Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line

References

• Ajmone-Cat M, Lavinia Salvatori M, De Simone R, Mancini M, Biagioni S, Bernardo A, Cacci E, Minghetti L. 2012. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. J Neurosci Res 90:575–587
   Google Scholar
• Aleshin S, Reiser G. 2013. Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain. Biol Chem 394:1553–1570
   Google Scholar
• Avallone R, Rustichelli C, Campioli E, Notarangelo FMP, Braghiroli D, Baraldi M. 2009. Alpha-Linolenic acid and Linoleic acid in serum and tissues after flaxseed (Linum usitatissimum) oil in vivo administration. J Food Lipids 16: 287–296
   Google Scholar
• Bazan NG. 2006. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol 26:901–913
   PubMed Web of Science ®Google Scholar
• Belayev L, Khoutorova L, Atkins KD, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG. 2011. Docosahexaenoic acid therapy of experimental ischemic stroke. Transl Stroke Res 2:33–41
   PubMed Web of Science ®Google Scholar
• Bernardo A, Minghetti L. 2006. PPAR-gamma agonists as regulators of microglial activation and brain inflammation. Curr Pharm Des 12:93–109
   PubMed Web of Science ®Google Scholar
• Bernardo A, Minghetti L. 2008. Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists. PPAR Res 2008:864140
   PubMed Web of Science ®Google Scholar
• Brenna JT. 2002. Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 5:127–132
   PubMed Web of Science ®Google Scholar
• Calder PC. 2009. Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie 91:791–795
   PubMed Web of Science ®Google Scholar
• Calder PC. 2014. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta (in press)
   Google Scholar
• Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. 2000. Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci Off J Soc Neurosci 20:558–567
   PubMed Web of Science ®Google Scholar
• Crawford MA. 2006. Docosahexaenoic acid in neural signaling systems. Nutr Health 18:263–276
   PubMedGoogle Scholar
• Daynes RA, Jones DC. 2002. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2:748–759
   PubMed Web of Science ®Google Scholar
• De Simone R, Ajmone-Cat MA, Minghetti L. 2004. Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Mol Neurobiol 29:197–212
   Google Scholar
• De Smedt-Peyrusse V, Sargueil F, Moranis A, Harizi H, Mongrand S, Layé S. 2008. Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. J Neurochem 105:296–307
   PubMed Web of Science ®Google Scholar
• Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BHF, Langmann T. 2009. Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. J Neurochem 110:1863–1875
   Google Scholar
• Groeger AL, Cipollina C, Cole MP, Woodcock SR, Bonacci G, Rudolph TK, Rudolph V, et al. 2010. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Nat Chem Biol 6:433–441
   PubMed Web of Science ®Google Scholar
• Khair-El-Din T, Sicher SC, Vazquez MA, Chung GW, Stallworth KA, Kitamura K, Miller RT, Lu CY. 1996. Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. J Exp Med 183:1241–1246
   PubMed Web of Science ®Google Scholar
• Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, et al. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA 94:4318–4323
   PubMed Web of Science ®Google Scholar
• McNamara RK, Carlson SE. 2006. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prost Leukot Essent Fatty Acids 75:329–349
   PubMed Web of Science ®Google Scholar
• Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, et al. 2008. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem 283:19927–19935
   PubMed Web of Science ®Google Scholar
• Niemoller TD, Bazan NG. 2010. Docosahexaenoic acid neurolipidomics. Prostaglandins Other Lipid Mediat 91:85–89
   PubMed Web of Science ®Google Scholar
• Palacios-Pelaez R, Lukiw WJ, Bazan NG. 2010. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol 41:367–374
   PubMed Web of Science ®Google Scholar
• Perry VH, Bolton SJ, Anthony DC, Betmouni S. 1998. The contribution of inflammation to acute and chronic neurodegeneration. Res Immunol 149:721–725
   PubMedGoogle Scholar
• Polazzi E, Contestabile A. 2002. Reciprocal interactions between microglia and neurons: from survival to neuropathology. Rev Neurosci 13:221–242
   PubMed Web of Science ®Google Scholar
• Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, et al. 1998a. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci USA 95:7614–7619
   PubMed Web of Science ®Google Scholar
• Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. 1998b. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79–82
   PubMed Web of Science ®Google Scholar
• Rustichelli C, Avallone R, Campioli E, Braghiroli D, Baraldi M. 2012. Polyunsaturated fatty acid levels in rat tissues after chronic treatment with dietetic oils. J Sci Food Agric 92:239–245
   Google Scholar
• Sergeeva M, Strokin M, Reiser G. 2005. Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. Reprod Nutr Dev 45:633–646
   PubMedGoogle Scholar
• Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. 1998. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241–252
   PubMed Web of Science ®Google Scholar
• Wang JY, Wen LL, Huang YN, Chen YT, Ku MC. 2006. Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharm Des 12:3521–3533
   PubMed Web of Science ®Google Scholar
• Willson TM, Lambert MH, Kliewer SA. 2001. Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem 70:341–367
   PubMed Web of Science ®Google Scholar
• Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA. 1995. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 270:23975–23983
   PubMed Web of Science ®Google Scholar