354
Views
20
CrossRef citations to date
0
Altmetric
TELOMERE SHORTENING AND VASCULAR DYSFUNCTION

Telomere shortening and ionizing radiation: A possible role in vascular dysfunction?

, &
Pages 830-839 | Received 01 Feb 2012, Accepted 27 Jun 2012, Published online: 07 Aug 2012

References

  • Adaikalakoteswari A, Balasubramanyam M, Mohan V. 2005. Telomere shortening occurs in Asian Indian type 2 diabetic patients. Diabetic Medicine22:1151–1156.
  • Andreassi MG, Botto N. 2003. DNA damage as a new emerging risk factor in atherosclerosis. Trends in Cardiovascular Medicine13: 270–275.
  • Andreassi MG. 2008. DNA damage, vascular senescence and atherosclerosis. Journal of Molecular Medicine86:1033–1043.
  • Aviv A. 2011. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutation Research730:68–74.
  • Aviv H, Khan MY, Skurnick J, Okuda K, Kimura M, Gardner J, Priolo L, Aviv A. 2001. Age dependent aneuploidy and telomere length of the human vascular endothelium. Atherosclerosis159:281–287.
  • Ayouaz A, Raynaud C, Heride C, Revaud D, Sabatier L. 2008. Telomeres: Hallmarks of radiosensitivity. Biochimie90:60–72.
  • Baird DM. 2005. New developments in telomere length analysis. Experimental Gerontology40:363–368.
  • Balaban RS, Nemoto S, Finkel T. 2005. Mitochondria, oxidants, and aging. Cell120:483–495.
  • Balasubramanyam M, Adaikalakoteswari A, Finny Monickaraj S, Mohan V. 2007. Telomere shortening & metabolic/vascular diseases. Indian Journal of Medical Research125:441–450.
  • Belloni P, Latini P, Palitti F. 2011. Radiation-induced bystander effect in healthy G(o) human lymphocytes: Biological and clinical significance. Mutation Research713:32–38.
  • Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C Temmar M, Bean KE, Thomas F, Aviv A. 2004. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension43:182–185.
  • Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A. 2001. Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension37:381–385.
  • Bhatti P, Sigurdson AJ, Mabuchi K. 2008. Can low-dose radiation increase risk of cardiovascular disease?The Lancet372:697–699.
  • Blackburn EH. 2001a. Switching and signaling at the telomere. Cell106:661–673.
  • Blackburn EH. 2001b. Telomeres and telomerase: The means to the end (Nobel Lecture). Angewandte Chemie International Edition49:7405–7421.
  • Blasco MA. 2007. The epigenetic regulation of mammalian telomeres. Nature Reviews Genetics8:299–309.
  • Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ. 2010. Telomere length dynamics in vascular disease: A review. European Journal of Vascular and Endovascular Surgery40:17–26.
  • Center for Devices and Radiological Health, U.S. Food. and Drug Administration. 2010. Initiative to Reduce Unnecessary Radiation Exposure from Medical Imaging. Available from: http://www.fda.gov/Radiation-EmittingProducts/RadiationSafety/RadiationDoseReduction/ucm199994.htm.
  • Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. 1995. Proceedings of the National Academy of Sciences of the USA92:11190–11194.
  • Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, Reddel RR. 2007. Protein composition of catalytically active human telomerase from immortal cells. Science315:1850–1853.
  • Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. BEIR VII Phase 2. 2006. Health risks from exposure to low levels of ionizing radiation. Washington, DC: The National Academies Press. Available from: http://www.nap.edu/openbook.php?isbn = 030909156X.
  • Cone M. 2010. President's Cancer Panel: Environmentally caused cancers are ‘grossly underestimated’ and ‘needlessly devastate American lives’. Environmental Health News. Available from: http://www.environmentalhealthnews.org/ehs/news/presidents-cancer-panel.
  • Cong YS, Wright WE, Shay JW. 2002. Human telomerase and its regulation. Microbiology and Molecular Biology Reviews66:407–425.
  • D’Adda di Fagagna F, Soo-Hwang T, Jackson SP. 2004. Functional links between telomeres and proteins of the DNA-damage response. Genes & Development18:1781–1799.
  • Das B, Saini D, Seshadri M. 2009. Telomere length in human adults and high level natural background radiation. PLoS ONE4:e8440. Available from: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008440
  • Drissi R, Wu J, Hu Y, Bockhold CA, Dome JS. 2011. Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells. Cancer Prevention Research. 4: 1973–81.
  • Edo MD, Andrés V. 2005. Aging, telomeres, and atherosclerosis. Cardiovascular Research66:213–221.
  • European (EU) Scientific Seminar. 2008. Emerging Evidence for radiation-induced circulatory diseases. Proceedings from a scientific seminar held in Luxembourg on 25 November 2008. Available from: ec.europa.eu/energy/nuclear/radiation_protection/doc/publication/158.pdf.
  • Flores I, Benetti R, Blasco MA. 2006. Telomerase regulation and stem cell behavior. Current Opinion in Cell Biology18:254–260.
  • Flores I, Cayuela ML, Blasco MA. 2005. Effects of telomerase and telomere length on epidermal stem cell behavior. Science309: 1253–1256.
  • Franco S, Segura I, Riese HH, Blasco MA. 2002. Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Research62:552–559.
  • Friedrich U, Griese E, Schwab M, Fritz P, Thon K, Klotz U. 2000. Telomere length in different tissues of elderly patients. Mechanisms of Ageing and Development119:89–99.
  • Fuster JJ, Andrés V. 2006. Telomere biology and cardiovascular disease. Circulation Research99:1167–1180.
  • Goytisolo FA, Samper E, Martin-Caballero J, Finnon P, Herrera E, Flores, JM Bouffler SD, Blasco MA. 2000. Short telomeres results in organismal hypersensitivity to ionizing radiation in mammals. The Journal of Experimental Medicine192:1625–1636.
  • Haendeler J, Hoffmann J, Diehl JF, Vasa M, Spyridopoulos I, Zeiher AM, Dimmeler S. 2004. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circulation Research94:768–775.
  • Harley CB, Futcher AB, Greider CW. 1990. Telomeres shorten during ageing of human fibroblasts. Nature345:458–460.
  • Ilyenko I, Lyaskivska O, Bazyka D. 2011. Analysis of relative telomere length and apoptosis in humans exposed to ionising radiation. Experimental Oncology33:235–238.
  • International Commission on Radiological Protection (ICRP). 2011. Statement on Tissue Reactions. Approved by the Commission on January 20, 2011. Available from: www.icrp.org/docs/Tissue%20Reactions%20Report%20Draft%20for%20Consultation.pdf.
  • Jeggo PA, Geuting V, Löbrich M. 2011. The role of homologous recombination in radiation-induced double-strand break repair. Radiotherapy and Oncology101:7–12.
  • Kammori M, Nakamura K, Kawahara M, Mimura Y, Kaminishi M, Takubo K. 2002. Telomere shortening with aging in human thyroid and parathyroid tissue. Experimental Gerontology37:513–521.
  • Khanna KK, Jackson SP. 2001. DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genetics27:247–254.
  • Kumazaki T, Sakano T, Yoshida T, Hamada K, Sumida H, Teranishi Y, Nishiyama M, Mitsui Y. 1998. Enhanced expression of mitochondrial genes in senescent endothelial cells and fibroblasts. Mechanisms of Ageing and Development101:91–99.
  • Kurz DJ, Kloeckener-Gruissem B, Akhmedov A, Eberli FR, Bühler I, Berger W, Bertel O, Lüscher TF. 2006. Degenerative aortic valve stenosis, but not coronary disease, is associated with shorter telomere length in the elderly. Arteriosclerosis, Thrombosis, and Vascular Biology26:e114–117.
  • Latre L, Tusell L, Martin M, Miró R, Egozcue J, Blasco MA, Genescà A. 2003. Shortened telomeres join to DNA breaks interfering with their correct repair. Experimental Cell Research287:282–288.
  • Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, Tapio S, Elliott P. 2008. A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms. Radiation Research169:99–109.
  • Mainous AG, Diaz VA. 2010. Telomere length as a risk marker for cardiovascular disease: The next big thing?Expert Review of Molecular Diagnostics10:969–971.
  • Marrone A, Stevens D, Vulliamy T, Dokal I, Mason PJ. 2004. Heterozygous telomerase RNA mutations found in diskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency. Blood104:3936–3942.
  • Mettler FA Jr, Bhargavan M, Faulkner K, Gilley DB, Gray JE, Ibbott GS, Lipoti JA, Mahesh M, McCrohan JL, Stabin MG, Thomadsen BR, Yoshizumi TT. 2009. Radiologic and nuclear medicine studies in the United States and worldwide: Frequency, radiation dose, and comparison with other radiation sources – 1950–2007. Radiology253:520–531.
  • Minamino T, Komuro I. 2007. Vascular cell senescence: Contribution to atherosclerosis. Circulation Research100:15–26.
  • Minamino T, Mitsialis SA, Kourembanas S. 2001. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Molecular and Cellular Biology21:3336–3342.
  • Mullenders L, Atkinson M, Paretzke H, Sabatier L, Bouffler S. Assessing cancer risks of low-dose radiation. 2009. Nature Reviews Cancer9: 596–604.
  • Murname JP, Sabatier L. 2004. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays26:1164–1174.
  • Oeseburg H, de Boer RA, van Gilst WH, van der Hast P. 2010. Telomere biology in healthy aging and disease. European Journal of Physiology459:259–268.
  • Passos JF, von Zglinicki T. 2005. Mitochondria, telomeres and cell senescence. Experimental Gerontology40:466–472.
  • Picano E. 2004. Sustainability of medical imaging. Education and debate. British Medical Journal328:578–580.
  • Picano E, Vano E. 2011. The radiation issue in cardiology: The time for action is now. Cardiovascular Ultrasound9:35.
  • Prithivirajsingh S, Story MD, Bergh SA, Geara FB, Ang KK, Ismail SM Stevens CW, Buchholz TA, Brock WA. 2004. Accumulation of the common mitochondrial DNA deletion induced by ionizing radiation. FEBS Letters571:227–232.
  • Rich T, Allen RL, Wyllie AH. 2000. Defying death after DNA damage. Nature407:777–783.
  • Rubio MA, Davalos AR, Campisi J. 2004. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Experimental Cell Research298:17–27.
  • Rufer N, Brummendorf TH, Kolvraa S , Bischoff C, Christensen K, Wadsworth L Schulzer M, Lansdorp PM. 1999. Telomere fluorescence measurements in granulocytes and T lymphocyte subset point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. Journal of Experimental Medicine190:157–167.
  • Russo GL, Tedesco I, Russo M, Cioppa A, Andreassi MG, Picano E. 2012. Cellular adaptive response to chronic radiation exposure in interventional cardiologists. European Heart Journal33:408–414.
  • Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium. 2007. Genomewide Association Analysis of Coronary Artery Disease. New England Journal of Medicine357:443–453.
  • Schoeftner S, Blasco MA. 2009. A ‘higher order’ of telomere regulation: Telomere heterochromatin and telomeric RNAs. EMBO Journal28:2323–2336.
  • Schultz-Hector S, Trott KR. 2007. Radiation-induced cardiovascular diseases: Is the epidemiologic evidence compatible with the radiobiologic data?International Journal of Radiation Oncology Biology Physics67:10–18.
  • Seemann I, Gabriels K, Visser NL, Hoving S, te Poele JA, Pol JF, Gijbels MJ, Janssen BJ, van Leeuwen FW, Daemen MJ, Heeneman S, Stewart FA. 2011. Irradiation induced modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature. Radiother Oncol103:143–50.
  • Serrano AL, Andres V. 2004. Telomeres and cardiovascular disease: Does size matter?Circulation Research94:575–584.
  • Sharma GG, Hall EJ, Dhar S, Gupta A, Rao PH, Pandita TK. 2003. Telomere stability correlates with longevity of human beings exposed to ionizing radiations. Oncological Report10:1733–1736.
  • Shrivastav M, De Haro LP, Nickoloff JA. 2008. Regulation of DNA double-strand break repair pathway choice. Cell Research18: 134–147.
  • Slagboom PE, Droog S, Boomsma DI. 1994. Genetic determination of telomere size in humans: A twin study of three age groups. The American Journal of Human Genetics55:876–882.
  • Slijepcevic P. 2006. The role of DNA damage response proteins at telomeres – an ‘integrative’ model. DNA Repair5:1299–1306.
  • Slijepcevic P, Natarajan AT, Bryant PE. 1998. Telomeres and radiation induced chromosome breakage. Mutagenesis13:45–49.
  • Stewart JR, Fajardo LF. 1971. Radiation-induced heart disease: Clinical and experimental aspects. Radiologic Clinics of North America9:511–531.
  • Takubo K, Izumiyama-Shimomura N, Honma N, Sawabe M, Arai T, Kato M, Oshimura M, Nakamura K. 2002. Telomere lengths are characteristic in each human individual. Experimental Gerontology37:523–531.
  • Tezcan E, Atmaca M, Kuloglu M, Ustundag B. 2003. Free radicals in patients with post-traumatic stress disorder. European Archives of Psychiatry and Clinical Neuroscience253:89–91.
  • United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). 2008. Report: ‘Sources and effects of ionizing radiation’. Volume I. Annex Ahttp://www.unscear.org/docs/reports/2008/ 09-86753_Report_2008_Annex_A.pdf and Annex B www.unscear.org/docs/reports/2008/09-86753_Report_2008_Annex_B.pdf (accessed October 25, 2011).
  • Vasa M, Breitschopf K, Zeiher AM, Dimmeler S. 2000. Nitric oxide activates telomerase and delays endothelial cell senescence. Circulation Research87:540–542.
  • Venneri L, Rossi F, Botto N, Andreassi MG, Salcone N, Emad A Lazzeri M, Gori C, Vano E, Picano E. 2009. Cancer risk from professional exposure in staff working in cardiac catheterization laboratory: Insights from the National Research Council's Biological Effects of Ionizing Radiation VII Report. American Heart Journal157:118–124.
  • von Zglinicki T, Pilger R, Sitte N. 2000. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radical Biology & Medicine28:64–74.
  • von Zglinicki T. 2000. Role of oxidative stress in telomere length regulation and replicative senescence. Annals of New York Academy of Sciences908:99–110.
  • von Zglinicki T. 2002. Oxidative stress shortens telomeres. Trends in Biochemical Sciences27:339–344.
  • von Zglinicki T, Petrie J, Kirkwood TB. 2003. Telomere-driven replicative senescence is a stress response. Nature Biotechnology21:229–230.
  • von Zglinicki T, Martin-Ruiz C, Saretzki G. 2005. Telomeres, cell senescence and human ageing. Signal Transduction3:103–114.
  • Wang L, Kuwahara Y, Li L , Baba T, Shin RW, Ohkubo Y, Ono K, Fukumoto M. 2007. Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation. International Journal of Radiation Biology83:433–442.
  • Wang Z, Rhee DB, Lu J, Bohr CT, Zhou F, Vallabhaneni H, de Souza-Pinto NC, Liu Y. 2010. Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet6(5):e1000951.
  • Wei Y-H, Wu S-B, Ma Y-S, Lee H-C. 2009. Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging. Chang Gung Medical Journal32: 113–132.
  • Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA. 2011. The association of telomere length and cancer: A meta-analysis. Cancer Epidemiology, Biomarkers and Prevention20:1238–1250.
  • Wong JM, Collins K.Telomere maintenance and disease. 2003. The Lancet362:983–988.
  • Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. 2000. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics26:85–88.
  • Wong LS, de Boer RA, Samani NJ, van Veldhuisen DJ, van der Hast P. 2008. Telomere biology in heart failure. European Journal of Heart Failure10:1049–1056.
  • Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, et al. 2004. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Research64:3096–3102.
  • Zhou BB, Elledge SJ. 2000. The DNA damage response: Putting checkpoints in perspectives. Nature408:433–439.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.