Mobile phone radiation induces mode-dependent DNA damage in a mouse spermatocyte-derived cell line: A protective role of melatonin

References

• Agarwal A, Desai NR, Makker K, Varghese A, Mouradi R, Sabanegh E, Sharma R. 2009. Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: An in vitro pilot study. Fertility and Sterility92:1318–1325.
   PubMed Web of Science ®Google Scholar
• Aitken RJ, Bennetts LE, Sawyer D, Wiklendt AM, King BV. 2005. Impact of radio frequency electromagnetic radiation on DNA integrity in the male germline. International Journal of Andrology28:171–179.
   PubMed Web of Science ®Google Scholar
• Aitken RJ, De Iuliis GN, McLachlan RI. 2009. Biological and clinical significance of DNA damage in the male germ line. International Journal of Andrology32:46–56.
   PubMedGoogle Scholar
• Avci B, Akar A, Bilgici B, Tuncel OK. 2012. Oxidative stress induced by 1.8 GHz radio frequency electromagnetic radiation and effects of garlic extract in rats. International Journal of Radiation Biology88:799–805.
   PubMed Web of Science ®Google Scholar
• Baan R, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Islami F, Galichet L, Straif K. 2011. Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncology12:624–626.
   PubMed Web of Science ®Google Scholar
• Bartsch H, Bartsch C, Seebald E, Deerberg F, Dietz K, Vollrath L, Mecke D. 2002. Chronic exposure to a GSM-like signal (mobile phone) does not stimulate the development of DMBA-induced mammary tumors in rats: Results of three consecutive studies. Radiation Research157:183–190.
   PubMed Web of Science ®Google Scholar
• Bit-Babik G, Chou CK, Faraone A, Gessner A, Kanda M, Balzano Q. 2003. Estimation of the SAR in the human head and body due to radiofrequency radiation exposure from handheld mobile phones with hands-free accessories. Radiation Research159:550–557.
   PubMed Web of Science ®Google Scholar
• Chavdoula ED, Panagopoulos DJ, Margaritis LH. 2010. Comparison of biological effects between continuous and intermittent exposure to GSM-900-MHz mobile phone radiation: Detection of apoptotic cell-death features. Mutation Research700:51–61.
   PubMed Web of Science ®Google Scholar
• Dasdag S, Ketani MA, Akdag Z, Ersay AR, Sari I, Demirtas OC, Celik MS. 1999. Whole-body microwave exposure emitted by cellular phones and testicular function of rats. Urological Research27:219–223.
   PubMed Web of Science ®Google Scholar
• De Iuliis GN, Newey RJ, King BV, Aitken RJ. 2009. Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. PloS One4:e6446.
   PubMed Web of Science ®Google Scholar
• Fairbairn DW, Olive PL, O’Neill KL. 1995. The comet assay: A comprehensive review. Mutation Research339:37–59.
   PubMed Web of Science ®Google Scholar
• Falzone N, Huyser C, Franken DR, Leszczynski D. 2010. Mobile phone radiation does not induce pro-apoptosis effects in human spermatozoa. Radiation Research174:169–176.
   PubMed Web of Science ®Google Scholar
• Fischer TW, Slominski A, Zmijewski MA, Reiter RJ, Paus R. 2008. Melatonin as a major skin protectant: From free radical scavenging to DNA damage repair. Experimental Dermatology17:713–730.
   PubMed Web of Science ®Google Scholar
• Franzellitti S, Valbonesi P, Ciancaglini N, Biondi C, Contin A, Bersani F, Fabbri E. 2010. Transient DNA damage induced by high-frequency electromagnetic fields (GSM 1.8 GHz) in the human trophoblast HTR-8/SVneo cell line evaluated with the alkaline comet assay. Mutation Research683:35–42.
   PubMed Web of Science ®Google Scholar
• Gos P, Eicher B, Kohli J, Heyer WD. 2000. No mutagenic or recombinogenic effects of mobile phone fields at 900 MHz detected in the yeast Saccharomyces cerevisiae. Bioelectromagnetics21:515–523.
   PubMed Web of Science ®Google Scholar
• Hardeland R, Tan DX, Reiter RJ. 2009. Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines. Journal of Pineal Research47: 109–126.
   PubMed Web of Science ®Google Scholar
• Hardell L, Carlberg M, Ohlson CG, Westberg H, Eriksson M, Hansson Mild K. 2007a. Use of cellular and cordless telephones and risk of testicular cancer. International Journal of Andrology30:115–122.
   PubMed Web of Science ®Google Scholar
• Hardell L, Carlberg M, Soderqvist F, Hansson Mild K. 2008. Meta- analysis of long-term mobile phone use and the association with brain tumours. International Journal of Oncology32:1097–1103.
   PubMed Web of Science ®Google Scholar
• Hardell L, Carlberg M, Soderqvist F, Mild KH, Morgan LL. 2007b. Long-term use of cellular phones and brain tumours: Increased risk associated with use for > or = 10 years. Occupational and Environmental Medicine64:626–632.
   PubMed Web of Science ®Google Scholar
• Hung CS, Anderson C, Horne JA, McEvoy P. 2007. Mobile phone ‘talk-mode’ signal delays EEG-determined sleep onset. Neuroscience Letters421:82–86.
   PubMed Web of Science ®Google Scholar
• Kilgallon SJ, Simmons LW. 2005. Image content influences men's semen quality. Biology Letters1:253–255.
   PubMed Web of Science ®Google Scholar
• La Vignera S, Condorelli RA, Vicari E, D’Agata R, Calogero AE. 2012. Effects of the exposure to mobile phones on male reproduction: A review of the literature. Journal of Andrology33:350–356.
   PubMed Web of Science ®Google Scholar
• Lai H, Singh NP. 1995. Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics16:207–210.
   PubMed Web of Science ®Google Scholar
• Lai H, Singh NP. 1996. Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. International Journal of Radiation Biology69:513–521.
   PubMed Web of Science ®Google Scholar
• Lai H, Singh NP. 1997. Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics18:446–454.
   PubMed Web of Science ®Google Scholar
• Li L, Bisht KS, LaGroye I, Zhang P, Straube WL, Moros EG, Roti Roti JL. 2001. Measurement of DNA damage in mammalian cells exposed in vitro to radiofrequency fields at SARs of 3–5 W/kg. Radiation Research156:328–332.
   PubMed Web of Science ®Google Scholar
• Lu YS, Huang BT, Huang YX. 2012. Reactive oxygen species formation and apoptosis in human peripheral blood mononuclear cell induced by 900 MHz mobile phone radiation. Oxidative Medicine and Cellular Longevity2012:740280.
   PubMed Web of Science ®Google Scholar
• Mailankot M, Kunnath AP, Jayalekshmi H, Koduru B, Valsalan R. 2009. Radio frequency electromagnetic radiation (RF-EMR) from GSM (0.9/1.8 GHz) mobile phones induces oxidative stress and reduces sperm motility in rats. Clinics (Sao Paulo)64:561–565.
   PubMed Web of Science ®Google Scholar
• Malyapa RS, Ahern EW, Straube WL, Moros EG, Pickard WF, Roti Roti JL. 1997. Measurement of DNA damage after exposure to 2450 MHz electromagnetic radiation. Radiation Research148: 608–617.
   PubMed Web of Science ®Google Scholar
• Martinez-Alfaro M, Hernandez-Cortes D, Wrobel K, Cruz-Jimenez G, Rivera-Leyva JC, Pina-Zentella RM, Carabez Trejo A. 2012. Effect of melatonin administration on DNA damage and repair responses in lymphocytes of rats subchronically exposed to lead. Mutation Research742:37–42.
   PubMed Web of Science ®Google Scholar
• Olsen AK, Lindeman B, Wiger R, Duale N, Brunborg G. 2005. How do male germ cells handle DNA damage?Toxicology and Applied Pharmacology207:521–531.
   PubMedGoogle Scholar
• Ono T, Saito Y, Komura J, Ikehata H, Tarusawa Y, Nojima T, Goukon K, Ohba Y, Wang J, Fujiwara O, Sato R. 2004. Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero. The Tohoku Journal of Experimental Medicine202:93–103.
   PubMed Web of Science ®Google Scholar
• Ozguner F, Bardak Y, Comlekci S. 2006. Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: A comparative study. Molecular and Cellular Biochemistry282:83–88.
   PubMed Web of Science ®Google Scholar
• Panagopoulos DJ. 2012. Effect of microwave exposure on the ovarian development of drosophila melanogaster. Cell Biochemistry and Biophysics63:121–132.
   PubMed Web of Science ®Google Scholar
• Panagopoulos DJ, Chavdoula ED, Margaritis LH. 2010. Bioeffects of mobile telephony radiation in relation to its intensity or distance from the antenna. International Journal of Radiation Biology86: 345–357.
   PubMed Web of Science ®Google Scholar
• Panagopoulos DJ, Chavdoula ED, Nezis IP, Margaritis LH. 2007. Cell death induced by GSM 900-MHz and DCS 1800-MHz mobile telephony radiation. Mutation Research626:69–78.
   PubMed Web of Science ®Google Scholar
• Panagopoulos DJ, Karabarbounis A, Margaritis LH. 2004. Effect of GSM 900-MHz mobile phone radiation on the reproductive capacity of Drosophila melanogaster. Electromagnetic Biology and Medicine23:29–43.
   Web of Science ®Google Scholar
• Panagopoulos DJ, Margaritis LH. 2002. Effects of different kinds of EMFs on the offspring production of insects. In: Kostarakis P, editor. 2nd International Workshop, Biological effects of electromagnetic fields; Proceedings, Rhodes, Greece, 7–11 October 2002. pp 438–452.
   Google Scholar
• Panagopoulos DJ, Margaritis LH. 2003. Effects of electromagnetic fields on the reproductive capacity of Drosophila melanogaster. In: Stavroulakis P, editor. Biological effects of electromagnetic fields. Berlin: Springer. pp 545–578.
   Google Scholar
• Panagopoulos DJ, Messini N, Karabarbounis A, Philippetis AL, Margaritis LH. 2000. Radio frequency electromagnetic radiation within ‘safety levels’ alters the physiological function of insects. In: Kostarakis P, Stavroulakis P, editors. Millennium International Workshop on biological effects of electromagnetic fields; Proceedings, Heraklion, Crete, Greece, 17–20 October, 2000. pp 169–175.
   Google Scholar
• Sliwinski T, Rozej W, Morawiec-Bajda A, Morawiec Z, Reiter R, Blasiak J. 2007. Protective action of melatonin against oxidative DNA damage: Chemical inactivation versus base-excision repair. Mutation Research634:220–227.
   PubMed Web of Science ®Google Scholar
• Speit G, Schutz P, Hoffmann H. 2007. Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in cultured mammalian cells are not independently reproducible. Mutation Research626:42–47.
   PubMed Web of Science ®Google Scholar
• Tomas-Zapico C, Coto-Montes A. 2005. A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. Journal of Pineal Research39:99–104.
   PubMed Web of Science ®Google Scholar
• Verschaeve L, Juutilainen J, Lagroye I, Miyakoshi J, Saunders R, de Seze R, Tenforde T, van Rongen E, Veyret B, Xu, Z. 2010. In vitro and in vivo genotoxicity of radiofrequency fields. Mutation Research705:252–268.
   PubMed Web of Science ®Google Scholar
• Volkow ND, Tomasi D, Wang GJ, Vaska P, Fowler JS, Telang F, Alexoff D, Logan J, Wong C. 2011. Effects of cell phone radiofrequency signal exposure on brain glucose metabolism. The Journal of the American Medical Association305:808–813.
   PubMed Web of Science ®Google Scholar
• Wdowiak A, Wdowiak L, Wiktor H. 2007. Evaluation of the effect of using mobile phones on male fertility. Annals of Agricultural and Environmental Medicine (AAEM)14:169–172.
   PubMed Web of Science ®Google Scholar
• Weisbrot D, Lin H, Ye L, Blank M, Goodman R. 2003. Effects of mobile phone radiation on reproduction and development in Drosophila melanogaster. Journal of Cellular Biochemistry89:48–55.
   PubMed Web of Science ®Google Scholar
• Zeni O, Schiavoni A, Perrotta A, Forigo D, Deplano M, Scarfi MR. 2008. Evaluation of genotoxic effects in human leukocytes after in vitro exposure to 1950 MHz UMTS radiofrequency field. Bioelectromagnetics29:177–184.
   PubMed Web of Science ®Google Scholar