Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate

References

• Adair RK. 2003. Biophysical limits on athermal effects of RF and microwave radiation. Bioelectromagnetics 24:39–48.
   PubMed Web of Science ®Google Scholar
• Agarwal A, Deepinder F, Sharma RK, Ranga G, Li J. 2008. Effect of cell phone usage on semen analysis in men attending infertility clinic: An observational study. Fertility and Sterility 89:124–128.
   PubMed Web of Science ®Google Scholar
• Alvarez E, Leiro J, Orallo F. 2002. Effect of (-)-epigallocatechin-3-gallate on respiratory burst of rat macrophages. International Immunopharmacology 2:849–855.
   PubMedGoogle Scholar
• Ayata A, Mollaoglu H, Yilmaz HR, Akturk O, Ozguner F, Altuntas I. 2004. Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin. The Journal of Dermatology 31:878–883.
   PubMed Web of Science ®Google Scholar
• Balci M, Devrim E, Durak I. 2007. Effects of mobile phones on oxidant/antioxidant balance in cornea and lens of rats. Current Eye Research 32:21–25.
   PubMed Web of Science ®Google Scholar
• Belyaev I. 2005. Non-thermal biological effects of microwaves. Microwave Review 11:13–29.
   Google Scholar
• Cassini A, Pompelam A, Maellaro A, Comborti M. 1986. Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene intoxicated mice. American Journal of Pathology 123:520–531.
   PubMed Web of Science ®Google Scholar
• Challis LJ. 2005. Mechanisms for interaction between RF fields and biological tissue. Bioelectromagnetics 7:98–106.
   PubMed Web of Science ®Google Scholar
• Chan MMY, Fong D, Ho CT, Huang HI. 1997. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochemical Pharmacology 54:1281–1286.
   PubMed Web of Science ®Google Scholar
• Desai NR, Kesari KK, Agarwal A. 2009. Pathophysiology of cell phone radiation: Oxidative stress and carcinogenesis with focus on male reproductive system. Reproductive Biology and Endocrinology 22;7:114. Review.
   Google Scholar
• Dröge W. 2002. Aging-related changes in the thiol/disulfide redox state: Implications for the use of thiol antioxidants. Experimental Gerontology 37:1333–1345.
   PubMed Web of Science ®Google Scholar
• Durak I, Yurtarslani Z, Canbolat O, Akyol O. 1993. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clinica Chimica Acta 214:103–104.
   PubMed Web of Science ®Google Scholar
• Eberhardt MK. 2000. Reactive oxygen metabolites: Chemistry and medical consequences. 1st ed. New York: CRC Press: 117–149.
   Google Scholar
• Fejes I, Zavaczki Z, Szollosi J, Koloszar S, Daru J, Kovacs L, Pal A. 2005. Is there a relationship between cell phone use and semen quality? Archives of Andrology 51:385–393.
   PubMed Web of Science ®Google Scholar
• Ferreira AR, Knakievicz T, Pasquali MA, Gelain DP, Dal-Pizzol F, Fernández CE, de Salles AA, Ferreira HB, Moreira JC. 2006. Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring. Life Science 80:43–50.
   PubMed Web of Science ®Google Scholar
• Foster KR, Schwan HP. 1996. Dielectric properties of tissues. In: Polk C, Postow E, editors. CRC handbook of biological effects of electromagnetic fields. Boca Raton, FL: Chemical Rubber Co. pp 25–102.
   Google Scholar
• Friedman J, Kraus S, Hauptman Y, Schiff Y, Seger R. 2007. Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochemical Journal 405:559–568.
   PubMed Web of Science ®Google Scholar
• Gatta L, Pinto R, Ubaldi V, Pace L, Galloni P, Lovisolo GA, Marino C, Pioli C. 2003. Effects of in vivo exposure to GSM-modulated 900 MHz radiation on mouse peripheral lymphocytes. Radiation Research 160:600–605.
   PubMed Web of Science ®Google Scholar
• Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analyses of nitrate, nitrite and [15N] nitrate in biological fluids. Analytical Biochemistry 126:131–138.
   PubMed Web of Science ®Google Scholar
• Grissom CB. 1995. Magnetic field effects in biology: A survey of possible mechanisms with emphasis on radical-pair recombination. Chemical Review 95:3–24.
   Web of Science ®Google Scholar
• Güler G, Tomruk A, Ozgur E, Seyhan N. 2010. The effect of radiofrequency radiation on DNA and lipid damage in non-pregnant and pregnant rabbits and their newborns. General Physiology Biophysics 29:59–66.
   PubMed Web of Science ®Google Scholar
• Güler G, Türközer Z, Tomruk A, Seyhan N. 2008. The protective effects of N-acetyl L-cysteine and epigallocatechin 3-gallate on electric field-induced hepatic oxidative stress. International Journal of Radiation Biology 84:669–680.
   PubMed Web of Science ®Google Scholar
• Güler G, Türközer Z, Ozgur E, Seyhan N. 2009. Antioxidants alleviate electric field-induced effects on lung tissue based on assays of heme oxygenase-1, protein carbonyl content, malondialdehyde, nitric oxide, and hydroxyproline. Science of the Total Environment 407:1326–1332.
   PubMed Web of Science ®Google Scholar
• Guney M, Ozguner F, Oral B, Karahan N, Mungan T. 2007. 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: Protection by vitamins E and C. Toxicology and Industrial Health 23:411–420.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Gutteridge JMC. 1999. Free radicals in biology and medicine. 3rd ed, New York: Oxford University Press.
   Google Scholar
• Hausladen A, Stamler JS. 1999. Nitrosative stress. Methods in Enzymology 300:389–395.
   PubMed Web of Science ®Google Scholar
• Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. 1990. Assessment of myeloperoxidase activity in whole rat kidney. Journal of Pharmacological Methods 24:285–295.
   PubMedGoogle Scholar
• Ilhan A, Gurel A, Armutcu F, Kamilsi S, Iraz M, Akyol O, Ozen S. 2004. Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clinica Chimica Acta 340:153–162.
   PubMed Web of Science ®Google Scholar
• Irmak MK, Fadıllıoğlu E, Gülec M, Erdogan H, Yagmurca M, Akyol O. 2002. Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits. Cell Biochemistry and Function 20:279–283.
   PubMed Web of Science ®Google Scholar
• Köylü H, Mollaoglu H, Ozguner F, Nazyroglu M, Delibab N. 2006. Melatonin modulates 900 Mhz microwave-induced lipid peroxidation changes in rat brain. Toxicology and Industrial Health 22:211–216.
   PubMed Web of Science ®Google Scholar
• Lai H, Singh NP. 1996. Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. International Journal Radiation Biology 69:513–521.
   PubMed Web of Science ®Google Scholar
• Lai H, Singh NP. 1997. Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics 18:446–454.
   PubMed Web of Science ®Google Scholar
• Lambert JD, Sang S, Yang CS. 2008. N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct. Free Radical Biology and Medicine 44:1069–1074.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Roseberg NJ, Farr AL, Randell RJ. 1951. Protein measurement with Folin phenol reagent. Journal of Biological Chemistry 193:265–275.
   PubMed Web of Science ®Google Scholar
• Majano PL, Medina J, Zubı I, Sunyer L, Lara-Pezzi E, Maldonado-Rodriguez A, Lopez-Cabrera M, Moreno-Otero R. 2004. N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes. Journal of Hepatology 40:632–637.
   PubMed Web of Science ®Google Scholar
• Mansour HH, Hafez HF, Fahmy NM, Hanafi N. 2008. Protective effect of N-acetylcysteine against radiation-induced DNA damage and hepatic toxicity in rats. Biochemical Pharmacology 75:773–780.
   PubMed Web of Science ®Google Scholar
• Mathews CK, Van Holde KE, Ahern KG. 1997. Biochemistry. 3rd ed. San Francisco: Addison-Wesley Publishing Company.
   Google Scholar
• McKenna DJ, Jones K, Hughes K. 2002. Botanical medicines: The desk reference for major herbal supplements. 2nd ed. New York: The Haworth Herbal Press.
   Google Scholar
• Meister A. 1994. Glutathione-ascorbic acid antioxidant system in animals. Journal of Biological Chemistry 269(13):9397–9400.
   PubMedGoogle Scholar
• Meral I, Mert H, Mert N, Deger Y, Yoruk I, Yetkin A, Keskin S. 2007. Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Research 1169:120–124.
   PubMed Web of Science ®Google Scholar
• Michaelson SM, Elson EC. 1996. Dielectric properties of tissues. In: Polk C, Postow E, editors. CRC handbook of biological effects of electromagnetic fields. Boca Raton, FL: Chemical Rubber Co. pp 435–534.
   Google Scholar
• Miranda KM, Espey MG, Wink DA. 2001. A rapid simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5:67–71.
   Web of Science ®Google Scholar
• Misra HP, Fridovich I. 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry 247:3170–3175.
   PubMed Web of Science ®Google Scholar
• Nair V, Cooper CS, Vietti DE, Turner GA. 1986. The chemistry of lipid peroxidation metabolites: Crosslinking reactions of malondialdehyde. Lipids 21:6–9.
   PubMed Web of Science ®Google Scholar
• Nasta F, Prisco MG, Pinto R, Lovisolo GA, Marino C, Pioli C. 2006. Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production. Radiation Research 165:664–670.
   PubMed Web of Science ®Google Scholar
• Oktem F, Ozguner F, Mollaoglu H, Koyu A, Uz E. 2005. Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: Protection by melatonin. Archives of Medical Research 36:350–355.
   PubMed Web of Science ®Google Scholar
• Oral B, Guney M, Ozguner F, Karahan N, Mungan T, Comlekci S, Cesur G. 2006. Endometrial apoptosis induced by a 900-MHz mobile phone: Preventive effects of vitamins E and C. Advances in Therapy 23:957–973.
   PubMed Web of Science ®Google Scholar
• Ozguner F, Altinbas A, Ozaydin M, Dogan A, Vural H, Kisioglu AN, Cesur G, Yildirim NG. 2005c. Mobile phone-induced myocardial oxidative stress: Protection by a novel antioxidant agent caffeic acid phenethyl ester. Toxicology and Industrial Health 21:223–230.
   PubMed Web of Science ®Google Scholar
• Ozguner F, Bardak Y, Comlekci S. 2006. Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: A comparative study. Molecular and Cellular Biochemistry 282:83–88.
   PubMed Web of Science ®Google Scholar
• Ozguner F, Oktem F, Armagan A, Yilmaz R, Koyu A, Demirel R, Vural H, Uz E. 2005a. Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. Molecular and Cellular Biochemistry 276:31–37.
   PubMed Web of Science ®Google Scholar
• Ozguner F, Oktem F, Ayata A, Koyu A, Yilmaz HR. 2005b. A novel antioxidant agent caffeic acid phenethyl ester prevents long-term mobile phone exposure-induced renal impairment in rat. Molecular and Cellular Biochemistry 277:73–80.
   PubMed Web of Science ®Google Scholar
• Pacher P, Beckman JS, Liaudet L. 2007. Nitric oxide and peroxynitrite in health and disease. Physiological Reviews 87:315–424.
   PubMed Web of Science ®Google Scholar
• Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70:158–170.
   PubMed Web of Science ®Google Scholar
• Schwan HP, Foster KR. 1980. RF-field interactions with biological systems: Electrical properties and biophysical mechanisms. Proceeding of the IEEE 68:104–113.
   Web of Science ®Google Scholar
• Sokolovic D, Djindjic B, Nikolic J, Bjelakovic G, Pavlovic D, Kocic G, Krstic D, Cvetkovic T, Pavlovic V. 2008. Melatonin reduces oxidative stress induced by chronic exposure of microwave radiation from mobile phones in rat brain. Journal of Radiation Research (Tokyo) 49:579–586.
   PubMed Web of Science ®Google Scholar
• Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34:497–500.
   PubMed Web of Science ®Google Scholar
• Taflove A, Hagness SC. 2005. Computational electrodynamics: The finite-difference time-domain method. 3rd ed. Norwood, MA: Artech House.
   Google Scholar
• Timmel CR, Cintolesi F, Brocklehurst B, Hore PJ. 2001. Model calculations of magnetic fields effects on the recombination reactions of radicals with anisotropic hyperfine interactions. Chemical Physics Letters 334:387–395.
   Web of Science ®Google Scholar
• Tomruk A, Güler G, Dincel AS. 2010. The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in non-pregnant, pregnant, and newly born rabbits. Cell Biochemistry Biophysics 56:39–47.
   PubMed Web of Science ®Google Scholar
• Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology 39:44–84.
   PubMed Web of Science ®Google Scholar
• Verschaeve L. 2009. Genetic damage in subjects exposed to radio frequency radiation. Mutation Research 681:259–270.
   PubMed Web of Science ®Google Scholar
• Warner DS, Sheng H, Batinic-Haberle I. 2004. Oxidants, antioxidants and the ischemic brain. The Journal of Experimental Biology 207:3221–3231.
   PubMed Web of Science ®Google Scholar
• Woodward JR, Timmel CR, McLauchlan KA, Hore PJ. 2001. Radio frequency magnetic field effects on electron-hole recombination. Physical Review Letters 87:077602.
   Google Scholar
• Yildirim Z, Kotuk M, Iraz M, Kuku I, Ulu R., Armutcu F, Ozen S. 2005. Attenuation of bleomycin-induced lung fibrosis by oral sulfhydryl containing antioxidants in rats: Erdosteine and N-acetylcysteine. Pulmonary Pharmacology Therapeutics 18:367–373.
   PubMed Web of Science ®Google Scholar