Serum vitamin B12 and folate levels in patients with non-alcoholic fatty liver disease

References

• Andersson A, Brattstrom L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. 1992. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest. 22:79–87.
   PubMed Web of Science ®Google Scholar
• Badiou S, Bariolet S, Laurens C, Aillaud N, Bargnoux AS, Mariano-Goulart D, . 2010. Comparison of isotopic and immunoenzymatic methods for folate and vitamin B12 determination. Clin Lab. 56:547–552.
   PubMed Web of Science ®Google Scholar
• Bailey SW, Ayling JE. 2009. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci USA. 106:15424–15429.
   PubMed Web of Science ®Google Scholar
• Baril L, Carmel R. 1978. Comparison of radioassay and microbiological assay for serum folate, with clinical assessment of discrepant results. Clin Chem. 24:2192–2196.
   PubMed Web of Science ®Google Scholar
• Bosy-Westphal A, Ruschmeyer M, Czech N, Oehler G, Hinrichsen H, Plauth M, . 2003. Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation. Am J Clin Nutr. 77:1269–1277.
   PubMed Web of Science ®Google Scholar
• Brasileiro RS, Escrivao MA, Taddei JA, D'Almeida V, Ancona-Lopez F, Carvalhaes JT. 2005. Plasma total homocysteine in Brazilian overweight and non-overweight adolescents: a case-control study. Nutr Hosp. 20:313–319.
   PubMedGoogle Scholar
• Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. 1999. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr. 70:904–910.
   PubMed Web of Science ®Google Scholar
• Charatcharoenwitthaya P, Levy C, Angulo P, Keach J, Jorgensen R, Lindor KD. 2007. Open-label pilot study of folic acid in patients with nonalcoholic steatohepatitis. Liver Int. 27:220–226.
   PubMed Web of Science ®Google Scholar
• Chen AR, Zhang HG, Wang ZP, Fu SJ, Yang PQ, Ren JG, . 2010. C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population. Clin Invest Med. 33:290–297.
   Web of Science ®Google Scholar
• Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R. 2010. Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr. 140:1736–1741.
   PubMed Web of Science ®Google Scholar
• Clarke R, Grimley EJ, Schneede J, Nexo E, Bates C, Fletcher A, . 2004. Vitamin B12 and folate deficiency in later life. Age Ageing. 33:34–41.
   PubMed Web of Science ®Google Scholar
• Cravo ML, Camilo ME. 2000. Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins B(6) and B(12) status. Nutrition. 16:296–302.
   PubMed Web of Science ®Google Scholar
• Cylwik B, Czygier M, Daniluk M, Chrostek L, Szmitkowski M. 2010. Vitamin B12 concentration in the blood of alcoholics. Pol Merkur Lekarski. 28:122–125.
   PubMedGoogle Scholar
• Ermens AA, Vlasveld LT, Lindemans J. 2003. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 36:585–590.
   PubMed Web of Science ®Google Scholar
• Fakhrzadeh H, Ghotbi S, Pourebrahim R, Nouri M, Heshmat R, Bandarian F, . 2006. Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003–2004)/a cross-sectional population based study. BMC Public Health. 6:29.
   PubMed Web of Science ®Google Scholar
• Fragasso A, Mannarella C, Ciancio A, Sacco A. 2010. Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med. 21:97–100.
   PubMed Web of Science ®Google Scholar
• Friso S, Lamon-Fava S, Jang H, Schaefer EJ, Corrocher R, Choi SW. 2007. Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women. Br J Nutr. 97:617–621.
   PubMed Web of Science ®Google Scholar
• Gammon CS, von Hurst PR, Coad J, Kruger R, Stonehouse W. 2012. Vegetarianism, vitamin B12 status, and insulin resistance in a group of predominantly overweight/obese South Asian women Nutrition 28:20–24.
   Google Scholar
• Gulsen M, Yesilova Z, Bagci S, Uygun A, Ozcan A, Ercin CN, . 2005. Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 20:1448–1455.
   PubMed Web of Science ®Google Scholar
• Halsted CH, Villanueva JA, Devlin AM, Niemela O, Parkkila S, Garrow TA, . 2002. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci USA. 99:10072–10077.
   PubMed Web of Science ®Google Scholar
• Hatzis CM, Bertsias GK, Linardakis M, Scott JM, Kafatos AG. 2006. Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study. Nutr J. 5:5.
   PubMed Web of Science ®Google Scholar
• Hirsch S, Poniachick J, Avendano M, Csendes A, Burdiles P, Smok G, . 2005. Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver. Nutrition. 21:137–141.
   PubMed Web of Science ®Google Scholar
• Huang RF, Hsu YC, Lin HL, Yang FL. 2001. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr. 131:33–38.
   PubMed Web of Science ®Google Scholar
• Hughes K, Ong CN. 2000. Homocysteine, folate, vitamin B12, and cardiovascular risk in Indians, Malays, and Chinese in Singapore. J Epidemiol Community Health. 54:31–34.
   PubMed Web of Science ®Google Scholar
• Kim DS, Kim YK, Park HK, Cho YI, Jeong SK. 2010. Serum folate and low-density lipoprotein particle size. J Atheroscler Thromb. 17:1218–1225.
   PubMed Web of Science ®Google Scholar
• Kleiner DE, Brunt EM, Van NM, Behling C, Contos MJ, Cummings OW, . 2005. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–1321.
   PubMed Web of Science ®Google Scholar
• Koplay M, Gulcan E, Ozkan F. 2011. Association between serum vitamin B12 levels and the degree of steatosis in patients with nonalcoholic fatty liver disease. J Investig Med. 59:1137–1140.
   PubMed Web of Science ®Google Scholar
• Mahabir S, Ettinger S, Johnson L, Baer DJ, Clevidence BA, Hartman TJ, Taylor PR. 2008. Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study. Eur J Clin Nutr. 62:644–650.
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419.
   PubMed Web of Science ®Google Scholar
• Nygard O, Refsum H, Ueland PM, Vollset SE. 1998. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr. 67:263–270.
   PubMed Web of Science ®Google Scholar
• Papandreou D, Rousso I, Malindretos P, Makedou A, Arvanitidou M. 2010. Effects of oral folate supplementation on serum total homocysteine and cholesterol levels in hyperhomocysteinemic children. Nutr Clin Pract. 25:390–393.
   PubMed Web of Science ®Google Scholar
• Pfeiffer CM, Zhang M, Lacher DA, Molloy AM, Tamura T, Yetley EA, . 2011. Comparison of serum and red blood cell folate microbiologic assays for national population surveys. J Nutr. 141:1402–1409.
   PubMed Web of Science ®Google Scholar
• Planells E, Sanchez C, Montellano MA, Mataix J, Llopis J. 2003. Vitamins B6 and B12 and folate status in an adult Mediterranean population. Eur J Clin Nutr. 57:777–785.
   PubMed Web of Science ®Google Scholar
• Polyzos SA, Kountouras J, Zavos C. 2009. Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr Mol Med. 72:299–314.
   Web of Science ®Google Scholar
• Polyzos SA, Kountouras J, Patsiaoura K, Katsiki E, Zafeiriadou E, Deretzi G, . 2012. Serum homocysteine levels in patients with nonalcoholic fatty liver disease. Ann Hepatol. 11:68–76.
   PubMed Web of Science ®Google Scholar
• Ray JG, Cole DE, Boss SC. 2000. An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise?. Clin Biochem. 33:337–343.
   PubMed Web of Science ®Google Scholar
• Sazci A, Akpinar G, Aygun C, Ergul E, Senturk O, Hulagu S. 2008. Association of apolipoprotein E polymorphisms in patients with non-alcoholic steatohepatitis. Dig Dis Sci. 53:3218–3224.
   PubMed Web of Science ®Google Scholar
• Semmler A, Moskau S, Grigull A, Farmand S, Klockgether T, Smulders Y, . 2010. Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis. Nutr J. 9:31.
   PubMed Web of Science ®Google Scholar
• Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, . 2004. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol. 151:483–489.
   PubMed Web of Science ®Google Scholar
• Shane B. 2008. Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull. 29:S5–S16.
   PubMed Web of Science ®Google Scholar
• Smulders YM, Stehouwer CD. 2005. Folate metabolism and cardiovascular disease. Semin Vasc Med. 5:87–97.
   PubMedGoogle Scholar
• Tanrikulu-Kilic F, Bekpinar S, Unlucerci Y, Orhan Y. 2006. Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women. Physiol Res. 55:285–290.
   PubMed Web of Science ®Google Scholar
• Vaya A, Carmona P, Badia N, Perez R, Mijares AH, Corella D. 2011. Homocysteine levels and the metabolic syndrome in a Mediterranean population: a case-control study. Clin Hemorheol Microcirc. 47:59–66.
   PubMed Web of Science ®Google Scholar
• Verhoef P, Meleady R, Daly LE, Graham IM, Robinson K, Boers GH. 1999. Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status. European COMAC Group. Eur Heart J. 20:1234–1244.
   PubMed Web of Science ®Google Scholar
• Weggemans RM, de Groot LC, Haller J. 1997. Factors related to plasma folate and vitamin B12. The SENECA study. Int J Food Sci Nutr. 48:141–150.
   PubMed Web of Science ®Google Scholar
• Wouters MG, Moorrees MT, van der Mooren MJ, Blom HJ, Boers GH, Schellekens LA, . 1995. Plasma homocysteine and menopausal status. Eur J Clin Invest. 25:801–805.
   PubMed Web of Science ®Google Scholar