Dermal absorption of benzene in occupational settings: Estimating flux and applications for risk assessment

References

• ACGIH (American Conference of Governmental Industrial Hygienists). (2001). Benzene. Basis for Threshold Limit Value (TLV). Cincinnati, OH: ACGIH.
   Google Scholar
• Adami G, Larese F, Barbieri P, Lo Coco F, Reisenhofer E. (2006). Penetration of benzene, toluene, and xylenes contained in gasolines through human abdominal skin in vitro. Toxicology In Vitro 20:1321–1330.
   PubMed Web of Science ®Google Scholar
• Alikhan A, Farahmand S, Maibach HI. (2009). Correlating percutaneous absorption with physicochemical parameters in vivo in man: Agricultural, steroid, and other organic compounds. J Appl Toxicol 29: 590–596.
   PubMed Web of Science ®Google Scholar
• Barry BW, Harrison SM, Dugard PH. (1985a). Correlation of thermodynamic activity and vapour diffusion through human skin for the model compound, benzyl alcohol. J Pharmacy Pharmacol 37: 84–90.
   PubMed Web of Science ®Google Scholar
• Barry BW, Harrison SM, Dugard PH. (1985b). Vapour and liquid diffusion of model penetrants through human skin; correlation with thermodynamic activity. J Pharmacy Pharmacol 37:226–235.
   PubMed Web of Science ®Google Scholar
• Bird RB, Stewart WE, Lightfoot EN. (2007). Transport Phenomena. Rev. 2nd ed.; NewYork: J. Wiley & Sons: New York.
   Google Scholar
• Blank IH, and McAuliffe BS. (1985). Penetration of benzene through human skin. J Invest Dermatol 85:522–526.
   PubMed Web of Science ®Google Scholar
• Blank IH, and Scheuplein RJ. (1969). Transport into and within the skin. Brit J Dermatol 81:4–10.
   Web of Science ®Google Scholar
• Bowman A, and Maibach HI. (2000). Influence of evaporation and solvent mixtures on the absorption of toluene and n-butanol in human skin in vitro. Ann Occup Hyg 44:125–135.
   PubMedGoogle Scholar
• Brandau R, Lippold BH . (1982). Dermal and Transdermal Absorption. Stuttgart: Wissenschaftliche Verlag Gesellschaft, 257 p., Stuggart, 1982.
   Google Scholar
• Brenner D, Kalnas J, Teitelbaum DT. (1998). Skin absorption of benzene as a contaminant in other solvents. Eur J Oncol 3:399–405.
   Google Scholar
• Brenner D, Kalnas J, Teitelbaum DT. (1999). Chronic myelogenous leukaemia due to skin absorption of benzene as a contaminant in other solvents: A report of two cases. Eur. J. Oncol 4:603–605.
   Google Scholar
• Bronough RL, Stewart RF, Congdon ER, Giles AL. (1982). Methods for in vitro percutaneous absorption studies I. Comparison with in vivo results. Toxicol Appl Pharmacol 62:474–480.
   PubMed Web of Science ®Google Scholar
• Bronaugh RL, and Maibach HI. (1983). In vitro percutaneous absorption. In: Marzulli FN, Maibach HI, eds. Dermatotoxicology, 2nd ed. by Marzulli FN and Maibach HI. New York: Hemisphere Publishing, pp.117–129.
   Google Scholar
• Bronaugh RL, and Stewart RF. (1985). Methods for in vitro percutaneous absorption studies. V. Permeation through damaged skin. J Pharm Sci. 74:1062–1066.
   PubMed Web of Science ®Google Scholar
• Bronaugh RL, Stewart RF, Wester RC, Bucks D, Maibach HI, Anderson J. (1985). Comparison of percutaneous absorption of fragrances by humans and monkeys. Food Chem Toxicol. 23:111–114.
   PubMed Web of Science ®Google Scholar
• Bronaugh RL, Stewart RF, Simon M. (1986a). Method for in vitro percutaneous absorption studies. VII: Use of excised human skin. J Pharm. Sci. 75:1094–1097.
   Google Scholar
• Bronaugh RL, Weingarten DP, Lowe NJ. (1986b). Differential Rates of percutaneous absorption through the eczematous and normal skin of a monkey. J Invest Dermatol. 87:451–453.
   PubMed Web of Science ®Google Scholar
• Brouwer, D.H, Semple, S, Marquart, J,Cherrie, JW. (2001). A dermal model for spray painters. Part I: Subjective exposure modeling of spray paint deposition. Ann Occup Hyg 45:15–23.
   PubMedGoogle Scholar
• Bucks D, Guy RH, Maibach HI. (1991). Effects of occlusion. In: Bronough RL, Maibach HI, eds. In Vitro Percutaneous Absorption: Principles, Fundamentals and Applications. Boca Raton, FL: CRC Press: pp., 85–114.
   Google Scholar
• Bunge AL, and Cleek RL. (1995). A new method for estimating dermal absorption from chemical exposure: 2. Effect of molecular weight and octanol-water partitioning. Pharmaceutical Res 12:88–95.
   PubMed Web of Science ®Google Scholar
• Chilcott RP, Barai N, Beezer AE, Brain SI, Brown MB, Bunge AL, Burgess SE, Cross S, Dalton CH, Dias M, Farinha A, Finnin BC, Gallagher SJ, Green DM, Gunt H, Gwyther RL, Heard CM, Jarvis CA, Kamiyama F, Kasting GB, Ley EE, Lim ST, McNaughton GS, Morris A, Nazemi MH, Pellett MA, DuPlessis J, Quan YS, Raghavan SL, Roberts M, Romonchuk W, Roper CS, Schenk D, Simpson A, Traversa BD, Trottet L, Watkinson a, Wilkinson SC, Williams FM, Yamamoto A, and Hadgraft J. (2005). Inter- and intralaboratory variation of in vitro diffusion cell measurements: An international multicenter study using quasi-standardized methods and materials. J Pharmaceutical Sci 94:632–638.
   PubMed Web of Science ®Google Scholar
• Chowhan ZT, and Pritchard R. (1978). Effect of surfactants on percutaneous absorption of naproxen I: Comparisons of rabbit, rat, and human excised skin. J Pharmaceut Sci. 67:1272–1274.
   PubMed Web of Science ®Google Scholar
• Cleek RL, and Bunge AL. (1993). A new method for estimating dermal absorption from chemical exposure. 1. General approach. Pharmaceutical Res 10:497–506.
   PubMed Web of Science ®Google Scholar
• COSHH Essentials. (2010). http://www.coshh-essentials.org.uk/. Accessed on: July 19, 2010.
   Google Scholar
• EC (European Commission). (2004). Guidance Document on Dermal Absorption Brussels, Belgium: Health and Consumer Protection Directorate-General, Directorate E: Food Safety: Plant Health, Animal Health and Welfare, International Questions. Sanco/222/2000 rev. 7. 19 March 2004.
   Google Scholar
• ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals). (1993). Percutaneous absorption. Monograph No. 20. ECETOC, Brussels, Belgium.: ECETOC.
   Google Scholar
• Feldmann RJ, and Maibach HI. (1967). Regional variation in percutaneous penetration of 14C cortisol in man. J Invest Dermatol. 48:181–183.
   PubMed Web of Science ®Google Scholar
• Fiserova-Bergerova V. (1993). Relevance of occupational skin exposure. Ann Occup Hyg 37:673–685.
   PubMed Web of Science ®Google Scholar
• Fiserova-Bergerova V, Pierce JT, Droz PO. (1990). Dermal absorption potential of industrial chemicals: Criteria for skin notation. Am J Ind Med 17:617–635.
   PubMed Web of Science ®Google Scholar
• Fiserova-Bergerova V. (1993). Relevance of occupational skin exposure. Ann Occ Hyg 37:673–685.
   PubMed Web of Science ®Google Scholar
• Franz TJ. (1975). Percutaneous absorption. On the relevance of in vitro data. J Investigative Dermatology 64:190–196.
   PubMed Web of Science ®Google Scholar
• Franz TJ. (1978). The finite dose technique as a valid in vitro model for the study of percutaneous absorption in man. Curr Probl Dermatol 7:58–68.
   PubMedGoogle Scholar
• Franz TJ.. (1982). Percutaneous absorption of benzene. In: MacFarland HN, ed. Proceedings of the Symposium: The Toxicology of Petroleum Hydrocarbons. MacFarland HN, ed. Washington, DC: American Petroleum Institute, May 1982. pp. 108–114.
   Google Scholar
• Franz TJ. (1984). Percutaneous absorption of benzene. Chapter 5 In: McFalrand HN, ed. Advances in Modern Environmental Toxicology. Vol. 6. McFalrand, HN (ed). Scientific Publishers: Princeton, NJ.: Scientific Publishers, pp. 61–70.
   Google Scholar
• Franz TJ, Lehman PA, Raney SG. (2009). Use of excised human skin to assess the bioequivalence of topical products. Skin Pharmacol Physiol 22:276–286.
   PubMed Web of Science ®Google Scholar
• Frasch FH, and Barbero AM. (2008). The transient dermal exposure: Theory and experimental examples using skin and silicone membranes. J Pharm Sci 97:1578–1592.
   PubMed Web of Science ®Google Scholar
• Frasch FH, and Barbero AM. (2009). A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals. Cutaneous and Ocular Toxicol 28 (3):107–113.
   PubMed Web of Science ®Google Scholar
• Frasch FH, Zang LY, Barbero AM, Anderson SE. (2010). In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles. J Toxicol Environ Health, Part A 73 (20):1394–1405.
   PubMed Web of Science ®Google Scholar
• Gilbert TE. (1971). Rate of evaporation of liquids into air. J Paint Technol 43 (562):93–97.
   Google Scholar
• Hanke J, Dutkiewicz T, Piotrowski J. (1961). The absorption of benzene through human skin. Reprinted in English in 2000 asin: Int J Occup Environ Health 6:104–111.
   Google Scholar
• Hawkins GS, and Reifenrath WG. (1986). Influence of skin source, penetration cell fluid, and partition coefficient on in vitro skin penetration. J Pharmaceut Sci 75:378–381.
   PubMed Web of Science ®Google Scholar
• Hui X, Wester RC, Barbadillo S, Cashmore A, Maibach HI. (2009). In vitro percutaneous absorption of benzene in human skin. Cutan Ocular Toxicol 28:65–70.
   PubMed Web of Science ®Google Scholar
• IPCS (International Programme on Chemical Safety). (2004). Harmonization Document No. 1. IPCS Risk Assessment Terminology. Part 1: IPCS/OECD Key Generic Terms Used in Chemical Hazard/Risk Assessment. Part 2: IPCS Glossary of Key Exposure Assessment Terminology. Geneva, Switzerland: World Health Organization (WHO) Press, 2004.
   Google Scholar
• Jacobs RR, and Phanprasit W. (1993). An in vitro comparison of the permeation of chemicals in vapor and liquid phase through pig skin. Am Ind Hyg Assoc J 54:569–575.
   PubMed Web of Science ®Google Scholar
• Jakasa I, and Kezic S. (2008). Evaluation of in vivo animal and in vitro models for prediction of dermal absorption in man. Human Experimental Toxicol 27:281–288.
   PubMed Web of Science ®Google Scholar
• Jakobson I, Wahlberg JE, Holmberg B, Johansson G. (1982). Uptake via the blood and elimination of 10 organic solvents following epicutaneous exposure of anesthetized guinea pigs. Toxicol. Appl. Pharmacol. 63:181–187.
   PubMed Web of Science ®Google Scholar
• Kurihara-Bergstrom, T. G. L., Flynn GL, Higuchi WI. (1986). Physicochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: Kinetic and thermodynamic determinants of dimethyl sulfoxide mediated mass transfer of alkanols. J Pharmaceutical Sci 75:479–486.
   PubMed Web of Science ®Google Scholar
• Laitinen J, Kangas J, Pekari K, Liesivuori J. (1994). Short time exposure to benzene and gasoline at garages. Chemosphere 28:197–205.
   Web of Science ®Google Scholar
• Leung H.W., D.J. Paustenbach DJ. (1994). Techniques for estimating the percutaneous absorption of chemicals due to occupational and environmental exposure. Appl. Occup. Environ. Hyg, 9:187–197.
   Google Scholar
• Loden M. (1985). The in vitro hydrolysis of diisopropyl fluorophosphate during penetration trhough human full-thickness skin and isolated epidermis. J Invest Dermatology 85:335–339.
   PubMed Web of Science ®Google Scholar
• Loden M. (1986a). The in vitro permeability of human skin to benzene, ethylene glycol, formaldehyde, and n-Hexane. Acta Pharmacol et Toxicol 58:382–389.
   PubMedGoogle Scholar
• Loden M. (1986b). The effect of 4 barrier creams on the absorption of water, benzene, and formaldehyde into excised human skin. Contact Dermatitis 14:292–296.
   PubMed Web of Science ®Google Scholar
• Maibach HI, and Anjo DM. (1981). Percutaneous penetration of benzene and benzene contained in solvents used in the rubber industry. Arch Environ Health 36:256–260.
   PubMed Web of Science ®Google Scholar
• Maibach HI, Feldmann RJ, Milby TH, Serat WF. (1971). Regional variation in percutaneous penetration in man. Arch Environ Health 23:208–211.
   PubMed Web of Science ®Google Scholar
• Marquart, J, Brouwer DH, Gijsbers JHJ, Links IHM, Warren N, van Hemmen JJ. (2003). Determinants of dermal exposure relevant for exposure modeling in regulatory risk assessment. Ann Occup Hyg 47:599–607.
   PubMedGoogle Scholar
• Marzulli FN. (1962). Barriers to skin penetration. J Invest Dermatol 39:397–393.
   Web of Science ®Google Scholar
• Marzulli FN, Brown DWC, Maibach HI. (1969). Techniques for studying skin penetration. Toxicol Appl Pharmacol, Supplement 3:76–83.
   Google Scholar
• Marzulli FN. (1962). Barriers to skin penetration. J Invest Dermatol. 39:397–393.
   Web of Science ®Google Scholar
• McDougal JN, and Boeniger MF. (2002). Methods for assessing risks of dermal exposures in the workplace. Crit Rev Toxicology 32:291–327.
   PubMed Web of Science ®Google Scholar
• McDougal JN, Jepson GW, Clewell HJ, Gargas ML, Andersen ME. (1990). Dermal absorption of organic chemical vapors in the rats and humans. Fundam Appl Toxicol 14:299–308.
   PubMedGoogle Scholar
• Modjtahedi BS, and Maibach HI. (2008). In vivo percutaneous absorption of benzene in man: Forearm and palm. Food Chemical Toxicol 46:1171–1174.
   PubMed Web of Science ®Google Scholar
• Morgan DL, Copper SW, Carlock DL, Sykora JJ, Sutton B, Mattie DR, McDougal JN. (1991). Dermal absorption of neat and aqueous volatile organic chemicals in the Fischer 344 rat. Environ Res 55:51–63.
   PubMed Web of Science ®Google Scholar
• Monash University. (2001). Lympho-haematopoietic Cancer and Exposure to Benzene in the Australian Petroleum Industry: Technical Report and Appendices. Monash University and Deakin University, June 2001.
   Google Scholar
• Nakai JS, Chu I, Li-Muller A, Aucoin R. (1997). Effect of environmental conditions on the penetration of benzene through human skin. J Toxicol Environ Health 51:447–462.
   PubMed Web of Science ®Google Scholar
• Nies E, and Korinth G. (2008). Commentary on “Penetration of benzene, toluene and xylenes contained in gasolines through human abdominal skin in vitro”. Toxicology In Vitro 21:275–277.
   Google Scholar
• NIOSH (National Institute for Occupational Safety and Health). (2003). NIOSH Manual of Analytic Methods. http://www.cdc.gov/niosh/nmam. Accessed on: July 19, 2010.
   Google Scholar
• NIOSH (National Institute for Occupational Safety and Health). (2009). Current Intelligence Bulletin 61: A Strategy for Assigning New NIOSH Skin Notations. Cincinnati, OH: National Institute for Occupational Safety and Health. DHHS (NIOSH) Publication No. 2009–147. July 2009.
   Google Scholar
• OECD (Organisation for Economic Cooperation and Development). (2004a). OECD guideline for the testing of chemicals: Skin absorption: In vivo method. No. 427. Paris, France: Organisation for Economic Cooperation and Development. Adopted 13 April 2004.
   Google Scholar
• OECD (Organisation for Economic Cooperation and Development). (2004b). OECD guideline for the testing of chemicals: Skin absorption: In vitro method. No. 428. Paris, France: Organisation for Economic Cooperation and Development. Adopted 13 April 2004.
   Google Scholar
• Oppl R. F., Kalberlah F. P. G., Evans PG, and J. J. Van Hemmen JJ. (2003). A toolkit for dermal risk assessment and management: An overview. Ann Occ Hyg 47:629–640.
   PubMedGoogle Scholar
• OSHA (Occupational Safety and Health Administration). (1987). 29 CFR Part 1910: Occupational Exposure to Benzene; Final Rule Federal Register. Vol. 52, No. 176. Sept 11, 1987. pp. 34460–34578.
   Google Scholar
• OSHA (Occupational Safety and Health Administration). (1989). Medical surveillance guidelines for benzene. Occupational Safety and Health Standards, Toxic and Hazardous Substances. http://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=10045. Accessed on: July 19, 2010.
   Google Scholar
• OSHA (Occupational Safety and Health Administration). (2002). Benzene sampling and analytical methods. http://www.osha.gov/dts/sltc/methods/validated/1005/1005.html. Accessed on: July 19, 2010.
   Google Scholar
• Riviere J. (2005). Chemical Mixtures. Chapter 14 in Dermal Absorption Models in Toxicology and Pharmacology. JE Riviere (ed), Boca Raton, FL:: Taylor & Francis Group, p. 283–304.
   Google Scholar
• Ross JH, Dong MH, Krieger RI. (2000). Conservatism in pesticide exposure assessment. Reg Toxicol Pharmacol 31:53–58.
   PubMed Web of Science ®Google Scholar
• Sahmel J, Boeniger M, Knutsen J, ten Berge W, Fehrenbacher M.C. (2009). Dermal exposure modeling. Chapter 13, pp. 105–132, In: Keil C, Simmons C, Anthony R, eds. Mathematical Models for Estimating Occupational Exposure to Chemicals, 2nd ed. Keil C, Simmons, C and Anthony, R., eds. Fairfax, VA: American Industrial Hygiene Association Press, 105–132.
   Google Scholar
• Scheuplein RJ. (1965). Mechanisms of percutaneous adsorption. I. Routes of penetration and the influence of solubility. J Invest Dermatol 45:334–345.
   PubMed Web of Science ®Google Scholar
• Schneider, T, Vermeulen R, Brouwer DH, Cherrie JW, Kromhout H, Fogh CL. (1999). Conceptual model for assessment of dermal exposure. Occup. Environ. Med. 56:765–773.
   Web of Science ®Google Scholar
• Schneider T., et al. (2000). Dermal exposure assessment. Ann Occup Hyg 44:493–499.
   PubMed Web of Science ®Google Scholar
• Sheehan P, Bogen KT, Hicks J, Goswami E, Brorby G, Lau EC, and Ott B. (2010). Benzene inhalation by parts washers: New estimates based on measures of occupational exposure to solvent coaromatics. Risk Analy 30:1249–1267.
   PubMed Web of Science ®Google Scholar
• Stempfer BN, and Bunge AL. (2004). How much chemical in the skin will evaporate? Presentation Presented at Perspectives in Percutaneous Penetration (PPP) Conference, 13-17 April, 2004. La Grande Motte, France.
   Google Scholar
• Susten AS, Dames BL, Burg JR, Niemeier RW. (1985). Percutaneous penetration of benzene in hairless mice: An estimate of dermal absorption during tire-building operations. Am J Ind Med 7:323–335.
   PubMed Web of Science ®Google Scholar
• Susten AS, Dames BL, Niemeier RW. (1986). In vivo percutaneous absorption studies of volatile solvents in hairless mice. I. Description of a skin-depot. J Appl Toxicol 6:43–46.
   PubMed Web of Science ®Google Scholar
• Susten AS, Niemeier RW, Simon SD. (1990). In vivo percutaneous absorption studies of volatile solvents in hairless mice. II. Toluene, ethyl benzene, and aniline. J Appl Toxicol 10: 217–225.
   PubMed Web of Science ®Google Scholar
• Thrall KD, Poet TS, Corley RA, Tanofo H, Edwards JA, Weitz KK, Hui X, Maibach HI, Wester RC. (2000). A real-time in vivo method for studying the percutaneous absorption of volatile chemicals. Int J Occup Environ Health 6:96–103.
   PubMedGoogle Scholar
• Treffel P, Muret P, Muret-D′Aniello P, Coumes-Marquet S, Agache P. (1992). Effect of occlusion on in vitro percutaneous absorption of two compounds with different physicochemical properties. Skin Pharmacol 5:108–113.
   PubMedGoogle Scholar
• Tsuruta H. (1982). Percutaneous absorption of organic solvents. III. On the penetration rates of hydrophobic solvents through the excised rat skin. Ind Health 20: 335–345.
   PubMedGoogle Scholar
• Tsuruta H. (1996). Skin absorption of solvent mixtures: Effect of vehicles on skin absorption of toluene. Ind Health 34:369–378.
   PubMed Web of Science ®Google Scholar
• US EPA (US Environmental Protection Agency). (1992). Dermal Exposure Assessment: Principles and Applications. Interim Report. Washington, DC: Office of Health and Environmental Assessment, Exposure Assessment Group. EPA/600/8-91/011B. January 1992.
   Google Scholar
• US EPA (US Environmental Protection Agency). (1997). Exposure Factors Handbook. Washington, DC: Office of Research and Development, National Center for Environmental Assessment. EPA/600/P-95/002Fa. August 1997.
   Google Scholar
• US EPA (US Environmental Protection Agency). (2004). Risk Assessment Guidance for Superfund (RAGS). Volume I: Human Health Evaluation Manual (Part E, Supplemental Guidance for Dermal Risk Assessment). Washington, DC: Office of Superfund Remediation and Technology Innovation. EPA/540/R/99/005. July 2004.
   Google Scholar
• US EPA (US Environmental Protection Agency). (2007). Dermal Exposure Assessment: A Summary of EPA Approaches. Washington, DC: National Center for Environmental Assessment, Office of Research and Development. EPA/600/R-07/040F. September 2007.
   Google Scholar
• US EPA (US Environmental Protection Agency). (2010). Chemical Screening Tool for Exposures and Environmental Releases. Washington, DC: Office of Pollution Prevention and Toxics. http://www.epa.gov/opptintr/exposure/pubs/chemsteer.htm Accessed on: July 19, 2010.
   Google Scholar
• van Wendel de Joode B, Brouwer DH, Vermeulen R, van Hemmen JJ, Heederick D, Kromhout H. (2003). DREAM: A method for semi-quantitative dermal exposure assessment. Ann Occup Hyg 47:71–87.
   PubMed Web of Science ®Google Scholar
• Vecchia BE, and Bunge AL. (2005). Animal models: A comparison of permeability coefficients for excised skin from humans and animals. In: Riviere JE, ed.Chapter 15 in Dermal Absorption Models in Toxicology and Pharmacology. J.E. Riviere (ed), Boca Raton, FL: Taylor & Francis Group: Boca Raton, p., 303–365.
   Google Scholar
• Wahlberg JE. (1976). Percutaneous toxicity of solvents: A comparative investigation in the guinea pig with benzene, toluene, and 1,1,2-trichloroethane. Ann Occup Hyg 19:115–119.
   PubMedGoogle Scholar
• Walker JD, Whittaker C, and McDougal JN. (1996). Role of the TSCA Interagency Testing Committee in meeting the U.S. Government′s data needs: Designating chemicals for percutaneous absorption testing,. In: Marzulli FN, Maibach HI, eds. Dermatotoxicology, Eds, 5th ed. Washington, DC: Hemisphere Publishing Corporation, pp. 371–381.
   Google Scholar
• Warren ND, Marquart H, Christopher Y, Laitinen J, and Van Hemmen JJ. (2006). Task-based dermal exposure models for regulatory risk assessment. Ann Occup Hyg 50:491–503.
   PubMed Web of Science ®Google Scholar
• Wester RC, Maibach HI. (2000). Benzene percutaneous absorption: Dermal exposure relative to other benzene sources. Int J Occup Environ Health 6:122–126.
   PubMedGoogle Scholar
• Wester RC, and Noonan PK. (1980). Relevance of animal models for percutaneous absorption. Int J Pharmaceutics 7:99–110.
   Web of Science ®Google Scholar
• Wester RC and Maibach HI. (2000). Benzene percutaneous absorption: Dermal exposure relative to other benzene sources. Int J Occup Environ Health 6:122–126.
   PubMedGoogle Scholar
• Williams FM. (2006). In vitro studies – —How good are they at replacing in vivo studies for measurement of skin absorption? Environ Toxicol Pharmacol 21:199–203.
   PubMed Web of Science ®Google Scholar
• Williams PRD, and Paustenbach DJ. (2003). Reconstruction of benzene exposure for the pliofilm cohort (1936–1976) using Monte Carlo techniques. J Toxicol Environ Health Part A 66:677–781.
   PubMed Web of Science ®Google Scholar
• WHO (World Health Organization). (2006). Environmental Health Criteria 235: Dermal Absorption. Geneva: WHO Press.
   Google Scholar
• Zendzian RP, and Dellarco M. (2003). Validating in vitro dermal absorption studies: An introductory case study. Chapter 18 In: Salem H, Katz SA, eds. Alternative Toxicological Methods. Harry Salem and Sidney A. Katz (eds). CRC Press, Boca Raton, FL.: CRC Press, 207–220.
   Google Scholar