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Review Article

Methyl methacrylate and respiratory sensitization: A Critical review

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Pages 230-268 | Received 23 Jul 2010, Accepted 14 Oct 2010, Published online: 14 Mar 2011

References

  • ADA. (2007). Distributions of Dentists in the US by Region and State. Chicago: American Dental Association.
  • ADA. (2008). 2008 Survey of Dental Practice: Employment of Dental Practice Personnel. Chicago: American Dental Association.
  • Agius RM. (2000). Why are some low-molecular-weight agents asthmagenic. Occup Med. 15:369–383.
  • Agius RM, Elton RA, Sawyer L, Taylor P. (1994). Occupational asthma and the chemical properties of low molecular weight organic substances. Occup Med. 44:34–36.
  • Agius RM, Nee J, McGovern B, Robertson A. (1991). Structure activity hypotheses in occupational asthma caused by low molecular weight substances. Ann Occup Hyg. 35:129–137.
  • AHRQ. (2002). Management of Allergic and Nonallergic Rhinitis: Evidence Report/Technology Assessment Number 54. (AHRQ Publication No. 02-E024). Rockville, MD: Agency for Health Care Research and Quality, US Department of Health and Human Services. Available at: at: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hserta&part=A82200#A82204. Accessed June 15, 2010.
  • Alarie Y. (1973a). Sensory irritation by airborne chemicals. CRC Crit Rev Toxicol. 2:299–363.
  • Alarie Y. (1973b). Sensory irritation of the upper airways by airborne chemicals. Toxicol Appl Pharmacol. 24:279–297.
  • Alarie Y, Nielsen GD, Andonian-Haftvan J, Abraham MH. (1995). Physicochemical properties of nonreactive volatile organic chemicals to estimate RD50: Alternatives to animal studies. Toxicol Appl Pharmacol. 134:92–99.
  • Aleksic M, Thain E, Roger D, Saib O, Davies M, Li J, Aptula A, Zazzeroni R. (2009). Reactivity profiling: Covalent modification of single nucleophile peptides for skin sensitization risk assessment. Toxicol Sci. 108:401–411.
  • ATS. (1979). Standardization of spirometry. Am Rev Respir Dis. 119:831–838.
  • ATS. (1987). Standardization of spirometry—1987 update. Am Rev Respir Dis. 136:1285–1298.
  • Arts JH, de Jong WH, van Triel JJ, Schijf MA, De Klerk A, van Loveren H, Kuper CF. (2008). The respiratory local lymph node assay as a tool to study respiratory sensitizers. Toxicol Sci. 106:423–434.
  • Arts JH, Kuper CF. (2007). Animal models to test respiratory allergy of low molecular weight chemicals: A guidance. Methods. 41:61–71.
  • Arts JH, Kuper CF, Spoor SM, Bloksma N. (1998). Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals. Toxicol Appl Pharmacol. 152:66–76.
  • ASTM. (2004). Standard Test method for estimating sensory irritancy of airborne chemicals. (ASTM E981-04). West Conshohocken: ASTM International.
  • Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K, Mapp C, Milton D, Schwartz D, Toren K, Viegi G. (2003). American thoracic society statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med. 167:787–797.
  • Balmes JR. (1991). Surveillance for occupational asthma,. In: Harber P, Balmes JR, eds. Prevention of Pulmonary Disease in the Workplace: State of the Art Reviews in Occupational Medicine (6/1). Harber P, Balmes, eds. Philadelphia: Hanley & Belfus. pp, 101–110.
  • Banks DE, Jalloul A. (2007). Occupational asthma, work-related asthma and reactive airways dysfunction syndrome. Curr Opin Pulmon Med. 13:131–136.
  • Basker RM, Hunter AM, Highet AS. (1990). A severe asthmatic reaction to poly(methyl methacrylate) denture base resin. Br Dent J. 169:250–251.
  • Basketter D, Ball N, Cagen S, Carillo JC, Certa H, Eigler D, Garcia C, Esch H, Graham C, Haux C, Kreiling R, Mehling A. (2009a). Application of a weight of evidence approach to assessing discordant sensitisation datasets: Implications for REACH. Regul Toxicol Pharmacol. 55:90–96.
  • Basketter DA, Balikie L, Dearman R, Kimber I, Ryan CA, Gerberick GF, Harvey P, Evans P, White IR, Rycroft RJ. (2000). Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Dermatitis. 42:344–348.
  • Basketter DA, McFadden JF, Gerberick F, Cockshott A, Kimber I. (2009b). Nothing is perfect, not even the local lymph node assay: A commentary and the implications for REACH. Contact Dermatitis. 60:65–69.
  • Basketter DA, Seibel E, Scholes EW, Lees D, Kimber I, Botham PA. (1993). Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays. Food Chem Toxicol. 31:63–67.
  • Beach J, Rowe BH, Blitz S, Crumley E, Hooton N, Russell K, Spooner C, Klaasen T. (2005). Diagnosis and management of work-related asthma. Evid Rep Technol Assess (Summ). 129:1–8.
  • Berger A. (2000). Th1 and Th2 responses: What are they? Br Med J. 321:424–424.
  • Bernstein DI, Campo P, Baur X., (2006a). Clinical assessment and management of occupational asthma,. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 161–178.
  • Bernstein IL, Berstein DI, Chan-Yeung M, Malo JL. (2006b). Definition and classification of asthma in the workplace,. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace: and: And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 1–8.
  • Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, Sicherer S, Golden DBK, Kahn DA, Nicklas RA, et al. (2008). Allergy diagnostic testing: An updated practice parameter. Ann Allergy Asthma Immunol. 100:S1–S148
  • Betts CJ. (2004). MMA (Methylmethacrylate): Local Lymph Node Assay. Macclesfield, UK: Central Toxicology Laboratory.
  • Betts CJ, Dearman RJ, Heylings JR, Kimber I, Basketter DA. (2006). Skin sensitization potency of methyl methacrylate in the local lymph node assay: Comparisons with guinea-pig data and human experience. Contact Dermatitis. 55:140–147.
  • Bohme A, Thaens D, Paschke LL, Schuurmann G. (2009). Kinetic glutathione chemoassay to quantify thiol reactivity of organic electrophiles—Application to alpha,beta-unsaturated ketones, acrylates, and propiolates. Chem Res Toxicol. 22:742–750.
  • Boman A, Jacobsen D, Klastrup S, Svendsen O, Wahlberg JE. (1996). Potency Evaluation of Contact Allergens. Dose-Response Studies Using the Guinea Pig Maximization Test. Lille Skensved, Denmark: Department of Occupational Dermatology, National Institute of Occupational Health.
  • Bos PMJ, Busschers M, Arts JHE. (2002). Evaluation of the sensory irritation test (Alarie test) for the assessment of respiratory tract irritation. J Occup Environ Med. 44:968–976.
  • Boulet LP. (1988). Increases in airway responsiveness following acute exposure to respiratory irritants: Reactive airway dysfunction syndrome or occupational asthma. Chest. 94:476–481.
  • Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, et al. (2008). Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 63 (Suppl 86):8–160.
  • Boverhof DR, Billington R, Gollapudi BB, Hotchkiss JA, Krieger SM, Poole A, Wiescinski CM, Woolhiser MR. (2008). Respiratory sensitization and allergy: Current research approaches and needs. Toxicol Appl Pharmacol. 226:1–13.
  • Bratt H, Hathway DE. (1977). Fate of methyl methacrylate in rats. Br J Cancer. 36:114–119.
  • Briatico-Vangosa G, Braun CL, Cookman G, Hofmann T, Kimber I, Loveless SE, Morrow T, Pauluhn J, Sorensen T, Niessen HJ. (1994). Respiratory allergy: Hazard identification and risk assessment. Fundam Appl Toxicol. 23:145–158.
  • Brooks SM, Weiss MA, Bernstein IL. (1985). Reactive airways dysfunction syndrome (RADS): Persistent asthma syndrome after high level irritant exposures. Chest. 88:376–384.
  • Buckley LA, James RA, Barrow CS. (1984). Differences in nasal cavity toxicity between rats and mice exposed to acrylic vapor. Toxicologist. 4:1.
  • Buehler EV. (1965). Delayed contact hypersensitivity in the guinea pig. Arch Dermatol. 91:171–177.
  • Bull JE, Parker D, Turk JL. (1985). Predictive value of assessment of lymph node weight and T-lymphocyte proliferation in contact sensitivity in acrylates. J Invest Dermatol. 85:403–406.
  • BLS. (2010). Occupational Outlook Handbook, 2010–11 Edition. Washington, DC: US Department of Labor. Available at: http://www.bls.gov/oco/. Accessed June 15, 2010.
  • Burge PS. (1982). Single and serial measurements of lung function in the diagnosis of occupational asthma. Eur J Respir Dis. 63 (Suppl 123):47–59.
  • Burge PS, Moscato G, Johnson A, Chan-Yeung M. (2006). Physiological assessment: Serial measurements of lung function and bronchial responsiveness,. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 199–226.
  • Cameron LA, Taha RA, Tsicopoulos A, Kurimoto M, Olivenstein R, Wallaert B, Minshall EM, Hamid QA. (1999). Airway epithelium expresses interleukin-18. Eur Respir J. 14:553–559.
  • Campo P, Wisnewski AV, Lummus Z, Cartier A, Malo JL. (2007). Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI-exposed workers. Clin Exp Allergy. 37:1095–1102.
  • Cary R. (1995). Methyl Methacrylate. Criteria Document for an Occupational Exposure Limit. London: Health and Safety Executive.
  • Cavelier C, Jelen G, Herve-Bazin B, Foussereau J. (1981a). Irritation and allergy to acrylates and methacrylates.—Part I: Common monoacrylates and monomethacrylates. Ann Dermatol Venereol. 108:549–556.
  • Cavelier C, Jelen G, Herve-Bazin B, Foussereau J. (1981b). Irritation and allergy to acrylates and methacrylates.—Part II. Polyfunctional acrylic monomers (author’s transl) (article in French). Ann Dermatol Venereol. 108:559–566.
  • CEFIC. (1995). Occupational Exposure and Environmental Emissions—Methyl Methacrylate. Brussels: CEFIC Methacrylates Sector Group and the Methacrylates Producers Association.
  • Cerveri I, Bruschi C, Zoia MC, Maccarini L, Grassi M, Lebowitz MD, Rampulla C, Grassi C. (1989). Smoking habit and bronchial reactivity in normal subjects. A population-based study. Am Rev Respir Dis. 140:191–196.
  • Chan PC, Eustis SL, Huff JE, Haseman JK, Ragan H. (1988). Two-year inhalation carcinogenesis studies of methyl methacrylate in rats and mice: Inflammation and degeneration of nasal epithelium. Toxicology. 52:237–252.
  • Chan K, O’Brien O’Brien PJ. (2008). Structure-activity relationships for hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated esters, acrylates and methacrylates. J Appl Toxicol. 28:1004–1015.
  • Chung CW, Giles AL Jr. (1977). Sensitization potentials of methyl, ethyl, and n-butly methacrylates and mutual cross-sensitivity in guinea pigs. J Invest Dermatol. 68:187–190.
  • Clemmensen S. (1984). Cross-reaction patterns in guinea pigs sensitized to acrylic monomers. Drug Chem Toxicol. 7:527–540.
  • Collins JJ, Page LC, Caporossi JC, Utidjian HM, Saipher JN. (1989). Mortality patterns among men exposed to methyl methacrylate. J Occup Med. 31:41–46.
  • Connolly M, McAdoo J, Bourke JF. (2007). Gentamicin-induced anaphylaxis. Irish J Med Sci. 176:317–318.
  • Corsini E, Mitjans M, Galbiati V, Lucchi L, Galli CL, Marinovich M. (2009). Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens. Toxicol In Vitro. 23:789–796.
  • Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, Cockcroft DW, Fish JE, Sterk PJ. (2000). Guidelines for methacholine and exercise challenge testing—1999. Am J Respir Crit Care Med. 161:309–329.
  • Cromer J. (1976). A Study of Methyl Methacrylate Exposures and Employee Health (PB274–789). Washington, DC: National Institute for Occupational Safety and Health.
  • Crout DH, Lloyd EJ, Singh J. (1982). Metabolism of methyl methacrylate: Evidence for metabolism by the valine pathway of catabolism in rat and in man. Xenobiotica. 12:821–829.
  • Cunningham AR, Cunningham SL, Consoer DM, Moss ST, Karol MH. (2005). Development of an information-intensive structure-activity relationship model and its application to human respiratory chemical sensitizers. SAR & QSAR Environ Res. 16:273–285.
  • Darre E, Vedel P, Jensen JS. (1987). Air concentrations of methyl methacrylate monomer after mixing different acrylic bone cements. Adv Orthop Surg. 10:258–259.
  • de Jong WH, Arts JH, De Klerk A, Schijf MA, Ezendam J, Kuper CF, van Loveren H. (2009). Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure. Toxicology. 261:103–111.
  • Dearman RJ, Betts CJ, Caddick HT, Flanagan BF, Kimber I. (2008). Cytokine profiling of chemical allergens in mice: Measurement of message versus protein. Toxicology. 252:17–25.
  • Dearman RJ, Betts CJ, Farr C, McLaughlin J, Berdasco N, Wiench K, Kimber I. (2007). Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assay. Contact Dermatitis. 57:242–247.
  • Dearman RJ, Betts CJ, Humphreys N, Flanagan BF, Gilmour NJ, Basketter DA, Kimber I. (2003a). Chemical allergy: Considerations for the practical application of cytokine profiling. Toxicol Sci. 71:137–145.
  • Dearman RJ, Moussavi A, Kemeny DM, Kimber I. (1996). Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Immunology. 89:502–510.
  • Dearman RJ, Skinner RA, Humphreys NE, Kimber I. (2003b). Methods for the identification of chemical respiratory allergens in rodents: Comparisons of cytokine profiling with induced changes in serum IgE. J Appl Toxicol. 23:199–207.
  • DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP. (1981). Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett. 9:137–143.
  • Delbressine LPC, Seutter-Berlage R, Seutter E. (1981). Identification of urinary mercapturic acids formed from acrylate, metacrylate and crotonate in the rat. Xenobiotica. 11:241–247.
  • Della Torre L, Valsecchi F, Sala C, Cesana MA. (1982). Evaluation of occupational risk and biological effects in a factory of polymethylmethacrylate sheets. Lavoro Umano. 30:72–79.
  • Desai D, Brightling C. (2009). Cytokine and anti-cytokine therapy in asthma: Ready for the clinic? Clin Exp Immunol. 158:10–19.
  • Descotes J. (1988). Identification of contact allergens: The mouse ear sensitization assay. J Toxicol Cutan Ocular Toxicol. 7:263–272.
  • Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, Li JT, Bernstein IL, Berger W, Spector S, Schuller D. (1998). Diagnosis and management of rhinitis: Complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immun. 81:478–518.
  • ECETOC. (1995). Joint Assessment of Commodity Chemicals No. 30. Methyl Methacrylate (CAS No. 80-62-6). Brussels: European Chemical Industry Ecology and Toxicology Centre.
  • ECETOC.(2003). Technical Report No. 87: Contact Sensitisation: Classification According to Potency. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals.
  • ECETOC.(2008). Document No. 46: Potency Values from the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals.
  • Ellis AK, Keith PK. (2006). Nonallergic rhinitis with eosinophilia syndrome. Curr Allergy Asthma Rep. 6:215–220.
  • Elovaara E, Kivisto H, Vainio H. (1983). Effects of methyl methacrylate on non-protein thiols and drug metabolizing enzymes in rat liver and kidneys. Arch Toxicol. 52:109–121.
  • Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA. (1976). Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 113:131–139.
  • Enoch SJ, Cronin MT, Schultz TW, Madden JC. (2008). Quantitative and mechanistic read across for predicting the skin sensitization potential of alkenes acting via Michael addition. Chem Res Toxicol. 21:513–520.
  • Enoch SJ, Roberts DW, Cronin MTD. (2009). Electrophilic reaction chemistry of low molecular weight respiratory sensitizers. Chem Res Toxicol. 22:1447–1453.
  • Enoch SJ, Roberts DW, Cronin MT. (2010). Mechanistic category formation for the prediction of respiratory sensitization. Chem Res Toxicol,. (in press). Epub ahead of print, (atdoi: http://pubs.acs.org/doi/abs/10.1021/tx100218h).
  • EPA. (1994). Methyl Methacrylate: Fact Sheet (EPA 749-F-95-014a). Washington, DC: US Environmental Protection Agency.
  • EPA. (1998). Toxicological Review of Methyl Methacrylate (CAS No. 80-62-6. Washington, DC: US Environmental Protection Agency. Available at: http://www.epa.gov/ncea/iris/toxreviews/1000tr.pdf. Accessed June 15, 2010.
  • EPA. (2003). Health Effects Test Guidelines. OPPTS 870.2600 Skin Sensitization (EPA 712-C-030197). Washington, DC: U.S. Environmental Protection Agency (EPA).
  • EPA. (2007). Protecting the Health of Nail Salon. Washington, DC: US Environmental Protection Agency. Available Workers at: http://www.epa.gov/dfe/pubs/projects/salon/index.htm. Accessed June 15, 2010.
  • Espehaug B, Furnes O, Havelin LI, Engesaeter LB, Vollset SE, Kindseth O. (2006). Registration completeness in the Norwegian Arthroplasty Register. Acta Orthop. 77:49–56.
  • EU. (2002). European Union Risk Assessment Report: Methyl Methacrylate. Luxembourg: European Communities.
  • Francis HC, Prys-Picard CO, Fishwick D, Stenton C, Burge PS, Bradshaw LM, Ayres JG, Campbell SM, Niven RM. (2007). Defining and investigating occupational asthma: A consensus approach. Occup Environ Med. 64:361–365.
  • Frederick CB, Reynolds CH. (1989). Modeling the reactivity of acrylic acid and acrylate anion with biological nucleophiles. Toxicol Lett. 47:241–247.
  • Freidig AP, Verhaar HJM, Hermens JLM. (1999). Quantitative structure-property relationships for the chemical reactivity of acrylates and methacrylates. Environ Toxicol Chem. 18:1133–1139.
  • Fujisawa S, Atsumi T, Kadoma Y. (2000). Cytotoxicity of methyl methacrylate (MMA) and related compounds and their interaction with dipalmitoylphosphatidylcholine (DPPC) liposomes as a model for biomembranes. Oral Dis. 6:215–221.
  • Fujisawa S, Kadoma Y. (2009). Prediction of the reduced glutathione (GSH) reactivity of dental methacrylate monomers using NMR spectra—Relationship between toxicity and GSH reactivity. Dent Mater J. 28:722–729.
  • Gad SC, Dunn BJ, Dobbs DW, Reilly C, Walsh RD. (1986). Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST). Toxicol Appl Pharmacol. 84:93–114.
  • Gautrin D, Bernstein IL, Brooks SM, Henneberger PK. (2006). Reactive airways dysfunction syndrome and irritant-induced asthma,. in In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 581–629.
  • Gerberick F, Aleksic M, Basketter D, Casati S, Karlberg AT, Kern P, Kimber I, Lepoittevin JP, Natsch A, Ovigne JM, Rovida C, Sakaguchi H, Schultz T. (2008). Chemical reactivity measurement and the predictive identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64. Altern Lab Anim. 36:215–242.
  • Gerberick GF, Ryan CA, Dearman RJ, Kimber I. (2007a). Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals. Methods. 41:54–60.
  • Gerberick GF, Ryan CA, Kern PS, Schlatter H, Dearman RJ, Kimber I, Patlewicz GY, Basketter DA. (2005). Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis. 16:157–202.
  • Gerberick GF, Vassallo JD, Bailey RE, Chaney JG, Morall SW, Lepoittevin JP. (2004). Development of a peptide reactivity assay for screening contact allergens. Toxicol Sci. 81:332–343.
  • Gerberick GF, Vassallo JD, Foertsch LM, Price BB, Chaney JG, Lepoittevin J-P. (2007b). Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach. Toxicol Sci. 97:417–427.
  • Geurtsen W. (2000). Biocompatibility of resin-modified filling materials. Crit Rev Oral Biol Med. 11:333–355.
  • Gildea LA, Ryan CA, Foertsch LM, Kennedy JM, Dearman RJ, Kimber I, Gerberick GF. (2006). Identification of gene expression changes induced by chemical allergens in dendritic cells: Opportunities for skin sensitization testing. J Invest Dermatol. 126:1813–1822.
  • Glindmeyer HW, Lefante JJ, Freyder LM, Friedman M, Weill H. (2003). Relationship of asthma to irritant gas exposures in pulp and paper mills. Respir Med. 97:541–548.
  • Goon AT, Isaksson M, Zimerson E, Goh CL, Bruze M. (2006). Contact allergy to (meth)acrylates in the dental series in southern Sweden: Simultaneous positive patch test reaction patterns and possible screening allergens. Contact Dermatitis. 55:219–226.
  • Gosepath J, Brieger J, Muttray A, Best S, Pourianfar M, Jung D, Letzel S, Mann WJ. (2007). mRNA-induction and cytokine release during in vitro exposure of human nasal respiratory epithelia to methyl methacrylate. Toxicol Lett. 171:29–37.
  • Graham C, Rosenkranz HS, Karol MH. (1997). Structure-activity model of chemicals that cause human respiratory sensitization. Regul Toxicol Pharmacol. 26:296–306.
  • Granchi D, Ciapetti G, Savarino L, Cenni E, Pizzoferrato A, Baldini N, Giunti A. (2002). Effects of bone cement extracts on the cell-mediated immune response. Biomaterials. 23:1033–1041.
  • Greim H, Ahlers J, Bias R, Broecker B, Hollander H, Gelbke HP, Jacobi S, Klimisch HJ, Mangelsdorf I, Mayr W, et al. (1995). Assessment of structurally related chemicals: Toxicity and ecotoxicity of acrylic acid and acrylic acid alkyl esters (acrylates), methacrylic acid and methacrylic acid alkyl esters (methacrylates). Chemosphere. 31:2637–2659.
  • Griem P, Goebel C, Scheffler H. (2003). Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data. Regul Toxicol Pharmacol. 38:269–290.
  • Hall FJ. (1977). Anaphylaxis after gentamycin. Lancet. 2:455–455.
  • Hankinson JL. (2000). Beyond the peak flow meter: Newer technologies for determining and documenting changes in lung function in the workplace. Occup Med. 15:411–420.
  • Haskell Laboratory. (1977). Guinea Pig Sensitization Studies—Method of C. Chung. Wilmington: Du Pont.
  • Haskell Laboratory. (1978). Guinea pig maximization test (GPMT)—A standard Procedure for Identifying contact allergens. Material tested Thiram, Epon. 826, methacrylic acid, methyl ester. Wilmington: Du Pont.
  • Hayashi M, Higashi K, Kato H, Kaneko H. (2001). Assessment of preferential Th1 or Th2 induction by low-molecular-weight compounds using a reverse transcription-polymerase chain reaction method: Comparison of two mouse strains, C57BL/6 and BALB/c. Toxicol Appl Pharmacol. 177:38–45.
  • Henriks-Eckerman ML, Alanko K, Jolanki R, Kerosuo H, Kanerva L. (2001). Exposure to airborne methacrylates and natural rubber latex allergens in dental clinics. J Environ Monit. 3:302–305.
  • Henriks-Eckerman ML, Kanerva L. (1997). Product analysis of acrylic resins compared to information given in material safety data sheets. Contact Dermatitis. 36:164–165.
  • Henriks-Eckerman ML, Suuronen K, Jolanki R, Alanko K. (2004). Methacrylates in dental restorative materials. Contact Dermatitis. 50:233–237.
  • Hext PM, Pinto PJ, Gaskell BA. (2001). Methyl methacrylate toxicity in rat nasal epithelium: Investigation of the time course of lesion development and recovery from short term vapour inhalation. Toxicology. 156:119–128.
  • ICCVAM. (1999). The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. (NIH Publication No. 99–4494). Available at: http://iccvam.niehs.nih.gov/docs/immunotox_docs/llna/llnarep.pdf. Research Triangle Park, NC: National Toxicology Program.
  • IPCS. (1998). Methyl Methacrylate: Concise International Chemical Assessment Document No. 4. Geneva: World Health Organization.
  • Ishihara M, Fujisawa S. (2009). A structure-activity relationship study on the mechanisms of methacrylate-induced toxicity using NMR chemical shift of beta-carbon, RP-HPLC log P and semiempirical molecular descriptor. Dent Mater J. 28:113–120.
  • Isola D, Kimber I, Sarlo K, Lalko J, Sipes IG. (2008). Chemical respiratory allergy and occupational asthma: What are the key areas of uncertainty? J Appl Toxicol. 28:249–253.
  • Jarvis J, Seed MJ, Elton R, Sawyer L, Agius R. (2005). Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds. Occup Environ Med. 62:243–250.
  • Jensen EJ, Dahl R, Steffensen F. (1998). Bronchial reactivity to cigarette smoke in smokers: Repeatability, relationship to methacholine reactivity, smoking and atopy. Eur Respir J. 11:670–676.
  • Jiranek W. (2005). Antibiotic-loaded cement in total hip replacement: Current indications, efficacy, and complications. Orthopedics. 28 (Suppl 8):S873–S877.
  • Jiranek WA, Hanssen AD, Greenwald AS. (2006). Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. 88:2487–2500.
  • Kaiser. (2010). United States: Number of Dentists, 2008. Menlo Park: Henry J. Kaiser Family Foundation. Available at: http://www.statehealthfacts.org. Accessed June 15, 2010.
  • Kanazawa Y, Yoshida T, Kojima K. (1999). Structure-activity relationships in allergic contact dermatitis induced by methacrylates. Studies of the influence of side-chain length of methacrylates. Contact Dermatitis. 40:19–23.
  • Kanerva L. (1993). Letter to J.M. Mackay dated October 18,10/18/1993.
  • Kanerva L, Estlander T, Jolanki R. (1989). Allergic contact dermatitis from dental composite resins due to aromatic epoxy acrylates and aliphatic acrylates. Contact Dermatitis. 20:201–211.
  • Kanerva L, Estlander T, Keskinen H, Jolanki R. (2000). Occupational allergic airborne contact dermatitis and delayed bronchial asthma from epoxy resin revealed by bronchial provocation test. Eur J Dermatol. 10:475–477.
  • Kanerva L, Henriks-Eckerman ML, Estlander T, Jolanki R, Tarvainen K. (1994). Occupational allergic contact dermatitis and composition of acrylates in dentin bonding systems. J Eur Acad Dermatol Venerol. 3:157–168.
  • Kanerva L, Henriks-Eckerman ML, Jolanki R, Estlander T. (1997). Plastics/acrylics: Material Safety Data Sheets need to be improved. Clinics in Dermatology. 15:533–546.
  • Karol MH. (1994). Animal models of occupational asthma. Eur Respir J. 7:555–568.
  • Karol MH, Macina OT, Cunningham A. (2001). Cell and molecular biology of chemical allergy. Ann Allergy Asthma Immunol. 87 (6 Suppl 3):28–32.
  • Karol MH, Stadler J, Magreni C. (1985). Immunotoxicologic evaluation of the respiratory system: Animal models for immediate- and delayed-onset pulmonary hypersensitivity. Fundam Appl Toxicol. 5:459–472.
  • Katsuno K, Manabe A, Itoh K, Hisamitsu H, Wakumoto S, Nakayama S, Yoshida T. (1995). A delayed hypersensitivity reaction to dentin primer in the guinea pig. J Dent. 23:295–299.
  • Katz JN. (2006). Total joint replacement in osteoarthritis. Best Pract Res Clin Rheumatol. 20:145–153.
  • Kennes B, Garcia-Herreros P, Dierckx P. (1981). Asthma from plexiglas powders. Clin Allergy. 11:49–54.
  • Kiefer H. (2007). Current trends in total hip arthroplasty in Europe and experiences with the bicontact hip system,. In: Sofue M, Endo N, eds. Treatment of Osteoarthritic Change in the Hip: Joint Preservation or Joint Replacement? Sofue M, Endo N, eds. Japan: Springer. pp, 205–210.
  • Kimber I, Agius R, Basketter D, Corsini E, Cullinan P, Dearman R, Gimenez-Arnau E, Greenwell L, Hartung T, Kuper F, Maestrelli P, Roggen E, Rovida C. (2007). Chemical respiratory allergy: Opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60. Altern Lab Anim. 35:243–265.
  • Kimber I, Basketter DA, Dearman RJ. (2010). Chemical allergens—What are the issues? Toxicology. 268:139–142.
  • Kimber I, Dearman RJ. (2002). Chemical respiratory allergy: Role of IgE antibody and relevance of route of exposure. Toxicology. 181–182:311–315.
  • Kimber I, Dearman RJ. (2005). What makes a chemical a respiratory sensitizer? Curr Opin Allergy Clin Immunol. 5:119–124.
  • Kipen HM, Blume R, Hutt D. (1994). Asthma experience in an occupational and environmental medicine clinic: Low-dose reactive airways dysfunction syndrome. J Occup Med. 36:1133–1137.
  • Kirby BS, Doyle A, Gilula L. (2003). Acute bronchospasm due to exposure to polymethylmethacrylate vapors during percutaneous vertebroplasty. AJR Am J Roentgenol. 180:543–544.
  • Klonne DR, Dodd DE, Pritts IM, Nachreiner DJ, Fowler EH, Troup CM, Homan ER, Ballantyne B. (1987). Dimethylethanolamine: Acute, 2-week, and 13-week inhalation toxicity studies in rats. Fundam Appl Toxicol. 9:512–521.
  • Kory RC, Callahan R, Boren HG, Syner JC. (1961). The Veterans Administration–Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med. 30:243–258.
  • Kuwabara Y, Alexeeff GV, Broadwin R, Salmon AG. (2007). Evaluation and application of the RD(50) for determining acceptable exposure levels of airborne sensory irritants for the general public. Environ Health Perspect. 115:1609–1616.
  • Landsteiner K, Jacobs J. (1936). Studies on the sensitisation of animals with simple chemical compounds. J Exp Med. 64:625–639.
  • Lapp NL, Amandus HE, Hall R, Morgan WK. (1974). Lung volumes and flow rates in black and white subjects. Thorax. 29:185–188.
  • Lee CM. (1984). Unusual reaction to methyl methacrylate monomer. Anesth Analg. 63:372–372.
  • Lemiere C, Biagini RE, Zeiss CR. (2006). Immunological and inflammatory assessments,. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 179–197.
  • Leroyer C, Perfetti L, Trudeau C, L’Archeveque J, Chan-Yeung M, Malo JL. (1998). Comparison of serial monitoring of peak expiratory flow and FEV1 in the diagnosis of occupational asthma. Am J Respir Crit Care Med. 158:827–832.
  • Leung HW, Blaszcak DL. (1998). The skin sensitization potential of four alkylalkanolamines. Vet Hum Toxicol. 40:65–67.
  • Lindberg E, Iregren A, Malmberg P, Vesterberg O, Wennberg A. (1991). Health Risks of Exposure to Methyl Methacrylate (MMA). A Pilot Study. Bethesda, MD: National Institute of Occupational Health.
  • Liu T, Loftenius A, EIGhazali G, Troye-Blomberg M, Ma S, Ekstrand J. (1999). Differential regulation of in vitro cytokine production by human blood cells in response to methylmethacrylate. J Toxicol Environ Health, Part A. 56:165–182.
  • Loveless SE, Api AM, Crevel RWR, Cebruyne E, Gamer A, Jowsey IR, Kern P, Kimber I, Lea L, Lloyd PMZ, Steiling W, Veenstra G, Woolhiser M, Hennes C. (2010). Potency values from the local lymph node assay: Application to classification, labelling and risk assessment. Regul Toxicol Pharmacol. 56:54–66.
  • Lozewicz S, Davidson AG, Hopkirk A, Burge PS, Boldy DA, Riordan JF, McGivern DV, Platts BW, Davies D, Newman Taylor AJ. (1985). Occupational asthma due to methyl methacrylate and cyanoacrylates. Thorax. 40:836–839.
  • Lucas LJ. (1995). An investigation of the mortality patterns of acrylic sheet manufacturing workers exposed to methyl methacrylate and ethyl acrylate: Final Report. West Paterson, NJ: Cytec Industries.
  • Maestrelli P, Fabbri LM, Mapp CE. (2006). Pathophysiology,. In Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 109–140.
  • Magnusson B, Kligman AM. (1970). Allergic Contact Dermatitis in the Guinea Pig. Identification of Contact Allergens. Springfield: C.C. Thomas.
  • Mainwaring G, Foster JR, Lund V, Green T. (2001). Methyl methacrylate toxicity in rat nasal epithelium: Studies of the mechanism of action and comparisons between species. Toxicology. 158:109–118.
  • Malchau H, Garellick G, Eisler T, Karrholm J, Herberts P. (2005). Presidential guest address: The Swedish Hip Registry: Increasing the sensitivity by patient outcome data. Clin Orthop Relat Res. 441:19–29.
  • Malo JL, Newman-Taylor A. (2007). Defining occupational asthma and confirming the diagnosis: What do experts suggest? Occup Environ Med. 64:359–360.
  • Marez T, Edme JL, Boulenguez C, Shirali P, Haguenoer JM. (1993). Bronchial symptoms and respiratory function in workers exposed to methylmethacrylate. Br J Ind Med. 50:894–897.
  • Marzulli F, Maguire HC Jr. (1983). Validation of guinea pig tests for skin hypersensitivity,. In: Marzulli FN, Maibach, eds. Dermatotoxicology. Marzulli FN, Maibach, eds. Washington, DC: Hemisphere Publishing Corporation. pp, 237–250.
  • McCarthy TJ, Hayes EP, Schwartz CS, Witz G. (1994). The reactivity of selected acrylate esters toward glutathione and deoxyribonucleosides in vitro: Structure-activity relationships. Fundam Appl Toxicol. 22:543–548.
  • McCarthy TJ, Witz G. (1997). Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology. 116:153–158.
  • McFadden ER, Gilbert IA. (1992). Asthma. N Engl J Med. 327:1928–1937.
  • McLaughlin RE, Barkalow JA, Allen MS. (1979). Pulmonary toxicity of methyl methacrylate vapors: An environmental study. Arch Environ Health. 34:336–338.
  • Mizunuma K, Kawai T, Yasugi T, Horiguchi S, Takeda S, Miyashita K, Taniuchi T, Moon CS, Ikeda M. (1993). Biological monitoring and possible health effects in workers occupationally exposed to methyl methacrylate. Int Arch Occup Environ Health. 65:227–232.
  • Monroe C. (1981). Report of a Respiratory Health Survey of the Knoxville Facility of the Rohm and Haas Company. Philadelphia: Rohm and Haas.
  • Morris JB. (1992). Uptake of Inspired Methyl Methacrylate and Methacrylic Acid Vapours in the Upper Respiratory Tract of the F344 Rat. Washington, DC: Methacrylate Producers Association.
  • Morris JB, Frederick CB. (1995). Upper respiratory tract uptake of acrylate ester and acid vapors. Inhal Toxicol. 7:557–574.
  • Morris JF, Koski A, Johnson LC. (1971). Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 103:57–67.
  • Muller G, Knop J, Enk AH. (1996). Is cytokine expression responsible for differences between allergens and irritants? Am J Contact Dermatitis. 7:177–184.
  • Mutschler J, Gimenez-Arnau E, Foertsch L, Gerberick GF, Lepoittevin JP. (2009). Mechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon CG isothiazolinones. Toxicol In Vitro. 23:439–446.
  • NICNAS. (2009). Methyl Methacrylate (MMA) in Cosmetic Nail Preparations. Australian Department of Health and Ageing. Available at: http://www.nicnas.gov.au. Accessed June 15, 2010.
  • National Library of Medicine. (2010). ChemicalIDplus Lite. (Available at: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp).
  • Natsch A, Emter R. (2008). Skin sensitizers induced antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals. Toxicol Sci. 102:110–119.
  • Nethercott JR, Jakubovic HR, Pilger C, Smith JW. (1983). Allergic contact dermatitis due to urethan acrylate in ultraviolet cured inks. Br J Ind Med. 40:241–250.
  • NJ DoH. (2010). Hazardous Substance Fact Sheet: Dimethylaminoethanol (at: http://nj.gov/health/eoh/rtkweb/documents/fs/3111.pdf).
  • Nexant. (2006). Methyl Methacrylate (04/05-2). White Plains, NY: Nexant Chemical Systems.
  • New Jersey Department of Health. (2010). Hazardous Substance Fact Sheet: Dimethylaminoethanol. Available at: http://nj.gov/health/eoh/rtkweb/documents/fs/3111.pdf.
  • Ng ML, Warlow RS, Chrishanthan N, Ellis C, Walls R. (2000). Preliminary criteria for the definition of allergic rhinitis: A systematic evaluation of clinical parameters in a disease cohort (I). Clin Exp Allergy. 30:1314–1331.
  • Nicholson PJ, Cullinan P, Taylor AJN, Burge PS, Boyle C. (2005). Evidence based guidelines for the prevention, identification, and management of occupational asthma. Occup Environ Med. 62:290–299.
  • Nielsen GD. (1991). Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Toxicol. 21:183–208.
  • Nikolaizik WH, Trociewicz K, Ratjen F. (2002). Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis. Eur Respir J. 20:122–126.
  • NIOSH. (1990). National Occupational Exposure Survey conducted from 1981 to 1983. Available at: http://www.cdc.gov/noes/. Accessed June 15, 2010.
  • NIOSH.(2003). Methyl and Ethyl Methacrylate (Method 2537, Issue 3), in NIOSH Manual of Analytical Methods. Washington, DC: National Institute for Occupational Safety and Health.
  • Nishiwaki Y, Saitoh T, Takebayashi T, Tanaka S, Etoh N, Eitaki Y, Omae K. (2001). Cross-sectional study of health effects of methyl methacrylate monomer among dental laboratory technicians. J Occup Health. 43:375–378.
  • Niven R. (2009). E-mail to Jonathan Borak, December 12/11/, 2009.
  • Nyquist G, Koch G, Magnusson B. (1972). Contact allergy to medicaments and materials used in dentistry. 3. Sensitization and sensitivity study in guinea pigs on methyl methacrylate used in a dentifrice. Odontol Revy. 23:197–204.
  • OECD. (1992). Guideline 406. Guideline for Testing of Chemicals. Skin Sensitisation. Paris: OECD.
  • OECD. (2002). Guideline 429. Guideline for the Testing of Chemicals. Skin Sensitisation: Local Lymph Node Assay. Paris: OECD.
  • OECD. (2009). OECD Guideline for the Testing of Chemicals. Draft Proposal For An Update To Test Guideline 429. Skin Sensitisation: Local Lymph Node Assay. Paris: OECD.
  • OSHA. (2010). Methyl Methacrylate: Method # No. 94, in Sampling and Analytical Methods. Washington, DC: Occupational Safety and Health Administration.
  • Parker D, Long PV, Bull JE, Turk JL. (1985). Epicutaneous induction of tolerance with acrylates and related compounds. Contact Dermatitis. 12:146–154.
  • Parker D, Turk JL. (1983). Contact sensitivity to acrylate compounds in guinea pigs. Contact Dermatitis. 9:55–60.
  • Patlewicz G, Aptula AO, Uriarte E, Roberts DW, Kern PS, Gerberick GF, Kimber I, Dearman RJ, Ryan CA, Basketter DA. (2007). An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential. SAR & QSAR Environ Res. 18:515–541.
  • Pauluhn J. (2008). Brown Norway rat asthma model of diphenylmethane-4,4’-diisocyanate (MDI): Impact of vehicle for topical induction. Regul Toxicol Pharmacol. 50:144–154.
  • Pauluhn J, Mohr U. (2005). Experimental approaches to evaluate respiratory allergy in animal models. Exp Toxicol Pathol. 56:203–234.
  • Pausch FE, Jacobi S, Clajus P. (1994). Medical examination of workers in acrylic sheet production exposed to methyl methacrylate. Darmstadt, Germany: Roehm GmbH.
  • Pemberton MA. (2010). Personal Communication: Mark A. Pemberton (Chairman, MPA Science Committee, Methacrylates Producers Association).
  • Perrin B, Lagier F, L’Archeveque J, Cartier A, Boulet LP, Cote J, Malo JL. (1992). Occupational asthma: Validity of monitoring of peak expiratory flow rates and non-allergic bronchial responsiveness as compared to specific inhalation challenge. Eur Respir J. 5:40–48.
  • Pickering CAC, Bainbridge D, Birtwistle IH, Griffiths DL. (1986). Occupational asthma due to methyl methacrylate in an orthopedic theatre sister. Br Med MJ. 292:1362–1363.
  • Pickering CAC, Niven R, Simpson J. (1993). A Study of the Prevalence of Occupational Asthma at the ICI Acrylics site at Darwen, Lancashire. Manchester, UK: North West Lung Centre.
  • Piirila P, Kanerva L, Keskinen H, Estlander T, Hytonen M, Tuppurainen M, Nordman H. (1998). Occupational respiratory hypersensitivity caused by preparations containing acrylates in dental personnel. Clin Exp Allergy. 28:1404–1411.
  • Pretolani M, Vargaftig BB. (1993). From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models? Biochem Pharmacol. 45:791–800.
  • Quillen DM, Feller DB. (2006). Diagnosing rhinitis: Allergic vs. nonallergic. Am Fam Physician. 73:1583–1590.
  • Rajaniemi R, Tola S. (1985). Subjective symptoms among dental technicians exposed to the monomer methyl methacrylate. Scand J Work Environ Health. 11:281–286.
  • Reynaud-Gaubert M, Philip-Joet F, Arnaud A. (1991). Professional asthma due to methylmethacrylate ([French).]. Presse Med. 209:386–386.
  • Roberts DW, Aptula AO. (2008). Determinants of skin sensitisation potential. J Appl Toxicol. 28:377–387.
  • Roberts DW, Aptula AO, Patlewicz G. (2007a). Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay. Chem Res Toxicol. 20:44–60.
  • Roberts DW, Aptula AO, Patlewicz G, Pease C. (2008). Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential. J Appl Toxicol. 28:443–454.
  • Roberts DW, Fraginals R, Lepoittevin JP, Benezra C. (2009). Refinement of the relative alkylation index (RAI) model for skin sensitization and application to mouse and guinea-pig test data for alkyl alkanesulphonates. Arch Dermatol Res. 283:387–394.
  • Roberts DW, Natsch A. (2009). High throughput kinetic profiling approach for covalent binding to peptides: Application to skin sensitization potency of Michael acceptor electrophiles. Chem Res Toxicol. 22:592–603.
  • Roberts DW, Patlewicz G, Kern PS, Gerberick F, Kimber I, Dearman RJ, Ryan CA, Basketter DA, Aptula AO. (2007b). Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol. 20:1019–1030.
  • Robinson MK, Nusair TL, Fletcher ER, Ritz HL. (1990). Review of the Buehler guinea pig skin sensitization test and its use in a risk assessment process for human skin sensitization. Toxicology. 61:91–107.
  • Roche E, de la Cuadra J, Alegre V. (2008). Sensitization to acrylates caused by artificial acrylic nails: Review of 15 cases. Actas Dermo-sifiliográficas. 99:788–794.
  • Rodford R, Patlewicz G, Walker JD, Payne MP. (2003). Quantitative structure-activity relationships for predicting skin and respiratory sensitization. Environ Toxicol Chem. 22:1855–1861.
  • Roggen E, Aufderheide M, Cetin Y, Dearman RJ, Gibbs S, Hermanns I, Kimber I, Regal JF, Rovida C, Warheit DB, Uhlig S, Casati S. (2008). The development of novel approaches to the identification of chemical and protein respiratory allergens. Altern Lab Anim. 36:591–598.
  • Rustemeyer T, de Groot J, von Blomberg BME, Frosch PJ, Scheper RJ. (1998). Cross-reactivity patterns of contact-sensitizing methacrylates. Toxicol Appl Pharmacol. 148:83–90.
  • Rustemeyer T, Frosch PJ. (1996). Occupational skin diseases in dental laboratory technicians. Contact Dermatitis. 34:125–133.
  • Rustemeyer T, Preuss M, von Blomberg BM, Das PK, Scheper RJ. (2003). Comparison of two in vitro dendritic cell maturation models for screening contact sensitizers using a panel of methacrylates. Exp Dermatol. 12:682–691.
  • Ryan CA, Gerberick GF, Gildea LA, Hulette BC, Betts CJ, Cumberbatch M, Dearman RJ, Kimber I. (2009). Interactions of contact allergens with dendritic cells: Opportunities and challenges for the development of novel approaches to hazard assessment. Toxicol Sci. 88:4–11.
  • Sarlo K, Karol MH. (1994). Guinea pig predictive tests for respiratory allergy,. In: Dean JH, Luster MI Munson, AE, Kimber I, eds. Immunotoxicology and Immunopharmacology. Dean JH, Luster, Munson, Kimber, eds. New York: Raven Press. pp, 703–720.
  • Sarlo K, Ritz HL. (1997). Predictive assessment of respiratory sensitizing potential in guinea pigs,. In Kimber I, Dearman, eds. Toxicology of Chemical Respiratory Hypersensitivity. Kimber I, Dearman, eds. London: Taylor & Francis. pp, 107–120.
  • Sauni R, Kauppi P, Alanko K, Henriks-Eckerman ML, Tuppurainen M, Hannu T. (2008). Occupational asthma caused by sculptured nails containing methacrylates. Am J Ind Med. 51:968–974.
  • Savonius B, Keskinen H, Tuppurainen M, Kanerva L. (1993). Occupational respiratory disease caused by acrylates. Clin Exp Allergy. 23:416–424.
  • SCENIHR (2008). The Safety of Dental Amalgam and Alternative Dental Restoration Materials for Patients and Users. Brussels: European Commission. (Available at: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_011.pdf). Brussels: European Commission Accessed October 12, 2010.
  • Scherpereel A, Tillie-Leblond I, Pommier de Santi P, Tonnel AB. (2004). Exposure to methyl methacrylate and hypersensitivity pneumonitis in dental technicians. Allergy. 59:890–892.
  • Schretlen-Doherty JS, Troutman WG. (1995). Tobramycin-induced hypersensitivity reaction. Ann Pharmacother. 29:704–706.
  • Schultz TW, Rogers K, Aptula AO. (2009). Read-across to rank skin sensitization potential: Subcategories for the Michael acceptor domain. Contact Dermatitis. 60:21–31.
  • Schultz TW, Yarbrough JW, Hunter RS, Aptula AO. (2007). Verification of the structural alerts for Michael acceptors. Chem Res Toxicol. 20:1359–1363.
  • Schulze S, Wollina U. (2003). Gentamicin-induced anaphylaxis. Allergy. 58:88–89.
  • Schweikl H, Schmalz G, Spruss T. (2001). The induction of micronuclei in vitro by unpolymerized resin monomers. J Dent Res. 80:1615–1620.
  • Scolnick B, Collins J. (1986). Systemic reaction to methylmethacrylate in an operating room nurse. J Occup Med. 28:196–198.
  • Seed M, Agius R. (2010). Further validation of computer-based prediction of chemical asthma hazard. Occup Med. 60:115–120.
  • Seed MJ, Cullinan P, Agius RM. (2008). Methods for the prediction of low-molecular-weight occupational respiratory sensitizers. Curr Opin Allergy Clin Immunol. 8:103–109.
  • Selgrade MK, Boykin EH, Haykal-Coates N, Woolhiser MR, Wiescinski C, Andrews DL, Farraj AK, Doerfler DL, Gavett SH. (2006). Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates. Toxicol Sci. 94:108–117.
  • Smith CK, Hotchkiss SAM. (2001). Allergic Contact Dermatitis. Chemical and Metabolic Mechanisms. New York: Taylor & Francis.
  • Smyth HF, Carpenter CP, Weil CS. (1951). Range-finding toxicity data: List IV. AMA Arch Ind Hyg Occup Med. 4:119–122.
  • Stadler JC. (1993). Inhalation Sensory Irritation (RD50) Study in Mice with Selected Methacrylates and Methacrylic Acid (Project No. 9498-001). Washington, DC: Haskell Laboratory for Toxicology and Industrial Medicine.
  • Stoll S, Muller G, Kurimoto M, Saloga J, Tanimoto T, Yamauchi H, Okamura H, Knop J, Enk AH. (1997). Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes. J Immunol. 159:298–302.
  • Tansy MF, Landin WE, Kendall FM. (1980). LC50 value for rats acutely exposed to methyl methacrylate monomer vapor. J Dent Res. 59:1074–1074.
  • Tarlo SM, Balmes J, Balkissoon R, Beach J, Beckett W, Bernstein D, Blanc PD, Brooks SM, Cowl CT, Daroowalla F, Harber P, et al. (2008). Diagnosis and management of work-related asthma. (American College of Chest Physicians Consensus Statement). Chest. 134 (Suppl 3):1S–41S.
  • Tarlo SM, Broder I. (1989). Irritant-induced occupational asthma. Chest. 96:297–300.
  • Thomas P, Schuh A, Ring J, Thomsen M. (2008). Orthopedic surgical implants and allergies: Joint statement by the implant allergy working group (AK 20) of the DGOOC (German Association of Orthopedics and Orthopedic Surgery), DKG (German Contact Dermatitis Research Group) and DGAKI (German Society for Allergology and Clinical Immunology). Orthopade. 37:75–88.
  • Thorette C, Grigoriu B, Canut E, Sobaszek A, Tonnel AB, Tillie-Leblond I. (2006). Pulmonary disease in dental laboratory technicians. Rev Mal Respir. 23 (Suppl 2):4S8–4S16.
  • Toebak MJ, Gibbs S, Bruynzeel DP, Scheper RJ, Rustmeyer T. (2009). Dendritic cells: Biology of the skin. Contact Dermatitis. 60:2–20.
  • Toebak MJ, Moed H, von Blomberg MB, Bruynzeel DP, Gibbs S, Scheper RJ, Rustemeyer T. (2006). Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells. Contact Dermatitis. 55:238–245.
  • Tomenson JA, Bonner SM, Edwards JC, Pemberton MA, Cummings TF, Paddle GM. (2000). Study of two cohorts of workers exposed to methyl methacrylate in acrylic sheet production. Occup Environ Med. 57:810–817.
  • Ulrich P, Grenet O, Bluemel J, Vohr HW, Wiemann C, Grundler O, Suter W. (2001). Cytokine expression profiles during murine contact allergy: T helper 2 cytokines are expressed irrespective of the type of contact allergen. Arch Toxicol. 75:470–479.
  • UN. (2007a). Germ cell mutagenicity,. In: Globally Harmonized System of Classification and Labelling of Chemicals (GHS). New York: United Nations. pp, 147–155.
  • UN. (2007b). Globally Harmonized System of Classification and Labelling of Chemicals (GHS). New York: United Nations.
  • Ungers LJ, Vendrely TG. (2006). Comparison of sampling and analytical methods used during the preparation of methyl methacrylate bone cements. J Occup Environ Hyg. 3:351–357.
  • Ungers LJ, Vendrely TG, Barnes CL. (2007). Control of methyl methacrylate during the preparation of orthopedic bone cements. J Occup Environ Hyg. 4:272–280.
  • US EPA. (1994). Methyl Methacrylate: Fact Sheet (EPA 749-F-95-014a). Washington, DC: US Environmental Protection Agency.
  • US EPA. (1998). Toxicological Review of Methyl Methacrylate (CAS No. 80-62-6. Washington, DC: US Environmental Protection Agency. Available at: http://www.epa.gov/ncea/iris/toxreviews/1000tr.pdf. Accessed June 15, 2010.
  • US EPA. (2003). Health Effects Test Guidelines. OPPTS 870.2600 Skin Sensitization (EPA 712-C-030197). Washington, DC: US Environmental Protection Agency.
  • US EPA. (2007). Protecting the Health of Nail Salon. Washington, DC: US Environmental Protection Agency. Available at: http://www.epa.gov/dfe/pubs/projects/salon/index.htm. Accessed June 15, 2010.
  • US FDA. (2010). Nail Products. Available at: http://www.fda.gov/Cosmetics/ProductandIngredientSafety/ProductInformation/ucm127068.htm#meth. Accessed June 15, 2010.
  • Vallieres M, Cockroft DW, Taylor DM, Dolovitch J, Hargreave FE. (1977). Dimethyl ethanolamine-induced asthma. Am Rev Respir Dis. 115:867–871.
  • Van Der Walle HB, Bensink T. (1982). Cross reaction pattern of 26 acrylic monomers on guinea pig skin. Contact Dermatitis. 8:376–382.
  • Van Der Walle HB, Delbressine LP, Seutter E. (1982a). Concomitant sensitization to hydroquinone and P-methyoxyphenol in the guinea pig; inhibitors in acrylic monomers. Contact Dermatitis. 8:147–154.
  • Van Der Walle HB, Klecak G, Bensink T. (1982b). Sensitizing potential of 14 mono (meth) acrylates in the guinea pig. Contact Dermatitis. 8:223–235.
  • van Loveren H, Cockshott A, Gebel T, Gundert-Remy U, de Jong WH, Matheson J, MGarry H, Musset L, Selgrade MK, Vickers C. (2008). Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment. Regul Toxicol Pharmacol. 50:155–199.
  • Van Och FM, van Loveren H, Van Wolfswinkel JC, Machielsen AJ, Vandebriel RJ. (2005). Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line. Toxicology. 210:95–109.
  • Vandebriel RJ, de Jong WH, Spiekstra SW, Van Dijk M, Fluitman A, Garssen J, van Loveren H. (2000). Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4. Toxicol Appl Pharmacol. 162:77–85.
  • Vandebriel RJ, van Loveren H. (2010). Non-animal sensitization testing: State-of-the-art. Crit Rev Toxicol. 40:389–404.
  • Vandebriel RJ, Van Och FM, van Loveren H. (2005). In vitro assessment of sensitizing activity of low molecular weight compounds. Toxicol Appl Pharmacol. 207 (Suppl 2):S142–S148.
  • Vandenplas O, Cartier A, Malo JL. (2006). Occupational challenge test,. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace And Related Conditions. Bernstein IL, Chan-Yeung, Malo, Bernstein, eds. New York: Taylor & Francis. pp, 227–252.
  • Vandenplas O, Malo JL. (1997). Inhalation challenges with agents causing occupational asthma. Eur Respir J. 10:2612–2629.
  • Vankerckhoven H, Lambrechts P, Van Beylen M, Vanherle G. (1981). Characterization of composite resins by NMR and TEM. J Dent Res. 60:1957–1965.
  • Vos GA, Stephens JP. (2008). A cross-industry assessment of personal exposures to methyl methacrylate. J Occup Environ Hyg. 5:22–27.
  • Wahlberg JE, Boman A. (1985). Guinea pig maximization test. Curr Probl Dermatol. 14:59–106.
  • Walker AM, Cohen AJ, Loughlin JE, Rothman KJ, DeFonso LR. (1991). Mortality from cancer of the colon or rectum among workers exposed to ethyl acrylate and methyl methacrylate. Scand J Work Environ Health. 17:7–19.
  • Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CC, Schuller D, Spector SL, Tilles SA. (2008). The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Asthma Immunol. 122:S1–S84
  • Weed DL, Hursting SD. (1998). Biologic plausibility in causal inference: Current method and practice. Am J Epidemiol. 147:415–425.
  • Wittczak T, Palczynski C, Szulc B, Gorski P. (1996). Bronchial asthma with inflammation of the nose mucous membrane induced by occupational exposure to methyl methacrylate in a dental technician. Med Pr. 47:259–266.
  • Wittczak T, Walusiak J, Ruta U, Palczynski C. (2003). Occupational asthma and allergic rhinitis due to xerographic toner. Allergy. 58:957–957.
  • Wondrousch D, Bohme A, Thaens D, Ost N, Schuurmann G. (2010). Local electrophilicity predicts the toxicity-relevant reactivity of Michael acceptors. J Phys Chem Lett. 1:1605–1610.
  • Work Safe Alberta. (2009). Use of Methyl Methacrylate-Containing Products for Fingernail Sculpting (CH062—Chemical Hazards). Government of Alberta. Available at: http://employment.alberta.ca/documents/WHS/WHS-PUB_ch062.pdf. Accessed June 15, 2010.
  • Yarbrough JW, Schultz TW. (2007). Abiotic sulfhydryl reactivity: A predictor of aquatic toxicity for carbonyl-containing alpha,beta-unsaturated compounds. Chem Res Toxicol. 20:558–562.
  • Yoshii E. (1997). Cytotoxic effects of acrylates and methacrylates: Relationships of monomer structures and cytotoxicity. J Biomed Mater Res. 37:517–524.
  • Young R.(2010). Personal communication: Randy Young (NIOSH, Division of Surveillance, Hazard Evaluations and Field Studies), (3/23/March 23, 2010).
  • Zissu D. (1995). Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals. J Appl Toxicol. 15:207–213.