Stress, glucocorticoids and liquorice in human pregnancy: Programmers of the offspring brain

References

• Alastalo H, Räikkönen K, Pesonen A-K, Osmond C, Barker DJ, Kajantie E, Heinonen K, Forsen TJ, Eriksson JG. 2009. Cardiovascular health of Finnish war evacuees 60 years later. Ann Med. 41:66–72.
   PubMed Web of Science ®Google Scholar
• Austin MP, Hadzi-Pavlovic D, Leader L, Saint K, Parker G. 2005. Maternal trait anxiety, depression and life event stress in pregnancy: Relationships with infant temperament. Early Hum Dev. 81:183–190.
   PubMed Web of Science ®Google Scholar
• Barker DJ. 1991. The intrauterine environment and adult cardiovascular disease. Ciba Found Symp. 156:3–10 discussion 10–6.
   PubMedGoogle Scholar
• Barker DJ. 1998. In utero programming of chronic disease. Clin Sci (Lond). 95:115–128.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. 1989. Weight in infancy and death from ischaemic heart disease. Lancet. 2:577–580.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Osmond C, Rodin I, Fall CH, Winter PD. 1995. Low weight gain in infancy and suicide in adult life. Br Med J. 311:1203.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. 2005. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 353:1802–1809.
   PubMed Web of Science ®Google Scholar
• Belmaker RH, Agam G. 2008. Major depressive disorder. N Engl J Med. 358:55–68.
   PubMed Web of Science ®Google Scholar
• Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CR. 1993. Glucocorticoid exposure in utero: New model for adult hypertension. Lancet. 341:339–341.
   PubMed Web of Science ®Google Scholar
• Benediktsson R, Calder AA, Edwards CR, Seckl JR. 1997. Placental 11 beta-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf). 46:161–166.
   PubMed Web of Science ®Google Scholar
• Bergman K, Sarkar P, O'Connor TG, Modi N, Glover V. 2007. Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. J Am Acad Child Adolesc Psychiatry. 46:1454–1463.
   PubMed Web of Science ®Google Scholar
• Bolt RJ, van Weissenbruch MM, Lafeber HN, Delemarre-van de Waal HA. 2001. Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol. 32:76–91.
   Google Scholar
• Brand SR, Engel SM, Canfield RL, Yehuda R. 2006. The effect of maternal PTSD following in utero trauma exposure on behavior and temperament in the 9-month-old infant. Ann N Y Acad Sci. 1071:454–458.
   PubMed Web of Science ®Google Scholar
• Brennan PA, Pargas R, Walker EF, Green P, Newport DJ, Stowe Z. 2008. Maternal depression and infant cortisol: Influences of timing, comorbidity and treatment. J Child Psychol Psychiatry. 49:1099–1107.
   PubMed Web of Science ®Google Scholar
• Broekman BF, Chan YH, Chong YS, Quek SC, Fung D, Low YL, Ooi YP, Gluckman PD, Meaney MJ, Wong TY, Saw SM. 2009. The influence of birth size on intelligence in healthy children. Pediatrics. 123:e1011–e1016.
   PubMed Web of Science ®Google Scholar
• Brouwers EPM, van Baar AL, Pop VJM. 2001. Maternal anxiety during pregnancy and subsequent infant development. Inf Behav Dev. 24:95–106.
   Web of Science ®Google Scholar
• Buss C, Davis EP, Muftuler LT, Head K, Sandman CA. 2009. High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6–9-year-old children. Psychoneuroendocrinology. 35:141–153.
   Google Scholar
• Cheung YB. 2002. Early origins and adult correlates of psychosomatic distress. Soc Sci Med. 55:937–948.
   PubMedGoogle Scholar
• Clark PM, Hindmarsh PC, Shiell AW, Law CM, Honour JW, Barker DJP. 1996. Size at birth and adrenocortical function in childhood. Clin Endocrinol. 45:721–726.
   PubMed Web of Science ®Google Scholar
• Cornelius MD, Day NL. 2009. Developmental consequences of prenatal tobacco exposure. Curr Opin Neurol. 22:121–125.
   PubMed Web of Science ®Google Scholar
• Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. 2005. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet. 365:1856–1862.
   PubMed Web of Science ®Google Scholar
• Dave-Sharma S, Wilson RC, Harbison MD, Newfield R, Azar MR, Krozowski ZS, Funder JW, Shackleton CH, Bradlow HL, Wei JQ, Hertecant J, Moran A, Neiberger RE, Balfe JW, Fattah A, Daneman D, Akkurt HI, De Santis C, New MI. 1998. Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess. J Clin Endocrinol Metab. 83:2244–2254.
   PubMed Web of Science ®Google Scholar
• Davis EP, Snidman N, Wadhwa PD, Glynn LM, Schetter CD, Sandman CA. 2004. Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy. 6:319–331.
   Web of Science ®Google Scholar
• Davis EP, Glynn LM, Schetter CD, Hobel C, Chicz-Demet A, Sandman CA. 2007. Prenatal exposure to maternal depression and cortisol influences infant temperament. J Am Acad Child Adolesc Psychiatry. 46:737–746.
   PubMed Web of Science ®Google Scholar
• Dawson G, Ashman SB. 2000. On the origins of a vulnerability to depression: The influence of the early social environment on the development of psychobiological systems related to risk for affective disorder. Mahwah, NJ: Erlbaum.
   Google Scholar
• Dawson G, Ashman SB, Hessl D, Spieker S, Frey K, Panagiotides H, Embry L. 2001. Autonomic and brain electrical activity in securely- and insecurely-attached infants of depressed mothers. Inf Behav Dev. 24:135–149.
   Google Scholar
• de Bruijn ATCE, van Bakel HJA, van Baar AL. Sex differences in the relation between prenatal maternal emotional complaints and child outcome. Early Hum Dev. 2009a; 85:319–324.
   PubMed Web of Science ®Google Scholar
• de Bruijn ATCE, van Bakel HJA, Wijnen H, Pop VJM, van Baar AL. Prenatal maternal emotional complaints are associated with cortisol responses in toddler and preschool aged girls. Dev Psychobiol. 2009b; 51:553–563.
   PubMed Web of Science ®Google Scholar
• de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, Wolfe-Coote S, Meaney MJ, Levitt NS, Seckl JR. 2007. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic–pituitary–adrenal axis function. J Clin Invest. 117:1058–1067.
   PubMed Web of Science ®Google Scholar
• Diego MA, Field T, Hernandez-Reif M, Cullen C, Schanberg S, Kuhn C. 2004. Prepartum, postpartum, and chronic depression effects on newborns. Psychiatry. 67:63–80.
   PubMed Web of Science ®Google Scholar
• DiPietro JA, Ghera MM, Costigan KA. 2008. Prenatal origins of temperamental reactivity in early infancy. Early Hum Dev. 84:569–575.
   PubMedGoogle Scholar
• Doyle LW, Ford GW, Davis NM, Callanan C. 2000. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci. 98:137–142.
   Web of Science ®Google Scholar
• Edwards CR, Benediktsson R, Lindsay RS, Seckl JR. 1993. Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension?. Lancet. 341:355–357.
   PubMed Web of Science ®Google Scholar
• El Marroun H, Tiemeier H, Steegers EA, Jaddoe VW, Hofman A, Verhulst FC, van den Brink W, Huizink AC. 2009. Intrauterine cannabis exposure affects fetal growth trajectories: The generation R study. J Am Acad Child Adolesc Psychiatry. 48 12: 1173–1181.
   PubMed Web of Science ®Google Scholar
• Entringer S, Kumsta R, Hellhammer DH, Wadhwa PD, Wust S. 2009. Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults. Horm Behav. 55:292–298.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Osmond C, Kajantie E, Forsen TJ, Barker DJ. 2006. Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia. 49:2853–2858.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsén TJ, Kajantie E, Osmond C, Barker DJ. 2007. Childhood growth and hypertension in later life. Hypertension. 49:1415–1421.
   PubMed Web of Science ®Google Scholar
• Espy KA, Fang H, Johnson C, Stopp C, Wiebe SA, Respass J. 2011. Prenatal tobacco exposure: Developmental outcomes in the neonatal period. Dev Psychol. 47:153–156.
   PubMedGoogle Scholar
• Feldt K, Räikkönen K, Eriksson JG, Andersson S, Osmond C, Barker DJ, Phillips DI, Kajantie E. 2007. Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth. J Hum Hypertens. 21:401–410.
   PubMed Web of Science ®Google Scholar
• Field T, Sandberg D, Garcia R, Vega-Lahr N, Goldstein S, Guy L. 1985. Pregnancy problems, postpartum depression, and early mother–infant interactions. Dev Psychol. 21:1152–1156.
   Web of Science ®Google Scholar
• Fox SE, Levitt P, Nelson CA3rd. 2010. How the timing and quality of early experiences influence the development of brain architecture. Child Dev. 81:28–40.
   PubMed Web of Science ®Google Scholar
• French NP, Hagan R, Evans SF, Godfrey M, Newnham JP. 1999. Repeated antenatal corticosteroids: Size at birth and subsequent development. Am J Obstet Gynecol. 180:114–121.
   PubMed Web of Science ®Google Scholar
• Gale CR, O'Callaghan FJ, Godfrey KM, Law CM, Martyn CN. 2004. Critical periods of brain growth and cognitive function in children. Brain. 127:321–329.
   PubMed Web of Science ®Google Scholar
• Gitau R, Cameron A, Fisk NM, Glover V. 1998. Fetal exposure to maternal cortisol. Lancet. 352:707–708.
   PubMed Web of Science ®Google Scholar
• Glover V, Bergman K, Sarkar P, O'Connor TG. 2009. Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology. 34:430–435.
   PubMed Web of Science ®Google Scholar
• Glover V, O'Connor TG, O'Donnell K. 2010. Prenatal stress and the programming of the HPA axis. Neurosci Biobehav Rev. 35:17–22.
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Pinal C. 2005. The developmental origins of adult disease. Matern Child Nutr. 1:130–141.
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Cooper C, Thornburg KL. 2008. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 359:61–73.
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Bateson P, Beedle AS, Law CM, Bhutta ZA, Bhutta ZA, Anokhin KV, Bougnères P, Chandak GR, Dasgupta P, Smith GD, Ellison PT, Forrester TE, Gilbert SF, Jablonka E, Kaplan H, Prentice AM, Simpson SJ, Uauy R, West-Eberhard MJ. 2009. Towards a new developmental synthesis: Adaptive developmental plasticity and human disease. Lancet. 373:1654–1657.
   PubMed Web of Science ®Google Scholar
• Grant KA, McMahon C, Austin MP, Reilly N, Leader L, Ali S. 2009. Maternal prenatal anxiety, postnatal caregiving and infants' cortisol responses to the still-face procedure. Dev Psychobiol. 51:625–637.
   PubMed Web of Science ®Google Scholar
• Gunnell D, Rasmussen F, Fouskakis D, Tynelius P, Harrison G. 2003. Patterns of fetal and childhood growth and the development of psychosis in young males: A cohort study. Am J Epidemiol. 158:291–300.
   PubMed Web of Science ®Google Scholar
• Gutteling BM, de Weerth C, Buitelaar JK. 2004. Maternal prenatal stress and 4–6 year old children's salivary cortisol concentrations pre- and post-vaccination. Stress. 7:257–260.
   PubMed Web of Science ®Google Scholar
• Gutteling BM, de Weerth C, Buitelaar JK. 2005. Prenatal stress and children's cortisol reaction to the first day of school. Psychoneuroendocrinology. 30:541–549.
   PubMed Web of Science ®Google Scholar
• Gutteling BM, de Weerth C, Willemsen-Swinkels SH, Huizink AC, Mulder EJ, Visser GH, Buitelaar JK. The effects of prenatal stress on temperament and problem behavior of 27-month-old toddlers. Eur Child Adolesc Psychiatry. 2005b; 14:41–51.
   PubMed Web of Science ®Google Scholar
• Gutteling BM, de Weerth C, Zandbelt N, Mulder EJ, Visser GH, Buitelaar JK. 2006. Does maternal prenatal stress adversely affect the child's learning and memory at age six?. J Abnorm Child Psychol. 34:789–798.
   PubMed Web of Science ®Google Scholar
• Hanson MA, Gluckman PD. 2008. Developmental origins of health and disease: New insights. Basic Clin Pharmacol Toxicol. 102:90–93.
   PubMed Web of Science ®Google Scholar
• Harvison KW, Molfese DL, Woodruff-Borden J, Weigel RA. 2009. Neonatal auditory evoked responses are related to perinatal maternal anxiety. Brain Cogn. 71:369–374.
   PubMedGoogle Scholar
• Heinonen K, Räikkönen K, Pesonen AK, Kajantie E, Andersson S, Eriksson JG, Niemelä A, Vartia T, Peltola J, Lano A. 2008. Prenatal and postnatal growth and cognitive abilities at 56 months of age: A longitudinal study of infants born at term. Pediatrics. 121:e1325–e1333.
   PubMed Web of Science ®Google Scholar
• Heinonen K, Räikkönen K, Pesonen AK, Andersson S, Kajantie E, Eriksson JG, Wolke D, Lano A. 2010. Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age: A longitudinal study. BMC Pediatr. 15:10–91.
   Google Scholar
• Heinonen K, Räikkönen K, Pesonen AK, Andersson S, Kajantie E, Eriksson JG, Wolke D, Lano A. 2011. Longitudinal study of smoking cessation before pregnancy and children's cognitive abilities at 56 months of age. Early Hum Dev. 87 5: 353–359.
   PubMedGoogle Scholar
• Hellemans KG, Sliwowska JH, Verma P, Weinberg J. 2010. Prenatal alcohol exposure: Fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev. 34:791–807.
   PubMed Web of Science ®Google Scholar
• Henrichs J, Schenk JJ, Schimdt HG, Velders FP, Hofman A, Jaddoe VWV, Verhulst FC, Tiemeier H. 2009. Maternal pre- and postnatal anxiety and infant temperament. The generation R study. Inf Child Dev. 18:556–572.
   Web of Science ®Google Scholar
• Hernandez-Martinez C, Arija V, Balaguer A, Cavalle P, Canals J. 2008. Do the emotional states of pregnant women affect neonatal behaviour?. Early Hum Dev. 84:745–750.
   PubMed Web of Science ®Google Scholar
• Hernandez-Reif M, Field T, Diego M, Ruddock M. 2006. Greater arousal and less attentiveness to face/voice stimuli by neonates of depressed mothers on the Brazelton Neonatal Behavioral Assessment Scale. Inf Child Dev. 29:594–598.
   Google Scholar
• Holmes MC, Abrahamsen CT, French KL, Paterson JM, Mullins JJ, Seckl JR. 2006. The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci. 26:3840–3844.
   PubMed Web of Science ®Google Scholar
• Huizink AC, de Medina PG, Mulder EJ, Visser GH, Buitelaar JK. 2002. Psychological measures of prenatal stress as predictors of infant temperament. J Am Acad Child Adolesc Psychiatry. 41:1078–1085.
   PubMed Web of Science ®Google Scholar
• Huizink AC, Robles de Medina P, Mulder EJ, Visser GH, Buitelaar JK. 2003. Stress during pregnancy is associated with developmental outcome in infancy. J Child Psychol Psychiatry. 44:810–818.
   PubMed Web of Science ®Google Scholar
• Huizink AC, Bartels M, Rose RJ, Pulkkinen L, Eriksson CJ, Kaprio J. 2008. Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring. J Epidemiol Community Health. 62:e5.
   PubMed Web of Science ®Google Scholar
• IJzerman R, Stehouwer CD, de Geus EJ, van Weissenbruch MM, Delemarre-van de Waal HA, Boomsma DI. 2003. Low birth weight is associated with increased sympathetic activity: Dependence on genetic factors. Circulation. 108:566–571.
   PubMedGoogle Scholar
• Isbrucker RA, Burdock GA. 2006. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol. 46:167–192.
   PubMed Web of Science ®Google Scholar
• Jones A, Godfrey KM, Wood P, Osmond C, Goulden P, Phillips DI. 2006. Fetal growth and the adrenocortical response to psychological stress. J Clin Endocrinol Metab. 91:1868–1871.
   PubMed Web of Science ®Google Scholar
• Jones A, Beda A, Ward AM, Osmond C, Phillips DI, Moore VM, Simpson DM. 2007. Size at birth and autonomic function during psychological stress. Hypertension. 49:548–555.
   PubMedGoogle Scholar
• Kajantie E. 2008. Early-life events. Effects on aging. Hormones (Athens). 7:101–113.
   PubMedGoogle Scholar
• Kajantie E, Räikkönen K. 2010. Early life predictors of the physiological stress response later in life. Neurosci Biobehav Rev. 35:23–32.
   PubMedGoogle Scholar
• Kajantie E, Feldt K, Räikkönen K, Phillips DI, Osmond C, Heinonen K, Pesonen AK, Andersson S, Barker DJ, Eriksson JG. 2007. Body size at birth predicts hypothalamic–pituitary–adrenal axis response to psychosocial stress at age 60 to 70 years. J Clin Endocrinol Metab. 92:4094–4100.
   PubMed Web of Science ®Google Scholar
• Khashan AS, Abel KM, McNamee R, Pedersen MG, Webb RT, Baker PN, Kenny LC, Mortensen PB. Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry. 2008a; 65:146–152.
   PubMed Web of Science ®Google Scholar
• Khashan AS, McNamee R, Abel KM, Pedersen MG, Webb RT, Kenny LC, Mortensen PB, Baker PN. Reduced infant birthweight consequent upon maternal exposure to severe life events. Psychosom Med. 2008b; 70:688–694.
   PubMed Web of Science ®Google Scholar
• Kinney DK, Miller AM, Crowley DJ, Huang E, Gerber E. 2008. Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J Autism Dev Disord. 38:481–488.
   PubMed Web of Science ®Google Scholar
• Knorr U, Vinberg M, Kessing LV, Wetterslev J. 2010. Salivary cortisol in depressed patients versus control persons: A systematic review and meta-analysis. Psychoneuroendocrinology. 35:1275–1286.
   PubMed Web of Science ®Google Scholar
• Lahti J, Räikkönen K, Kajantie E, Heinonen K, Pesonen AK, Järvenpää AL, Strandberg T. 2006. Small body size at birth and behavioural symptoms of ADHD in children aged five to six years. J Child Psychol Psychiatry. 47:1167–1174.
   PubMed Web of Science ®Google Scholar
• Lahti J, Räikkönen K, Sovio U, Miettunen J, Hartikainen AL, Pouta A, Taanila A, Joukamaa M, Järvelin MR, Veijola J. 2009. Early-life origins of schizotypal traits in adulthood. Br J Psychiatry. 195:132–137.
   PubMed Web of Science ®Google Scholar
• Lahti J, Räikkönen K, Pesonen AK, Heinonen K, Kajantie E, Forsén T, Osmond C, Barker DJ, Eriksson JG. Prenatal growth, postnatal growth, and trait anxiety in late adulthood—the Helsinki Birth Cohort Study. Acta Psychiatr Scand. 2010a; 121:227–235.
   PubMed Web of Science ®Google Scholar
• Lahti M, Räikkönen K, Wahlbeck K, Heinonen K, Forsen T, Kajantie E, Pesonen AK, Osmond C, Barker DJ, Eriksson JG. Prenatal origins of hospitalization for personality disorders: The Helsinki birth cohort study. Psychiatry Res. 2010b; 179:226–230.
   PubMedGoogle Scholar
• Langley-Evans SC, Phillips GJ, Benediktsson R, Gardner DS, Edwards CR, Jackson AA, Seckl JR. 1996. Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta. 17:169–172.
   PubMed Web of Science ®Google Scholar
• Laplante DP, Barr RG, Brunet A, Galbaud du Fort G, Meaney ML, Saucier JF, Zelazo PR, King S. 2004. Stress during pregnancy affects general intellectual and language functioning in human toddlers. Pediatr Res. 56:400–410.
   PubMed Web of Science ®Google Scholar
• Laplante DP, Brunet A, Schmitz N, Ciampi A, King S. 2008. Project Ice Storm: Prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry. 47:1063–1072.
   PubMed Web of Science ®Google Scholar
• Levitt NS, Lambert EV, Woods D, Hales CN, Andrew R, Seckl JR. 2000. Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: Early programming of cortisol axis. J Clin Endocrinol Metab. 85:4611–4618.
   PubMed Web of Science ®Google Scholar
• Li J, Vestergaard M, Obel C, Christensen J, Precht DH, Lu M, Olsen J. A nationwide study on the risk of autism after prenatal stress exposure to maternal bereavement. Pediatrics. 2009a; 123:1102–1107.
   PubMed Web of Science ®Google Scholar
• Li J, Vestergaard M, Obel C, Precht DH, Christensen J, Lu M, Olsen J. Prenatal stress and cerebral palsy: A nationwide cohort study in Denmark. Psychosom Med. 2009b; 71:615–618.
   PubMed Web of Science ®Google Scholar
• Lindsay RS, Lindsay RM, Edwards CR, Seckl JR. Inhibition of 11-beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension. 1996a; 27:1200–1204.
   PubMed Web of Science ®Google Scholar
• Lindsay RS, Lindsay RM, Waddell BJ, Seckl JR. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia. 1996b; 39:1299–1305.
   PubMed Web of Science ®Google Scholar
• Lou HC, Hansen D, Nordentoft M, Pryds O, Jensen F, Nim J, Hemmingsen R. 1994. Prenatal stressors of human life affect fetal brain development. Dev Med Child Neurol. 36:826–832.
   PubMed Web of Science ®Google Scholar
• Lucassen PJ, Bosch OJ, Jousma E, Kromer SA, Andrew R, Seckl JR, Neumann ID. 2009. Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2. Eur J Neurosci. 29:97–103.
   PubMed Web of Science ®Google Scholar
• MacArthur BA, Howie RN, Dezoete JA, Elkins J. 1982. School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone. Pediatrics. 70:99–105.
   PubMed Web of Science ®Google Scholar
• Mairesse J, Lesage J, Breton C, Breant B, Hahn T, Darnaudery M, Dickson SL, Seckl J, Blondeau B, Vieau D, Maccari S, Viltart O. 2007. Maternal stress alters endocrine function of the feto-placental unit in rats. Am J Physiol Endocrinol Metab. 292:E1526–E1533.
   PubMed Web of Science ®Google Scholar
• Martin RP, Noyes J, Wisenbaker J, Huttunen M. 1999. Prediction of early childhood negative emotionality and inhibition from maternal distress during pregnancy. Merrill-Palmer Q. 45:370–391.
   Web of Science ®Google Scholar
• McGrath JM, Records K, Rice M. 2008. Maternal depression and infant temperament characteristics. Infant Behav Dev. 31:71–80.
   PubMed Web of Science ®Google Scholar
• Meaney MJ. 2010. Epigenetics and the biological definition of gene × environment interactions. Child Dev. 81:41–79.
   PubMed Web of Science ®Google Scholar
• Mennes M. 2008. Longitudinal study on the effects of maternal anxiety during pregnancy: Neuropsychological and neurophysiological examination of cognitive control in the adolescent offspring. Leuven: Katholieke Universiteit Leuven.
   Google Scholar
• Mennes M, Stiers P, Lagae L, Van den Bergh BR. 2006. Long-term cognitive sequelae of antenatal maternal anxiety: Involvement of the orbitofrontal cortex. Neurosci Biobehav Rev. 30:1078–1086.
   PubMed Web of Science ®Google Scholar
• Mennes M, Van den Bergh BR, Lagae L, Stiers P. 2009. Developmental brain alterations in 17 year old boys are related to antenatal maternal anxiety. Clin Neurophysiol. 120:1116–1122.
   PubMedGoogle Scholar
• Niederhofer H, Reiter A. 2004. Prenatal maternal stress, prenatal fetal movements and perinatal temperament factors influence behavior and school marks at the age of 6 years. Fetal Diagn Ther. 19:160–162.
   PubMedGoogle Scholar
• Obel C. 2003. Epidemiological studies of stress during pregnancy and fetal brain development. Denmark: University of Aarhus.
   Google Scholar
• Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. 2008. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics. 3:97–106.
   PubMed Web of Science ®Google Scholar
• O'Connor TG, Heron J, Golding J, Beveridge M, Glover V. 2002. Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry. 180:502–508.
   PubMed Web of Science ®Google Scholar
• O'Connor TG, Heron J, Golding J, Glover V. 2003. Maternal antenatal anxiety and behavioural/emotional problems in children: A test of a programming hypothesis. J Child Psychol Psychiatry. 44:1025–1036.
   PubMed Web of Science ®Google Scholar
• O'Connor TG, Ben-Shlomo Y, Heron J, Golding J, Adams D, Glover V. 2005. Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry. 58:211–217.
   PubMed Web of Science ®Google Scholar
• O'Keane V, Lightman S, Marsh M, Pawlby S, Papadopoulos AS, Taylor A, Moore R, Patrick K. 2011. Increased pituitary–adrenal activation and shortened gestation in a sample of depressed pregnant women: A pilot study. J Affect Disord. 130:300–305.
   PubMed Web of Science ®Google Scholar
• O'Regan D, Welberg LL, Holmes MC, Seckl JR. 2001. Glucocorticoid programming of pituitary–adrenal function: Mechanisms and physiological consequences. Semin Neonatol. 6:319–329.
   PubMedGoogle Scholar
• Pesonen AK, Räikkönen K, Strandberg TE, Järvenpää AL. 2005. Continuity of maternal stress from the pre- to the postnatal period: Associations with infant's positive, negative and overall temperamental reactivity. Inf Behav Devel. 28:36–47.
   Web of Science ®Google Scholar
• Pesonen AK, Räikkönen K, Kajantie E, Heinonen K, Strandberg TE, Järvenpää AL. 2006. Fetal programming of temperamental negative affectivity among children born healthy at term. Dev Psychobiol. 48:633–643.
   PubMed Web of Science ®Google Scholar
• Pesonen AK, Räikkönen K, Heinonen K, Kajantie E, Forsen T, Eriksson JG. 2007. Depressive symptoms in adults separated from their parents as children: A natural experiment during World War II. Am J Epidemiol. 166:1126–1133.
   PubMed Web of Science ®Google Scholar
• Pesonen AK, Räikkönen K, Heinonen K, Andersson S, Hovi P, Järvenpää AL, Eriksson JG, Kajantie E. Personality of young adults born prematurely: The Helsinki study of very low birth weight adults. J Child Psychol Psychiatry. 2008a; 49:609–617.
   PubMedGoogle Scholar
• Pesonen AK, Räikkönen K, Heinonen K, Kajantie E, Forsen T, Eriksson JG. Reproductive traits following a parent-child separation trauma during childhood: A natural experiment during World War II. Am J Hum Biol. 2008b; 20:345–351.
   PubMedGoogle Scholar
• Pesonen AK, Räikkönen K, Matthews K, Heinonen K, Paavonen JE, Lahti J, Komsi N, Lemola S, Järvenpää AL, Kajantie E, Strandberg T. 2009. Prenatal origins of poor sleep in children. Sleep. 32:1086–1092.
   PubMed Web of Science ®Google Scholar
• Pesonen AK, Räikkönen K, Feldt K, Heinonen K, Osmond C, Phillips DI, Barker DJ, Eriksson JG, Kajantie E. 2010. Childhood separation experience predicts HPA axis hormonal responses in late adulthood: A natural experiment of World War II. Psychoneuroendocrinology. 35:758–767.
   PubMed Web of Science ®Google Scholar
• Pesonen AK, Räikkönen K, Kajantie E, Heinonen K, Osmond C, Barker DJ, Forsén T, Eriksson JG. 2011. Intergenerational social mobility following early life stress. Ann Med. 43 4: 320–328.
   PubMed Web of Science ®Google Scholar
• Phillips DI, Jones A. 2006. Fetal programming of autonomic and HPA function: Do people who were small babies have enhanced stress responses?. J Physiol. 572:45–50.
   PubMed Web of Science ®Google Scholar
• Phillips DI, Fall CHD, Whorwood CB, Seckl JR, Wood PJ, Barker DJP, . 1998. Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?. J Clin Endocrinol Metab. 83:757–760.
   PubMed Web of Science ®Google Scholar
• Phillips DI, Walker BR, Reynolds RM, Flanagan DE, Wood PJ, Osmond C, Barker DJ, Whorwood CB. 2000. Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension. 35:1301–1306.
   PubMed Web of Science ®Google Scholar
• Ponirakis A, Susman EJ, Stifter CA. 1998. Negative emotionality and cortisol during adolescent pregnancy and its effects on infant health and autonomic nervous system reactivity. Dev Psychobiol. 33:163–174.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Pesonen AK. 2009. Early life origins of psychological development and mental health. Scand J Psychol. 50:583–591.
   PubMedGoogle Scholar
• Räikkönen K, Pesonen AK, Kajantie E, Heinonen K, Forsen T, Phillips DI, Osmond C, Barker DJ, Eriksson JG. 2007. Length of gestation and depressive symptoms at age 60 years. Br J Psychiatry. 190:469–474.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Pesonen A-K, Heinonen K, Lahti J, Kajantie E, Forsen T, Osmond C, Barker DJ, Eriksson JG. Infant growth and hostility in adult life. Psychosom Med. 2008a; 70:306–313.
   PubMedGoogle Scholar
• Räikkönen K, Pesonen AK, Heinonen K, Kajantie E, Hovi P, Järvenpää AL, Eriksson JG, Andersson S. Depression in young adults with very low birth weight: The Helsinki study of very low-birth-weight adults. Arch Gen Psychiatry. 2008b; 65:290–296.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Forsén T, Henriksson M, Kajantie E, Laaksonen I, Leskinen JT, Laaksonen I, Osmond C, Barker DJ, Eriksson JG. Growth trajectories and intellectual abilities in young adulthood: The Helsinki Birth Cohort Study. Am J Epidemiol. 2009a; 15:447–455.
   Google Scholar
• Räikkönen K, Pesonen AK, Heinonen K, Lahti J, Komsi N, Eriksson JG, Seckl JR, Järvenpää AL, Strandberg TE. Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children. Am J Epidemiol. 2009b; 170:1137–1146.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Lahti M, Heinonen K, Pesonen AK, Wahlbeck K, Kajantie E, Osmond C, Barker DJP, Eriksson JG. 2011. Risk of severe mental disorders in adults separated temporarily from their parents in childhood: The Helsinki birth cohort study. J Psychiatr Res. 45:332–338.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Matthews KA, Pesonen AK, Pyhälä R, Paavonen EJ, Feldt K, Jones A, Phillips DI, Seckl JR, Heinonen K, Lahti J, Komsi N, Järvenpää AL, Eriksson JG, Strandberg TE, Kajantie E. Poor sleep and altered hypothalamic–pituitary–adrenocortical and sympatho–adrenal–medullary system activity in children. J Clin Endocrinol Metab. 2010b; 95:2254–2261.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Seckl JR, Heinonen K, Pyhälä R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Järvenpää AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic–pituitary–adrenocortical axis function in children. Psychoneuroendocrinology. 2010c; 35:1587–1593.
   PubMed Web of Science ®Google Scholar
• Reynolds RM, Walker BR, Syddall HE, Andrew R, Wood PJ, Whorwood CB, Phillips DI. 2001. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab. 86:245–250.
   PubMed Web of Science ®Google Scholar
• Reynolds RM, Godfrey KM, Barker M, Osmond C, Phillips DI. 2007. Stress responsiveness in adult life: Influence of mother's diet in late pregnancy. J Clin Endocrinol Metab. 92:2208–2210.
   PubMedGoogle Scholar
• Rieger M, Pirke KM, Buske-Kirschbaum A, Wurmser H, Papousek M, Hellhammer DH. 2004. Influence of stress during pregnancy on HPA activity and neonatal behavior. Ann N Y Acad Sci. 1032:228–230.
   PubMedGoogle Scholar
• Rodriguez A. 2010. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry. 51:134–143.
   PubMed Web of Science ®Google Scholar
• Rodriguez A, Bohlin G. 2005. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?. J Child Psychol Psychiatry. 46:246–254.
   PubMed Web of Science ®Google Scholar
• Roelofs K, van Peer J, Berretty E, Jong P, Spinhoven P, Elzinga BM. 2009. Hypothalamus–pituitary–adrenal axis hyperresponsiveness is associated with increased social avoidance behavior in social phobia. Biol Psychiatry. 65:336–343.
   PubMed Web of Science ®Google Scholar
• Rogerson FM, Kayes KM, White PC. 1997. Variation in placental type 2 11beta-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight. Mol Cell Endocrinol. 128:103–109.
   PubMed Web of Science ®Google Scholar
• Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. 2001. Effects of prenatal exposure to the Dutch famine on adult disease in later life: An overview. Mol Cell Endocrinol. 185:93–98.
   PubMed Web of Science ®Google Scholar
• Sarkar P, Bergman K, O'Connor TG, Glover V. 2008. Maternal antenatal anxiety and amniotic fluid cortisol and testosterone: Possible implications for foetal programming. J Neuroendocrinol. 20:489–496.
   PubMed Web of Science ®Google Scholar
• Schlotz W, Jones A, Godfrey KM, Phillips DI. 2008. Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children. J Child Psychol Psychiatry. 49:1228–1236.
   PubMed Web of Science ®Google Scholar
• Schmidt LA, Miskovic V, Boyle MH, Saigal S. 2008. Shyness and timidity in young adults who were born at extremely low birth weight. Pediatrics. 122:e181–e187.
   Google Scholar
• Seckl JR. 2001. Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms. Mol Cell Endocrinol. 185:61–71.
   PubMed Web of Science ®Google Scholar
• Seckl JR. 2008. Glucocorticoids, developmental “programming” and the risk of affective dysfunction. Prog Brain Res. 167:17–34.
   PubMed Web of Science ®Google Scholar
• Seckl JR, Meaney MJGlucocorticoid programmingBiobehavioral stress response: Protective and damaging effects. New York: Annals of the New York Academy of Sciences2004a63–84 Vol. 1032.
   Google Scholar
• Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci. 2004b; 1032:63–84.
   PubMed Web of Science ®Google Scholar
• Seckl JR, Meaney MJ. 2006. Glucocorticoid “programming” and PTSD risk. Ann N Y Acad Sci. 1071:351–378.
   PubMed Web of Science ®Google Scholar
• Seckl JR, Holmes MC. 2007. Mechanisms of disease: Glucocorticoids, their placental metabolism and fetal “programming” of adult pathophysiology. Nat Clin Pract Endocrinol Metab. 3:479–488.
   PubMedGoogle Scholar
• Shenkin SD, Starr JM, Deary IJ. 2004. Birth weight and cognitive ability in childhood: A systematic review. Psychol Bull. 130:989–1013.
   PubMed Web of Science ®Google Scholar
• Sloboda DM, Challis JR, Moss TJ, Newnham JP. 2005. Synthetic glucocorticoids: Antenatal administration and long-term implications. Curr Pharm Des. 11:1459–1472.
   PubMedGoogle Scholar
• Speirs HJ, Seckl JR, Brown RW. 2004. Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. J Endocrinol. 181:105–116.
   PubMed Web of Science ®Google Scholar
• Stewart PM, Whorwood CB, Mason JI. 1995. Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life. J Steroid Biochem Mol Biol. 55:465–471.
   PubMed Web of Science ®Google Scholar
• Strandberg TE, Järvenpää AL, Vanhanen H, McKeigue PM. 2001. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol. 153:1085–1088.
   PubMed Web of Science ®Google Scholar
• Strandberg TE, Andersson S, Järvenpää AL, McKeigue PM. 2002. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol. 156:803–805.
   PubMed Web of Science ®Google Scholar
• Strang-Karlsson S, Räikkönen K, Kajantie E, Andersson S, Hovi P, Heinonen K, Pesonen AK, Järvenpää AL, Eriksson JG, Paavonen EJ. Sleep quality in young adults with very low birth weight—the Helsinki study of very low birth weight adults. J Pediatr Psychol. 2008a; 33:387–395.
   PubMed Web of Science ®Google Scholar
• Strang-Karlsson S, Räikkönen K, Pesonen AK, Kajantie E, Paavonen EJ, Lahti J, Hovi P, Heinonen K, Järvenpää AL, Eriksson JG, Andersson S. Very low birth weight and behavioral symptoms of attention deficit hyperactivity disorder in young adulthood: The Helsinki study of very-low-birth-weight adults. Am J Psychiatry. 2008b; 165:1345–1353.
   PubMed Web of Science ®Google Scholar
• Trautman PD, Meyer-Bahlburg HFL, Postelnek J, New MI. 1995. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study. Psychoneuroendocrinology. 20:439–449.
   PubMed Web of Science ®Google Scholar
• Tuovinen S, Räikkönen K, Kajantie E, Pesonen AK, Heinonen K, Osmond C, Barker DJ, Eriksson JG. 2010. Depressive symptoms in adulthood and intrauterine exposure to pre-eclampsia: The Helsinki Birth Cohort Study. Br J Obstet Gynaecol. 117:1236–1242.
   Google Scholar
• Tuovinen SH, Räikkönen K, Kajantie E, Lehtinen J, Henriksson M, Pesonen AK, Heinonen K, Osmond C, Barker D, Eriksson JG. Hypertensive disorders in pregnancy and intellectual abilities in the offspring in young adulthood: The Helsinki birth cohort study. Ann Med. 2011 Apr 15. [Epub ahead of print].
   PubMedGoogle Scholar
• Van den Bergh BR. 1990. The influence of maternal emotions during pregnancy on fetal and neonatal behavior, Win, 1990. J Prenatal Perinatal Psychol Health. 5:119–130.
   Google Scholar
• Van den Bergh BR. 1992. Maternal emotions during pregnancy and fetal and neonatal behavior. Oxford University Press: Oxford, UK.
   Google Scholar
• Van den Bergh BR, Marcoen A. 2004. High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Dev. 75:1085–1097.
   PubMed Web of Science ®Google Scholar
• Van den Bergh BR, Mennes M, Oosterlaan J, Stevens V, Stiers P, Marcoen A, Lagae L. High antenatal maternal anxiety is related to impulsivity during performance on cognitive tasks in 14- and 15-year-olds. Neurosci Biobehav Rev. 2005a; 29:259–269.
   PubMed Web of Science ®Google Scholar
• Van den Bergh BR, Mulder EJ, Mennes M, Glover V. Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: Links and possible mechanisms. A review. Neurosci Biobehav Rev. 2005b; 29:237–258.
   PubMed Web of Science ®Google Scholar
• Van den Bergh BR, Mennes M, Stevens V, van der Meere J, Borger N, Stiers P, Marcoen A, Lagae L. 2006. ADHD deficit as measured in adolescent boys with a continuous performance task is related to antenatal maternal anxiety. Pediatr Res. 59:78–82.
   PubMed Web of Science ®Google Scholar
• van der Wal MF, van Eijsden M, Bonsel GJ. 2007. Stress and emotional problems during pregnancy and excessive infant crying. J Dev Behav Pediatr. 28:431–437.
   PubMedGoogle Scholar
• Van den Bergh BR, Van Calster B, Smits T, Van Huffel S, Lagae L. 2008. Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: A prospective study on the fetal origins of depressed mood. Neuropsychopharmacology. 33:536–545.
   PubMed Web of Science ®Google Scholar
• Vaughn B, Bradley C, Joffe L, Seifer R, Barglow P. 1987. Maternal characteristics measured prenatally are predictive of ratings of temperamental “difficulty” on the Carey Infant Temperament Questionnaire. Dev Psychol. 23:152–161.
   Web of Science ®Google Scholar
• Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG. 2001. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch Gen Psychiatry. 58:48–52.
   PubMed Web of Science ®Google Scholar
• Warner MJ, Ozanne SE. Mechanisms involved in the developmental programming of adulthood disease. Biochem J. 2010427.
   Google Scholar
• Welberg LA, Seckl JR, Holmes MC. 2000. Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci. 12:1047–1054.
   PubMed Web of Science ®Google Scholar
• Wisborg K, Barklin A, Hedegaard M, Henriksen TB. 2008. Psychological stress during pregnancy and stillbirth: Prospective study. BJOG: Int J Obstet Gynaecol. 115:882–885.
   PubMed Web of Science ®Google Scholar
• Wust S, Entringer S, Federenko IS, Schlotz W, Hellhammer DH. 2005. Birth weight is associated with salivary cortisol responses to psychosocial stress in adult life. Psychoneuroendocrinology. 30:591–598.
   PubMed Web of Science ®Google Scholar
• Yeh TF, Lin YJ, Lin HC, Huang CC, Hsieh WS, Lin CH, Tsai CH. 2004. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N Engl J Med. 350:1304–1313.
   PubMed Web of Science ®Google Scholar
• Yehuda R, Engel SM, Brand SR, Seckl J, Marcus SM, Berkowitz GS. 2005. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. J Clin Endocrinol Metab. 90:4115–4118.
   PubMed Web of Science ®Google Scholar