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Research Article

Role of nanocarrier systems in cancer nanotherapy

, , , , &
Pages 310-321 | Received 15 Jan 2009, Accepted 21 Mar 2009, Published online: 28 Oct 2009

References

  • Al-Jamal KT, Ramaswamy C, Florence AT. (2005). Supramolecular structures from dendrons and dendrimers. Adv Drug Deliv Rev. 57:2238–2270.
  • Allemann E, Gurny R, Doelker E. (1993). Drug-loaded nanoparticles—preparation methods and drug targeting issues. Eur J Pharm Biopharm. 39:173–191.
  • Allen TM, Cullis PR. (2004). Drug delivery systems: entering the mainstream. Science. 303:1818–1822.
  • Andresen TL, Jensen SS, Jorgensen K. (2005). Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog Lipid Res. 44:68–97.
  • Araujo L, Lobenberg R, Kreuter J. (1999). Influence of the surfactant concentration on the body distribution of nanoparticles. J Drug Targ. 6:373–385.
  • Aulenta F, Hayes W, Rannard S. (2003). Dendrimers: a new class of nanoscopic containers and delivery devices. Eur Polym J. 39:1741–1771.
  • Azarmi S, Huang Y, Chen H, McQuarrie S, Abrams D, Roa W, et al. (2006a). Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells. J Pharm Pharm Sci. 9:124–132.
  • Azarmi S, Tao X, Chen H, Wang Z, Finlay WH, Lobenberg R, et al. (2006b). Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles. Int J Pharm. 319:155–161.
  • Bhadra D, Bhadra S, Jain S, Jain NK. (2003). A PEGylated dendritic nanoparticulate carrier of fluorouracil. Int J Pharm. 257:111–124.
  • Blagosklonny MV. (2003). Targeting cancer cells by exploiting their resistance. Trends Mol Med. 9:307–312.
  • Boas U, Heegaard PM. (2004). Dendrimers in drug research. Chem Soc Rev. 33:43–63.
  • Bosman AW, Janssen HM, Meijer EW. (1999). About dendrimers: structure, physical properties, and applications. Chem Rev. 99:1665–1688.
  • Brannon-Peppas L, Blanchette JO. (2004). Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev. 56:1649–1659.
  • Butts C, Murray N, Maksymiuk A, Goss G, Marshall E, Soulieres D, et al. (2005). Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J Clin Oncol. 23:6674–6681.
  • Cammas SK. (1996). NATO ASI Series, Series E. In: Webber SE (Ed.), Solvents and Self-Organization of Polymers (pp 83–113 ). Amsterdam, The Netherlands: Kluwer Academic.
  • Chari RV. (1998). Targeted delivery of chemotherapeutics: tumor-activated prodrug therapy. Adv Drug Deliv Rev. 31:89–104.
  • Chaurasia M, Chourasia MK, Jain NK, Jain A, Soni V, Gupta Y, et al. (2006). Cross-linked guar gum microspheres: a viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer. AAPS PharmSciTech. 7:74.
  • Cheng MM, Cuda G, Bunimovich YL, Gaspari M, Heath JR, Hill HD, et al. (2006). Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol. 10:11–19.
  • Cheung RY, Rauth AM, Ronaldson PT, Bendayan R, Wu XY. (2006). In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin. Eur J Pharm Biopharm. 62:321–331.
  • Choe YH, Conover CD, Wu D, Royzen M, Gervacio Y, Borowski V, et al. (2002). Anticancer drug delivery systems: multiloaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors. J Contr Rel. 79:55–70.
  • Colas JC, Shi W, Rao VS, Omri A, Mozafari MR, Singh H. (2007). Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting. Micron. 38:841–847.
  • Cortesi R, Esposito E, Gambarin S, Telloli P, Menegatti E, Nastruzzi C. (1999). Preparation of liposomes by reverse-phase evaporation using alternative organic solvents. J Microencapsul. 16:251–256.
  • Daemen T, Hofstede G, Ten Kate MT, Bakker-Woudenberg IA, Scherphof GL. (1995). Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages. Int J Cancer. 61:716–721.
  • Dass CR, Choong PF. (2006). Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability. J Contr Rel. 113:155–163.
  • De Brabander-van den Berg EMM, Nijenhuis A, Mure M, Keulen J, Reintjens R, Vandenbooren F, et al. (1994). Large-scale production of polypropylenimine dendrimers. Macromolecular Symposia, International Symposium on New Macromolecular Architectures and Supramolecular Polymers. 77:51–62.
  • De Jaeghere F, Doelker E, Gurny R. (1999). Nanospheres. In: Mathiowitz E. (Ed.), Encyclopedia of Controlled Drug Delivery (pp 641–656 ). New York: John Wiley & Sons.
  • Deamer DW, Uster PS. (1983). Liposome preparation methods. In: Ostro MJ (Ed.), Liposomes (pp 27–51 ). New York: Marcel Dekker.
  • Desoguilles S, Vauthier C, Bazile D, Vacus J, Grossiord JL, Veillard M, et al. (2003). The design of nanoparticles obtained by solvent evaporation: a comprehensive study. Langmuir. 19:9504–9510.
  • Dufes C, Uchegbu IF, Schtzlein AG. (2005). Dendrimers in gene delivery. Adv Drug Deliv Rev. 57:2177–2202.
  • Duncan R. (2003). The dawning era of polymer therapeutics. Nat Rev Drug Discov. 2:347–360.
  • Duncan R, Malik N. (1996). Dendrimers: biocompatibility and potential for delivery of anticancer agents. Proceedings of the International Symposium on Controlled Release of Bioactive Materials. 23:105–106.
  • Dwivedi AM. (2002). Residual solvent analysis in pharmaceuticals. Pharm Technol Eur. 14:26–28.
  • Emerich DF. (2005). Nanomedicine—prospective therapeutic and diagnostic applications. Expert Opin Biol Ther. 5:1–5.
  • Frenkel V. (2008). Ultrasound mediated delivery of drugs and genes to solid tumors. Adv Drug Deliv Rev. 60:1193–1208.
  • Gardikis K, Hatziantoniou S, Viras K, Wagner M, Demetzos C. (2006). Interaction of dendrimers with model lipid membranes assessed by DSC and RAMAN spectroscopy. In: Mozafari MR (Ed.), Nanocarrier Technologies: Frontiers of Nanotherapy (pp 207–220 ). The Netherlands: Springer.
  • Gelperina SE, Khalansky AS, Skidan IN, Smirnova ZS, Bobruskin AI, Severin SE, et al. (2002). Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. Toxicol Lett. 126:131–141.
  • Gibaud S, Rousseau C, Weingarten C, Favier R, Douay L, Andreux JP, et al. (1998). Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF). J Contr Rel. 52:131–139.
  • Gillies ER, Frechet JM. (2005). Dendrimers and dendritic polymers in drug delivery. Drug Discov Today. 10:35–43.
  • Goncalves A, Braud AC, Viret F, Genre D, Gravis G, Tarpin C, et al. (2003). Phase I study of pegylated liposomal doxorubicin (Caelyx) in combination with carboplatin in patients with advanced solid tumors. Anticancer Res. 23:3543–3548.
  • Gradishar WJ. (2006). Albumin-bound paclitaxel: a next-generation taxane. Expert Opin Pharmacother. 7:1041–1053.
  • Grant GJ, Barenholz Y, Bolotin EM, Bansinath M, Turndorf H, Piskoun B, et al. (2004). A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia. Anesthesiology. 101:133–137.
  • Guan HH, Budzynski W, Koganty RR, Krantz MJ, Reddish MA, Rogers JA, et al. (1998). Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses. Bioconjug Chem. 9:451–458.
  • Haensler J, Szoka FC, Jr. (1993). Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem. 4:372–379.
  • Harrington KJ, Lewanski C, Northcote AD, Whittaker J, Peters AM, Vile RG, et al. (2001). Phase II study of pegylated liposomal doxorubicin (Caelyx™) in patients with inoperable, locally advanced squamous cell cancer of the head and neck. Eur J Cancer. 37:2015–2022.
  • Harrington KJ, Rowlinson-Busza G, Syrigos KN, Abra RM, Uster PS, Peters AM, et al. (2000a). Influence of tumour size on uptake of (111)ln-DTPA-labelled pegylated liposomes in a human tumour xenograft model. Br J Cancer. 83:684–688.
  • Harrington KJ, Rowlinson-Busza G, Syrigos KN, Uster PS, Abra RM, Stewart JS. (2000b). Biodistribution and pharmacokinetics of 111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model: implications for novel targeting strategies. Br J Cancer 83:232–238.
  • Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, et al. (2000). Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 156:1363–1380.
  • Hawker CJ, Wooley KL, Frechet JMJ. (1993). Unimolecular micelles and globular amphiphiles: dendritic macromolecules as novel recyclable solubilization agents. J Chem Soc. 1:1287–1297.
  • Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, et al. (1998). Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A. 95:4607–4612.
  • Hood JD, Bednarski M, Frausto R, Guccione S, Reisfeld RA, Xiang R, et al. (2002). Tumor regression by targeted gene delivery to the neovasculature. Science. 296:2404–2407.
  • Huang G, Zhou Z, Srinivasan R, Penn MS, Kottke-Marchant K, Marchant RE, et al. (2008). Affinity manipulation of surface-conjugated RGD peptide to modulate binding of liposomes to activated platelets. Biomaterials. 29:1676–1685.
  • Hughes GA. (2005). Nanostructure-mediated drug delivery. Nanomedicine. 1:22–30.
  • Jansen JF, de Brabander-van den Berg EM, Meijer EW. (1994). Encapsulation of guest molecules into a dendritic box. Science. 266:1226–1229.
  • Jansen JFGA, Meijer EW, De Brabander-van den Berg EMM. (1995). The dendritic box: shape-selective liberation of encapsulated guests. J Am Chem Soc. 117:4417–4418.
  • Johnsson M, Bergstrand N, Edwards K. (1999). Optimization of drug loading procedures and characterization of liposomal formulations of two novel agents intended for boron neutron capture therapy (BNCT). J Liposome Res. 9:53–79.
  • Johnston SR, Gore ME. (2001). Caelyx: phase II studies in ovarian cancer. Eur J Cancer. 37(Suppl 9):S8–S14.
  • Karanth H, Murthy RS. (2007). pH-sensitive liposomes—principle and application in cancer therapy. J Pharm Pharmacol. 59:469–483.
  • Kasaai MR, Charlet G, Paquin P, Arul J. (2003). Fragmentation of chitosan by microfluidization process. Innov Food Sci Emerg Technol. 4:403–413.
  • Kawashima Y. (2001). Panoparticulate systems for improved drug delivery. Adv Drug Deliv Rev. 47:1–2.
  • Khosravi-Darani K, Pardakhty A, Honarpisheh H, Rao VS, Mozafari MR. (2007). The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy. Micron. 38:804–818.
  • Kojima C, Kono K, Maruyama K, Takagishi T. (2000). Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjug Chem. 11:910–917.
  • Kono K, Kojima C, Hayashi N, Nishisaka E, Kiura K, Watarai S, et al. (2008). Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin. Biomaterials. 29:1664–1675.
  • Kono K, Liu M, Frechet JM. (1999). Design of dendritic macromolecules containing folate or methotrexate residues. Bioconjug Chem. 10:1115–1121.
  • Lai PS, Lou PJ, Peng CL, Pai CL, Yen WN, Huang MY, et al. (2007). Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J Contr Rel. 122:39–46.
  • Langner, M., Kozubek, A. (2006). Pharmacokinetic modulation with particulate drug formulations. In: Mozafari MR (Ed.), Nanocarrier Technologies Frontiers of Nanotherapy (pp 113–138 ). The Netherlands: Springer.
  • Leamon CP, Low PS. (2001). Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discov Today. 6:44–51.
  • Leamon CP, Reddy JA. (2004). Folate-targeted chemotherapy. Adv Drug Deliv Rev. 56:1127–1141.
  • Lemoine D, Preat V. (1998). Polymeric nanoparticles as delivery system for influenza virus glycoproteins. J Contr Rel. 54:15–27.
  • Lu Y, Low PS. (2003). Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects. J Contr Rel. 91:17–29.
  • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. (2000). Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Contr Rel. 65:271–284.
  • Mahmud A, Xiong XB, Aliabadi HM, Lavasanifar A. (2007). Polymeric micelles for drug targeting. J Drug Target. 15:553–584.
  • Malik N, Evagorou EG, Duncan R. (1999). Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs. 10:767–776.
  • Matsumura Y, Maeda H. (1986). A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46:6387–6392.
  • McDonald DM, Baluk P. (2002). Significance of blood vessel leakiness in cancer. Cancer Res. 62:5381–5385.
  • Mehta J, Kelsey S, Chu P, Powles R, Hazel D, Riley U, et al. (1997). Amphotericin B lipid complex (ABLC) for the treatment of confirmed or presumed fungal infections in immunocompromised patients with hematologic malignancies. Bone Marrow Transpl. 20:39–43.
  • Mitra S, Gaur U, Ghosh PC, Maitra AN. (2001). Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Contr Rel. 74:317–323.
  • Moghimi SM, Hunter AC. (2000). Poloxamers and poloxamines in nanoparticle engineering and experimental medicine. Trends Biotechnol. 18:412–420.
  • Moghimi SM, Hunter AC, Murray JC. (2005). Nanomedicine: current status and future prospects. FASEB J. 19:311–330.
  • Moghimi SM, Vega E, Garcia ML, Al-Hanbali OAR, Rutt KJ. (2006). Polymeric nanoparticles as drug carriers and controlled release implant devices. In: Torchilin VP (Ed.), Nanoparticulates as Drug Carriers (pp 29–42 ). London: Imperial College Press.
  • Monnard PA, Deamer DW. (2001). Nutrient uptake by protocells: a liposome model system. Orig Life Evol Biosph. 31:147–155.
  • Morgan MT, Nakanishi Y, Kroll DJ, Griset AP, Carnahan MA, Wathier M, et al. (2006). Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro. Cancer Res. 66:11913–11921.
  • Morrow KJ, Jr, Bawa R, Wei C. (2007). Recent advances in basic and clinical nanomedicine. Med Clin North Am. 91:805–843.
  • Mozafari MR, Reed CJ, Rostron C. (2004). Formation of the initial cell membranes under primordial Earth conditions. Cell Mol Biol Lett. 9 (S2), 97–99.
  • Mozafari MR. (2005). Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett. 10:711–719.
  • Mozafari MR. (2006). Bioactive entrapment and targeting using nanocarrier technologies: an introduction. Nanocarrier Technologies Frontiers of Nanotherapy. The Netherlands: Springer.
  • Mozafari MR, Flanagan J, Matia-Merino L, Omri A, Suntres ZE, Singh H. (2006). Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods. J Sci Food Agric. 86:2038–2045.
  • Mozafari MR, Mortazavi SM. (2005). Nanoliposomes: from Fundamentals to Recent Developments. Oxford, UK: Trafford Publishing Ltd.
  • Mozafari MR, Reed CJ, Rostron C. (2007). Cytotoxicity evaluation of anionic nanoliposomes and nanolipoplexes prepared by the heating method without employing volatile solvents and detergents. Pharmazie. 62:205–209.
  • Mozafari MR, Reed CJ, Rostron C, Kocum C, Piskin E. (2002). Construction of stable anionic liposome-plasmid particles using the heating method: a preliminary investigation. Cell Mol Biol Lett. 7:923–927.
  • Myc A, Patri AK, Baker JR, Jr. (2007). Dendrimer-based BH3 conjugate that targets human carcinoma cells. Biomacromolecules. 8:2986–2989.
  • Newkome GR, Nayak A, Behera RK, Moorefield CN, Baker GR. (1992). Cascade polymers: synthesis and characterization of four- directional spherical dendritic macromolecules based on adamantane. J Organic Chem. 57:358–362.
  • Nie S, Xing Y, Kim GJ, Simons JW. (2007). Nanotechnology applications in cancer. Annu Rev Biomed Eng. 9:257–288.
  • Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y. (1993). Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J Contr Rel. 25:89–98.
  • Nomura SM, Yoshikawa Y, Yoshikawa K, Dannenmuller O, Chasserot-Golaz S, Ourisson G, et al. (2001). Towards proto-cells: “primitive” lipid vesicles encapsulating giant DNA and its histone complex. Chembiochem. 2:457–459.
  • Pan H, Han L, Chen W, Yao M, Lu W. (2008). Targeting to tumor necrotic regions with biotinylated antibody and streptavidin modified liposomes. J Contr Rel. 125:228–235.
  • Park EK, Lee SB, Lee YM. (2005). Preparation and characterization of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials. 26:1053–1061.
  • Patri AK, Majoros IJ, Baker JR. (2002). Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol. 6:466–471.
  • Patri AK, Myc A, Beals J, Thomas TP, Bander NH, Baker JR, Jr. (2004). Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy. Bioconjug Chem. 15:1174–1181.
  • Peek LJ, Middaugh CR, Berkland C. (2008). Nanotechnology in vaccine delivery. Adv Drug Deliv Rev. 60: 915–928.
  • Perez AT, Domenech GH, Frankel C, Vogel CL. (2002). Pegylated liposomal doxorubicin (Doxil) for metastatic breast cancer: the Cancer Research Network, Inc., experience. Cancer Invest. 20(Suppl 2):22–29.
  • Pozzi G, Birault V, Werner B, Dannenmuller O, Nakatani Y, Ourisson G, et al. (1996). Single-chain polyprenyl phosphates form primitive membranes. Angewandte Chemie. 35:177–180.
  • Quintana A, Raczka E, Piehler L, Lee I, Myc A, Majoros I, et al. (2002). Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res. 19:1310–1316.
  • Sahoo SK, Labhasetwar V. (2003). Nanotech approaches to drug delivery and imaging. Drug Discov Today. 8:1112–1120.
  • Sahoo SK, Parveen S, Panda JJ. (2007). The present and future of nanotechnology in human health care. Nanomedicine. 3:20–31.
  • Schiavon O, Pasut G, Moro S, Orsolini P, Guiotto A, Veronese FM. (2004). PEG-Ara-C conjugates for controlled release. Eur J Med Chem. 39:123–133.
  • Scholes PD, Coombes AGA, Illum L, Daviz SS, Vert M, Davies MC. (1993). The preparation of sub-200-nm poly(lactide-co- glycolide) microspheres for site-specific drug delivery. J Contr Rel. 25:145–153.
  • Schwonzen M, Kurbacher CM, Mallmann P. (2000). Liposomal doxorubicin and weekly paclitaxel in the treatment of metastatic breast cancer. Anticancer Drugs. 11:681–685.
  • Shaffer C. (2005). Nanomedicine transforms drug delivery. Drug Discov Today. 10:1581–1582.
  • Shehata M, Mukherjee A, Sharma R, Chan S. (2007). Liposomal doxorubicin in breast cancer. Women’s Health. 3:557–569.
  • Singla AK, Garg A, Aggarwal D. (2002). Paclitaxel and its formulations. Int J Pharm. 235:179–192.
  • Sofou S, Sgouros G. (2008). Antibody-targeted liposomes in cancer therapy and imaging. Expert Opin Drug Deliv. 5:189–204.
  • Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, et al. (1997). Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Contr Rel. 43:197–212.
  • Stiriba SE, Frey H, Haag R. (2002). Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed Engl. 41:1329–1334.
  • Sudimack J, Lee RJ. (2000). Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev. 41:147–162.
  • Sun B, Ranganathan B, Feng SS. (2008). Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer. Biomaterials. 29:475–486.
  • Sundar S, Jha TK, Thakur CP, Mishra M, Singh VP, Buffels R. (2003). Single-dose liposomal amphotericin B in the treatment of visceral leishmaniasis in India: a multicenter study. Clin Infect Dis. 37:800–804.
  • Suntres ZE, Shek PN. (1995). Liposome-associated antioxidants for pulmonary applications. In: Shek PN (Ed.), Biomedical Applications of Liposomes (pp 179–198 ). Singapore: Harwood Academic.
  • Suntres ZE, Shek PN. (1996). Alleviation of paraquat-induced lung injury by pretreatment with bifunctional liposomes containing alpha-tocopherol and glutathione. Biochem Pharmacol. 52:1515–1520.
  • Suzuki R, Takizawa T, Kuwata Y, Mutoh M, Ishiguro N, Utoguchi N, et al. (2008). Effective anti-tumor activity of oxaliplatin encapsulated in transferrin-PEG-liposome. Int J Pharm. 346(1–2):143–150.
  • Svenson S, Tomalia DA. (2005). Dendrimers in biomedical applications—reflections on the field. Adv Drug Deliv Rev. 57:2106–2129.
  • Tang N, Du G, Wang N, Liu C, Hang H, Liang W. (2007). Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. J Natl Cancer Inst. 99:1004–1015.
  • Tomalia DA. (1996). Starburst dendrimers—nanoscopic supermolecules according to dendritic rules and principles. Macromolec Symp. 101:243–255.
  • Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, et al. (1985). A new class of polymers: starburst-dendritic macromolecules. Polymer J. 17:117–132.
  • Tomalia DA, Esfand R. (1997). Dendrons, dendrimers, and dendrigrafts. Chem Industry. 11:416–420.
  • Tsuruo T. (2003). Molecular cancer therapeutics: recent progress and targets in drug resistance. Intern Med. 42:237–243.
  • Uchegbu, I.F. (2000). Niosomes and other synthetic surfactant vesicles with antitumour drugs. In: Uchegbu IF (Ed.), Synthetic Surfactant Vesicles (pp 115–133 ). The Netherlands: Harwood Academic.
  • Uchegbu IF, Vyas SP. (1998). Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm. 172:33–70.
  • Vasir JK, Labhasetwar V. (2005). Targeted drug delivery in cancer therapy. Technol Cancer Res Treat. 4:363–374.
  • Vasir JK, Reddy MK, Labhasetwar V. (2005). Nanosystems in drug targeting: opportunities and challenges. Curr Nanosci. 1:45–62.
  • Vauthier C, Dubernet C, Fattal E, Pinto-Alphandary H, Couvreur P. (2003). Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications. Adv Drug Deliv Rev. 55:519–548.
  • Vemuri S, Rhodes CT. (1995). Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharm Acta Helv. 70:95–111.
  • Wang D, Kopeckova JP, Minko T, Nanayakkara V, Kopecek J. (2000). Synthesis of star-like N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers. Biomacromolecules. 1:313–319.
  • Wang YM, Sato H, Adachi I, Horikoshi I. (1996). Preparation and characterization of poly(lactic-co-glycolic acid) microspheres for targeted delivery of a novel anticancer agent, taxol. Chem Pharm Bull 44:1935–1940.
  • Wei C, Wei W, Morris M, Kondo E, Gorbounov M, Tomalia DA. (2007). Nanomedicine and drug delivery. Med Clin North Am. 91:863–870.
  • Wilkinson JM. (2003). Nanotechnology applications in medicine. Med Device Technol. 14:29–31.
  • Williams D. (2004). Nanotechnology: a new look. Med Device Technol. 15:9–10.
  • Williams J, Lansdown R, Sweitzer R, Romanowski M, LaBell R, Ramaswami R, et al. (2003). Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors. J Contr Rel. 91:167–172.
  • Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. (2007). Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 59:491–504.
  • Wörner C, Mülhaupt R. (1993). Polynitrile- and polyamine-functional poly(trimethylene imine) dendrimers. Angewandte Chemie Int Ed Engl. 32:1306–1308.
  • Xiang G, Wu J, Lu Y, Liu Z, Lee RJ. (2008). Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int J Pharm 356:29–36.
  • Yoo HS, Park TG. (2000). In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. Polym Prep. 41:992–993.
  • Yurdugul S, Mozafari MR. (2004). Recent advances in micro- and nanoencapsulation of food ingredients. Cell Mol Biol Lett. 9 (S2):64–65.
  • Zanta MA, Boussif O, Adib A, Behr JP. (1997). In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug Chem. 8:839–844.
  • Zhang Y, Schlachetzki F, Pardridge WM. (2003). Global non-viral gene transfer to the primate brain following intravenous administration. Mol Ther. 7:11–18.
  • Zhou RX, Du B, Lu ZR. (1999). In vitro release of 5-fluorouracil with cyclic core dendritic polymer. J Contr Rel. 57:249–257.

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