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Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial

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Pages 476-482 | Published online: 17 Nov 2011

References

  • Abumweis SS, Barake R, Jones PJ. 2008. Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials. Food Nutr Res. 52 e-publication.
  • Acuff RV, Cai DJ, Dong ZP, Bell D. 2007. The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects. Lipids Health Dis. 6:11.
  • Berger A, Jones PJ, Abumweis SS. 2004. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis. 3:5.
  • Bittner V. 2003. Non-high-density lipoprotein cholesterol and cardiovascular disease. Curr Opin Lipidol. 14:367–371.
  • Carr TP, Krogstrand KL, Schlegel VL, Fernandez ML. 2009. Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. J Nutr. 139:1445–1450.
  • Cohen JC, Boerwinkle E, Mosley THJr, Hobbs HH. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 354:1264–1272.
  • Cui Y, Blumenthal RS, Flaws JA, Whitman MK, Langenberg P, Bachorik PS, Bush TL. 2001. Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. Arch Intern Med. 161:1413–1419.
  • de Graaf J, de Sauvage Nolting PR, Van Dam M, Belsey EM, Kastelein JJ, Haydn Pritchard P, Stalenhoef AF. 2002. Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. Br J Nutr. 88:479–488.
  • Demonty I, Ras RT, van der Knaap HC, Duchateau GS, Meijer L, Zock PL, Geleijnse JM, Trautwein EA. 2009. Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J Nutr. 139:271–284.
  • Doornbos AM, Meynen EM, Duchateau GS, van der Knaap HC, Trautwein EA. 2006. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 60:325–333.
  • Food and Drug Administration. 2000. Food labeling: health claims; plant sterol/stanol esters and coronary heart disease. Food and Drug Administration, HHS. Interim final rule. Fed Reg. 65:54686–54739.
  • Food and Drug Administration. 2010. Food labeling: health claim; phytosterols and risk of coronary heart disease; proposed rule. Fed Reg. 75:76526–76571.
  • Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:499–502.
  • Goldberg AC, Ostlund REJr, Bateman JH, Schimmoeller L, McPherson TB, Spilburg CA. 2006. Effect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugs. Am J Cardiol. 97:376–379.
  • Gremaud G, Dalan E, Piguet C, Baumgartner M, Ballabeni P, Decarli B, Leser ME, Berger A, Fay LB. 2002. Effects of non-esterified stanols in a liquid emulsion on cholesterol absorption and synthesis in hypercholesterolemic men. Eur J Nutr. 41:54–60.
  • Grundy SM, Cleeman JI, Merz CN, Brewer HBJr, Clark LT, Hunninghake DB, Pasternak RC, Smith SCJr, Stone NJ, Coordinating Committee of the National Cholesterol Education Program. 2004. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol. 44:720–732.
  • Hallikainen MA, Uusitupa MI. 1999. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am J Clin Nutr. 69:403–410.
  • Hallikainen MA, Sarkkinen ES, Gylling H, Erikkilä AT, Uusitupa MI. 2000. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr. 54:715–725.
  • Hegsted DM, Ausman LM, Johnson JA, Dallal GE. 1993. Dietary fat and serum lipids: an evaluation of the experimental data. Am J Clin Nutr. 57:875–883.
  • Hui DY, Labonté ED, Howles PN. 2008. Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption. Am J Physiol Gastrointest Liver Physiol. 294:G839–G843.
  • Ikeda I, Sugano M. 1998. Inhibition of cholesterol absorption by plant sterols for mass intervention. Curr Opin Lipidol. 9:527–531.
  • Jones PJ. 2008. Dietary agents that target gastrointestinal and hepatic handling of bile acids and cholesterol. J Clin Lipidol. 2:S4–S10.
  • Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA. 1999. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr. 69:1144–1150.
  • Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R, Stresa Workshop Participants. 2003. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 78:965–978.
  • Kris-Etherton PM, Yu S. 1997. Individual fatty acid effects on plasma lipids and lipoproteins: human studies. Am J Clin Nutr. 65 5 Suppl.: 1628S–1644S.
  • Liu J, Sempos CT, Donahue RP, Dorn J, Trevisan M, Grundy SM. 2006. Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease. Am J Cardiol. 98:1363–1368.
  • Maki KC, Davidson MH, Umporowicz DM, Schaefer EJ, Dicklin MR, Ingram KA, Chen S, McNamara JR, Gebhart BW, Ribaya-Mercado JD, Perrone G, Robins SJ, Franke WC. 2001. Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet. Am J Clin Nutr. 74:33–43.
  • Maki KC, Shinnick F, Seeley MA, Veith PE, Quinn LC, Hallissey PJ, Temer A, Davidson MH. 2003. Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults. J Nutr. 133:808–813.
  • McPherson TB, Ostlund RE, Goldberg AC, Bateman JH, Schimmoeller L, Spilburg CA. 2005. Phytostanol tablets reduce human LDL-cholesterol. J Pharm Pharmacol. 57:889–896.
  • Miettinen TA, Gylling H. 2004. Plant stanol and sterol esters in prevention of cardiovascular diseases. Ann Med. 36:126–134.
  • Miller M, Ginsberg HN, Schaefer EJ. 2008. Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease. Am J Cardiol. 101:1003–1008.
  • Mussner MJ, Parhofer KG, Von Bergmann K, Schwandt P, Broedl U, Otto C. 2002. Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake. Metabolism. 51:189–194.
  • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). 2002. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 106:3143–3421.
  • Nestel P, Cehun M, Pomeroy S, Abbey M, Weldon G. 2001. Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods. Eur J Clin Nutr. 55:1084–1090.
  • Ostlund REJr. 2002. Phytosterols in human nutrition. Ann Rev Nutr. 22:533–549.
  • Ostlund REJr, Spilburg CA, Stenson WF. 1999. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am J Clin Nutr. 70:826–831.
  • Pischon T, Girman CJ, Sacks FM, Rifai N, Stampfer MJ, Rimm EB. 2005. Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men. Circulation. 29:3375–3383.
  • Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP. 2009. A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. J Nutr. 139:1143–1149.
  • Pouteau E, Monnard IE, Piguet-Welsch C, Groux MJ, Sagalowicz L, Berger A. 2003. Non-esterified plant sterols solubilized in low fat milks inhibit cholesterol absorption – a stable isotope double-blind crossover study. Eur J Nutr. 42:154–164.
  • Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. 2005. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 294:326–333.
  • Robinson JG, Smith B, Maheshwari N, Schrott H. 2005. Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis. J Am Coll Cardiol. 46:1855–1862.
  • Robinson JG, Wang S, Smith BJ, Jacobson TA. 2009. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J Am Coll Cardiol. 53:316–322.
  • Sánchez-Muniz FJ, Maki KC, Schaefer EJ, Ordovas JM. 2009. Serum lipid and antioxidant responses in hypercholesterolemic men and women receiving plant sterol esters vary by apolipoprotein E genotype. J Nutr. 139:13–19.
  • Thomsen AB, Hansen HB, Christiansen C, Green H, Berger A. 2004. Effect of free plant sterols in low-fat milk on serum lipid profile in hypercholesterolemic subjects. Eur J Clin Nutr. 58:860–870.
  • Volpe R, Nittynen L, Korpela R, Sirtori C, Bucci A, Fraone N, Pazzucconi F. 2001. Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia. Br J Nutr. 86:233–239.
  • von Bergmann K, Sudhop T, Lütjohann D. 2005. Cholesterol and plant sterol absorption: recent insights. Am J Cardiol. 96:10D–14D.