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Stress
The International Journal on the Biology of Stress
Volume 15, 2012 - Issue 2
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Original Research Reports

Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent

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Pages 218-226 | Received 14 Dec 2010, Accepted 20 Jul 2011, Published online: 29 Aug 2011

References

  • Belzung C, Griebel G. 2001. Measuring normal and pathological anxiety-like behaviour in mice: A review. Behav Brain Res. 125 1–2: 141–149.
  • Bertrand PP, Bertrand RL. 2010. Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci. 153 1–2: 47–57.
  • Bowers SL, Bilbo SD, Dhabhar FS, Nelson RJ. 2008. Stressor-specific alterations in corticosterone and immune responses in mice. Brain Behav Immun. 22 1: 105–113.
  • Brinks V, van der Mark M, de Kloet R, Oitzl M. 2007. Emotion and cognition in high and low stress sensitive mouse strains: A combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice. Front Behav Neurosci. 1 8: 1–12.
  • Browne CA, Clarke G, Dinan T, Cryan JF.. 2011. Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains. Neuropharmacology. 60 4: 683–691.
  • Camilleri M, Andrews CN, Bharucha AE, Carlson PJ, Ferber I, Stephens D, Smyrk TC, Urrutia R, Aerssens J, Thielemans L, Gohlmann H, van den Wyngaert I, Coulie B. 2007. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. 132 1: 17–25.
  • Clarke G, Quigley EM, Cryan JF, Dinan TG. 2009. Irritable bowel syndrome: Towards biomarker identification. Trends Mol Med. 15 10: 478–489.
  • Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. 2004. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 126 7: 1657–1664.
  • Colucci R, Blandizzi C, Bellini M, Ghisu N, Tonini M, Del Tacca M. 2008. The genetics of the serotonin transporter and irritable bowel syndrome. Trends Mol Med. 14 7: 295–304.
  • Cryan JF, Holmes A. 2005. The ascent of mouse: Advances in modelling human depression and anxiety. Nat Rev Drug Discov. 4 9: 775–790.
  • Cryan JF, Leonard BE. 2000. 5-HT1A and beyond: The role of serotonin and its receptors in depression and the antidepressant response. Hum Psychopharmacol. 15 2: 113–135.
  • Dunlop SP, Coleman NS, Blackshaw E, Perkins AC, Singh G, Marsden CA, Spiller RC. 2005. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol. 3 4: 349–357.
  • Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. 2009. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis. Gut. 58 3: 367–378.
  • Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J. 2010. Mood and gut feelings. Brain Behav Immun. 24 1: 9–16.
  • Govindarajan A, Rao BS, Nair D, Trinh M, Mawjee N, Tonegawa S, Chattarji S. 2006. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proc Natl Acad Sci USA. 103 35: 13208–13213.
  • Griebel G, Belzung C, Perrault G, Sanger DJ. 2000. Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berl). 148 2: 164–170.
  • Gros DF, Antony MM, McCabe RE, Swinson RP. 2009. Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. J Anxiety Disord. 23 2: 290–296.
  • Hirata T, Keto Y, Nakata M, Takeuchi A, Funatsu T, Akuzawa S, Sasamata M, Miyata K. 2008. Effects of serotonin 5-HT(3) receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats. Eur J Pharmacol. 587 1–3: 281–284.
  • Jacobson LH, Cryan JF. 2007. Feeling strained? Influence of genetic background on depression-related behavior in mice: A review. Behav Genet. 37 1: 171–213.
  • Jun S, Kohen R, Cain KC, Jarrett ME, Heitkemper MM. 2011. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil. 23 3: 233–239 e116.
  • Kadowaki M, Nagakura Y, Tomoi M, Mori J, Kohsaka M. 1993. Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 266 1: 74–80.
  • Kapeller J, Houghton LA, Monnikes H, Walstab J, Moller D, Bonisch H, Burwinkel B, Autschbach F, Funke B, Lasitschka F, Gassler N, Fischer C, Whorwell PJ, Atkinson W, Fell C, Buchner KJ, Schmidtmann M, van der Voort I, Wisser AS, Berg T, Rappold G, Niesler B. 2008. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet. 17 19: 2967–2977.
  • Kawano K, Mori T, Fu L, Ito T, Niisato T, Yoshida S, Shiokawa S, Sato Y, Murakami H, Shishikura T. 2005. Comparison between partial agonist (ME3412) and antagonist (alosetron) of 5-hydroxytryptamine 3 receptor on gastrointestinal function. Neurogastroenterol Motil. 17 2: 290–301.
  • Kulikov AV, Osipova DV, Naumenko VS, Popova NK. 2005. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Genes Brain Behav. 4 8: 482–485.
  • Larauche M, Gourcerol G, Million M, Adelson DW, Taché Y. 2010. Repeated psychological stress-induced alterations of visceral sensitivity and colonic motor functions in mice: Influence of surgery and postoperative single housing on visceromotor responses. Stress. 13 4: 343–354.
  • Larsson MH, Miketa A, Martinez V. 2009. Lack of interaction between psychological stress and DSS-induced colitis affecting colonic sensitivity during colorectal distension in mice. Stress. 12 5: 434–444.
  • Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M. 2010. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. 85 2: 95–109.
  • Melgar S, Engstrom K, Jagervall A, Martinez V. 2008. Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice. Stress. 11 5: 348–362.
  • Miwa J, Echizen H, Matsueda K, Umeda N. 2001. Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion. 63 3: 188–194.
  • Mussell M, Kroenke K, Spitzer RL, Williams JB, Herzog W, Lowe B. 2008. Gastrointestinal symptoms in primary care: Prevalence and association with depression and anxiety. J Psychosom Res. 64 6: 605–612.
  • Nakade Y, Fukuda H, Iwa M, Tsukamoto K, Yanagi H, Yamamura T, Mantyh C, Pappas TN, Takahashi T. 2007. Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats. Am J Physiol Gastrointest Liver Physiol. 292 4: G1037–G1044.
  • Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S. 2006. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci. 26 2: 530–534.
  • O'Mahony S, Chua AS, Quigley EM, Clarke G, Shanahan F, Keeling PW, Dinan TG. 2008. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterol Motil. 20 6: 680–688.
  • O'Mahony CM, Clarke G, Gibney SM, Dinan T, Cryan JF. Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression. Pharmacol Biochem Behav. 2011 in press.
  • O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, Cryan JF, Dinan TG. 2009. Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry. 65 3: 263–267.
  • O'Mahony CM, Sweeney FF, Daly E, Dinan TG, Cryan JF. 2010. Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour. Behav Brain Res. 213 2: 148–154.
  • Owens MJ, Nemeroff CB. 1994. Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clin Chem. 40 2: 288–295.
  • Quigley EM. 2006. Changing face of irritable bowel syndrome. World J Gastroenterol. 12 1: 1–5.
  • Robinson OJ, Cools R, Crockett MJ, Sahakian BJ. 2010. Mood state moderates the role of serotonin in cognitive biases. J Psychopharmacol. 24 4: 573–583.
  • Sanger GJ. 2008. 5-hydroxytryptamine and the gastrointestinal tract: Where next?. Trends Pharmacol Sci. 29 9: 465–471.
  • Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH. 2008. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 3 10: e3301.
  • Savignac HM, Dinan TG, Cryan JF. Resistance to early-life stress in mice: Effects of genetic background and stress duration. Front Behav Neurosci. 2011a; 5:13.
  • Savignac HM, Finger BC, Pizzo RC, O'Leary OF, Dinan TG, Cryan JF. Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain. Neuroscience. 2011b 2011 May 27. [Epub ahead of print].
  • Spiller R. 2002. Serotonergic modulating drugs for functional gastrointestinal diseases. Br J Clin Pharmacol. 54 1: 11–20.
  • Spiller R. 2008. Serotonergic agents and the irritable bowel syndrome: What goes wrong?. Curr Opin Pharmacol. 8 6: 709–714.
  • Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR. 2000. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 47 6: 804–811.
  • Taché Y, Martinez V, Million M, Wang L. 2001. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: Role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol. 280 2: G173–G177.
  • Tsukamoto K, Ariga H, Mantyh C, Pappas TN, Yanagi H, Yamamura T, Takahashi T. 2007. Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats. Am J Physiol Regul Integr Comp Physiol. 293 1: R64–R69.
  • Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M. 2003. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 299 5603: 76.
  • Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. 2004. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science. 305 5681: 217.

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