423
Views
17
CrossRef citations to date
0
Altmetric
Hormones and Cancer

Membrane-receptor initiated proliferative effects of dienogest in human breast cancer cells

, , , , , & show all
Pages 160-162 | Received 16 Apr 2012, Accepted 17 Jul 2012, Published online: 02 Nov 2012

References

  • Oettel M, Gräser T, Hoffman H. Why dienogest as a progestogenic component of postmenopausal nonandrogenic hormone replacement therapy. Drugs Today 2001;37:3–15.
  • Lippert TH, Mueck AO. The clinical importance of dienogest. In: Teichmann AT, editor. Dienogest – Preclinical and Clinical Features of a New Progestogen. New York: Walter de Gruyter Verlag Berlin; 1995. pp 261–227.
  • McCormack PL. Dienogest: a review of its use in the treatment of endometriosis. Drugs 2010;70:2073–2088.
  • Mueck AO. Dienogest: an oral progestogen for the treatment of endometriosis. Expert Rev Obstet Gynecol 2011;6:5–15.
  • Mueck AO, Seeger H, Bühling KJ. Why use of dienogest for the first contraceptive pill with estradiol? Gynecol Endocrinol 2010;26:109–113.
  • Keder LM. A new estradiol-dienogest oral contraceptive marks “The Pill’s” 50th anniversary. Am J Ther 2011;18:38–44.
  • Düsterberg B, Nishino Y. Pharmacokinetic and pharmacological features of oestradiol valerate. Maturitas 1982;4:315–324.
  • Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002;288:321–333.
  • The Women’s Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. JAMA 2004;291:1701–1712.
  • Seeger H, Mueck AO. HRT and breast cancer caused: caused by progestogens? Experimental vs. clinical data. J Steroid Biochem Molecular Biology 2008;109:11–15.
  • Fournier A, Berrino F, Clavel-Chapelon F. Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res Treat 2008;107:103–111.
  • Krämer EA, Seeger H, Krämer B, Wallwiener D, Mueck AO. The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cells. Eur J Obstet Gynecol Reprod 2006;27:139–141.
  • Neubauer H, Yang Y, Seeger H, Fehm T, Cahill MA, Tong X, Ruan X, Mueck AO. The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells. Menopause 2011;18:845–850.
  • Stanczyk FZ. Can the increase in breast cancer observed in the estrogen plus progestin arm of the Women’s Health Initiative trial be explained by progesterone receptor membrane component 1? Menopause 2011;18:833–834.
  • Neubauer H, Clare SE, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Vogel U, et al. Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. Breast Cancer Res 2008;10:R85.
  • Neubauer H, Adam G, Seeger H, Mueck AO, Solomayer E, Wallwiener D, Cahill MA, Fehm T. Membrane-initiated effects of progesterone on proliferation and activation of VEGF in breast cancer cells. Climacteric 2009;12:230–239.
  • Neubauer H, Chen R, Schneck H, Knorrp T, Templin MF, Fehm T, Cahill MA, et al. New insight on a possible mechanism of progestogens in terms of breast cancer risk. Horm Mol Biol Clin Invest 2011;6:185–192.
  • Ruan X, Neubauer H, Yang Y, Schneck H, Schultz S, Fehm T, Cahill MA, et al. Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells. Climacteric 2012;15:467–472.
  • Ruan X, Schneck H, Schultz S, Fehm T, Cahill MA, Seeger H, Chen R, et al. Nomegestrol acetate sequentially or continuously combined to estradiol did not negatively affect membrane-receptor associated progestogenic effects in human breast cancer cells. Gynecol Endocrinol 2012 Apr 12. [Epub ahead of print].
  • Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines. J Steroid Biochem Mol Biol 1995;55:423–437.
  • Cappelletti V, Miodini P, Fioravanti L, Di Fronzo G. Effect of progestin treatment on estradiol-and growth factor-stimulated breast cancer cell lines. Anticancer Res 1995;15:2551–2555.
  • Catherino WH, Jeng MH, Jordan VC. Norgestrel and gestodene stimulate breast cancer cell growth through an oestrogen receptor mediated mechanism. Br J Cancer 1993;67:945–952.
  • Franke HR, Vermes I. Differential effects of progestogens on breast cancer cell lines. Maturitas 2003;46 Suppl 1:S55–S58.
  • Ruan X, Seeger H, Mueck AO. The pharmacology of dienogest. Maturitas 2012;71:337–344.
  • Ruan X, Seeger H, Mueck AO. The pharmacology of nomegestrol acetate. Maturitas 2012;71:345–353.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.