185
Views
8
CrossRef citations to date
0
Altmetric
Research Article

The role of ubiquitin-proteasome system in glioma survival and growth

, &
Pages 106-113 | Received 22 Feb 2013, Accepted 22 Apr 2013, Published online: 21 May 2013

References

  • Adams J. 2003. The proteasome: Structure, function, and role in the cell. Cancer Treat Rev 29:3–9
  • Alberts GF, Winkles JA. 2004. Murine FGF-inducible kinase is rapidly degraded via the nuclear ubiquitin-proteosome system when overexpressed in NIH 3T3 cells. Cell Cycle 3:678–684
  • Arora S, Yang JM, Hait WN. 2005. Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase. Cancer Res 65:3806–3810
  • Baron V, Schwartz M. 2000. Cell adhesion regulates ubiquitin-mediated degradation of the platelet-derived growth factor receptor beta. J Biol Chem 275:39318–39323
  • Beinke S, Ley SC. 2004. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem J 382:393–409
  • Brognard J, Sierecki E, Gao T, Newton AC. 2007. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25:917–931
  • Brown RE, Law A. 2006. Morphoproteomic demonstration of constitutive nuclear factor-κB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann Clin Lab Sci 36:421–426
  • Burger AM, Seth AK. 2004. The ubiquitin-mediated protein degradation pathway in cancer: Therapeutic implications. Eur J Cancer 40:2217–2229
  • Cancer Genome Atlas Research Network. 2008. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061–1068
  • Chapman G, Liu L, Sahlgren C, Dahlqvist C, Lendahl U. 2006. High levels of Notch signaling down-regulate Numb and Numblike. J Cell Biol 175:535–540
  • Chitra S, Nalini G, Rajasekhar G. 2012. The ubiquitin proteasome system and efficacy of proteasome inhibitors in diseases. Int J Rheum Dis 15:249–260
  • Chondrogianni N, Gonos ES. 2012. Structure and function of the ubiquitin-proteasome system: Modulation of components. Prog Mol Biol Transl Sci 109:41–74
  • Chuang JY, Wang YT, Yeh SH, Liu YW, Chang WC, Hung JJ. 2008. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol Biol Cell 19:1139–1151
  • Ciechanover A, Orian A, Schwartz AL. 2000. Ubiquitin-mediated proteolysis: Biological regulation via destruction. Bioessays 22:442–451
  • Dahmane N, Sánchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A. 2001. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128:5201–5212
  • Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, et al. 2010. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res 70:2951–2961
  • Dai S, Huang ML, Hsu CY, Chao KS. 2003. Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells. Int J Radiat Oncol Biol Phys 55:1027–1036
  • Di K, Linskey ME, Bota DA. 2012. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. Oncogene doi: 10.1038/onc.2012.531. [Epub ahead of print]
  • Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, et al. 2006. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 8:1415–1423
  • Eichhorn PJ, Rodón L, Gonzàlez-Juncà A, Dirac A, Gili M, Martínez-Sáez E, Aura C, et al. 2012. USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med 18:429–435
  • Froment P, Dupont J, Christophe-Marine J. 2008. Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. Cell Cycle 7:3098–3103
  • Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL. 2007. Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Clin Cancer Res 13:2441–2448
  • Glasgow E, Mishra L. 2008. Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer 15:59–72
  • Glogowska A, Stetefeld J, Weber E, Ghavami S, Hoang-Vu C, Klonisch T. 2012. Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells. Neoplasia 14:396–409
  • Goswami S, Gupta A, Sharma SK. 1998. Interleukin-6-mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG. J Neurochem 71:1837–1845
  • Gur G, Rubin C, Katz M, Amit I, Citri A, Nilsson J, Amariglio N, et al. 2004. LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. EMBO J 23:3270–3281
  • Hayashi S, Yamamoto M, Ueno Y, Ikeda K, Ohshima K, Soma G, Fukushima T. 2001. Expression of nuclear factor-kappa B, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas. Neurol Med Chir (Tokyo) 41:187–195
  • He S, Deng J, Li G, Wang B, Cao Y, Tu Y. 2012. Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma. Jpn J Clin Oncol 42:196–201
  • Heldin CH, ten Dijke P. 1999. SMAD destruction turns off signalling. Nat Cell Biol 1:E195–197
  • Herrmann J, Ciechanover A, Lerman LO, Lerman A. 2004. The ubiquitin-proteasome system in cardiovascular diseases -- A hypothesis extended. Cardiovasc Res 61:11–21
  • Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. 1999. NF-κB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19:2690–2698
  • Hoeller D, Hecker CM, Dikic I. 2006. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 6:776–788
  • Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S. 2003. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115:565–576
  • Izaguirre DI, Zhu W, Hai T, Cheung HC, Krahe R, Cote GJ. 2012. PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol Carcinog 51:895–906
  • Janssens S, Tschopp J. 2006. Signals from within: The DNA-damage-induced NF-κB response. Cell Death Differ 13:773–784
  • Jiang W, Cazacu S, Xiang C, Zenklusen JC, Fine HA, Berens M, Armstrong B, et al. 2008. FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-κB signaling pathway. Neoplasia 10:235–243
  • Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, et al. 2012. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and skp1-cullin-f-box ubiquitin ligase activity. Stem Cells 30:1313–1326
  • Joy A, Moffett J, Neary K, Mordechai E, Stachowiak EK, Coons S, Rankin-Shapiro J, et al. 1997. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells. Oncogene 14:171–183
  • Kermorgant S, Zicha D, Parker PJ. 2003. Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met. J Biol Chem 278:28921–28929
  • Kim K, Brush JM, Watson PA, Cacalano NA, Iwamoto KS, McBride WH. 2008. Epidermal growth factor receptor vIII expression in U87 glioblastoma cells alters their proteasome composition, function, and response to irradiation. Mol Cancer Res 6:426–434
  • Korkolopoulou P, Levidou G, Saetta AA, El-Habr E, Eftichiadis C, Demenagas P, Thymara I, et al. 2008. Expression of nuclear factor-kappaB in human astrocytomas: Relation to pI kappa Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival. Hum Pathol 39:1143–1152
  • Krakauer T. 2008. Nuclear factor-kappaB: Fine-tuning a central integrator of diverse biologic stimuli. Int Rev Immunol 27:286–292
  • Lennartsson J, Wardega P, Engström U, Hellman U, Heldin CH. 2006. Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation. J Biol Chem 281:39152–39158
  • Li X, Liu J, Gao T. 2009a. β-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol 29:6192–6205
  • Li JJ, Liu DP, Liu GT, Xie D. 2009b. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene 28:1759–1768
  • Li G, Xu Y, Guan D, Liu Z, Liu DX. 2011. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J Biol Chem 286:20251–20259
  • Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, et al. 2006. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66:3593–3602
  • Magnani M, Crinelli R, Bianchi M, Antonelli A. 2000. The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-κB (NF-κB). Curr Drug Targets 1:387–399
  • Mani A, Gelmann EP. 2005. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 23:4776–4789
  • Mao H, Lebrun DG, Yang J, Zhu VF, Li M. 2012. Deregulated signaling pathways in glioblastoma multiforme: Molecular mechanisms and therapeutic targets. Cancer Invest 30:48–56
  • McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, et al. 2009. Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell 16:44–54
  • Monnier L, Milano G, Penault-Llorca F, Merlin JL. 2004. Targeting of membrane receptor tyrosine kinases: Is there resistance in the HER? [Article in French] Bull Cancer 91:685–694
  • Nagai S, Washiyama K, Kurimoto M, Takaku A, Endo S, Kumanishi T. 2002. Aberrant nuclear factor-κB activity and its participation in the growth of human malignant astrocytoma. J Neurosurg 96:909–917
  • Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJ. 1998. Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci USA 95:5724–5729
  • Otsuka G, Nagaya T, Saito K, Mizuno M, Yoshida J, Seo H. 1999. Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-alpha by impairment of cell cycle progression in human glioma cells. Cancer Res 59:4446–4452
  • Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, et al. 2006. Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem 281:21640–21651
  • Platten M, Wick W, Weller M. 2001. Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc Res Tech 52:401–410
  • Preusser M, Haberler C, Hainfellner JA. 2006. Malignant glioma: Neuropathology and neurobiology. Wien Med Wochenschr 156:332–337
  • Ruano Y, Mollejo M, Camacho FI, Rodríguez de Lope A, Fiaño C, Ribalta T, Martínez P, et al. 2008. Identification of survival-related genes of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma multiforme. Cancer 112:1575–1584
  • Rubtsov YP, Rudensky AY. 2007. TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol 7:443–453
  • Ruiz i Altaba A, Mas C, Stecca B. 2007. The Gli code: An information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 17:438–447
  • Ruiz i Altaba A, Palma V, Dahmane N. 2002. Hedgehog-Gli signalling and the growth of the brain. Nat Rev Neurosci 3:24–33
  • Sallinen SL, Sallinen PK, Kononen JT, Syrjäkoski KM, Nupponen NN, Rantala IS, Helén PT, et al. 1999. Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis. J Pathol 188:289–293
  • Sarkar FH, Li Y, Wang Z, Kong D. 2008. NF-κB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 27:293–319
  • Schmidt MH, Dikic I. 2006. Ubiquitin and NEDD8: Brothers in arms. Sci STKE 2006:pe50
  • Schmidt MH, Furnari FB, Cavenee WK, Bögler O. 2003. Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci USA 100:6505–6510
  • Seton-Rogers S. 2009. Tumour suppressors: Different roads to inactivation. Nat Rev Cancer 9:610
  • Smith D, Shimamura T, Barbera S, Bejcek BE. 2008. NF-κB controls growth of glioblastomas/astrocytomas. Mol Cell Biochem 307:141–147
  • Sonoda Y, Ozawa T, Hirose Y, Aldape KD, McMahon M, Berger MS, Pieper RO. 2001. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res 61:4956–4960
  • Stachowiak EK, Maher PA, Tucholski J, Mordechai E, Joy A, Moffett J, Coons S, Stachowiak MK. 1997. Nuclear accumulation of fibroblast growth factor receptors in human glial cells – Association with cell proliferation. Oncogene 14:2201–2211
  • Stecca B, Ruiz i Altaba A. 2009. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J 28:663–676
  • Stutz MA, Shattuck DL, Laederich MB, Carraway KL 3rd, Sweeney C. 2008. LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII. Oncogene 27:5741–5752
  • Sugawa N, Ekstrand AJ, James CD, Collins VP. 1990. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 87:8602–8606
  • Thaker NG, Zhang F, McDonald PR, Shun TY, Lewen MD, Pollack IF, Lazo JS. 2009. Identification of survival genes in human glioblastoma cells by small interfering RNA screening. Mol Pharmacol 76:1246–1255
  • Thomas CY, Chouinard M, Cox M, Parsons S, Stallings-Mann M, Garcia R, Jove R, Wharen R. 2003. Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells. Int J Cancer 104:19–27
  • Thompson SJ, Loftus LT, Ashley MD, Meller R. 2008. Ubiquitin-proteasome system as a modulator of cell fate. Curr Opin Pharmacol 8:90–95
  • Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. 2007. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience 145:795–811
  • Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M, Yokosawa H, Nomura Y. 1999. Transient nuclear factor κB (NF-κB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-κB linked to chemokine production. J Biol Chem 274:15875–15882
  • Walter KA, Hossain MA, Luddy C, Goel N, Reznik TE, Laterra J. 2002. Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. Mol Cell Biol 22:2703–2715
  • Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. 2011. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem 286:19777–19788
  • Wen PY, Kesari S. 2008. Malignant gliomas in adults. N Engl J Med 359:492–507
  • Westermark B, Heldin CH, Nistér M. 1995. Platelet-derived growth factor in human glioma. Glia 15:257–263
  • Wu TF, Zhang W, Su ZP, Chen SS, Chen GL, Wei YX, Sun T, et al. 2012. UHRF2 mRNA expression is low in malignant glioma but silencing inhibits the growth of U251 glioma cells in vitro. Asian Pac J Cancer Prev 13:5137–5142
  • Xu T, Zhou Q, Zhou J, Huang Y, Yan Y, Li W, Wang C, et al. 2011. Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis. Cancer Sci 102:959–966
  • Yamamoto M, Fukushima T, Hayashi S, Ikeda K, Tsugu H, Kimura H, Soma G, Tomonaga M. 2000. Correlation of the expression of nuclear factor-kappa B, tumor necrosis factor receptor type 1 (TNFR 1) and c-Myc with the clinical course in the treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2). Anticancer Res 20:611–618
  • Yang W, Wang L, Roehn G, Pearlstein RD, Ali-Osman F, Pan H, Goldbrunner R, et al. 2013. Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer Sci 104:70–77
  • Yang Y, Zhang C, Li L, Gao Y, Luo X, Zhang Y, Liu W, Fei Z. 2012. Up-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma. World J Surg Oncol 10:169
  • Yeo CW, Ng FS, Chai C, Tan JM, Koh GR, Chong YK, Koh LW, et al. 2012. Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. Cancer Res 72:2543–2553
  • Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R. 1999. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem 274:31707–31712
  • Yuan J, Tu Y, Mao X, He S, Wang L, Fu G, Zong J, Zhang Y. 2012. Increased expression of FAT10 is correlated with progression and prognosis of human glioma. Pathol Oncol Res 18:833–839
  • Yue S, Chen Y, Cheng SY. 2009. Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. Oncogene 28:492–499
  • Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, et al. 2004. NF-κ B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci USA 101:13618–13623
  • Zhang F, Laiho M. 2003. On and off: Proteasome and TGF-beta signaling. Exp Cell Res 291:275–281
  • Zhang P, Lathia JD, Flavahan WA, Rich JN, Mattson MP. 2009. Squelching glioblastoma stem cells by targeting REST for proteasomal degradation. Trends Neurosci 32:559–565
  • Zhao Z, Tan X, Zhao A, Zhu L, Yin B, Yuan J, Qiang B, Peng X. 2012. microRNA-214-mediated UBC9 expression in glioma. BMB Rep 45:641–646
  • Zhou YX, Chen SS, Wu TF, Ding DD, Chen XH, Chen JM, Su ZP, et al. 2012. A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251. Anal Cell Pathol (Amst) 35:167–178
  • Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, et al. 2013. c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Mol Cell 49:499–510

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.