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Review Article

Personal care products and endocrine disruption: A critical review of the literature

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Pages 1-30 | Received 21 Jan 2010, Accepted 10 Aug 2010, Published online: 11 Oct 2010

References

  • ACS (American Cancer Society). (2008). Antiperspirants and breast cancer risk. Available at: http://www.cancer.org/docroot/MED/content/MED_6_1x_Antiperspirants.asp. Accessed January 15, 2010
  • Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz, D, Chang DPY, Gee SJ, Hammock BD. (2008). In vitro biologic activities of the antimicrobials triclocarban, its analogs and triclosan in bioassay screens: Receptor-based bioassay screens. Environ Health Perspect 116:1203–1210
  • Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM. (2000). The estrogen receptor relative binding affinities of 188 natural and xenochemicals: Structural diversity of ligands. Toxicol Sci 54:138–153.
  • Bustamante-Montes LP, Hernandez-Valero MA, Garcia-Fabila M, Halley-Castillo E, Karam-Calderon MA, Borja-Aburto VH. (2008). Prenatal phthalate exposure and decrease in ano-genital distance in Mexican newborns [abstract]. Epidemiology 19(Supp):570.
  • Byford JR, Shaw LE, Drew MGB, Pope GS, Sauer MJ, Darbre PD. (2002). Oestrogenic activity of parabens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol 80:49–60.
  • Carr BR, Bradshaw KD. (2006). Disorders of the ovary and female reproductive tract. In: Jameson JL, ed. Harrison’s Endocrinology. New York: McGraw-Hill, 173–194.
  • Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. (2008). Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology 149:1173–1179.
  • CIR (Cosmetic Ingredient Review). (2005). Annual review of cosmetic ingredient safety assessments—2002/2003. Int J Toxicol 24(Suppl 1):1–102.
  • Colon I, Caro D, Bourdony CJ, Rosario O. (2000). Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect 108:895–900.
  • Cooke PS, Holsberger DR, Witorsch RJ, Sylvester PW, Meredith JM, Treinen KA, Chapin, RE. (2004). Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology,reproduction, and toxicology. Toxicol Appl Pharmacol 194:309–335.
  • Crofton KM, Paul KB, DeVito MJ, Hedge JM. (2007). Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. Environ Toxicol Pharmacol 24:194–197.
  • Darbre PD, Byford J., Shaw LE, Horton,RA Pope, GS, Sauer MJ. (2002). Oestrogenic activity of isobutylparaben in vitro and in vivo. J Appl Toxicol 22:219–226.
  • Darbre PD, Byford JR, Shaw LE, Hall S, Coldham NG, Pope GS, Sauer MJ. (2003). Oestrogenic activity of benzylparaben. J Appl Toxicol 23:43–51.
  • Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS. (2004). Concentrations of parabens in human breast tumours. J Appl Toxicol 24:5–13.
  • Darbre PD, Harvey PW. (2008). Paraben esters: Review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Appl Toxicol 28:561–578.
  • Daston GP. (2004). Developmental toxicity evaluation of butylparaben in Sprague Dawley rats. Birth Defects Res B 71:296–302.
  • Durrer S, Ehnes C, Fuetsch M, Maerkel K, Schlumpf M, Lichtensteiger W. (2007). Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor. Environ Health Perspect 115(Suppl 1):42–50.
  • Duty SM, Silva MJ, Barr DB, Brock JW, Ryan L, Chen Z, Herrick RF, Christiani DC, Hauser R. (2003a). Phthalate exposure and human semen parameters. Epidemiology 14:269–277.
  • Duty SM, Silva MJ, Barr DB, Brock JW, Ryan L, Chen Z, Herrick RF, Christiani DC, Hauser R. (2003b). The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 111:1164–1169.
  • Duty SM, Calafat AM, Silva MJ, Ryan L, Hauser R. (2005). Phthalate exposure and reproductive hormones in adult men. Hum Reprod 20:604–610.
  • Endocrine Society. (2009). Endocrine-Disrupting Chemicals. An Endocrine Society Scientific Statement, Chevy Chase, MD.
  • Fisher JS. (2004). Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 127:305–315.
  • Forest MG, De Peretti E, Bertrand J. (1976). Hypothalamic-pituitary-gonadal relationships from birth to puberty. Clin Endocrinol 5:551–569.
  • Foster PM, Thomas LV, Cook MW, Gangolli SD. (1980). Study of the testicular effects and changes in zinc excretion produced by some n-alkyl phthalates in the rat. Toxicol Appl Pharmacol 54:392–398.
  • Foster PM, Mylchreest E, Gaido KW, Sar M. (2001). Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update 7:231–235.
  • Foster PMD. (2006). Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 29:140–147.
  • Gaido K, Hensley JB, Liu D, Wallace DG, Borghoff S, Johnson KJ, Hall SJ, Boekelheide K. (2007). Fetal mouse phthalate exposure shows that gonocyte multinucleation is not associated with decreased testicular testosterone. Toxicol Sci 97:491–503.
  • Gee RH, Charles A, Taylor N, Darbre PD. (2008). Oestrogenic and androgenic activity of triclosan in breast cancer cells. J Appl Toxicol 28:78–91.
  • Golden R, Gandy J, Vollmer G. (2005). A review of the endocrine activity of parabens and implications for potential risks to human health. Crit Rev Toxicol 35:435–458.
  • Gomez E, Pillon A, Fenet H, Rosain D, Duchesne MJ, Nicolas JC, Balaguer P, Casellas. (2005). Estrogenic activity of cosmetic components in reporter cell lines: Parabens, UV screens, and musks. J Toxicol Environ Health A 68:239–251.
  • Gonzalez H, Farbrot A, Larko O, Wennberg AM. (2006). Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation. Br J Dermatol 154:337–340.
  • Gray LE Jr, Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J. (1999). Administration of potentially antiandrogenic pesticides (procymidone, linuron, ipodione, chlozolinate, p,p’-DDE, and ketoconzole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane suphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 15:94–118.
  • Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks, L. (2000). Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP alters sexual differentiation of the male rat. Toxicol Sci 58:350–365.
  • Gunnarsson D, Leffler P, Ekwurtzel E, Martinsson G, Liu K, Selstam G. (2008). Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes. Reproduction 135: 693–703.
  • Hallmark N, Walker M, McKinnell C, Mahood IK, Scott H, Bayne R, Coutts S, Anderson RA, Greig I, Keith Morris Sharpe, RM. (2007). Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: Comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect 115:390–396.
  • Hill AB. (1965). The environment and disease: Association and causation. Proc R Soc Med 58:295–300.
  • Hoberman AM, Schreur DK, Leazer T, Daston GP, Carthew P, Re T, Loretz L, Mann P. (2008). Lack of effect of butylparaben and methylparaben on the reproductive system in male rats. Birth Defects Res B Dev Reprod Toxicol 83:123–133.
  • Hofkamp L, Bradley S, Tresguerres J, Lichtensteiger W, Schlumpf M, Timms B. (2008). Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters. Environ Health Perspect 116:867–872.
  • Hong E-J, Ji Y-K, Choi K-C, Manabe N, Jeung E-B. (2005). Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k. J Reprod Dev 51:253–263.
  • Hossaini A, Larsen JJ, Larsen JC. (2000). Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays. Food Chem Toxicol 38:319–323.
  • Hotchkiss A, Parks-Saldutti L, Ostby J, Lambright C, Furr J, Vandenbergh, J, Gray LE Jr. (2004). A mixture of the ‘‘antiandrogens’’ linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion. Biol Reprod 71:1852–1861.
  • Howdeshell KL, Furr J, Lambright CR, Rider CV, Wilson VS, Gray LE Jr. (2007). Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: Altered fetal steroid hormones and genes. Toxicol Sci 99:190–202.
  • Howdeshell KL, Wilson VS, Furr J, Lambright CR, Rider CV, Blystone CR, Hothkiss, AK, Gray LE Jr. (2008). A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner. Toxicol Sci 105:153–165.
  • Huang P-C, Kuo P-L, Chou Y-Y, Lin S-J, Lee C-C. (2009). Association between prenatal exposure to phthalates and the health of newborns. Environ Int 35:14–20.
  • Hubinger JC, Havery DC. (2006). Analysis of consumer cosmetic products for phthalate esters. J Cosmet Sci 57:127–157.
  • Inai K, Aoki Y, Akamizu H, Eto R, Nishida T, Tokuoka S. (1985). Tumorigenicity study of butyl and isobutyl p-hydroxybenzoates administered orally to mice. Food Chem Toxicol 23:575–578.
  • Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC. (2004). Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol 123:57–61.
  • Janjua NB, Mortensen GK, Andersson AM, Konshoj B, Skakkebaek NE, Wulf HC. (2007). Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans. Environ Sci Technol 41:5564–5570.
  • Jarry H, Christoffel J, Rimoldi G, Koch L, Wuttke W. (2004). Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment. Toxicology 205:87–93.
  • Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. (1995). A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 103:582–587.
  • Johnson KJ, McCahan ISM, Si X, Campion L, Herrmann R, Barthold JS. (2008). The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure. Toxicol Sci 105:360–367.
  • Kamrin MA. (2009). Phthalate risks, phthalate regulation, and public health: A review. J Toxicol Environ Health B 12:157–174.
  • Kang KS, Che JH, Ryu DY, Kirn TW, Li GX, Lee YS. (2002). Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben). J Vet Med Sci 64:227–235.
  • Katch VL, Martin R, Martin J. (1979). Effects of exercise intensity on food consumption in the male rat. Am J Clin Nutr 32:1401–1407.
  • Klammer H, Schlecht C, Wuttke W, Jarry H. (2005). Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo. A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology 215:90–96.
  • Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Kohrle J, Jarry H. (2007). Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology 238:192–199.
  • Koo HJ, Lee BM. (2004). Estimated exposure to phthalates in cosmetics and risk assessment. J Toxicol Environ Health A 67:1901–1914.
  • Lambrot R, Muczynskii V, Lécureuil C, Angenard G, Coffigny H, Pairault C, Moison D, Frydman R, Habert R, Rouiller-Fabre1 V. (2009). Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production. Environ Health Perspect 117:32–37.
  • Liu K, Lehmann KP, Sar M, Young SS, Gaido KW. (2005). Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Biol Reprod 73:180–192.
  • Lehmann KP, Phillips S, Sar M, Foster PMD, Gaido KW. (2004). Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci 81:60–68.
  • Lemini G, Silva G, Timossi C, Luque D, Valverde A, Gozalez-Martinez M, Hernandez A, Rubio-Poo Chavez, Lara, B Valenzuela F. (1997). Estrogenic effects of p-hydroxybenzoic acid in CD1 mice. Environ Res 75:130–134.
  • Lemini G, Jaimez R, Avila ME, Franco Y, Larrea F, Lemus AE. (2003). In vivo and in vitro estrogen bioactivities of alkyl parabens. Toxicol Ind Health 19:69–79.
  • Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi A-M Virtanen, HE, Petersen JH, Anna-Maria Andersson A-M Jorma, Toppari J, Niels E, Skakkebæk NE. (2006). Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in three month old infants. Environ Health Perspect 114:270–276.
  • Matthews C, Davidson J, Bauer E, Morrison JL, Richardson AP. (1956). p-Hydroxybenzoic esters as preservatives. II. Acute and chronic toxicity in dogs, rats and mice. J Am Pharm Assoc 45:260–267.
  • McEwen GN Jr, Renner G. (2006). Validity of anogenital distance as a marker of in utero phthalate exposure. Environ Health Perspect 114:A19–A20.
  • Morohoshi K, Yamamoto H, Kamata R, Shiraishi F, Koda T, Morita M. (2005). Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays. Toxicol In Vitro 19:457–469.
  • Mylchreest E, Catttley RC, Foster PM. (1998). Male reproductive tract malformations in rats following gestational and lactational exposure to di (n-butyl) phthalate: An antiandrogenic mechanism? Toxicol Sci 43:47–60.
  • Mylchreest E, Wallace DG, Cattley RC, Foster PMD. (2000). Dose dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Toxicol Sci 55:143–151.
  • Nathan BM, Palmert MR. (2005). Regulation and disorders of pubertal timing. Endocrin Metab Clin N Am 34:617–641.
  • Okubo T, Yokoyama Y, Kano K, Kano I. (2001). ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER alpha and PR. Food Chem Toxicol 39:1225–1232.
  • Oishi S. (2001). Effects of butylparaben on the male reproductive system in rats. Toxicol Ind Health 17:31–39.
  • Oishi S. (2002a). Effects of butyl paraben on the male reproductive system in mice. Arch Toxicol 76:423–429.
  • Oishi S. (2002b). Effects of propyl paraben on the male reproductive system. Food Chem Toxicol 40:1807–1813.
  • Oishi S. (2004). Lack of spermatotoxic effects of methyl and ethyl esters of p-hydroxybenzoic acid in rats. Food Chem Toxicol 42:1845–1849.
  • Ormond G, Nieuwenhuijsen MJ, Nelson P, Toledano MB, Iszatt N, Geneletti S, Elliott P. (2009). Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: Case-control study. Environ Health Perspect 117:303–307.
  • Parveen M, Inoue A, Ise R, Tanjil M, Kiyama R. (2008). Evaluation of estrogenic activity of phthalate esters by gene expression profiling using a focused microarray (ESTRARRAY). Environ Toxicol Chem 27:1416–1425.
  • Piegorsch WW, Bailer AJ. (1997). Statistics for Environmental Biology and Toxicology. London: Chapman & Hall.
  • Pierik FJ, Deddens JA, Burdorf A, de Muinck Keizer-Schrama SM, Jong FH, Weber RF. (2009). The hypothalamus-pituitary-testis axis in boys during the first six months of life: A comparison of cryptorchidism and hypospadias cases with controls. Int J Androl 32:453–461.
  • Prusakiewics JJ, Harville HM, Zhang Y, Ackermann C, Voorman RL. (2008). Parabens inhibit human skin estrogen sulfotransferase activity: Possible link to paraben estrogenic effects. Toxicology 232:248–256.
  • Resko JA, Ellinwood WE. (1985). Negative feedback regulation of gonadotropin secretion by androgens in fetal rhesus macaques. Biol Reprod 33:346–352.
  • Rider CV, Furr J, Wilson VS, Gray LE Jr. (2008). A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl 31:249–262.
  • Rodricks JV, Swenberg JA, Borzelleca JF, Maronpot RR, Shipp AM. (2010). Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Crit Rev Toxicol 40:422–484. Early Online.
  • Routledge EJ, Parker J, Odum J, Ashby J, Sumpter J. (1998). Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol Appl Pharmacol 153:12–19.
  • Salazar-Martinez E, Romano-Riquer P, Yanez-Marquez E, Longnecker MP, Hernandez-Avila M. (2004). Anogenital distance in human male and female newborns: A descriptive, cross-sectional study. Environ Health 3:8–13.
  • SCCP (Scientific Committee on Consumer Products). (2007). Opinion on phthalates in cosmetic products. In: Health & Consumer Protection Directorate General, European Commission; 11th Plenary Meeting; 21 March 2007.
  • Schlecht C, Klammer H, Jarry H, Wuttke W. (2004). Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats. Toxicology 205:123–130.
  • Schlecht C, Klammer H, Frauendorf H, Wuttke W, Jarry H. (2008). Pharmacokinetics and metabolism of benzophenone 2 in the rat. Toxicology 245:11–17.
  • Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W. (2001). In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect 109:239–244.
  • Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, Gruetter M, Herzog I, Reolon S, Ceccatelli R, Faass O, Stutz E, Jarry H, Wuttke W, Lichtensteiger W. (2004). Endocrine activity and developmental toxicity of cosmetic UV filters—An update. Toxicology 205:113–122.
  • Schlumpf M, Kypke K, Vökt CC, Birchler M, Durrer S, Faass O, Ehne C, Fuetsch M, Gaille C, Henseler M, Hofkamp L, Maerkel K, Reolon S, Zenker A, Timms B, Tresguerres JAF, Lichtensteiger W. (2008). Endocrine active UV filters: Developmental toxicity and exposure through breast milk. Chimia 62:345–351.
  • Schmutzler C, Hamann I, Hofmann PJ, Kovacs G, Stemmler L, Mentrup B, Schomburg LA, Ambrugger P, Gruters A, Seidlova-Wuttke D, Jarry H, Wuttke W, Kohrle J. (2004). Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. Toxicology 205:95–102.
  • Schmutzler C, Gotthardt I, Hofmann PJ, Radovic B, Kovacs G, Stemmler L, Nobis I, Bacinski A, Mentrup B, Ambrugger P, Grüters A, Malendowicz LK, Christoffel J, Jarry H, Seidlovà-Wuttke D, Wuttke W, Köhrle J. (2007a). Endocrine disruptors and the thyroid gland—A combined in vitro and in vivo analysis of potential new biomarkers. Environ Health Perspect 115(Suppl 1):77–83.
  • Schmutzler C, Bacinski A, Gotthardt I, Huhne K, Ambrugger P, Klammer H, Schlecht C, Hoang-Vu C, Gruters A, Wuttke W, Jarry H, Kohrle J. (2007b). The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. Endocrinology 148:2835–2844.
  • Schreurs RHMM, Quaedackers ME, Seinen W, van der Burg B. (2002). Transcriptional Activation of estrogen receptor ERα and Erβ by polycyclic musks is cell type dependent. Toxicol Applied Pharmacol 183:1–9.
  • Schreurs RHMM, Legler J, Artola-Garicano E, Sinnige T, Lanser PH, Seinen W, van der Burg B. (2004). In vitro and in vivo antiestrogenic effects of polycyclic musks in zebrafish. Environ Sci Technol 38:997–1002.
  • Schreurs RHMM, Sonneveld E, Jansen JHJ, Seinen W, van der Burg B. (2005). Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci 83:264–275.
  • Seidlovka-Wuttke D, Jarry H, Wuttke W. (2004). Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphthalate (DBP) in uterus, vagina and bone. Toxicology 205:103–112.
  • Seinen W, Lemmen JG, Pieters RHH, Verbruggen EMJ, van der Burg B. (1999). AHTN and HHCB show weak estrogenic—but no uterotrophic activity. Toxicol Lett 111:161–168.
  • Sharpe RM. (2008). Toxicological highlight: “Additional” effects of phthalate mixtures on fetal testosterone production. Toxicol Sci 105:1–4.
  • Sharpe RM, Skakkebaek NE. (2008). Testicular dysgenesis syndrome. Mechanistic insights and potential new downstream effects. Fertil Steril 89(Suppl 1):e33–e38.
  • Soni MG, Taylor SL, Carabin IG, Burdock GA. (2005). Safety assessment of esters of p-hydroxy benzoic acid (parabens). Food Chem Toxicol 43:985–1015.
  • Swan SH. (2008). Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res 108:177–184.
  • Swan SH, Main KM, Liu F, Stewart SL, Krus RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL, and the Study for Future Families Research Team. (2005). Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113:1056–1061.
  • Swan SH, Main K, Krus R, Stewart S, Redmon B, Ternand C, Sullivan S. (2006). Anogenital distance and phthalate exposure, Swan et al. respond. Environ Health Perspect 114:A20–A21.
  • Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J,Hansen PR, Frederiksen H, Nellemann C. (2008). Do parabens have the ability to interfere with steroidogenesis? Toxicol Sci 106:206–213.
  • Thomas JA. (1997). Phytoestrogens and hormonal modulation: A minireview. Environ Nutr Interact 1:5–12.
  • Thomas JA, Schein LG, Gupta PK, McCafferty RE, Felice PR, Donovan MP. (1979). Failure of monoethylhexyl phthalate to cause teratogenic effects in offspring of rabbits. Toxicol Appl Pharmacol 51:523–528.
  • Thomas JA, Northup SJ. (1982). Toxicity and metabolism of monethylhexyl phthalate and diethylhexyl phthalate: Survey of recent literature. J Toxicol Environ Health 9:141–152.
  • US EPA. (2009). Endocrine Disruptor Screening Program: Policies and procedures for initial screening. Federal Register 74:17560–17577.
  • van der Burg B,Schreurs R, van der Linden S, Seinen W, Brouwer A, Sonneveld E. (2008). Review article: Endocrine effects of polycyclic musks: Do we smell a rat? Int J Androl 31:188–193.
  • van Meeuwen JA, van Son O, Piersma AH, de Jong PC, van den Berg M. (2008). Aromatase inhibiting and combined estrogenic effects of parabens and estrogenic effects of other additives in cosmetics. Toxicol Appl Pharmacol 230:372–382.
  • vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, et al. (2007). Chapel Hill Bisphenol A Expert Panel Consensus Statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 24:131–138.
  • Vrijheid M, Armstrong B, Dolk H, van Tongeren M, Botting B. (2003). Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. Occup Environ Med 60:543–550.
  • Welsh, M, Saunder PTK, Fisken M, Scott HM, Hutchison GR, Smith LB, Sharpe RM. (2008). Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J. Clin Invest 118:1479–1490.
  • Williams GH, Dluhy RG. (2006). Disorders of the adrenal cortex. In: Jameson JL, ed. Harrison’s Endocrinology. New York: McGraw Hill, 113–150.
  • Witorsch RJ. (2002a). Endocrine disruptors: Can biological effects and environmental risks be predicted? Regul Toxicol Pharmacol 36:118–130.
  • Witorsch, RJ. (2002b). Low dose in utero effects of xenoestrogens in mice and their relevance to humans: An analytical review of the literature. Food Chem Toxicol 40:905–912.
  • Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. (2009). The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol Sci 107:56–64.

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