Normal flora and bacterial vaginosis in pregnancy: an overview

References

• Aagaard K, Riehle K, Ma J, et al. (2012). A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One 7: e36466 (1--15)
   Web of Science ®Google Scholar
• Akinbiyi AA, Watson R, Feyi-Waboso P. (2008). Prevalence of Candida albicans and bacterial vaginosis in asymptomatic pregnant women in South Yorkshire, United Kingdom. Outcome of a prospective study. Arch Gynecol Obstet 278:463–6
   PubMed Web of Science ®Google Scholar
• Amsel R, Totten PA, Speigel CA, et al. (1983). Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations. Am J Med 74:14–22
   PubMed Web of Science ®Google Scholar
• Antonio MA, Hawes SE, Hillier SL. (1999). The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species. J Infec Dis 180:1950–6
   PubMed Web of Science ®Google Scholar
• Armstrong NR, Wilson JD. (2010). Tinidazole in the treatment of bacterial vaginosis. Int J Womens Health 1:59–65
   PubMedGoogle Scholar
• Berger BJ, Kolton J, Zenilman JM, et al. (1995). Bacterial vaginosis in Lesbians: a sexually transmitted disease. Clin Inf Dis 21:1402–5
   PubMed Web of Science ®Google Scholar
• Boskey ER, Atherly-Trim SA, O'Campo PJ, et al. (2004). Acceptability of a self-sampling technique to collect vaginal smears for gram stain diagnosis of bacterial vaginosis. Women's Health Issues? 14:14–8
   PubMed Web of Science ®Google Scholar
• Bradshaw CS, Tabrizi SN, Fairley CK, et al. (2006). The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy. J Infect Dis 194:828–36
   PubMed Web of Science ®Google Scholar
• Bradshaw CS, Vodstrcil LA, Hocking JS, et al. (2013). Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use. Clin Infect Dis 56:777–86
   PubMed Web of Science ®Google Scholar
• Briese V, Neumann G, Waldschläger J, et al. (2011). Efficacy and tolerability of a local acting antiseptic agent in the treatment of vaginal dysbiosis during pregnancy. Arch Gynecol Obstet 283:585–90
   PubMed Web of Science ®Google Scholar
• Brocklehurst P, Gordon A, Heatley E, Milan SJ. (2013). Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev Issue 1. Art. No.: CD000262. doi: 10.1002/14651858.CD000262.pub4
   Web of Science ®Google Scholar
• Brotman RM, Ravel J. (2008). Ready or not: the molecular diagnosis of bacterial vaginosis. Clin Infect Dis 47:44–6
   PubMed Web of Science ®Google Scholar
• Bunge KE, Beigi RH, Meyn LA, Hillier SL. (2009). The efficacy of retreatment with the same medication for early treatment failure of bacterial vaginosis. Sex Transm Dis 36:711–3
   PubMed Web of Science ®Google Scholar
• Castro J, Henriques A, Machado A, et al. (2013). Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on initial adherence to epithelial cells. Intern J Med Sci 10:1193–8
   PubMed Web of Science ®Google Scholar
• Cauci S. (2004). Vaginal immunity in bacterial vaginosis. Curr Infect Dis Rep 6:450–6
   PubMedGoogle Scholar
• Cauci S, Culhane JF. (2011). High sialidase levels increase preterm birth risk among women who are bacterial vaginosis-positive in early gestation. Am J Obstet Gynecol 204:142.e1–9
   Google Scholar
• Centers for Disease Control and Prevention. (2010). Sexually transmitted diseases treatment guidelines: bacterial vaginosis. Available from: http://www.cdc.gov/std/bv/treatment [last accessed 22 Aug 2012]
   Google Scholar
• Centers for Disease Control and Prevention. (2013). Fact sheet: bacterial vaginosis. Available from: http://www.cdc.gov/std/bv/stdfact-bacterial-vaginosis.htm [last accessed 13 Mar 2013]
   Google Scholar
• Cherpes TL, Hillier SL, Meyn LA, et al. (2008). A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. Sex Transm Dis 35:78–83
   PubMed Web of Science ®Google Scholar
• Cohen CR, Duerr A, Pruithithada N, et al. (1995). Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand. AIDS 9:1093–7
   PubMed Web of Science ®Google Scholar
• Coleman JS, Hitti J, Bukusi EA, et al. (2007). Infectious correlates of HIV-1 shedding in the female upper and lower genital tracts. AIDS 21:755–9
   PubMed Web of Science ®Google Scholar
• Cruciani F, Wasinger V, Turroni S, et al. (2013). Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment. J Antimicrob Chemother 68:2648–59
   PubMed Web of Science ®Google Scholar
• Danielsson D, Teigen PK, Moi H. (2011). The genital econiche: focus on microbiota and bacterial vaginosis. Ann N Y Acad Sci 1230:48–58
   PubMed Web of Science ®Google Scholar
• De Backer E, Verhelst R, Verstraelen H, et al. (2006). Antibiotic susceptibility of Atopobium vaginae. BMC Infect Dis 6:51.e1–6
   Google Scholar
• Denney JM, Culhane JF. (2009). Bacterial vaginosis: a problematic infection from both a perinatal and neonatal perspective. Semin Fetal Neonatal Med 14:200–3
   PubMed Web of Science ®Google Scholar
• Diaz N, Dessì D, Dessole S, et al. (2010). Rapid detection of co-infections by Trichomonas vaginalis, Mycoplasma hominis, and Ureaplasma urealyticum by a new multiplex polymerase chain reaction. Diagn Microbiol Infect Dis 67:30–6
   PubMed Web of Science ®Google Scholar
• Donati L, Di Vico A, Spagnuolo T, et al. (2010). Vaginal microbial flora and outcome of pregnancy. Arch Gynecol Obstet 281:589–600
   PubMed Web of Science ®Google Scholar
• Donders GGG. (2007). Definition and classification of abnormal vaginal flora. Best Prac Res Clin Obstet Gynecol 21:355–73
   PubMed Web of Science ®Google Scholar
• Donders GGG, Guaschino S, Peters K, et al. (2013). A multicenter, double-blind, randomized, placebo-controlled study of rifaximin for the treatment of bacterial vaginosis. Int J Gynaecol Obstet 120:131–6
   PubMed Web of Science ®Google Scholar
• Donders GGG, Van Bulck B, Caudron J, et al. (2000). Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion. Am J Obstet Gynecol 183:431–7
   PubMed Web of Science ®Google Scholar
• Eschenbach DA. (1993). Bacterial vaginosis and anaerobes in obstetric-gynecologic infection. Clin Infect Dis 16:S282–7
   Google Scholar
• Eschenbach DA. (1997). Amniotic fluid infection and cerebral palsy. Focus on the fetus. JAMA 278:247–8
   Google Scholar
• Ferris DG, Litaker MS, Woodward L, et al. (1995). Treatment of bacterial vaginosis: a comparison of oral metronidazole, metronidazole vaginal gel, and clindamycin vaginal cream. J Fam Pract 41:443–9
   PubMed Web of Science ®Google Scholar
• Ferris MJ, Masztal A, Aldridge KE, et al. (2004). Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis. BMC Infect Dis 4:5.e1–8
   Google Scholar
• Fethers KA, Fairley CK, Hocking JS, et al. (2008). Sexual risk factors and bacterial vaginosis: a systematic review and meta-analysis. Clin Infect Dis 47:1426–35
   PubMed Web of Science ®Google Scholar
• Fredricks DN, Fiedler TL, Marrazzo JM. (2005). Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353:1899–911
   PubMed Web of Science ®Google Scholar
• Fredricks DN, Fiedler TL, Thomas KK, et al. (2007). Targeted polymerase-chain-reaction for the detection of vaginal bacteria associated with bacterial vaginosis. J Clin Microbiol 45:3270–6
   PubMed Web of Science ®Google Scholar
• Fredricks DN, Fiedler TL, Thomas KK, et al. (2009). Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol 47:721–6
   PubMed Web of Science ®Google Scholar
• García-Castillo M, Morosini MI, Gálvez M, et al. (2008). Differences in biofilm development and antibiotic susceptibility among clinical Ureaplasma urealyticum and Ureaplasma parvum isolates. J Antimicrob Chemother 62:1027–30
   PubMed Web of Science ®Google Scholar
• Gardner HL, Dukes CD. (1955). Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol 69:962–76
   PubMed Web of Science ®Google Scholar
• Genc MR, Karas AE, Onderdonk AB, et al. (2005). Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women. AmJ Obstet Gynecol 192:916–21
   Web of Science ®Google Scholar
• Genc MR, Delaney ML, Onderdonk AB, Witkin SS. (2006). Vaginal nitric oxide in pregnant women with bacterial vaginosis. Am J Reprod Immunol 56:86–90
   PubMed Web of Science ®Google Scholar
• Genc MR, Onderdonk A. (2011). Endogenous bacterial flora in pregnant women and the influence of maternal genetic variation. BJOG 118:154–63
   PubMed Web of Science ®Google Scholar
• Giraldo P, Neuer A, Korneeva IL, et al. (1999). Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis. Am J Obstet Gynecol 180:524–9
   PubMed Web of Science ®Google Scholar
• Goffinet F, Maillard F, Mihoubi N, et al. (2003). Bacterial vaginosis: prevalence and predictive value for premature delivery and neonatal infection in women with preterm labour and intact membranes. Eur J Obstet Gynecol Reprod Biol 108:146–51
   PubMed Web of Science ®Google Scholar
• Govender L, Hoosen AA, Moodley J, et al. (1996). Bacterial vaginosis and associated infections in pregnancy. Int J Gynaecol Obstet 55:23–8
   PubMed Web of Science ®Google Scholar
• Greene JF III, Kuehl TJ, Allen SR. (2000). The Papanicolaou smear: inadequate screening test for bacterial vaginosis during pregnancy. Am J Obstet Gynecol 182:1048–9
   PubMed Web of Science ®Google Scholar
• Grether JK, Nelson KB. (2000). Possible decrease in prevalence of cerebral palsy in premature infants? J Pediatr 136:133
   PubMed Web of Science ®Google Scholar
• Greub G. (2012). Culturomics : a new approach to study the human microbiome, Clin Microbiol Infect 18:7–9
   PubMed Web of Science ®Google Scholar
• Guédou FA, Van Damme L, Deese J, Crucitti T, Mirembe F, Solomon S, Bekker M, Alary M. (2014). Intermediate vaginal flora and bacterial vaginosis are associated with the same factors: findings from an exploratory analysis among female sex workers in Africa and India. Sex Transm Infect, 90:61–4
   Google Scholar
• Guaschino S, De Seta F, Piccoli M, et al. (2006). Aetiology of preterm labour: bacterial vaginosis. BJOG 113:46–51
   PubMed Web of Science ®Google Scholar
• Guerra B, Ghi T, Quarta S, et al. (2006). Pregnancy outcome after early detection of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol 128:40–5
   PubMed Web of Science ®Google Scholar
• Guise JM, Mahon SM, Aickin M, et al. (2001). Screening for bacterial vaginosis in pregnancy. Am J Prev Med 20:62–72
   PubMed Web of Science ®Google Scholar
• Harper LM, Parry S, Stamilio DM, et al. (2012). The interaction effect of bacterial vaginosis and periodontal disease on the risk of preterm delivery. Am J Perinatol 29:347–52
   PubMed Web of Science ®Google Scholar
• Hauth JC, MacPherson C, Carey JC, et al. (2003). Early pregnancy threshold vaginal pH and Gram stain scores predictive of subsequent preterm birth in asymptomatic women. Am J Obstet Gynecol 188:831–5
   PubMed Web of Science ®Google Scholar
• Hay PE. (2000). Recurrent bacterial vaginosis. Curr Infect Dis Rep 2:506–12
   PubMedGoogle Scholar
• Hay PE. (2010). Bacterial vaginosis. Medicine 38:281–5
   Google Scholar
• Hay PE, Morgan DJ, Ison CA, et al. (1994). A longitudinal study of bacterial vaginosis during pregnancy. BJOG 101:1048–53
   Web of Science ®Google Scholar
• Hickey DK, Patel MV, Fahey JV, Wira CR. (2011). Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections. J Reprod Immunol 88:185–94
   PubMed Web of Science ®Google Scholar
• Hillier SL, Nugent RP, Eschenbach DA, et al. (1995). Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 333:1737–42
   PubMed Web of Science ®Google Scholar
• Hogan VK, Culhane JF, Hitti J, et al. (2007). Relative performance of three methods for diagnosing bacterial vaginosis during pregnancy. Matern Child Health J 11:532–9
   PubMed Web of Science ®Google Scholar
• Holst E. (1990). Reservoir of four organisms associated with bacterial vaginosis suggests lack of sexual transmission. J Clin Microbiol 28:2035–9
   PubMed Web of Science ®Google Scholar
• Hooven TA, Randis TM, Hymes SR, et al. (2012). Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity. Am J Obstet Gynecol 101:2870–2
   Google Scholar
• Howe L, Wiggins R, Soothill PW, et al. (1999). Mucinases and sialidase activity of the vaginal microflora: implica- tions for the pathogenesis of preterm labour. Int J STD AIDS, 10:442–7
   Google Scholar
• Huggins GR, Preti G. (1976). Volatile constituents of human vaginal secretions. Am J Obstet Gynecol 126:129–36
   PubMed Web of Science ®Google Scholar
• Hyman RW, Fukushima M, Jiang H, et al. (2014). Diversity of the vaginal microbiome correlates with preterm birth. Reprod Sci 21:32–40
   PubMed Web of Science ®Google Scholar
• Ison CA, Hay PE. (2002). Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 78:413–5
   PubMed Web of Science ®Google Scholar
• Johnson LF, Dorrington RE, Bradshaw D, Coetzee DJ. (2011). The effect of syndromic management interventions on the prevalence of sexually transmitted infections in South Africa. Sex Reprod Healthcare 2:13–20
   PubMed Web of Science ®Google Scholar
• Johnson LF, Lewis DA. (2008). The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis. Sex Transm Dis 35:946–59
   PubMed Web of Science ®Google Scholar
• Kinghorn GR, Jones BM, Chowdhury FH, Geary I. (1982). Balanoposthitis associated with Gardnerella vaginalis infection in men. Br J Vener Dis 58:127–9
   PubMedGoogle Scholar
• Kiss H, Kögler B, Petricevic L, et al. (2007). Vaginal Lactobacillus microbiota of healthy women in the late first trimester of pregnancy. BJOG 114:1402–7
   PubMed Web of Science ®Google Scholar
• Klatt TE, Cole DC, Eastwood DC, Barnabei VM. (2010). Factors associated with recurrent bacterial vaginosis. J Reprod Med 55:55–61
   PubMed Web of Science ®Google Scholar
• Klebanoff MA, Hauth JC, MacPherson CA, et al. (2004). Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. Am J Obstet Gynecol 190:363–70
   PubMed Web of Science ®Google Scholar
• Koumans EH, Sternberg M, Bruce C, et al. (2007). The prevalence of bacterial vaginosis in the United States, 2001-2004; Associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis 11:864–9
   Web of Science ®Google Scholar
• Krauss-Silva L, Almada-Horta A, Alves MB, et al. (2014). Basic vaginal pH, bacterial vaginosis and aerobic vaginitis: prevalence in early pregnancy and risk of spontaneous preterm delivery, a prospective study in a low socioeconomic and multiethnic South American population. BMC Pregn Childbirth 14:1–10
   PubMed Web of Science ®Google Scholar
• Kurki T, Sivonen A, Renkonen O-V, et al. (1992). Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet Gynecol 80:173–7
   PubMed Web of Science ®Google Scholar
• Laghi L, Picone G, Cruciani F, et al. (2014). Rifaximin modulates the vaginal microbiome and metabolome in women affected by bacterial vaginosis. Antimicrob Agents Chemother 58:3411–20
   PubMed Web of Science ®Google Scholar
• Lagier J-C, Armougom F, Million M, Hugon P, Pagnier I, Robert C, Bittar F, Fournous G, Gimenez G, Maraninchi M, Trape J-F, Koonin EV, La Scola B, Raoult D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clin Microbiol Infect, 18:1185–93
   Google Scholar
• Lambert JA, John S, Sobel JD, Akins RA. (2013a). Longitudinal analysis of vaginal microbiome dynamics in women with recurrent bacterial vaginosis: recognition of the conversion process. PLoS ONE 8:e82599 (1--10)
   Google Scholar
• Lambert JA, Kalra A, Dodge CT, et al. (2013b). Novel PCR-based methods enhance characterization of vaginal microbiota in a bacterial vaginosis patient before and after treatment. Appl Environ Microbiol 79:4181–5
   PubMed Web of Science ®Google Scholar
• Leitich H. (2003). Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 188:752–8
   PubMed Web of Science ®Google Scholar
• Leitich H, Kiss H. (2007). Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynecol 21:375–90
   PubMed Web of Science ®Google Scholar
• Lewis DA, Maruma E. (2010). Revision of the national guideline for first-line comprehensive management and control of sexually transmitted infections: what's new and why? South Afr J Epidemiol Infect 24:6–9
   Google Scholar
• Lin L, Yang H, Su J. (2011). Vaginal Lactobacillus distributions and functions in pregnant women. J Microbiol 5:1224–30
   Web of Science ®Google Scholar
• Ling ZD, Chang Q, Lipton JW, et al. (2004). Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain. Neuroscience 124:619–28
   PubMed Web of Science ®Google Scholar
• Livengood CH. (2009). Bacterial vaginosis: an overview for 2009. Rev Obstet Gynecol 2:28–37
   PubMedGoogle Scholar
• Lockitch G. (2004). Maternal-foetal risk assessment. Clin Biochem 37:447–9
   PubMed Web of Science ®Google Scholar
• Löfmark S, Edlund C, Nord CE. (2010). Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis 50:S16–23
   PubMed Web of Science ®Google Scholar
• Macklaim JM, Fernandes AD, Di Bella JM, et al. (2013). Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome 1:1–11. doi:10.1186/2049-2618-1-12
   PubMed Web of Science ®Google Scholar
• Marconi C, Cruciani F, Vitali B, Donders GGG. (2012). Correlation of Atopobium vaginae amount with bacterial vaginosis markers. Pathology 16:127–32
   Google Scholar
• Marconi C, Donders GG, Parada CMGL, et al. (2013). Do Atopobium vaginae, Megasphaera sp. and Leptotrichia sp. change the local innate immune response and sialidase activity in bacterial vaginosis? Sex Transm Infect 89:167–73
   Google Scholar
• McDonald HM, O'Loughlin JA, Vigneswaran R, et al. (1994). Bacterial vaginosis in pregnancy and efficacy of short course oral metronidazole treatment: a randomized controlled trial. Obstet Gynecol 84:343–8
   PubMed Web of Science ®Google Scholar
• McDonald HM, Brocklehurst P, Gordon A. (2007). Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev, Issue 1. Art. No.: CD000262. doi:10.1002/14651858.CD000262.pub3
   Web of Science ®Google Scholar
• McGregor JA, French JI, Jones W, et al. (1994). Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. Am J Obstet Gynecol 170:1048–60
   PubMed Web of Science ®Google Scholar
• McGregor JA, French JL, Parker R, et al. (1995). Prevention of premature birth by screening and treatment for common genital tract infections: results of a prospective controlled evaluation. Am J Obstet Gynecol 173:157–67
   PubMed Web of Science ®Google Scholar
• Menard J, Fenollar F, Raoult D, Boubli L. (2012). Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis. Eur J Clin Microbiol Infect Dis 31:513–8
   PubMed Web of Science ®Google Scholar
• Menard JP, Mazouni C, Fenollar F, et al. (2010). Diagnostic accuracy of quantitative real-time PCR assay versus clinical and Gram-stain identification of bacterial vaginosis. Eur J Clin Microbiol Infect Dis 29:1547–52
   PubMed Web of Science ®Google Scholar
• Mirmonsef P, Gilbert D, Zariffard MR, et al. (2011). The effects of commensal bacteria on innate immune responses in the female genital tract. Am J Reprod Immunol 65:190–5
   PubMed Web of Science ®Google Scholar
• Mitchell CM, Hitti JE, Agnew KJ, Fredricks DN. (2009). Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria. BMC Infect Dis 9:1–6
   PubMed Web of Science ®Google Scholar
• Morris MC, Rogers PA, Kinghorn GR. (2001). Is bacterial vaginosis a sexually transmitted infection? Sex Transm Infect 77:63–8
   PubMed Web of Science ®Google Scholar
• Myer L, Denny L, Telerant R, et al. (2005). Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study. J Infect Dis 192:1372–80
   PubMed Web of Science ®Google Scholar
• Nelson DB, Bellamy S, Nachamkin I, et al. (2007). First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women. Fertil Steril 88:1396–403
   PubMed Web of Science ®Google Scholar
• Nelson DB, Macones G. (2002). Bacterial vaginosis in pregnancy: current findings and future directions. Epidemiol Rev 24:102–8
   PubMed Web of Science ®Google Scholar
• Nugent RP, Krohn MA, Hillier SL. (1991). Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 29:297–301
   PubMed Web of Science ®Google Scholar
• Omole-Ohonsi A, Nwokedi EE. (2011). Sociodemographic characteristics and aetiological factors of vaginal discharge in pregnancy. Jos J Med 5:27–30
   Google Scholar
• Onderdonk AB, Lee ML, Lieberman E, et al. (2003). Quantitative microbiologic models for preterm delivery. J Clin Microbiol 41:1073–9
   PubMed Web of Science ®Google Scholar
• Patterson JL, Girerd PH, Karjane NW, Jefferson KK. (2007). Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid. Am J Obstet Gynecol 197:170–7
   PubMed Web of Science ®Google Scholar
• Pereira L, Culhane J, McCollum K, et al. (2005). Variation in microbiologic profiles among pregnant women with bacterial vaginosis. Am J Obstet Gynecol 193:746–51
   PubMed Web of Science ®Google Scholar
• Povlsen K, Thorsen P, Lind I. (2001). Relationship of Ureaplasma urealyticum biovars to the presence or absence of bacterial vaginosis in pregnant women and to the time of delivery. Eur J Clin Microbiol Infect Dis 20:65–67
   PubMed Web of Science ®Google Scholar
• Pretorius C, Jagatt A, Lamont RF. (2007). The relationship between periodontal disease, bacterial vaginosis, and preterm birth. J Perinat Med 35:93–9
   PubMed Web of Science ®Google Scholar
• Pridmore RD, Berger B, Desiere F, et al. (2004). The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proc Natl Acad Sci USA 101:2512–7
   PubMed Web of Science ®Google Scholar
• Rajan SS, Cavera VL, Zhang X, et al. (2014). Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis. Antimicrob Agents Chemother 58:2747–53
   PubMed Web of Science ®Google Scholar
• Ravel J, Gajer P, Abdob Z, et al. (2011). Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 108:4680–7
   PubMed Web of Science ®Google Scholar
• Rivkin A, Gim S. (2011). Rifaximin: new therapeutic indication and future directions. Clin Ther 33:812–27
   PubMed Web of Science ®Google Scholar
• Romero R, Hassan SS, Gajer P, et al. (2014). The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome 2:1–19. doi:10.1186/2049-2618-2-4
   PubMed Web of Science ®Google Scholar
• Romoren M, Velauthapillai M, Rahman M, et al. (2007) Trichomoniasis and bacterial vaginosis in pregnancy: inadequately managed with the syndromic approach. Bull World Health Organ 85:297–304
   PubMed Web of Science ®Google Scholar
• Royce RA, Thorp J, Granados JL, Savitz DA. (1999). Bacterial vaginosis associated with HIV infection in pregnant women from North Carolina. J Acquir Immun Defic Syndr Hum Retrovirol 20:382–6
   PubMedGoogle Scholar
• Ryckman KK, Simhan HN, Krohn M, Williams SM. (2009). Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry. J Reprod Immunol 79:174–82
   PubMed Web of Science ®Google Scholar
• Schmid G, Markowitz L, Joesoef R, Koumans E. (2000). Bacterial vaginosis and HIV infection. Sex Transm Infect 76:3–4
   PubMed Web of Science ®Google Scholar
• Schoeman J. (2002). Bacterial vaginosis – a literature review. Obstet Gynecol Forum 12:8–13
   Google Scholar
• Schwebke JR. (2009). Bacterial vaginosis: are we coming full circle? J Infect Dis 200:1633–5
   PubMed Web of Science ®Google Scholar
• Schwebke A, Taras D, Rusch K, Rusch V. (2006). Throwing the dice for the diagnosis of vaginal complaints? Ann Clin Microbiol Antimicrob 5:4–10
   PubMedGoogle Scholar
• Sha BE, Chen HY, Wang QJ, et al. (2005). Utility of Amsel criteria, Nugent score, and quantitative PCR for Gardnerella vaginalis, Mycoplasma hominis, and Lactobacillus spp. for diagnosis of bacterial vaginosis in human immunodeficiency virus-infected women. J Clin Microbiol 43:4607–12
   PubMed Web of Science ®Google Scholar
• Shipitsyna E, Roos A, Datcu R, et al. (2013). Composition of the vaginal microbiota in women of reproductive age--sensitive and specific molecular diagnosis of bacterial vaginosis is possible? PLoS One 8:e60670 (1--10)
   Web of Science ®Google Scholar
• Simhan HN, Bodnar LM, Krohn MA. (2008). Paternal race and bacterial vaginosis during the first trimester of pregnancy. Am J Obstet Gynecol 198:196.e1–4
   Google Scholar
• Sobel JD, Ferris D, Schwebke J, et al. (2006). Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol 194:1283–9
   PubMed Web of Science ®Google Scholar
• Sobel JD, Karpas Z, Lorber A. (2012). Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry. Eur J Clin Microbiol Infect Dis 163:81–4
   Google Scholar
• Sodhani P, Garg S, Bhalla P, et al. (2005). Prevalence of bacterial vaginosis in a community setting and role of the pap smear in its detection. Acta Cytol 49:634–8
   PubMed Web of Science ®Google Scholar
• Spiegel CA, Amsel R, Holmes KK. (1983). Diagnosis of bacterial vaginosis by direct Gram stain of vaginal fluid. J Clin Microbiol 18:170–7
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Fredricks DN. (2008). The human vaginal bacterial biota and bacterial vaginosis. Interdiscip Perspect Infect Dis 2008:1--22
   Google Scholar
• Srinivasan U, Misra D, Marazita ML, Foxman B. (2009). Vaginal and oral microbes, host genotype and preterm birth. Med Hypotheses 73:963–75
   PubMed Web of Science ®Google Scholar
• Struthers BJ. (1997). Metronidazole appears not to be a human teratogen: review of the literature. Infect Dis Obstet Gynecol 5:326–35
   PubMedGoogle Scholar
• Swidsinski A, Doerfell Y, Loening-Baucke V, et al. (2010). Gardnerella biofilm involves both females and males and is sexually transmitted. Gynecol Obstet Invest 70:256–63
   PubMed Web of Science ®Google Scholar
• Swidsinski A, Mendling W, Loening-Baucke V, et al. (2005). Adherent biofilms in bacterial vaginosis. Obstet Gynecol 106:1013–23
   PubMed Web of Science ®Google Scholar
• Taha TE, Hoover DR, Dallabetta GA, et al. (1998). Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV. AIDS 12:1699–706
   PubMed Web of Science ®Google Scholar
• Tolosa JE, Chaithongwongwatthana S, Daly S, et al. (2006). The International Infections in Pregnancy (IIP) study: variations in the prevalence of bacterial vaginosis and distribution of morphotypes in vaginal smears among pregnant women. Am J Obstet Gynaecol 195:1198–204
   PubMed Web of Science ®Google Scholar
• Trama JP, Pascal KE, Zimmerman J, et al. (2008). Rapid detection of Atopobium vaginae and association with organisms implicated in bacterial vaginosis. Mol Cell Probes 22:96–102
   PubMed Web of Science ®Google Scholar
• Turovskiy Y, Noll KS, Chikindas ML. (2011). The aetiology of bacterial vaginosis. J Appl Microbiol 110:1105–28
   PubMed Web of Science ®Google Scholar
• Twin J, Bradshaw CS, Garland SM, et al. (2013). The potential of metatranscriptomics for identifying screening targets for bacterial vaginosis. PLoS One 8:e76892 (1--8)
   Web of Science ®Google Scholar
• Udayalaxmi J, Bhat G, Kotigadde S, Kotian S. (2012). Effect of pH on the adherence, surface hydrophobicity and the biofilm formation of Gardnerella vaginalis. J Clin Diagn Res 6:967–9
   Google Scholar
• Verhelst R, Verstraelen H, Claeys G, et al. (2005). Comparison between Gram stain and culture for the characterization of vaginal microflora: definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora. BMC Microbiol 5:123–33
   Web of Science ®Google Scholar
• Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. (2010). The epidemiology of bacterial vaginosis in relation to sexual behaviour. BMC Infect Dis 10:81.e1–11
   Google Scholar
• Walther-António MRS, Jeraldo P, Berg Miller ME, et al. (2014). Pregnancy's stronghold on the vaginal microbiome. PLoS One 9:e98514 (1--10)
   Web of Science ®Google Scholar
• Wang B, Xiao BB, Shang CG, et al. (2014). Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure. Eur J Clin Microbiol Infect Dis. doi 10.1007/s10096-014-2128-5
   Web of Science ®Google Scholar
• Waters TP, Denney JM, Mathew L, et al. (2008). Longitudinal trajectory of bacterial vaginosis during pregnancy. Am J Obstet Gynecol 199:431.e1–5
   Web of Science ®Google Scholar
• Wilks M, Wiggins R, Whiley A, et al. (2004). Identification and H2O2 production of vaginal lactobacilli from pregnant women at high risk of pre-term birth and relation with outcome. J Clin Microbiol 42:713–7
   PubMed Web of Science ®Google Scholar
• Witkin SS, Linhares IM, Giraldo P. (2007a). Bacterial flora of the female genital tract: function and immune regulation. Best Prac Res Clin Obstet Gynecol 21:347–54
   PubMed Web of Science ®Google Scholar
• Witkin SS, Linhares IM, Giraldo P, Ledger WJ. (2007b). An altered immunity hypothesis for the development of symptomatic bacterial vaginosis. Clin Infect Dis 44:554–7
   PubMed Web of Science ®Google Scholar
• World Health Organization. (2005). Sexually transmitted and other reproductive tract infections: a guide to essential practice. Geneva, Switzerland. Available from: http://whqlibdoc.who.int/publications/2005/9241592656.pdf [last accessed 15 Apr 2013]
   Google Scholar
• World Health Organization. (2014). Sexually transmitted and other reproductive tract infections: a guide to essential practice. Geneva, Switzerland. Available from: http://apps.who.int/medicinedocs/en/d/Jh2942e/4.10.html#Jh2942e.4.10 [last accessed 30 Jul 2014]
   Google Scholar
• Yen S, Shafer M-A, Moncada J, et al. (2003). Bacterial vaginosis in sexually experienced and non-sexually experienced young women entering the military. Obstet Gynecol 102:927–33
   PubMed Web of Science ®Google Scholar
• Zariffard MR, Novak RM, Lurain N, et al. (2005). Induction of tumour necrosis factor-alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis. J Infect Dis 191:1913–21
   PubMed Web of Science ®Google Scholar
• Zhou X, Bent SJ, Schneider MG, et al. (2004). Characterisation of vaginal microbial communities in adult healthy women using cultivation-independent methods. Microbiology 150:2565–73
   PubMed Web of Science ®Google Scholar
• Zodzika J, Rezeberga D, Jermakova I, et al. (2011). Factors related to elevated vaginal pH in the first trimester of pregnancy. Acta Obstet Gynecol Scand 90:41–6
   PubMed Web of Science ®Google Scholar
• Zozaya-Hinchliffe M, Lillis R, Martin DH, Ferris MJ. (2010). Quantitative PCR assessments of bacterial species in women with and without bacterial vaginosis. J Clin Microbiol 48:1812–9
   PubMed Web of Science ®Google Scholar