Low-density platelet populations demonstrate low in vivo activity in sporadic Alzheimer disease

References

• Corash L, Costa JL, Shafer B, Donlon JA, Murphy D. Heterogeneity of human whole blood platelet subpopulations. III. Density-dependent differences in subcellular constituents. Blood 1984; 64: 185–193
   PubMedGoogle Scholar
• Karpatkin S, Charmatz A. Heterogeneity of human platelets. 3. Glycogen metabolism in platelets of different sizes. Br J Haematol 1970; 19: 135–143
   PubMedGoogle Scholar
• Polanowska-Grabowska R, Raha S, Gear AR. Adhesion efficiency, platelet density and size. Br J Haematol 1992; 82: 715–720
   PubMed Web of Science ®Google Scholar
• Karpatkin S, Strick N. Heterogeneity of human platelets. V. Differences in glycolytic and related enzymes with possible relation to platelet age. J Clin Invest 1972; 51: 1235–1243
   PubMedGoogle Scholar
• Milovanovic M, Lysen J, Ramström S, Lindahl TL, Richter A, Järemo P. Identification of low-density platelet populations with increased reactivity and elevated alpha-granule content. Thromb Res 2003; 111: 75–80
   PubMed Web of Science ®Google Scholar
• Milovanovic M, Lotfi K, Lindahl TL, Hallert C, Järemo P. Platelet density subpopulations in essential thrombocythemia and healthy volunteers. Pathophysiol Haemost Thromb 2010; 37: 35–42
   PubMedGoogle Scholar
• Järemo P, Sandberg-Gertzen H. Platelet density and size in inflammatory bowel disease. Thromb Haemost 1996; 75: 560–561
   PubMed Web of Science ®Google Scholar
• Järemo P. Platelet density in essential thrombocythemia and polycythemia vera. Platelets 1999; 10: 61–63
   PubMed Web of Science ®Google Scholar
• Järemo P, Lindahl TL, Lennmarken C, Forsgren H. The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. Eur J Clin Invest 2000; 30: 1113–1118
   PubMed Web of Science ®Google Scholar
• Järemo P, Milovanovic M, Nilsson S, Buller C, Post C and Winblad B. Alzheimer's disease is characterized by more low density erythrocytes with increased volume and enhanced β-amyloid X-40 content. Journal of Internal Medicine 2011;270:489–492.
   Google Scholar
• Gardella JE, Ghiso J, Gorgone GA, Marratta D, Kaplan AP, Frangione B, Gorevic PD. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA. Biochem Biophys Res Commun 1990; 173: 1292–1298
   PubMed Web of Science ®Google Scholar
• Chen M, Inestrosa NC, Ross GS, Fernandez HL. Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 1995; 213: 96–103
   PubMed Web of Science ®Google Scholar
• Valla J, Schneider L, Niedzielko T, Coon KD, Caselli R, Sabbagh MN, Ahern GL, Baxter L, Alexander G, Walker DG, et al. Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. Mitochondrion 2006; 6: 323–330
   PubMed Web of Science ®Google Scholar
• Baskin F, Rosenberg RN, Iyer L, Hynan L, Cullum CM. Platelet APP isoform ratios correlate with declining cognition in AD. Neurology 2000; 54: 1907–1909
   PubMed Web of Science ®Google Scholar
• Borroni B, Colciaghi F, Corsini P, Akkawi N, Rozzini L, Del Zotto E, Talarico G, Cattabeni F, Lenzi GL, Di Luca M, et al. Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. Neurol Sci 2002; 23: 207–210
   PubMed Web of Science ®Google Scholar
• Liu HC, Wang HC, Ko SY, Wang PN, Chi CW, Hong CJ, Lin KN, Liu TY. Correlation between platelet amyloid precursor protein isoform ratio and cognition in Alzheimer's disease. J Alzheimers Dis 2007; 11: 77–84
   PubMedGoogle Scholar
• Bush AI, Martins RN, Rumble B, Moir R, Fuller S, Milward E, Currie J, Ames D, Weidemann A, Fischer P, et al. The amyloid precursor protein of Alzheimer's disease is released by human platelets. J Biol Chem 1990; 265: 15977–15983
   PubMed Web of Science ®Google Scholar
• Casoli T, Di Stefano G, Giorgetti B, Grossi Y, Balietti M, Fattoretti P, Bertoni-Freddari C. Release of beta-amyloid from high-density platelets: Implications for Alzheimer's disease pathology. Ann N Y Acad Sci 2007; 1096: 170–178
   PubMed Web of Science ®Google Scholar
• Adolfsson R, Gottfries CG, Oreland L, Wiberg A, Winblad B. Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci 1980; 27: 1029–1034
   PubMed Web of Science ®Google Scholar
• Laske C, Leyhe T, Stransky E, Eschweiler GW, Bueltmann A, Langer H, Stellos K, Gawaz M. Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer's disease. J Psychiatr Res 2008; 42: 746–751
   PubMed Web of Science ®Google Scholar
• Stellos K, Panagiota V, Kögel A, Leyhe T, Gawaz M, Laske C. Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients. J Cereb Blood Flow Metab 2010; 30: 1817–1820
   PubMed Web of Science ®Google Scholar
• Ciabattoni G, Porreca E, Di Febbo C, Di Iorio A, Paganelli R, Bucciarelli T, Pescara L, Del Re L, Giusti C, Falco A, et al. Determinants of platelet activation in Alzheimer's disease. Neurobiol Aging 2007; 28: 336–342
   PubMed Web of Science ®Google Scholar
• Dale GL. Coated-platelets: An emerging component of the procoagulant response. J Thromb Haemost 2005; 3: 2185–2192
   PubMed Web of Science ®Google Scholar
• Prodan CI, Szasz R, Vincent AS, Ross ED, Dale GL. Coated-platelets retain amyloid precursor protein on their surface. Platelets 2006; 17: 56–60
   PubMed Web of Science ®Google Scholar
• Prodan CI, Ross ED, Vincent AS, Dale GL. Rate of progression in Alzheimer's disease correlates with coated-platelet levels – a longitudinal study. Transl Res 2008; 152: 99–102
   PubMed Web of Science ®Google Scholar
• Prodan CI, Ross ED, Stoner JA, Cowan LD, Vincent AS, Dale GL. Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease. Neurology 2011; 76: 247–252
   PubMed Web of Science ®Google Scholar
• Järemo P. Computerised method for recording platelet density distribution. Eur J Haematol 1995; 54: 304–309
   PubMed Web of Science ®Google Scholar
• Järemo P, Lindahl TL, Fransson SG, Richter A. Individual variations of platelet inhibition after loading doses of clopidogrel. J Int Med 2002; 252: 233–238
   PubMed Web of Science ®Google Scholar
• Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: Differential responses to aspirin in vitro. J Thromb Thrombol 2010; 30: 251–262
   PubMed Web of Science ®Google Scholar
• Shi C, Guo K, Yew DT, Yao Z, Forster EL, Wang H, Xu J. Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets. Exp Gerontol 2008; 43: 589–594
   PubMedGoogle Scholar
• Pavlov PF, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, Ankarcrona M. Mitochondrial {gamma}-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J 2011; 25: 78–88
   PubMed Web of Science ®Google Scholar