Zou Z, Suzuki H, Cuzzocrea S. 2009. Glycyrrhizin reduces secondary inflammatory process after spinal cord compression injury in mice. Shock. 31 4: 367–375.
   PubMed Web of Science ®Google Scholar
• Iarikov DE, Kim BG, Dai HN, McAtee M, Kuhn PL, Bregman BS. 2007. Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury. J Neurotrauma. 24 4: 690–702.
   Google Scholar
• Ikeda O, Murakami M, Ino H, Yamazaki M, Nemoto T, Koda M, Nakayama C, Moriya H. 2001. Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol.. 102 3: 239–245.
   PubMed Web of Science ®Google Scholar
• Ikeda O, Murakami M, Ino H, Yamazaki M, Koda M, Nakayama C, Moriya H. 2002. Effects of brain-derived neurotrophic factor (BDNF) on compression-induced spinal cord injury: BDNF attenuates down-regulation of superoxide dismutase expression and promotes up-regulation of myelin basic protein expression. J Neuropathol Exp Neurol. 61 2: 142–153.
   Google Scholar
• Iwabe S, Moreno-Mendoza NA, Trigo-Tavera F, Crowder C, García-Sánchez GA. 2007. Retrograde axonal transport obstruction of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in the retina and optic nerve of American Cocker Spaniel dogs with spontaneous glaucoma. Vet Ophthalmol. 10 Suppl 1: 12–19.
   Google Scholar
• Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV. 2011. Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. PLoS One. 6 1: e16135.
   PubMed Web of Science ®Google Scholar
• Jantas D, Szymanska M, Budziszewska B, Lason W. 2009. An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. Apoptosis. 14 7: 900–912.
   Google Scholar
• Kawamura K, Kawamura N, Sato W, Fukuda J, Kumagai J, Tanaka T. 2009. Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival. Endocrinology. 150 8: 3774–3782.
   PubMed Web of Science ®Google Scholar
• Kawamura K, Kawamura N, Kumazawa Y, Kumagai J, Fujimoto T, Tanaka T. 2011. Brain-derived neurotrophic factor/tyrosine kinase B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy. Endocrinology. 152 3: 1090–1100.
   Google Scholar
• Kim BG, Dai HN, McAtee M, Vicini S, Bregman BS. 2006. Remodeling of synaptic structures in the motor cortex following spinal cord injury. Exp Neurol. 198 2: 401–415.
   Google Scholar
• Kimura A, Hsu M, Seldin M, VErkman AS, Scharfman HE, Binder DK. 2010. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 67 6: 794–801.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Yokoyama M, Matsuoka Y, Omori M, Itano Y, Kaku R, Morita K, Ichikawa H. 2008. Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model. Brain Res. 1206:13–19.
   Google Scholar
• Koopmans GC, Brans M, Gómez-Pinilla F, Duis S, Gispen WH, Torres-Aleman I, Joosten EA, Hamers FP. 2006. Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. Eur J Neurosci. 23 4: 1035–1046.
   Google Scholar
• Küst BM, Copray JC, Brouwer N, Troost D, Boddeke HW. 2002. Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis. Exp Neurol. 177 2: 419–427.
   Google Scholar
• Lee H, McKeon RJ, Bellamkonda RV. 2010. Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. Proc Natl Acad Sci USA. 107 8: 3340–3345.
   PubMed Web of Science ®Google Scholar
• Li L, Xian CJ, Zhong JH, Zhou XF. 2006. Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats. Neurotox Res. 9 4: 269–283.
   Google Scholar
• Liu X, Jaenisch R. 2000. Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. Dev Dyn. 218 1: 94–101.
   Google Scholar
• Lu P, Jones LL, Tuszynski MH. 2005. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol. 191 2: 344–360.
   PubMed Web of Science ®Google Scholar
• Ma CH, Bampton ET, Evans MJ, Taylor JS. 2010. Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways. Neuroscience. 165 2: 463–474.
   Google Scholar
• Ma L, Wang DD, Zhang TY, Yu H, Wang Y, Huang SH, Lee FS, Chen ZY. 2011. Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation. J Neurosci. 31 6: 2079–2090.
   Google Scholar
• Mousavi K, Parry DJ, Jasmin BJ. 2004. BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. Am J Physiol Cell Physiol. 287 1: C22–C29.
   Google Scholar
• Munson JB, Foehring RC, Mendell LM, Gordon T. 1997. Fast-to-slow conversion following chronic low-frequency activation of medial gastrocnemius muscle in cats. II. Motoneuron properties. J Neurophysiol. 77 5: 2605–2615.
   Google Scholar
• Nagahara AH, Tuszynski MH. 2011. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 10 3: 209–219.
   PubMed Web of Science ®Google Scholar
• Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan JR. 2007. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 27 28: 7597–7603.
   PubMed Web of Science ®Google Scholar
• Novikova L, Novikov L, Kellerth JO. 1996. Brain-derived neurotrophic factor reduces necrotic zone and supports neuronal survival after spinal cord hemisection in adult rats. Neurosci Lett. 220 3: 203–206.
   Google Scholar
• Oppenheim RW, Yin QW, Prevette D, Yan Q. 1992. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature. 360 6406: 755–757.
   Google Scholar
• Perrin FE, Boniface G, Serguera C, Lonjon N, Serre A, Prieto M, Mallet J, Privat A. 2010. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One. 5 12: e15914.
   Google Scholar
• Qiao LY, Gulick MA, Bowers J, Kuemmerle JF, Grider JR. 2008. Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis. Neurogastroenterol Motil. 20 8: 928–938.
   Google Scholar
• Rind HB, Butowt R, von Bartheld CS. 2005. Synaptic targeting of retrogradely transported trophic factors in motoneurons: Comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin. J Neurosci. 25 3: 539–549.
   Google Scholar
• Rong R, Men BL, Li-Qun H, Chao Y, Wang T-H. 2011. Role of BDNF in neuroplasticity of the spinal cord in cats subjected to partial dorsal ganglionectomy. Growth Factors. 29 6: 263–270.
   PubMed Web of Science ®Google Scholar
• Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD. 2009. BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci. 29 47: 14932–14941.
   PubMed Web of Science ®Google Scholar
• Saygili E, Schauerte P, Küppers F, Heck L, Weis J, Weber C, Schwinger RH, Hoffmann R, Schröder JW, Marx N, Rana OR. 2010. Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA. J Mol Cell Cardiol. 49 1: 79–87.
   PubMed Web of Science ®Google Scholar
• Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde YA. 1992. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature. 360 6406: 757–759.
   PubMed Web of Science ®Google Scholar
• Sharma HS. 2007. A select combination of neurotrophins enhances neuroprotection and functional recovery following spinal cord injury. Ann N Y Acad Sci. 1122:95–111.
   PubMed Web of Science ®Google Scholar
• Sharma HS, Ali SF, Tian ZR, Patnaik R, Patnaik S, Sharma A, Boman A, Lek P, Seifert E, Lundstedt T. 2010. Nanowired-drug delivery enhances neuroprotective efficacy of compounds and reduces spinal cord edema formation and improves functional outcome following spinal cord injury in the rat. Acta Neurochir (Suppl). 106:343–350.
   PubMedGoogle Scholar
• Song XY, Li F, Zhang FH, Zhong JH, Zhou XF. 2008. Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. PLoS One. 3 3: e1707.
   Google Scholar
• Suh HI, Min J, Choi KH, Kim SW, Kim KS, Jeon SR. 2011. Axonal regeneration effects of Wnt3a-secreting fibroblast transplantation in spinal cord-injured rats. Acta Neurochir (Wien). 153 5: 1003–1010.
   PubMedGoogle Scholar
• Tender GC, Li YY, Cui JG. 2010. Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment. Spine J. 10 8: 715–720.
   Google Scholar
• Vavrek R, Girgis J, Tetzlaff W, Hiebert GW, Fouad K. 2006. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain. 129 Pt 6: 1534–1545.
   PubMed Web of Science ®Google Scholar
• Wang H, Wu LL, Song XY, Luo XG, Zhong JH, Rush RA, Zhou XF. 2006. Axonal transport of BDNF precursor in primary sensory neurons. Eur J Neurosci. 24 9: 2444–2452.
   PubMed Web of Science ®Google Scholar
• Widenfalk J, Lundströmer K, Jubran M, Brene S, Olson L. 2001. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci. 21 10: 3457–3475.
   Google Scholar
• Yan Q, Elliott J, Snider WD. 1992. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature. 360 6406: 753–755.
   Google Scholar
• Ying Z, Roy RR, Zhong H, Zdunowski S, Edgerton VR, Gomez-Pinilla F. 2008. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience. 155 4: 1070–1078.
   Google Scholar