Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF

References

• Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:766–81
   PubMed Web of Science ®Google Scholar
• Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006;91:2906–12
   PubMed Web of Science ®Google Scholar
• McTigue K, Larson JC, Valoski A, et al. Mortality and cardiac and vascular outcomes in extremely obese women. JAMA 2006;296:79–86
   PubMed Web of Science ®Google Scholar
• Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–38
   PubMed Web of Science ®Google Scholar
• Pasquali R, Pelusi C, Genghini S, et al. Obesity and reproductive disorders in women. Hum Reprod Update 2003;9:359–72
   PubMed Web of Science ®Google Scholar
• Bellver J, Pellicer A, Garcia-Velasco JA, et al. Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril 2013;100:1050–8
   PubMed Web of Science ®Google Scholar
• Merhi Z, Buyuk E, Berger DS, et al. Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF. Hum Reprod 2013;28:1661–9
   PubMed Web of Science ®Google Scholar
• Merhi Z. Weight loss by bariatric surgery and subsequent fertility. Fertil Steril 2007;87:430–12
   PubMed Web of Science ®Google Scholar
• Merhi Z. Bariatric surgery and subsequent sexual function. Fertil Steril 2007;87:710–11
   PubMed Web of Science ®Google Scholar
• Merhi Z. Impact of bariatric surgery on female reproduction. Fertil Steril 2009;92:1501–8
   PubMed Web of Science ®Google Scholar
• Merhi Z, Minkoff H, Feldman J, et al. Relationship of bariatric surgery to Mullerian-inhibiting substance levels. Fertil Steril 2008;90:221–4
   PubMed Web of Science ®Google Scholar
• Merhi Z, Pal L. Effect of weight loss by bariatric surgery on the risk of miscarriage. Gynecol Obstet Invest 2007;64:224–7
   PubMed Web of Science ®Google Scholar
• Merhi Z, McGee EA, Buyuk E. Role of advanced glycation end-products in obesity-related ovarian dysfunction. Minerva Andocrinol 2014;39:167–74
   PubMed Web of Science ®Google Scholar
• Rich-Edwards JW, Spiegelman D, Garland M, et al. Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology 2002;13:184–90
   PubMed Web of Science ®Google Scholar
• Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod 2007;22:414–20
   PubMed Web of Science ®Google Scholar
• van der Steeg JW, Steures P, Eijkemans MJ, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod 2008;23:324–8
   PubMed Web of Science ®Google Scholar
• Tamer Erel C, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol 2009;21:228–35
   PubMed Web of Science ®Google Scholar
• Bellver J, Rossal LP, Bosch E, et al. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril 2003;79:1136–40
   PubMed Web of Science ®Google Scholar
• Bellver J, Melo MA, Bosch E, et al. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007;88:446–51
   PubMed Web of Science ®Google Scholar
• Zhang D, Zhu Y, Gao H, et al. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol Endocrinol 2010;26:325–32
   PubMed Web of Science ®Google Scholar
• Moragianni VA, Jones SM, Ryley DA. The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertil Steril 2012;98:102–8
   PubMed Web of Science ®Google Scholar
• Dessolle L, Darai E, Cornet D, et al. Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers. Hum Reprod (Oxford, England) 2009;24:3082–9
   PubMed Web of Science ®Google Scholar
• DeUgarte DA, DeUgarte CM, Sahakian V. Surrogate obesity negatively impacts pregnancy rates in third-party reproduction. Fertil Steril 2010;93:1008–10
   PubMed Web of Science ®Google Scholar
• Williams SC, Gibbons WE, Muasher SJ, Oehninger S. Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropin-releasing hormone antagonist. Fertil Steril 2002;78:1068–72
   PubMed Web of Science ®Google Scholar
• Zarek SM, Muasher SJ. Mild/minimal stimulation for in vitro fertilization: an old idea that needs to be revisited. Fertil Steril 2011;95:2449–55
   PubMed Web of Science ®Google Scholar
• Teramoto S, Kato O. Minimal ovarian stimulation with clomiphene citrate: a large-scale retrospective study. Reprod Biomed Online 2007;15:134–48
   PubMed Web of Science ®Google Scholar
• Fauser BC, Van Heusden AM. Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev 1997;18:71–106
   PubMed Web of Science ®Google Scholar
• Verberg MF, Eijkemans MJ, Macklon NS, et al. The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis. Hum Reprod Update 2009;15:5–12
   PubMed Web of Science ®Google Scholar
• Kato K, Takehara Y, Segawa T, et al. Minimal ovarian stimulation combined with elective single embryo transfer policy: age-specific results of a large, single-centre, Japanese cohort. Reprod Biol Endocrinol 2012;10:35–42
   PubMed Web of Science ®Google Scholar
• Zhang J, Chang L, Sone Y, Silber S. Minimal ovarian stimulation (mini-IVF) for IVF utilizing vitrification and cryopreserved embryo transfer. Reprod Biomed Online 2010;21:485–95
   PubMed Web of Science ®Google Scholar
• Humaidan P, Polyzos NP. Human chronic gonadotropin vs. gonadotropin-releasing hormone agonist trigger in assisted reproductive technology – “The king is dead, long live the king!”. Fertil Steril 2014;102:339–41
   PubMed Web of Science ®Google Scholar
• Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894:1–253
   Google Scholar
• Kuwayama M. Highly efficient vitrification for cryopreservation of human oocytes and embryos: the Cryotop method. Theriogenology 2007;67:73–80
   PubMed Web of Science ®Google Scholar
• Wittemer C, Ohl J, Bailly M, et al. Does body mass index of infertile women have an impact on IVF procedure and outcome? J Assist Reprod Genet 2000;17:547–52
   PubMed Web of Science ®Google Scholar
• Dokras A, Baredziak L, Blaine J, et al. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006;108:61–9
   PubMed Web of Science ®Google Scholar
• Dechaud H, Anahory T, Reyftmann L, et al. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2006;127:88–93
   PubMed Web of Science ®Google Scholar
• Vilarino FL, Christofolini DM, Rodrigues D, et al. Body mass index and fertility: is there a correlation with human reproduction outcomes? Gynecol Endocrinol 2011;27:232–6
   PubMed Web of Science ®Google Scholar
• Matalliotakis I, Cakmak H, Sakkas D, et al. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod Biomed Online 2008;16:778–83
   PubMed Web of Science ®Google Scholar
• Shah DK, Missmer SA, Berry KF, et al. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol 2011;118:63–70
   PubMed Web of Science ®Google Scholar
• Bellver J, Ayllon Y, Ferrando M, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010;93:447–54
   PubMed Web of Science ®Google Scholar
• Lintsen AM, Pasker-de Jong PC, de Boer EJ, et al. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod 2005;20:1867–75
   PubMed Web of Science ®Google Scholar
• Fedorcsak P, Dale PO, Storeng R, et al. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004;19:2523–8
   PubMed Web of Science ®Google Scholar
• Fedorcsak P, Storeng R, Dale PO, et al. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000;79:43–8
   PubMed Web of Science ®Google Scholar
• Thum MY, El-Sheikhah A, Faris R, et al. The influence of body mass index to in-vitro fertilisation treatment outcome, risk of miscarriage and pregnancy outcome. J Obstet Gynecol: J Inst Obstet Gynecol 2007;27:699–702
   Web of Science ®Google Scholar
• Awartani KA, Nahas S, Al Hassan SH, et al. Infertility treatment outcome in sub groups of obese population. Reprod Biol Endocrinol 2009;7:52–56
   PubMed Web of Science ®Google Scholar
• Sneed ML, Uhler ML, Grotjan HE, et al. Body mass index: impact on IVF success appears age-related. Hum Reprod 2008;23:1835–9
   PubMed Web of Science ®Google Scholar
• Yilmaz N, Yilmaz S, Inal H, et al. Is there a detrimental effect of higher gonadotrophin dose on clinical pregnancy rate in normo-responders undergoing ART with long protocol? Arch Gynecol Obstet 2013;287:1039–44
   PubMed Web of Science ®Google Scholar
• Santos MA, Kuijk EW, Macklon NS. The impact of ovarian stimulation for IVF on the developing embryo. Reproduction 2010;139:23–34
   PubMed Web of Science ®Google Scholar