An appraisal of the published literature on the safety and toxicity of food-related nanomaterials

References

• Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia MA, McNeil SE. (2009). Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 61:428–437.
   PubMed Web of Science ®Google Scholar
• Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD. (2009). Cellular uptake and cytotoxicity of gold nanorods: Molecular origin of cytotoxicity and surface effects. Small 5:701–708.
   PubMed Web of Science ®Google Scholar
• Aprahamian M, Michel C, Humbert W, Devissaguet JP, Damge C. (1987). Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine. Biol Cell 61:69–76.
   PubMed Web of Science ®Google Scholar
• Araujo L, Lobenberg R, Kreuter J. (1999). Influence of the surfactant concentration on the body distribution of nanoparticles. J Drug Target 6:373–385.
   PubMed Web of Science ®Google Scholar
• Astete CE, Sabliov CM. (2006). Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed 17:2472–89.
   Google Scholar
• Aschberger K, Johnston HJ, Stone V, Aitken RJ, Lang Tran C, Hankin SM, Peters SA, Christensen FM et al. (2010). Review of fullerene toxicity and exposure - —Appraisal of a human health risk assessment, based on open literature. Regul Toxicol Pharmacol. 2010 Aug 25. Epub, ahead of print.
   PubMedGoogle Scholar
• Aschberger K, Johnston HJ, Stone V, Aitken RJ, Hankin SM, Peters SA, Lang Tran C, Christensen FM et al. (In press). Review of carbon nanotubes toxicity and exposure - —Appraisal of a human health risk assessment, based on open literature. Crit Rev Toxicol 40:759–790.
   PubMedGoogle Scholar
• Back EI, Frindt C, Ocenásková E, Nohr D, Stern M, Biesalski HK. (2006). Can changes in hydrophobicity increase the bioavailability of α-tocopherol? Eur J Nutr 45:1–6.
   PubMedGoogle Scholar
• Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Misra S, Hussain SM, et al. (2009). Evaluation of genotoxic effects of oral exposure to aluminum oxide nanomaterials in rat bone marrow. Mutat Res 676:41–47.
   PubMed Web of Science ®Google Scholar
• Barrett EG, Johnston C, Oberdorster G, Finkelstein JN. (1999). Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol Appl Pharmacol 161:111–122.
   PubMed Web of Science ®Google Scholar
• Behrens I, Pena AI, Alonso MJ, Kissel T. (2002). Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucous on particle adsorption and transport. Pharm Res 19:1185–1193.
   PubMed Web of Science ®Google Scholar
• Bhol KC, Schechter PJ. (2007). Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis. Dig Dis Sci 52:2732–2742.
   PubMed Web of Science ®Google Scholar
• Bisht S, Feldmann G, Koorstra JB, Mullendore M, Alvarez H, Karikari C et al. (2008). In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities. Mol Cancer Ther 7:3878–3888.
   PubMed Web of Science ®Google Scholar
• Borm PJA, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K et al. (2006). The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol 3: 11 [1-35].
   PubMedGoogle Scholar
• Bouwmeester H, Dekkers S, Noordam MY, Hagens WI, Bulder AS, de Heer C et al. (2009). Review of health safety aspects of nanotechnologies in food production. Regul Toxicol Pharmacol 53:52–62.
   PubMed Web of Science ®Google Scholar
• Card JW, Magnuson BA. (2010). A method to asses the quality of studies that examine the toxicity of engineered nanomaterials. Int J Toxicol 29:402–410.
   PubMed Web of Science ®Google Scholar
• Casey A, Herzog E, Lyng FM, Byrne HJ, Chambers G, Davoren M. (2008). Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cells. Toxicol Lett 179:78–84.
   PubMed Web of Science ®Google Scholar
• Chan Y-C Wu, C-C, Chan K-C Lin, Y-G, Liao J-W Wang, M-F et al. (2009). Nanonized black soybean enhances immune response in senescence-accelerated mice. Int J Nanomed 4:27–35.
   PubMedGoogle Scholar
• Characterization Matters. (2008). Recommended Minimum Physical and Chemical Parameters for Characterizing Nanomaterials on Toxicology Studies. Developed at: Workshop on Ensuring Appropriate Material Characterization in Nano-toxicity Studies, Oct. ober 28–29, 2008, Washington, DC. Characterization Matters, The Minimum Information for Nanomaterial Characterization (MINChar) Initiative. Nov. ember 24, 2008. Available at: http://characterizationmatters.files.wordpress.com/2008/11/minchar-parameters-list.pdf. Accessed 14 April 2010.
   Google Scholar
• Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L et al. (2008). Applications and implications of nanotechnologies for the food sector. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:241–258.
   PubMed Web of Science ®Google Scholar
• Chen HH, Yu C, Ueng TH, Chen S, Chen BJ, Huang KJ et al. (1998). Acute and subacute toxicity study of water-soluble polyalkylsulfonated c60 in rats. Toxicol Pathol 26:143–151.
   PubMed Web of Science ®Google Scholar
• Chen H, Weiss J, Shahidi F. (2006a). Nanotechnology in nutraceuticals and functional foods. Food Technol 60:30–36.
   Web of Science ®Google Scholar
• Chen Z, Meng H, Xing G, Chen C, Zhao Y, Jia G et al. (2006b). Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett 163:109–120.
   PubMed Web of Science ®Google Scholar
• Chen HS, Chang JH, Wu JSB. (2008). Calcium bioavailability of nanonized pearl powder for adults. J Food Sci 73:H246–H251.
   PubMed Web of Science ®Google Scholar
• Coyle P, Philcox JC, Carey LC, Rofe AM. (2002). Metallothionein: The multipurpose protein. Cell Mol Life Sci 59:627–647.
   PubMed Web of Science ®Google Scholar
• De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE. (2008). Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29:1912–1919.
   PubMed Web of Science ®Google Scholar
• des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V. (2006). Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. J Control Release 116:1–27.
   PubMed Web of Science ®Google Scholar
• Desai MP, Labhasetwar V, Amidon GL, Levy RJ. (1996). Gastrointestinal uptake of biodegradable microparticles: Effect of particle size. Pharm Res 13:1838–1845.
   PubMed Web of Science ®Google Scholar
• Desai MP, Labhasetwar V, Walter E, Levy RJ, Amidon GL. (1997). The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res 14:1568–1573.
   PubMed Web of Science ®Google Scholar
• Doak SH, Griffiths SM, Manshian B, Singh N, Williams PM, Brown AP et al. (2009). Confounding experimental considerations in nanogenotoxicology. Mutagenesis 24:285–293.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia MA, McNeil SE (2007). Immunological properties of engineered nanomaterials. Nat Nanotechnol 2:469–478.
   PubMed Web of Science ®Google Scholar
• Dutta D, Sundaram SK, Teeguarden JG, Riley BJ, Fifield LS, Jacobs JM, et al. (2007). Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials. Toxicol Sci 100:303–315.
   PubMed Web of Science ®Google Scholar
• El-Sayed M, Rhodes CA, Ginski M, Ghandehari H. (2003). Transport mechanism(s) of poly (amidoamine) dendrimers across caco-2 cell monolayers. Int J Pharm 265:151–157.
   PubMed Web of Science ®Google Scholar
• Florence AT. (1997). The oral absorption of micro-and nanoparticulates: Neither exceptional nor unusual. Pharm Res 14:259–266.
   PubMed Web of Science ®Google Scholar
• Florence AT. (2005). Nanoparticle uptake by the oral route: Fulfilling its potential? Drug Discov Today Technol 2:75–81.
   PubMedGoogle Scholar
• Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Moller P. (2009). Oxidatively damaged DNA in rats exposed by oral gavage to C(60) fullerenes and single-walled carbon nanotubes. Environ Health Perspect 117:703–708.
   PubMed Web of Science ®Google Scholar
• Gajdošíková A, Gajdošík A, Koneracká M, Závišová V, Štvrtina S, Krchnárová V et al. (2006). Acute toxicity of magnetic nanoparticles in mice. Neuroendocrinol Lett 27(Suppl. 2):96–99.
   PubMedGoogle Scholar
• Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. (2009). Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci 84:75–80.
   PubMed Web of Science ®Google Scholar
• Gonzalez L, Lison D, Kirsch-Volders M. (2008). Genotoxicity of engineered nanomaterials: A critical review. Nanotoxicology 2:252–273.
   Web of Science ®Google Scholar
• Goodman CM, McCusker CD, Yilmaz T, Rotello VM. (2004). Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 15:897–900.
   PubMed Web of Science ®Google Scholar
• Guo L, Von Dem Bussche A, Buechner M, Yan A, Kane AB, Hurt RH. (2008). Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing. Small 4:721–727.
   PubMed Web of Science ®Google Scholar
• Hagens WI, Oomen AG, de Jong WH, Cassee FR, Sips AJ. (2007). What do we (need to) know about the kinetic properties of nanoparticles in the body? Regul Toxicol Pharmacol 49:217–229.
   PubMed Web of Science ®Google Scholar
• Hall JB, Dobrovolskaia MA, Patri AK, McNeil SE. (2007). Characterization of nanoparticles for therapeutics. Nanomedicine (London) 2:789–803.
   PubMed Web of Science ®Google Scholar
• Hardman R. (2006). A toxicologic review of quantum dots: Toxicity depends on physico-chemical and environmental factors. Environ Health Perspect 114:165–172.
   PubMed Web of Science ®Google Scholar
• Hillery AM, Jani PU, Florence AT. (1994). Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles. J Drug Target 2:151–156.
   PubMed Web of Science ®Google Scholar
• Hillyer JF, Albrecht RM. (2001). Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90:1927–1936.
   PubMed Web of Science ®Google Scholar
• Hoet P, Bruske-Hohlfeld I, Salata O. (2004). Nanoparticles – —Known and unknown health risks. Journal of Nanobiotechnology 2:12.
   PubMedGoogle Scholar
• Huang S, Chen JC, Hsu CW, Chang WH. (2009). Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology 20: Paper 375102.
   Google Scholar
• Hussain N, Jani PU, Florence AT. (1997). Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat. Pharm Res 14:613–618.
   PubMed Web of Science ®Google Scholar
• Hussain N, Florence AT. (1998). Utilizing bacterial mechanisms of epithelial cell entry: Invasin-induced oral uptake of latex nanoparticles. Pharm Res 15:153–156.
   PubMed Web of Science ®Google Scholar
• Hussain N, Jani PU, Florence AT. (1997). Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat. Pharm Res 14:613–618.
   PubMed Web of Science ®Google Scholar
• Ishida T, Harashima H, Kiwada H. (2002). Liposome clearance. Biosci Rep 22:197–1224.
   PubMed Web of Science ®Google Scholar
• Jani P, Halbert GW, Langridge J, Florence AT. (1989). The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J Pharm Pharmacol 41:809–812.
   PubMed Web of Science ®Google Scholar
• Jani P, Halbert GW, Langridge J, Florence AT. (1990). Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J Pharm Pharmacol 42:821–826.
   PubMed Web of Science ®Google Scholar
• Jevprasesphant R, Penny J, Attwood D, McKeown NB, D’Emanuele A. (2003). Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharm Res 20:1543–1550.
   PubMed Web of Science ®Google Scholar
• Jia X, Li N, Chen J. (2005). A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life Sci 76:1989–2003.
   PubMed Web of Science ®Google Scholar
• Jones CF, Grainger DW. (2009). In vitro assessments of nanomaterial toxicity. Adv Drug Deliv Rev 61:438–456.
   PubMed Web of Science ®Google Scholar
• Keller S, Helbig D, Härtl A, Jahreis G. (2007). Nanoscale and customary non-esterified sitosterols are equally enriched in different body compartments of the guinea pig. Mol Nutr Food Res 51:1503–1509.
   PubMedGoogle Scholar
• Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD et al. (2008). Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 20:575–583.
   PubMed Web of Science ®Google Scholar
• Kitchens KM, Foraker AB, Kolhatkar RB, Swaan PW, Ghandehari H. (2007). Endocytosis and interaction of poly (amidoamine) dendrimers with Caco-2 cells. Pharm Res 24:2138–2145.
   PubMed Web of Science ®Google Scholar
• Klimisch H-J Andreae, M, Tillmann U. (1997). A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol 25:1–5.
   PubMedGoogle Scholar
• Koeneman BA, Zhang Y, Hristovski K, Westerhoff P, Chen Y, Crittenden JC et al. (2009). Experimental approach for an in vitro toxicity assay with non-aggregated quantum dots. Toxicol In Vitro 23:955–962.
   PubMed Web of Science ®Google Scholar
• Li HL, Zhao XB, Ma YK, Zhai GX, Li L, Lou HX. (2009). Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release 133:238–244.
   PubMed Web of Science ®Google Scholar
• Li SD, Huang L. (2008). Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm 5:496–504.
   PubMed Web of Science ®Google Scholar
• Longmire M, Choyke PL, Kobayashi H. (2008). Dendrimer-based contrast agents for molecular imaging. Curr Top Med Chem 8:1180–1186.
   PubMed Web of Science ®Google Scholar
• Lovric J, Bazzi HS, Cuie Y, Fortin GR, Winnik FM, Maysinger D. (2005). Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 83:377–385.
   PubMed Web of Science ®Google Scholar
• McCullough JS, Hodges GM, Dickson GR, Yarwood A, Carr KE. (1995). A morphological and microanalytical investigation into the uptake of particulate iron across the gastrointestinal tract of rats. J Submicrosc Cytol Pathol 27:119–124.
   PubMedGoogle Scholar
• Meng H, Chen Z, Xing G, Yuan H, Chen C, Zhao F et al. (2007). Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles. Toxicol Lett 175:102–110.
   PubMed Web of Science ®Google Scholar
• Mori T, Takada H, Ito S, Matsubayashi K, Miwa N, Sawaguchi T. (2006). Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225:48–54.
   PubMed Web of Science ®Google Scholar
• NCI/NCL. (2009). Assay Cascade Protocols. Frederick, (MD): National Cancer Institute (NCI), Nanotechnology Characterization Laboratory (NCL). Available at: http://ncl.cancer.gov/working_assay-cascade.asp. Accessed 14 April 2010.
   Google Scholar
• Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K et al. (2005). Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy (ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group). Part Fibre Toxicol 2: 8 [1-35].
   PubMedGoogle Scholar
• Ogawara K, Yoshida M, Higaki K, Kimura T, Shiraishi K, Nishikawa M et al. (1999). Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution. J Control Release 59:15–22.
   PubMed Web of Science ®Google Scholar
• Owen RL. (1977). Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: An ultrastructural study. Gastroenterology 72:440–41.
   PubMed Web of Science ®Google Scholar
• Pisal DS, Yellepeddi VK, Kumar A, Palakurthi S. (2008). Transport of surface engineered polyamidoamine (PAMAM) dendrimers across IPEC-J2 cell monolayers. Drug Deliv 15:515–522.
   PubMed Web of Science ®Google Scholar
• Poole CP Jr, Owens FJ. (2003). Introduction to Nanotechnology. Hoboken, (NJ): John Wiley & Sons, Inc.
   Google Scholar
• Powers KW, Brown SC, Krishna VB, Wasdo SC, Moudgil BM, Roberts SM. (2006). Research strategies for safety evaluation of nanomaterials. Part VI. characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90:296–303.
   PubMed Web of Science ®Google Scholar
• Rajagopalan P, Wudl F, Schinazi RF, Boudinot FD. (1996). Pharmacokinetics of a water-soluble fullerene in rats. Antimicrob Agents Chemother 40:2262–2265.
   PubMed Web of Science ®Google Scholar
• Rhoades J, Roller S. (2000). Antimicrobial actions of degraded and native chitosan against spoilage organisms in laboratory media and foods. Appl Environ Microbiol 66:80–86.
   PubMed Web of Science ®Google Scholar
• Rogers NJ, Franklin NM, Apte SC, Batley GE. (2007). The importance of physical and chemical characterization in nanoparticle toxicity studies. Integr Environ Assess Manag 3:303–304.
   PubMedGoogle Scholar
• Rohner F, Ernst FO, Arnold M, Hilbe M, Biebinger R, Ehrensperger F et al. (2007). Synthesis, characterization, and bioavailability in rats of ferric phosphate nanoparticles. J Nutr 137:614–619.
   PubMed Web of Science ®Google Scholar
• Rothen-Rutishauser BM, Schurch S, Haenni B, Kapp N, Gehr P. (2006). Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ. Sci. Technol 40:4353–4359.
   PubMed Web of Science ®Google Scholar
• Russell-Jones GJ, Arthur L, Walker H. (1999). Vitamin B12-mediated transport of nanoparticles across Caco-2 cells. Int J Pharm 179:247–255.
   PubMed Web of Science ®Google Scholar
• Salamat-Miller N, Johnston TP. (2005). Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium. Int J Pharm 294:201–216.
   PubMed Web of Science ®Google Scholar
• Schneider K, Schwarz M, Burkholder I, Kopp-Schneider A, Edler L, Kinsner-Ovaskainen A et al. (2009). “ToxRTool”, a new tool to assess the reliability of toxicological data. Toxicol Lett 189:138–144.
   PubMed Web of Science ®Google Scholar
• Shea TB, Ortiz D, Nicolosi RJ, Kumar R, Watterson AC. (2005). Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta. J Alzheimers Dis 7:297–301.
   PubMedGoogle Scholar
• Sinaga E, Jois SD, Avery M, Makagiansar IT, Tambunan US, Audus KL et al. (2002). Increasing paracellular porosity by E-cadherin peptides: Discovery of bulge and groove regions in the EC1-domain of E-cadherin. Pharm Res 19:1170–1179.
   PubMed Web of Science ®Google Scholar
• Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M et al. (2006). Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A 103:3357–3362.
   PubMed Web of Science ®Google Scholar
• Sneller MC, Strober W. (1986). M cells and host defense. J Infect Dis 154:737–741.
   PubMed Web of Science ®Google Scholar
• Sonaje K, Italia JL, Sharma G, Bhardwaj V, Tikoo K, Ravi Kumar MNV. (2007). Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats. Pharm Res 24:899–908.
   PubMed Web of Science ®Google Scholar
• Sonavane G, Tomoda K, Sano A, Ohshima H, Terada H, Makino K. (2008). In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size. Colloids Surf B Biointerfaces 65:1–10.
   PubMed Web of Science ®Google Scholar
• Stern ST, McNeil SE. (2008). Nanotechnology safety concerns revisited. Toxicol Sci 101:4–21.
   PubMed Web of Science ®Google Scholar
• Szentkuti L. (1997). Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucous gel layer of the rat distal colon. J Control Release 46:233–242.
   Web of Science ®Google Scholar
• Tuinier R, de Kruif GC. (2002). Stability of casein micelles in milk. J Chem Phys 117(3):1290–1295.
   Google Scholar
• Volkheimer G, Schulz FH, Aurich I, Strauch S, Beuthin K, Wendlandt, H. (1968). Persorption of particles. Digestion 1(2):78–80.
   PubMedGoogle Scholar
• Wang B, Feng W-Y, Wang T-C, Jia G, Wang M, Shi J-W et al. (2006). Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice. Toxicol Lett 161:115–123.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y et al. (2007). Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–185.
   PubMed Web of Science ®Google Scholar
• Wang L, Nagesha DK, Selvarasah S, Dokmeci MR, Carrier RL. (2008). Toxicity of CdSe nanoparticles in Caco-2 cell cultures. J Nanobiotechnol 6:11.
   PubMedGoogle Scholar
• Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM. (2007). Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 171:99–110.
   PubMed Web of Science ®Google Scholar
• Warheit DB, Sayes CM, Reed KL, Swain KA. (2008). Health effects related to nanoparticle exposures: Environmental, health and safety considerations for assessing hazards and risks. Pharmacol Ther 120:35–42.
   PubMed Web of Science ®Google Scholar
• Weiss J, Takhistov P, Mcclements DJ. (2006). Functional materials in food nanotechnology. J Food Sci 71:R107–R116.
   Web of Science ®Google Scholar
• Weiss J, Gaysinsky S, Davidson M, McClements J (2009). Nanostructured encapsulation systems: Food antimicrobials (Chapter 24). In: Barbosa-Canovas G, editor. Global Issues in Food Science and Technology. London, Engl.: Academic Press, pp. 425–480.
   Google Scholar
• Wolf JL, Bye WA. (1984). The membranous epithelial (M) cell and the mucosal immune system. Annu Rev Med 35:95–112.
   PubMed Web of Science ®Google Scholar
• Xu ZR, Han XY, Wang YZ (2004). Effects on growth and cadmium residues from feeding cadmium-added diets with and without montmorillonite nanocomposite to growing pigs. Vet Hum Toxicol 46:238–241.
   PubMedGoogle Scholar
• Yamago S, Tokuyama H, Nakamura E, Kikuchi K, Kananishi S, Sueki K et al. (1995). In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity. Chem Biol 2:385–389.
   PubMed Web of Science ®Google Scholar
• Yang W, Shen C, Ji Q, An H, Wang J, Liu Q et al. (2009). Food storage material silver nanoparticles interfere with DNA replication fidelity and bind with DNA. Nanotechnology 20: 085102.
   Google Scholar
• Yoksan R, Chirachanchai S. (2008). Amphiphilic chitosan nanosphere: Studies on formation, toxicity, and guest molecule incorporation. Bioorg Med Chem 16:2687–2696.
   PubMed Web of Science ®Google Scholar
• Yoo S, Park GT. (2004). Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin. J Pharm Sci 93:488–495.
   PubMed Web of Science ®Google Scholar
• Yu C-C, Wang J-J, Lee C-L, Lee S-H, Pan T-M. (2008). Safety and mutagenicity evaluation of nanoparticulate red mold rice. J Agric Food Chem 56:11038–11048.
   PubMedGoogle Scholar
• Yuan H, Chen J, Du Y-Z, Hu F-Q, Zeng S, Zhao H-L. (2007). Studies on oral absorption of stearic acid SLN by a novel fluorometric method. Colloids Surf B Biointerfaces 58:157–164.
   PubMed Web of Science ®Google Scholar
• Zha L-Y Xu, Z-R, Wang M-Q Gu, L-Y. (2008). Chromium nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco-2 cell monolayers. J Anim Physiol Anim Nutr 92:131–140.
   PubMedGoogle Scholar
• Zhang J, Gao X, Zhang L, Bao Y. (2001). Biological effects of a nano red elemental selenium. Biofactors 15:27–38.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang H, Yan X, Zhang L. (2005). Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci 76:1099–1109.
   PubMed Web of Science ®Google Scholar