304
Views
16
CrossRef citations to date
0
Altmetric
PROTECTION BY L-CARNITINE AGAINST RADIATION-INDUCED MUCOSAL INJURY

Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines

, , , , , & show all
Pages 732-740 | Received 14 Aug 2012, Accepted 14 Mar 2013, Published online: 16 Apr 2013

References

  • Abdelrazik H, Sharma R, Mahfouz R, Agarwal A. 2009. L-Carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos. Fertility and Sterility 91:589–596.
  • Agrawal A, Chandra D, Kale RK. 2001. Radiation induced oxidative stress: II. Studies in liver as a distant organ of tumor bearing mice. Molecular and Cellular Biochemistry 224:9–17.
  • Akpolat M, Topcu-Tarladacalışır Y, Dokmeci D, Turan FN, Uzal MC. 2011. Protective effects of ibuprofen and L-carnitine against whole body gamma irradiation-induced duodenal mucosal injury. Balkan Medical Journal 28:80–85.
  • Altas E, Ertekin MV, Gundogdu C, Demirci E. 2006. L-Carnitine reduces cochlear damage induced by gamma irradiation in guinea pigs. Annals of Clinical Laboratory Science 36:312–318.
  • Arockia Rani PJ, Panneerselvam C. 2001. Carnitine as a free radical scavenger in aging. Experimental Gerontology 36:1713–1726.
  • Boerrigter ME, Franceschi C, Arrigoni-Martelli E, Wei JY, Vijg J. 1993. The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes. Carsinogenesis 14:2131–2136.
  • Bradley P, Priebat D, Christensen R, Rothestein G. 1982. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. Journal of Investigative Dermatology 78:206–209.
  • Buell MG, Harding RK. 1989. Proinflammatory effects of local abdominal irradiation on rat gastrointestinal tract. Digestive Diseases and Sciences 34:390–399.
  • Caloglu M, Yurut-Caloglu V, Durmus-Altun G, Oz-Puyan F, Ustun F, Cosar-Alas R, Saynak M, Parlar S, Turan FN, Uzal C. 2009. Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats. Clinical Experimental Pharmacology Physiology 36:523–530.
  • Chiu CT, McArdle AH, Brown R, Scott H, Gurd F. 1970. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Archives Surgery 101:478–483.
  • Cifone MG, Alesse E, Di Marzio L. 1997. Effect of L-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients. Proceedings of the Association of American Physicians 109:146–153.
  • Desai A, Miller MJ, Huang X, Warren JS. 2003. Nitric oxide modulates MCP-1 expression in endothelial cells: Implications for the pathogenesis of pulmonary granulomatous vasculitis. Inflammation 27: 213–223.
  • Dokmeci D, Akpolat M, Aydogdu N, Doganay L, Turan FN. 2005. L-carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacological Report 57:481–488.
  • Dokmeci D, Akpolat M, Aydogdu N, Uzal C, Doganay L, Turan FN. 2006. The protective effect of L-carnitine on ionizing radiation induced free oxygen radicals. Scandinavian Journal of Laboratory Animal Science 33:75–83.
  • Empey LR, Papp JD, Jewell LD, Fedorak RN. 1992. Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Digestive Diseases and Sciences 37:205–214.
  • Fawcet DW. 1994. Bloom and Fawcet, A textbook of histology. 12th ed. New York, London: Chapman & Hall. pp 626.
  • Gorudko IV, Kostevich VA, Sokolov AV, Shamova EV, Buko IV, Konstantinova EE, Vasiliev VB, Cherenkevich SN, Panasenko OM. 2012. Functional activity of neutrophils in diabetes mellitus and coronary heart disease: Role of myeloperoxidase in the development of oxidative stress. Bulletin of Experimental Biology and Medicine 154:23–26.
  • Gremy O, Benderitter M, Linard C. 2006. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma- irradiation in the rat by modulating the cytokine pattern. World Journal of Gastroenterology 12:4996–5004.
  • Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ. 2000. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 404:407–411.
  • Gunter-Smith PJ. 1986. Gamma radiation affects active electrolyte transport by rabbit ileum: Basal Na and Cl transport. American Journal of Physiology-Gastrointestinal and Liver Physiology 250:540–545.
  • Hall PA, Coates PJ, Ansari B, Hopwood D. 1994. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. Journal of Cell Science 107:3569–3577.
  • Hong JH, Chiang CS, Tsao CY, Lin PY, McBride WH, Wu CJ. 1999. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. International Journal of Radiation Biology 75:1421–1427.
  • Huang FP, Niedbala W, Wei XQ, Xu D, Feng GJ, Robinson JH, Lam C, Liew FY. 1998. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. European Journal of Immunology 28:4062–4070.
  • Ikeda H, Yang CL, Tong J, Nishimaki H, Masuda K, Takeo T, Kasai K, Itoh G. 2002. Rat small intestinal goblet cell kinetics in the process of restitution of surface epithelium subjected to ischemia-reperfusion injury. Digestive Diseases and Sciences 47:590–601.
  • Ishii T, Shimpo Y, Matsuoka Y. 2000. Anti-apoptotic effect of acetyl- l-carnitine and L-carnitine in primary cultured neurons. The Japanese Journal of Pharmacology 83:119–124.
  • Izgut-Uysal VN, Agac A, Derin N. 2003. Effect of L-carnitine on carrageenan-induced inflammation in aged rats. Gerontology 49: 287–292.
  • Jagetia GC, Reddy TK. 2005. Modulation of radiation induced alteration in the antioxidant status of mice by naringin. Life Sciences 77:780–794.
  • Kanter M, Akpolat M. 2008. Vitamin C protects against ionizing radiation damage to goblet cells of the ileum in rats. Acta Histochemica 110:481–490.
  • Kanter M, Topcu-Tarladacalisir Y, Parlar S. 2010. Antiapoptotic effect of L-carnitine on testicular irradiation in rats. Journal of Molecular Histology 41:121–128.
  • Keskek M, Gocmen E, Kilic M, Gencturk S, Can B, Cengiz M, Okten RM, Koc M. 2006. Increased expression of cyclooxygenase-2 (COX-2) in radiation-induced small bowel injury in rats. The Journal of Surgical Research 135:76–84.
  • Kocer I, Taysi S, Ertekin MV, Karslioglu I, Gepdiremen A, Sezen O, Serifoglu K. 2007. The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: A rat model. Graefes Archive for Clinical Experimental Ophthalmology 245:588–594.
  • Kregel KC, Zhang HJ. 2007. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 292:18–36.
  • Langberg CW, Hauer-Jensen M, Sung CC, Kane CJ. 1994. Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation. Radiotherapy and Oncology 32:29–36.
  • Linard C, Marquette C, Mathieu J, Pennequin A, Clarençon D, Mathé D. 2004. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: Effect of an NF-kappaB inhibitor. International Journal of Radiation Oncology Biology Physics 58:427–434.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. The Journal of Biological Chemistry 193:165–275.
  • Mescka C, Moraes T, Rosa A, Mazzola P, Piccoli B, Jacques C, Dalazen G, Coelho J, Cortes M, Terra M, Regla Vargas C, Dutra-Filho CS. 2011. In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease. Metabolic Brain Disease 26:21–28.
  • Monti P, Wysocki J, van der Meeren A, Griffiths NM. 2005. The contribution of radiation-induced injury to the gastrointestinal tract in the development of multi-organ dysfunction syndrome or failure. British Journal of Radiology 27:89–94.
  • Moore FA. 1999. The role of the gastrointestinal tract in postinjury multiple organ failure. American Journal Surgery 178:449–453.
  • Moretti S, Famularo G, Marcellini S. 2002. L-carnitine reduces lymhocyte apoptosis and oxidant stres in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxidants & Redox Signaling 4:391–403.
  • Nejdfors P, Ekelund M, Westrom BR, Willen R, Jeppsson B. 2000. Intestinal permeability in humans is increased after radiation therapy. Diseases of the Colon & Rectum 43:1582–1587.
  • Onem G, Aral E, Enli Y, Oguz EO, Coskun E, Aybek H. 2006. Neuroprotective effects of L-carnitine and vitamin E alone or in combination against ischemia-reperfusion injury in rats. Journal of Surgical Researh 131:124–130.
  • Osborne JW, Prasad KN, Zimmerman GR. 1970. Changes in the rat intestine after x-irradiation of exteriorized short segments of ileum. Radiation Research 43:131–142.
  • Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Kolesnick R. 2001. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293:293–297.
  • Pisano C, Pratesi G, Laccabue D, Zunino F, Lo Giudice P, Bellucci A, Pacifici L, Camerini B, Vesci L, Castorina M, Cicuzza S, Tredici G, Marmiroli P, Nicolini G, Galbiati S, Calvani M, Carminati P, Cavaletti G. 2003. Paclitaxel and cisplatin-induced neurotoxicity: A protective role of acetyl-L-carnitine. Clinical Cancer Research 9:5756–5767.
  • Potten CS. 1996. What is an apoptotic index measuring? A commentary. British Journal of Cancer 74:1743–1748.
  • Potten CS, Merritt A, Hickman J, Hal, P, Faranda A. 1994. Characterization of radiation-induced apoptosis in the small intestine and its biological implications. International Journal of Radiation Biology 65:71–78.
  • Potten CS, Owen G, Roberts SA. 1990. The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine. International Journal of Radiation Biology 57:185–199.
  • Potten CS, Wilson JW, Booth C. 1997. Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells 15:82–93.
  • Qi SN, Zhang ZF, Wang ZY, Yoshida A, Ueda T. 2006. L-Carnitine inhibits apoptotic DNA fragmentation induced by a new spin-labeled derivative of podophyllotoxin via caspase-3 in Raji cells. Oncology Reports 15:119–122.
  • Rizzo AM, Berselli P, Zava S, Montorfano G, Negroni M, Corsetto P, Berra B. 2010. Endogenous antioxidants and radical scavengers. Advances in Experimental Medicine and Biology 698:52–67.
  • Schmitt D, Shen Z, Zhang R, Colles SM, Wu W, Salomon RG, Chen Y, Chisolm GM, Hazen SL. 1999. Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum. Biochemistry 38:16904–16915.
  • Setoguchi K, Takeya M, Akaike T, Suga M, Hattori R, Maeda H, Ando M, Takahashi K. 1996. Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats. American Journal of Pathology 149:2005–2022.
  • Smith DH, De Cosse JJ. 1986. Radiation damage to the small intestine. World Journal of Surgery 10:189–194.
  • Sridharan S, Shyamaladevi CS. 2002. Protective effect of N-acetylcysteine against gamma ray induced damages in rats – biochemical evaluations. Indian Journal of Experimental Biology 40:181–186.
  • Strup-Perrot C, Mathe D, Linard C, Violot D, Milliat F, Francois A, Bourhis J, Vozenin-Brotons MC. 2004. Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. American Journal of Physiology-Gastrointestinal and Liver Physiology 287:875–885.
  • Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34:497–500.
  • Taylan E, Resmi H. 2010. The analytical performance of a microplate method for total sulfhydryl measurement in biological samples. Turkish Journal of Biochemistry 35:275–278.
  • Uchida A, Mizutani Y, Nagamuta M and Ikenaga M. 1989. Effects of X-ray irradiation on natural killer (NK) cell system. I. Elevation of sensitivity of tumor cells and lytic function of NK cells. Immunopharmacology and Immunotoxicology 11:507–519.
  • Vanella A, Russo A, Acquaviva R, Campisi A, Di Giacomo C, Sorrenti V. 2000. L-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biology and Toxicology 16:99–104.
  • Walker RI, Conklin JJ. 1987. Mechanism and management of infectious complications of combined injury. In: Conklin JJ, Walker RI, editors. Military radiobiology. Orlando, FL: Academic Press. pp. 219–230.
  • Ye J, Li J, Yu Y, Wei Q, Deng W, Yu L. 2010. L-Carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regulatory Peptides 16:58–66.
  • Yeoh E, Horowitz M, Russo A, Muecke T, Robb T, Maddox A. 1993. Effect of pelvic irradiation on gastrointestinal function: A prospective longitudinal study. American Journal of Medicine 95:397–406.
  • Zhou X, Liu F, Zhai S. 2007. Effect of L-carnitine and/or L-acetyl- carnitine in nutrition treatment for male infertility: A systematic review. Asia Pacific Journal of Clinical Nutrition 16:383–390.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.