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Themed Reviews

Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism

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Pages 376-383 | Received 07 Aug 2010, Accepted 24 Jan 2011, Published online: 27 Mar 2011

References

  • Asakawa A, Inui A, Ueno N, Makino S, Fujino MA, Kasuga M. 1999. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology. 116 6: 1287–1292.
  • Asakawa A, Inui A, Ueno N, Makino S, Fujimiya M, Fujino MA, Kasuga M. 2001. Urocortin reduces oxygen consumption in lean and ob/ob mice. Int J Mol Med. 7 5: 539–541.
  • Bale TL. 2006. Stress sensitivity and the development of affective disorders. Horm Behav. 50 4: 529–533.
  • Bale TL, Vale WW. 2004. CRF and CRF receptors: Role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol. 44:525–557.
  • Bittencourt JC, Sawchenko PE. 2000. Do centrally administered neuropeptides access cognate receptors?: An analysis in the central corticotropin-releasing factor system. J Neurosci. 20 3: 1142–1156.
  • Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE. 1999. Urocortin expression in rat brain: Evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol. 415 3: 285–312.
  • Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Le AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de GG, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M. 2009. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 43 7: 491–498.
  • Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD, Stern MP, MacCluer JW, Blangero J. 1997. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet. 15 3: 273–276.
  • Cunha RP, Reiner A, Toledo CA. 2007. Involvement of urocortinergic neurons below the midbrain central gray in the physiological response to restraint stress in pigeons. Brain Res. 1147:175–183.
  • de Kloet ER, Joels M, Holsboer F. 2005. Stress and the brain: From adaptation to disease. Nat Rev Neurosci. 6 6: 463–475.
  • Delplanque J, Vasseur F, Durand E, Abderrahmani A, Dina C, Waeber G, Guy-Grand B, Clement K, Weill J, Boutin P, Froguel P. 2002. Mutation screening of the urocortin gene: Identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. J Clin Endocrinol Metab. 87 2: 867–869.
  • Derks NM. 2010. The role of the non-preganglionic Edinger–Westphal nucleus in sex-dependent stress adaptation in rodents Donders Series. Nijmegen: PrintPartners Ipskamp.
  • Derks NM, Roubos EW, Kozicz T. 2007. Presence of estrogen receptor beta in urocortin 1-neurons in the mouse non-preganglionic Edinger–Westphal nucleus. Gen Comp Endocrinol. 153 1–3: 228–234.
  • Derks NM, Gaszner B, Roubos EW, Kozicz LT. 2009. Sex differences in urocortin 1 dynamics in the non-preganglionic Edinger–Westphal nucleus of the rat. Neurosci Res. 66 1: 117–123.
  • Eckart K, Radulovic J, Radulovic M, Jahn O, Blank T, Stiedl O, Spiess J. 1999. Actions of CRF and its analogs. Curr Med Chem. 6 11: 1035–1053.
  • Fatima A, Haroon MF, Wolf G, Engelmann M, Spina MG. 2007. Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger–Westphal nucleus during late pregnancy in rats. Regul Pept. 143 1–3: 34–38.
  • Fonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE. 2009. Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. Alcohol Clin Exp Res. 33 11: 1956–1965.
  • Frackiewicz EJ, Sramek JJ, Cutler NR. 2000. Gender differences in depression and antidepressant pharmacokinetics and adverse events. Ann Pharmacother. 34 1: 80–88.
  • Gaszner B, Csernus V, Kozicz T. 2004. Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger–Westphal nucleus in the rat. J Comp Neurol. 480 2: 170–179.
  • Gaszner B, Korosi A, Palkovits M, Roubos EW, Kozicz T. 2007. Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger–Westphal nucleus. J Comp Neurol. 500 4: 708–719.
  • Gaszner B, Van Wijk DC, Korosi A, Jozsa R, Roubos EW, Kozicz T. 2009. Diurnal expression of period 2 and urocortin 1 in neurones of the non-preganglionic Edinger–Westphal nucleus in the rat. Stress. 12 2: 115–124.
  • Gysling K, Forray MI, Haeger P, Daza C, Rojas R. 2004. Corticotropin-releasing hormone and urocortin: Redundant or distinctive functions?. Brain Res Brain Res Rev. 47 1–3: 116–125.
  • Haeger P, Andres ME, Forray MI, Daza C, Araneda S, Gysling K. 2006. Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J Neurosci. 26 18: 4908–4916.
  • Hauger RL, Risbrough V, Brauns O, Dautzenberg FM. 2006. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: New molecular targets. CNS Neurol Disord Drug Targets. 5 4: 453–479.
  • Herman JP, Adams D, Prewitt C. 1995. Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm. Neuroendocrinology. 61 2: 180–190.
  • Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE. 2003. Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol. 24 3: 151–180.
  • Holsboer F, Gerken A, Steiger A, Benkert O, Muller OA, Stalla GK. 1984. Corticotropin-releasing-factor induced pituitary-adrenal response in depression. Lancet. 1 8367: 55.
  • Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T, Takahashi K, Suzuki H, Tezuka F, Yoshimi T, Nagura H. 1999. Urocortin expression in the human central nervous system. Clin Endocrinol (Oxf). 50 1: 107–114.
  • Joels M, Baram TZ. 2009. The neuro-symphony of stress. Nat Rev Neurosci. 10 6: 459–466.
  • Kaur S, Ryabinin AE. 2010. Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons. Alcohol Clin Exp Res. 34 9: 1525–1534.
  • Kinney JW, Scruggs B, Avery DD. 2001. Peripheral administration of urocortin suppresses operant responding for food reward. Peptides. 22 4: 583–587.
  • Koolhaas JM, Everts H, de Ruiter AJ, De Boer SF, Bohus B. 1998. Coping with stress in rats and mice: Differential peptidergic modulation of the amygdala-lateral septum complex. Prog Brain Res. 119:437–448.
  • Korosi A, Schotanus S, Olivier B, Roubos EW, Kozicz T. 2005. Chronic ether stress-induced response of urocortin 1 neurons in the Edinger–Westphal nucleus in the mouse. Brain Res. 1046 1–2: 172–179.
  • Kornstein SG. 1997. Gender differences in depression: implications for treatment. J Clin Psychiatry 58 Suppl. 15:12–8.
  • Kotz CM, Wang C, Levine AS, Billington CJ. 2002. Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats. Am J Physiol Regul Integr Comp Physiol. 282 2: R546–R551.
  • Kozicz T. 2007. On the role of urocortin 1 in the non-preganglionic Edinger–Westphal nucleus in stress adaptation. Gen Comp Endocrinol. 153 1–3: 235–240.
  • Kozicz T. 2009. Neurobiology of corticotropin releasing factor system components in stress; from adaptation to maladaptation. In: Kovacs M, Merchenthaler I. editors. Neuropeptides and peptide analogs. Kerala, India: Research Signpost. p 59–90.
  • Kozicz T. 2010. The missing link; the significance of urocortin 1/urocortin 2 in the modulation of the dorsal raphe serotoninergic system. Mol Psychiatry. 15 4: 340–341.
  • Kozicz T, Yanaihara H, Arimura A. 1998. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J Comp Neurol. 391 1: 1–10.
  • Kozicz T, Min L, Arimura A. 2001. The activation of urocortin immunoreactive neurons in the Edinger–Westphal nucelus following acute pain stress in rats. Stress. 4:85–90.
  • Kozicz T, Arimura A, Maderdrut JL, Lazar G. 2002. Distribution of urocortin-like immunoreactivity in the central nervous system of the frog Rana esculenta. J Comp Neurol. 453 2: 185–198.
  • Kozicz T, Tilburg-Ouwens D, Faludi G, Palkovits M, Roubos E. 2008. Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression. Neuroscience. 152 4: 1015–1023.
  • Kozicz T, Bittencourt JC, May PJ, Reiner A, Gamlin PDR, Palkovits M, Horn AKE, Toledo CA, Ryabinin AE. The Edinger–Westphal nucleus: A historical, structural and functional perspective on a dichotomous terminology. J Comp Neurol. 2011 Accepted manuscript online: 23 December 2010 11:00AM EST DOI: 10.1002/cne.22580.
  • Kudielka BM, Kirschbaum C. 2005. Sex differences in HPA axis responses to stress: a review. Biol Psychol. 69 1: 113–32.
  • Lanteri-Minet M, Isnardon P, de PJ, Menetrey D. 1993. Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins. Neuroscience. 55 3: 737–753.
  • Lefkowitz RJ, Shenoy SK. 2005. Transduction of receptor signals by beta-arrestins. Science. 308 5721: 512–517.
  • Legendre A, Papakonstantinou E, Roy MC, Richard D, Harris RB. 2007. Differences in response to corticotropin-releasing factor after short- and long-term consumption of a high-fat diet. Am J Physiol Regul Integr Comp Physiol. 293 3: R1076–R1085.
  • Linden AM, Greene SJ, Bergeron M, Schoepp DD. 2004. Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions. Neuropsychopharmacology. 29 3: 502–513.
  • Linden AM, Baez M, Bergeron M, Schoepp DD. 2006. Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus. Neuropharmacology. 51 2: 213–228.
  • Lowery EG, Thiele TE. 2010. Pre-clinical evidence that corticotropin-releasing factor (CRF) receptor antagonists are promising targets for pharmacological treatment of alcoholism. CNS Neurol Disord Drug Targets. 9 1: 77–86.
  • Mitra SW, Hoskin E, Yudkovitz J, Pear L, Wilkinson HA, Hayashi S, Pfaff DW, Ogawa S, Rohrer SP, Schaeffer JM, McEwen BS, Alves SE. 2003. Immunolocalization of estrogen receptor beta in the mouse brain: Comparison with estrogen receptor alpha. Endocrinology. 144 5: 2055–2067.
  • Morimoto M, Morita N, Ozawa H, Yokoyama K, Kawata M. 1996. Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: An immunohistochemical and in situ hybridization study. Neurosci Res. 26 3: 235–269.
  • Nemeroff CB. 1988. The role of corticotropin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry. 21 2: 76–82.
  • Neufeld-Cohen A, Evans AK, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry CA, Vale W, Chen A. 2009. Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol Psychiatry. 15 4: 426–41.
  • Ohata H, Suzuki K, Oki Y, Shibasaki T. 2000. Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats. Brain Res. 861 1: 1–7.
  • Palkovits M, Sebekova K, Gallatz K, Boor P, Sebekova KJr, Klassen A, Bahner U, Heidland A. 2009. Neuronal activation in the CNS during different forms of acute renal failure in rats. Neuroscience. 159 2: 862–882.
  • Pan W, Kastin AJ. 2008. Urocortin and the brain. Prog Neurobiol. 84 2: 148–156.
  • Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ. 2007. Unexpected amplification of leptin-induced Stat3 signaling by urocortin: Implications for obesity. J Mol Neurosci. 33 3: 232–238.
  • Reul JM, Holsboer F. 2002. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2 1: 23–33.
  • Romeo RD, Karatsoreos IN, Jasnow AM, McEwen BS. 2007. Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus. Neuroendocrinology. 85 4: 199–206.
  • Rotimi CN, Comuzzie AG, Lowe WL, Luke A, Blangero J, Cooper RS. 1999. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African–Americans. Diabetes. 48 3: 643–644.
  • Ryabinin AE, Weitemier AZ. 2006. The urocortin 1 neurocircuit: Ethanol-sensitivity and potential involvement in alcohol consumption. Brain Res Brain Res Rev. 52 2: 368–380.
  • Ryabinin AE, Tsivkovskaia NO, Ryabinin SA. 2005. Urocortin 1-containing neurons in the human Edinger–Westphal nucleus. Neuroscience. 134 4: 1317–1323.
  • Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK. 2009. Leptin targets in the mouse brain. J Comp Neurol. 514 5: 518–532.
  • Selye H. 1951. The general-adaptation-syndrome. Annu Rev Med. 2:327–342.
  • Skelton KH, Owens MJ, Nemeroff CB. 2000. The neurobiology of urocortin. Regul Pept. 93 1–3: 85–92.
  • Skelton KH, Nemeroff CB, Owens MJ. 2004. Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression. J Neurosci. 24 42: 9303–9312.
  • Spangler E, Cote DM, Anacker AM, Mark GP, Ryabinin AE. 2009. Differential sensitivity of the perioculomotor urocortin-containing neurons to ethanol, psychostimulants and stress in mice and rats. Neuroscience. 160 1: 115–125.
  • Spina M, Merlo-Pich E, Chan RK, Basso AM, Rivier J, Vale W, Koob GF. 1996. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science. 273 5281: 1561–1564.
  • Turek VF, Ryabinin AE. 2005. Expression of c-Fos in the mouse Edinger–Westphal nucleus following ethanol administration is not secondary to hypothermia or stress. Brain Res. 1063 2: 132–139.
  • Van Pett K, Viau V, Bittencourt JC, Chan RK, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE. 2000. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol. 428 2: 191–212.
  • Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C. 1995. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 378 6554: 287–292.
  • Vetter DE, Li C, Zhao L, Contarino A, Liberman MC, Smith GW, Marchuk Y, Koob GF, Heinemann SF, Vale W, Lee KF. 2002. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 31 4: 363–369.
  • Viau V, Sawchenko PE. 2002. Hypophysiotropic neurons of the paraventricular nucleus respond in spatially, temporally, and phenotypically differentiated manners to acute vs. repeated restraint stress: Rapid publication. J Comp Neurol. 445 4: 293–307.
  • Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M. 2009. Ethanol-sensitive brain regions in rat and mouse: A cartographic review, using immediate early gene expression. Alcohol Clin Exp Res. 33 6: 945–969.
  • Wang L, Martinez V, Rivier JE, Tache Y. 2001. Peripheral urocortin inhibits gastric emptying and food intake in mice: Differential role of CRF receptor 2. Am J Physiol Regul Integr Comp Physiol. 281 5: R1401–R1410.
  • Wang X, Su H, Copenhagen LD, Vaishnav S, Pieri F, Shope CD, Brownell WE, De BM, Paylor R, Bradley A. 2002. Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response. Mol Cell Biol. 22 18: 6605–6610.
  • Weitemier AZ, Ryabinin AE. 2005. Lesions of the Edinger–Westphal nucleus alter food and water consumption. Behav Neurosci. 119 5: 1235–1243.
  • Weninger SC, Dunn AJ, Muglia LJ, Dikkes P, Miczek KA, Swiergiel AH, Berridge CW, Majzoub JA. 1999. Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc Natl Acad Sci USA. 96 14: 8283–8288.
  • Weninger SC, Peters LL, Majzoub JA. 2000. Urocortin expression in the Edinger–Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology. 141 1: 256–263.
  • Xu L, Bloem B, Gaszner B, Roubos EW, Kozicz T. 2009. Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger–Westphal nucleus. Neuroscience. 162 4: 1141–1149.
  • Xu L, Bloem B, Gaszner B, Roubos E, Kozicz T. Stress-related changes in the activity of cocaine- and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger–Westphal nucleus in the rat. Neuroscience. 2010a; 170 2: 478–488.
  • Xu L, Scheenen WJJM, Leshan RL, Patterson CM, Elias CF, Bouwhuis S, Roubos EW, Myers MJJ, Kozicz T. Evidence that leptin signaling modulates the activity of stress-sensitive urocortin 1 neurons in the non-preganglionic Edinger–Westphal nucleus in the mouse. Endocrinology. 2010b; 152 3: 979–988.
  • Zalutskaya AA, Arai M, Bounoutas GS, Abou-Samra AB. 2007. Impaired adaptation to repeated restraint and decreased response to cold in urocortin knockout mice. Am J Physiol Endocrinol Metab. 293:E259–E263.

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