The Toxicokinetics and Metabolism of Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Dibenzofurans (PCDFs) and Their Relevance for Toxicity

References

• Abdel-Hamid F. M., Moore J. A., Matthews H. B. Comparative study of 3,4,3′,4′-tetrachloro-biphenyl in male and female rats and female monkeys. J. Toxicol. Environ. Health 1981; 7: 181
   PubMed Web of Science ®Google Scholar
• Abraham K., Krowke R., Neubert D. Pharmacokinetics and biological activity of 2,3,7,8-tetra-chlorodibenzo-p-dioxin. 1. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection. Arch. Toxicol. 1988; 62: 359
   PubMed Web of Science ®Google Scholar
• Abraham K., Wiesmuller T., Brunner H., Krowke R., Hagenmaier H., Neubert D. Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces. Arch. Toxicol. 1989; 63: 75
   PubMed Web of Science ®Google Scholar
• Abraham K., Krowke R., Neubert D. Absorption of TCDD following parenteral application in rats using various vehicles. Chemosphere 1989; 19: 893
   Google Scholar
• Abraham K., Weberruss U., Wiesmuller T., Hagenmaier H., Krowke R., Neubert D. Comparative studies on absorption and distribution in the liver and adipose tissue of PCDDs and PCDFs in rats and marmosets monkeys. Chemosphere 1989; 19: 887
   Google Scholar
• Abraham K., Wiesmuller T., Brunner H., Krowke R., Hagenmaier H., Neubert D. Absorption and tissue distribution of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in the rat. Arch. Toxicol. 1989; 63: 193
   PubMedGoogle Scholar
• Adams W. J., De Graeve G. M., Sabourin T. D., Cooney J. D., Mosher G. M. Toxicity and bioconcentration of 2,3,7,8-TCDD to fathead minnows. (Pimephales promelas), Chemosphere 1986; 15: 1503
   Google Scholar
• Ahlborg U. G., Waern F., Manzoor E., Haakansson H. Effects of combinations of PCDDs/PCDFs given to Sprague-Dawley rats. Chemosphere 1989; 18: 283
   Google Scholar
• Ahlborg U. G., Hakansson H., Lindstrom G., Rappe C. Studies on the retention of individual polychlorinated dibenzofurans (PCDFs) in the liver of different species. Chemosphere 1990; 20: 1235
   Google Scholar
• Aitio A., Parkki M. G. Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol. Appl. Pharmacol. 1978; 44: 107
   PubMed Web of Science ®Google Scholar
• Allen J. R., Van Miller J. P., Norback D. H. Tissue distribution, excretion and biological effects of [14C]tetrachlorodibenzo-p-dioxin in rats. Food Cosmet. Toxicol. 1975; 13: 501
   PubMedGoogle Scholar
• Appelgren L. E., Brandt I., Brittelos E. B., Gillner M., Gustafsson S. A. Autoradiography of 2,3,7,8-tetrachloro-[14C]dibenzo-p-dioxin TCDD: accumulation in the nasal mucosa. Chemosphere 1983; 12: 545
   Google Scholar
• Arstila A. U., Reggiani G., Sorvari T. E., Raisanen S., Wipf H. K. Elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in goat milk. Toxicol. Lett. 1981; 9: 215
   PubMedGoogle Scholar
• Astroff B., Safe S. Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rate. Toxicol. Appl. Pharmacol. 1988; 95: 435
   PubMed Web of Science ®Google Scholar
• Astroff B., Safe S. 6-Substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships. Toxicology 1989; 59: 285
   PubMed Web of Science ®Google Scholar
• Baars A. J., Jansen M., Breiner D. D. The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. Biochem. Pharmacol. 1978; 27: 2487
   PubMed Web of Science ®Google Scholar
• Bandiera S., Sawyer T., Romkes M., Zmudzka B., Safe L., Mason G., Keys B., Safe S. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology 1984; 32: 131
   PubMed Web of Science ®Google Scholar
• Banks Y. B., Brewster D. W., Birnbaum L. S. Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran. Fundam. Appl. Toxicol. 1990; 15: 163
   PubMedGoogle Scholar
• Banks Y. B., Birnbaum L. S. Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after low dose dermal exposure. Toxicol. Appl. Pharmacol. 1991; 107: 302
   PubMed Web of Science ®Google Scholar
• Bannister R., Davis D., Zacharewski T., Tizard I., Safe S. Aroclor 1254 as a 2,3,7,8-tetra-chlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. Toxicology 1987; 46: 29
   PubMed Web of Science ®Google Scholar
• Bannister R., Safe S. Synergistic interactions of 2,3,7,8-TCDD and 2,2′,4,4′,5,5′-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor. Toxicology 1987; 44: 159
   PubMed Web of Science ®Google Scholar
• Bannister R., Kelley M., Safe S. The effects of receptor modulators on the AHH induction activity of 2,3,7,8-TCDD in C57BL/6 and DBA/2 mice. Chemosphere 1987; 16: 1687
   Google Scholar
• Bannister R., Biegel L., Davis D., Astroff B., Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology 1989; 54: 139
   PubMed Web of Science ®Google Scholar
• Beatty P. W., Neal R. A. Induction of DT-diaphorase activity of rat liver by 2,3,7,8-tetrachloro-dibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 1976; 37: 189
   Google Scholar
• Beatty P., Neal R. A. Factors affecting the induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Pharmacol. 1978; 27: 505
   PubMedGoogle Scholar
• Beck H., Echart K., Kellert M., Mathar W., Ruehl Ch. S., Wittkowski R. Levels of PCDFs and PCDDs in samples of human origin and food in the Federal Republic of Germany. Chemosphere 1987; 16: 1977
   Google Scholar
• Beck H., Eckart K., Mathar W., Wittkowski R. PCDD arid PCDF body burden from food intake in the Federal Republic of Germany. Chemosphere 1989; 18: 417
   Web of Science ®Google Scholar
• Beck H., Dross A., Kleeman W. J., Matthar W. PCDD and PCDF concentrations in different organs from infants. Chemosphere 1990; 20: 903
   Google Scholar
• Bellward G. D., Norstrom R. J., Whitehead P. E., Elliott J. E., Bandiera S. M., Dworschak C., Chang T., Forbes S., Cadario B., Hart L. E. Comparison of polychlorinated dibenzodioxin levels with hepatic mixed-function oxidase induction in great blue herons. J. Toxicol. Environ. Health 1990; 30: 33
   PubMed Web of Science ®Google Scholar
• Biegel L., Harris M., Davis D., Rosengren R., Safe L., Safe S. 2,2′,4,4′,5,5′-Hexachloro-diphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol. Appl. Pharmacol. 1989; 97: 561
   PubMed Web of Science ®Google Scholar
• Birnbaum L. S., Decad G. M., Matthews H. B. Disposition and excretion of 2,3,7,8-tetrachloro-dibenzofuran in the rat. Toxicol. Appl. Pharmacol. 1980; 55: 34
   Google Scholar
• Birnbaum L. S., Decad G. M., Matthews H. B., McConnell E. E. Fate of 2,3,7,8-tetra-chlorodibenzofuran in the monkey. Toxicol. Appl. Pharmacol. 1981; 57: 189
   PubMedGoogle Scholar
• Birnbaum L. S., Weber H., Harris M. W., Lamb J. C., McKinney J. D. Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: increased incidence of cleft palate in mice. Toxicol. Appl. Pharmacol. 1985; 77: 292
   PubMed Web of Science ®Google Scholar
• Birnbaum L. S. Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus. Drug Metab. Dispos. 1986; 14: 34
   PubMedGoogle Scholar
• Birnbaum L. S., Harris M. W., Barnhart E. R., Morrissey R. E. Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice. Toxicol. Appl. Pharmacol. 1987; 90: 206
   PubMed Web of Science ®Google Scholar
• Birnbaum L. S., Harris M. W., Crawford D. D., Morrissey R. E. Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N mice. Toxicol. Appl. Pharmacol. 1987; 90: 246
   Google Scholar
• Birnbaum L. S., Couture L. A. Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats. Toxicol. Appl. Pharmacol. 1988; 93: 22
   PubMed Web of Science ®Google Scholar
• Birnbaum L. S., Couture L. A., Elwell M. R. Subchronic effects of exposure to octachlorodiben-zodioxin (OCDD). Chemosphere 1989; 18: 389
   Google Scholar
• Birnbaum L. S., Mc Donald M. M., Blair P. C., Clark A. M., Harris M. W. Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah locus. Fundam. Appl. Toxicol. 1990; 15: 186
   PubMedGoogle Scholar
• Bonaccorsi A., di-Domenico A., Fanelli R., Merli F., Motta R., Vanzati R., Zapponi G. A. The influence of soil particle adsorption on 2,3,7,8-tetrachlorodibenzo-p-dioxin biological uptake in the rabbit. Arch. Toxicol. Suppl. 1984; 7: 431
   PubMedGoogle Scholar
• Bosveld A. T. C., Vanden Berg M., Theelen R. M. C. Assessment of the EROD inducing potency of eleven 2,3,7,8-substituted PCDD/Fs and three co-planar PCBs in the chick embryo. Chemosphere 1992; 25: 911
   Web of Science ®Google Scholar
• Bouwman C. A., Seinen W., Koppe J. G., Vanden Berg M. Effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin or 2,2,4,4′,5,5′-hexachlorobiphenyl on vitamin K-dependent blood coagulation in female germfree WAG/Rij-rats. Toxicology 1992; 75: 109
   PubMedGoogle Scholar
• Bouwman C. A., Fase K., Koppe J. G., Seinen W., Vanden Berg M. Effects of 2,3,7,8-TCDD or 2,2′,4,4′,5,5′-HxCB on the activity of vitamin K-cycle enzymes in rats: a novel mechanism of action. Organohalogen Compounds 1992; 10: 13
   Google Scholar
• Bowman R. E., Tong H. Y., Gross M. L., Monson S. J., Weerasinghe N. C. A. Controlled exposure of female rhesus monkeys to 2,3,7,8-TCDD: concentrations of TCDD in fat of offspring, and its decline in time. Chemosphere 1989; 20: 199
   Google Scholar
• Bowman R. E., Schantz S. L., Weerasinghe N. C. A., Gross M. L., Barsotti D. A. Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity. Chemosphere 1989; 18: 243
   Web of Science ®Google Scholar
• Braune B. M., Norstrom R. J. Dynamics of organochlorine compounds in herring gulls. III. Tissue distribution and bioaccumulation in Lake Ontario gulls. Environ. Toxicol. Chem. 1989; 8: 957
   Web of Science ®Google Scholar
• Brewster D. W., Birnbaum L. S. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 1987; 90: 243
   PubMed Web of Science ®Google Scholar
• Brewster D. W., Elwell M. R., Birnbaum L. S. Toxicity and disposition of 2,3,4,7,8-penta-chlorodibenzofuran (4PeDCF) in the rhesus monkey. (Macaca mulatto), Toxicol. Appl. Pharmacol. 1988; 93: 231
   PubMedGoogle Scholar
• Brewster D. W., Birnbaum L. S. Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 1988; 95: 490
   PubMedGoogle Scholar
• Brewster D. W., Banks Y. B., Clark A. M., Birnbaum L. S. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three poly-chlorinated dibenzofurans. Toxicol. Appl. Pharmacol. 1989; 197: 156
   Google Scholar
• Brouwer A., Vanden Berg K. J. Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces vitamine A transport by inhibiting the formation of the protein complex, carrying both retinol and thyroxin. Toxicol. Appl. Pharmacol. 1986; 85: 301
   PubMed Web of Science ®Google Scholar
• Brownlee L. J., Evans C. H., Hollebone B. R. The relative induction of mixed-function oxidase specific activity to C-H and C-C1 bond strengths in poly-chlorinated derivatives of dibenzo-p-dioxin (PCDDs). J. Appl. Toxicol. 1986; 6: 67
   PubMed Web of Science ®Google Scholar
• Bruggeman W. A., Opperhuizen A., Wijbenga A., Hutzinger O. Bioaccumulation of super-lipophilic chemicals in fish. Toxicol. Environ. Chem. 1984; 7: 173
   Web of Science ®Google Scholar
• Brunner H., Wiesmuller T., Hagenmaier H., Abraham K., Krowke R., Neubert D. Distribution of PCDDs and PCDFs in rat tissues following various routes of administration. Chemosphere 1989; 19: 907
   Google Scholar
• Brunström B., Andersson L. Toxicity and 7-ethoxyresorufin-O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos. Arch. Toxicol. 1988; 62: 263
   PubMed Web of Science ®Google Scholar
• Brunström B. Mono-ortho-chlorinated chloro-biphenyls: toxicity and induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in chick embryos. Arch. Toxicol. 1990; 64: 188
   PubMed Web of Science ®Google Scholar
• Buckley-Kedderis L. B., Diliberto J. J., Birnbaum L. S. Disposition and excretion of intravenous 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in rats. Toxicol. Appl. Pharmacol. 1991; 108: 397
   PubMedGoogle Scholar
• Buckley-Kedderis L. B., Diliberto J. J., Birnbaum L. S. Biliary excretion of 2,3,7,8-tetra-bromodibenzo-p-dioxin (TBDD) and 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) metabolites in rats. Toxicologist 1991; 11: 272
   Google Scholar
• Buckley-Kedderis L., Diliberto J. J., Linko P., Goldstein J. A., Birnbaum L. S. Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2. Toxicol. Appl. Pharmacol. 1992; 111: 163
   Google Scholar
• Burka L. T., Mc Gown S. R., Tomer K. B. Identification of the biliary metabolites of 2,3,7,8-tetrachlorodibenzofuran in the rat. Chemosphere 1991; 21: 1231
   Google Scholar
• Buser H. R., Bosshardt H. P., Rappe C. Identification of polychlorinated dibenzofuran isomers in flyash and PCB pyrolyses. Chemosphere 1987; 8: 419
   Google Scholar
• Byard J. L. The toxicological significance of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in human adipose tissue. J. Toxicol. Environ. Health 1987; 22: 381
   PubMed Web of Science ®Google Scholar
• Carrier L. B., Brodeur J. Non-linear toxico-kinetic behavior of TCDD-like halogenated polycyclic aromatic hydrocarbons (H-PAH) in various species. Toxicologist 1991; 11: 237
   Google Scholar
• Chen P. H., Wong C. K., Rappe C., Nygren M. Polychlorinated biphenyls, dibenzofurans and quaterphenyls in toxic rice-bran oil and in the blood and tissues of patients with PCB poisoning (Yu-Cheng) in Taiwan. Environ. Health Perspect 1985; 59: 59
   PubMed Web of Science ®Google Scholar
• Choudry G. C., Olie K., Hutzinger O. Mechanisms in thermal formation of chlorinated compounds including polychlorinated dibenzo-p-dioxins. Chlorinated Dioxins and Related Compounds. Impact on the Environment, O. Hutzinger, R. W. Frei, E. Merian, E. Pocchiari. Pergamon Press, Oxford 1982; 275
   Google Scholar
• Chu I., Villeneuve D. C., Gilman A. P., Yagminas A., Le Cavelier P., Poon R., Kennedy S. W. Toxicity study of 3,3′,4,4′-tetrachlorobiphenyl and 2,3,4,4′,5-pentachlorobiphenyl in the rat. Organohalogen Compounds 1992; 10: 17
   Google Scholar
• Clement R. E., Tosine H. M., Taguchi V., Musial C. J., Uthe J. F. Investigation of American lobster.Homarus americanus, for the presence of chlorinated dibenzo-p-dioxins and dibenzofurans. Bull. Environ. Contain. Toxicol. 1987; 39: 1069
   PubMedGoogle Scholar
• Couture L. A., Elwell M. R., Birnbaum L. S. Dioxin-like effects observed in male rats following exposure to octachlorodibenzo-p-dioxin (OCDD) during a 13-week study. Toxicol. Appl. Pharmacol. 1988; 93: 31
   PubMed Web of Science ®Google Scholar
• Curtis L. R., Kerkvliet N. I., Baecher-Steppan L., Carpenter H. M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin pretreatment of female mice altered tissue distribution but not hepatic metabolism of a subsequent dose. Fundam. Appl. Toxicol. 1990; 14: 523
   PubMedGoogle Scholar
• Czuczwa J. M., Hites R. A. Environmental fate of combustion-generated polychlorinated dioxins and furans. Environ. Sci. Technol. 1984; 18: 444
   PubMed Web of Science ®Google Scholar
• Czuczwa J. M., Hites R. A. Airborne dioxins and dibenzofurans: sources and fates. Environ. Sci. Technol. 1986; 20: 195
   PubMed Web of Science ®Google Scholar
• Davis D., Safe S. Dose-response immuno-toxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachloro-dibenzo-p-dioxin. Toxicol. Lett. 1989; 48: 35
   PubMed Web of Science ®Google Scholar
• Davis D., Safe S. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology 1990; 63: 97
   PubMed Web of Science ®Google Scholar
• Decad G. M., Birnbaum L. S., Matthews H. B. 2,3,7.8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pigs. Toxicol. Appl. Pharmacol. 1981; 57: 231
   PubMedGoogle Scholar
• Decad G. M., Birnbaum L. S., Matthews H. B. Distribution and excretion of 2,3,7,8-tetra-chlorodibenzofuran in C57BL/6J and DBA/2J mice. Toxicol. Appl. Pharmacol. 1981; 59: 564
   PubMed Web of Science ®Google Scholar
• DeJongh J., Belfroid A., Sinnige T., Seinen W., Vanden Berg M. The induction and subsequent return to basal activity of liver enzyme activity in male C57BL/6 mice after a single oral dose of 1,2,3,7,8-PnCDD or 1,2,3,6,7,8-HCDD. Chemosphere 1990; 20: 1203
   Google Scholar
• DeJongh J., Wondergem F., Seinen W., Vanden Berg M. Toxicokinettc interactions in the liver of the C57BL/6J mouse after administration of a single oral dose of a binary mixture of some PCBs. Chemosphere 1992; 25: 1165
   Google Scholar
• DeJongh J., Nieboer R., Schröders I., Seinen W., Vanden Berg M. Interactive effects between PCDDs. PCDFs and PCBs on their hepatic disposition in C57BL/6J mice. Organohalogen Compounds 1992; 10: 37
   Google Scholar
• Dencker L. The role of receptors in 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) toxicity. Arch. Toxicol. Suppl. 1985; 8: 43
   PubMedGoogle Scholar
• Denomme M. A., Homonoko K., Fujita T., Sawyer T., Safe S. Effects of substituents on the cytosolic receptor-binding affinities and aryl hydrocarbon hydroxylase induction potencies of 7-substi-tuted 2,3-dichlorodibenzo-p-dioxins. Mol. Pharmacol. 1985; 27: 656
   PubMed Web of Science ®Google Scholar
• Denomme M. A., Homonoko K., Fujita T., Sawyer T., Safe S. Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies — a QSAR analysis. Chem. Biol. Interact 1986; 57: 175
   PubMed Web of Science ®Google Scholar
• DeVault D., Dunn W., Bergqvist P. A., Wiberg K., Rappe C. Polychlorinated dibenzofurans and polychlorinated dibenzo-p-dioxins in Great Lakes fish: a baseline and interlake comparison. Environ. Toxicol. Chem. 1989; 8: 1013
   Google Scholar
• Dickerson R., Howie L., Davis D., Safe S. The structure-dependent effects of heptachlorodibenzo-furan isomers in male C57BL/6 mice — immuno-toxicity and monooxygenase enzyme induction. Fundam. Appl. Toxicol. 1990; 15: 298
   PubMedGoogle Scholar
• Durham S. K., Brouwer A. 3,4,3′,4′-Tetra-chlorobiphenyl-induced effects in the rat liver. II. Electron microscopic autoradiographic localization of 3H-TCB. Toxicol. Pathol. 1989; 17: 782
   PubMedGoogle Scholar
• Durrin L. K., Jones P. B., Fisher J. M., Galeazzi D. R., Whitlock J. R. 2,3,7,8-Tetrachloro-dibenzo-p-dioxirt receptors regulate transcription of the cytochrome P1-450 gene. J. Cell. Biochem. 1987; 35: 153
   PubMed Web of Science ®Google Scholar
• Durrin L. K., Whitlock J. P. In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene. Mol. Cell. Biol. 1987; 7: 3008
   PubMed Web of Science ®Google Scholar
• Fehringer N. V., Walters S. M., Ayers R. J., Kozara R. J., Ogger J. D., Schneider L. F.A. survey of 2,3,7,8-TCDD residues in fish from the Great Lakes and selected Michigan rivers. Chemosphere 1985; 14: 909
   Google Scholar
• Fingerhut M. A., Halperin W. E., Marlow D. A., Piacitelli A., Honchar A., Sweeney M. H., Greife A. L., Dill P. A., Steenland K., Suruda A. J. Cancer mortality in workers exposed to 2,3,7,8-TCDD. N. Engl. J. Med. 1991; 324: 212
   PubMed Web of Science ®Google Scholar
• Firestone D., Clower M., Borsetti A. P., Teske R. H., Long P. E. Polychlorodibenzo-p-dioxin and pentachlorophenol residues in milk and blood of cows fed technical pentachlorophenol. J. Agric. Food Chem. 1979; 27: 1171
   PubMed Web of Science ®Google Scholar
• Fox G. A., Collins E. Hayakawa, Weseloh D. V., Ludwig J. P. Reproductive outcomes in colonial fish-eating birds: a biomarker for developmental toxins in Great Lakes food chains. J. Great Lakes Res. 1991; 17: 158
   Web of Science ®Google Scholar
• Fries G. F., Marrow G. S. Retention and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rats. J. Agric. Food Chem. 1975; 23: 265
   PubMed Web of Science ®Google Scholar
• Furst P., Meemken H. A., Groebel W. Determination of polychlorinated dibenzodioxins and dibenzofurans in human milk. Chemosphere 1986; 15: 1977
   Google Scholar
• Furst P., Meemken H. A., Kruger C., Groebel W. Polychlorinated dibenzodioxins and dibenzofurans in human milk samples from Western Germany. Chemosphere 1987; 16: 1983
   Web of Science ®Google Scholar
• Furst P., Kruger C., Meemken H. A., Groebel W. PCDD and PCDF levels in human milk — dependence on the period of lactation. Chemosphere 1989; 18: 439
   Google Scholar
• Gallo M. A., Hesse E. J., Macdonald G. J., Umbreit T. H. Interactive effects of estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus. Toxicol. Lett. 1986; 32: 123
   PubMed Web of Science ®Google Scholar
• Gasiewicz T. A., Neal R. A. 2,3,7,8-Tetra-chlorodibenzo-p-dioxin tissue distribution, excretion and effects on clinical parameters in guinea pigs. Toxicol. Appl. Pharmacol. 1979; 51: 329
   PubMed Web of Science ®Google Scholar
• Gasiewicz T. A., Geiger L. E., Rucci G., Neal R. A. Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice. Drug. Metab. Dispos. 1983; 11: 397
   PubMed Web of Science ®Google Scholar
• Gasiewicz T. A., Rucci G. Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species. Mol. Pharmacol. 1984; 26: 90
   PubMed Web of Science ®Google Scholar
• Gasiewicz T. A., Rucci G., Henry E. C., Baggs R. B. Changes in hamster hepatic cytochrome P-450, efhoxycoumarin-O-deethylase, and reduced NAD(P): menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity. Biochem. Pharmacol. 1986; 35: 2737
   PubMed Web of Science ®Google Scholar
• Geyer H., Scheunert I., Korte F. Biocon-centration potential of organic environmental chemicals in humans. Regul. Toxicol. Pharmacol. 1986; 6: 313
   PubMed Web of Science ®Google Scholar
• Geyer H. J., Scheunert I., Rapp K., Kettrup A., Korte F., Greim H., Rozman K. Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals. Toxicology 1990; 65: 97
   PubMed Web of Science ®Google Scholar
• Gilbertson M. Effects on fish and wildlife populations. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 103
   Google Scholar
• Gillner M., Brittebo E. B., Brandt I., Soderkvist P., Appelgren L. E., Gustafsson J. A. Uptake and specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the olfactory mucosa of mice and rats. Cancer Res. 1987; 47: 4150
   PubMed Web of Science ®Google Scholar
• Gobas F. A. P.C., Shiu W. Y., Mackay D., Opperhuizen A. Bioaccumulation of PCDD's and PCDE in fish after aqueous and dietary exposure. Chemosphere 1986; 15: 1985
   Google Scholar
• Gobas F. A. P.C. Bioaccumulation of some poly-chlorinated dibenzo-p-dioxins and octachlorodiben-zofuran in the guppy. (Poecilia reticulata), Chemosphere 1990; 20: 495
   Google Scholar
• Goksoyr A., Förlin L. The cytochrome P450 system in fish, aquatic toxicology and environmental monitoring. Aquat. Toxicol. 1992; 22: 287
   Web of Science ®Google Scholar
• Goldstein J. A., Safe S. Mechanism of action and structure-activity relationship for the chlorinated dibenzo-p-dioxins and related compounds. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 239
   Google Scholar
• Golor G., Wiesmuller T., Hagenmaier H., Neubert D. Biological activity and tissue concentrations of TCDD and OCDD in rats after s.c. application alone or in combination. Chemosphere 1990; 20: 1183
   Google Scholar
• Gonzalez F. J., Jaiswal A. K., Nebert D. W. P450 genes: evolution, regulation, and relationship to human cancer and pharmacokinetics. Cold Spring Harbor Symp. Quant. Biol. 1986; 51: 879
   PubMedGoogle Scholar
• Gorski T., Konopka L., Brodzki M. Persistence of some polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans of pentachlorophenol in human adipose tissue. Roczn. Pzh. T. 1984; 35: 297
   PubMedGoogle Scholar
• Graham M., Hileman F., Kirk D., Wendling J., Wilson J. Background human exposure to 2,3,7,8-TCDD. Chemosphere 1985; 14: 925
   Google Scholar
• Haake J. M., Safe S., Mayura K., Phillips T. D. Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Lett. 1987; 38: 299
   PubMed Web of Science ®Google Scholar
• Hagenmaier H., Wiesmuller T., Golor G., Krowke R., Helge H., Neubert D. Transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) via placenta and through milk in a marmoset monkey. Arch. Toxicol. 1990; 64: 601
   PubMedGoogle Scholar
• Hakansson H., Hanberg A. The distribution of [14C]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its effect on the vitamin A content in parenchymal and stellate cells of rat liver. J. Nutr. 1989; 119: 573
   PubMedGoogle Scholar
• Harris M., Zacharewski T., Piskorskapliszczynska J., Rosengren R., Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachloro-dibenzo-p-dioxin and related congeners — mechanistic studies. Toxicol. Appl. Pharmacol. 1990; 105: 243
   PubMed Web of Science ®Google Scholar
• Hart L. E., Cheng K. M., Whitehead P. E., Shah R. M., Lewis R. J., Ruschkowski S. R., Blair R. W., Bennett D. C., Bandiera S. M., Norstrom R. J. Dioxin contamination and growth and development in great blue heron embryos. J. Toxicol. Environ. Health 1991; 32: 331
   PubMed Web of Science ®Google Scholar
• Hebert C. D., Birnbaum L. S. The influence of aging on intestinal absorption of TCDD in rats. Toxicol. Lett. 1987; 37: 47
   PubMedGoogle Scholar
• Heida H., Olie K. TCDD and chlorinated dibenzofurans in topsoil and biological samples from a contaminated refuse dump. Chemosphere 1985; 14: 919
   Google Scholar
• Heida H., Olie K., Prins E. Selective accumulation of chlorobenzenes, polychlorinated dibenzofurans and 2,3,7,8-TCDD in wildlife of the Volgermeerpolder. Amsterdam, Holland. Chemosphere 1986; 15: 1995
   Web of Science ®Google Scholar
• Henderson L. O., Patterson D. G. Distribution of 2,3,7.8-tetrachlorodibenzo-p-dioxin in human whole blood and its association with, and extract-ability from, lipoproteins. Bull. Environ. Contam. Toxicol. 1988; 40: 604
   PubMedGoogle Scholar
• Hiles R. A., Bruce R. D. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin elimination in the rat: first order or zero order?. Food Cosmet. Toxicol. 1976; 14: 599
   PubMedGoogle Scholar
• Hoffman D. J., Rattner B. A., Sileo L., Docherty D., Kubiak T. J. Embryotoxicity, teratogenicity, and aryl hydrocarbon hydroxylase activity in Forster's tern on Green Bay, Lake Michigan. Environ. Res. 1987; 42: 176
   PubMed Web of Science ®Google Scholar
• Hoffman R. E., Stehr Green P. A. Localized contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin: the Missouri episode. Halogenated Biphenyls, Terphenyls. Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 471
   Google Scholar
• Holcomb M., Yao C., Safe S. Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships. Biochem. Pharmacol. 1988; 37: 1535
   PubMed Web of Science ®Google Scholar
• Holder J. W., Menzel H. M. Analysis of 2,3,7,8-TCDD tumor promotion activity and its relationship to cancer. Chemosphere. 1989; 19: 861
   Web of Science ®Google Scholar
• Hori S., Kashimoto T., Kunita N. Effect of polychlorinated dibenzofuran on the retention of polychlorinated biphenyl isomers in the liver and adipose tissue of mice. J. Food Hyg. Soc. Jpn. 1982; 23: 167
   Google Scholar
• Huetter R., Phillippi M. Studies on microbial metabolism of TCDD under laboratory conditions. Pergamon Ser. Environ. Sci. 1982; 5: 87
   Google Scholar
• Hutzinger O., Blumich M. J., Vanden Berg M., Olie K. Sources and fate of PCDDs and PCDFs: an overview. Chemosphere 1985; 14: 581
   Web of Science ®Google Scholar
• Hutzinger O., Fiedler H. Sources and emissions of PCDD/PCDF. Chemosphere. 1989; 18: 23
   Web of Science ®Google Scholar
• Ioannou Y. M., Birnbaum L. S., Matthews H. B. Toxicity and distribution of 2,3,7,8-tetrachloro-dibenzofuran in male guinea pigs. J. Toxicol. Environ. Health 1983; 12: 541
   PubMed Web of Science ®Google Scholar
• Ivens I., Neupert M., Loser E., Thies J. Storage and elimination of 2,3,7,8-tetrabromodibenzo-p-dioxin in liver and adipose tissue of the rat. Chemosphere 1990; 20: 1209
   Google Scholar
• Jacobson J. L., Jacobson S. W., Humphrey H. E. B. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J. Pediatr. 1990; 116: 38
   PubMed Web of Science ®Google Scholar
• Jensen A. A. Background levels in humans. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/ North-Holland, Amsterdam 1989; 345
   Google Scholar
• Jensen A. A. Polychlorobiphenyls (PCBs), poly-chlorodibenzo-p-dioxins (PCDDs) and polychlorodi-benzofurans (PCDFs) in human milk, blood and adipose tissue. Sci. Total Environ. 1987; 64: 259
   PubMed Web of Science ®Google Scholar
• Jones P. B., Galeazzi D. R., Fisher J. M., Whitlock J. P. Control of cytochrome P1-450 gene expression by dioxin. Science 1985; 227: 1499
   PubMed Web of Science ®Google Scholar
• Jones P. B., Durrin L. K., Fisher J. M., Whitlock J. P. Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5′-ward of the cytochrome P1-450 gene. J. Biol. Chem. 1986; 261: 6647
   PubMed Web of Science ®Google Scholar
• Jones D., Safe S., Morcom E., Holcomb M., Coppock C., Ivie I. Bioavailability of grain and soil-borne triated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to lactating Holstein cows. Chemosphere 1989; 18: 1257
   Web of Science ®Google Scholar
• Kahn P. C., Cochfeld M., Nygren M., Hansson M., Rappe C., Velez H., Ghent-Guenther T., Wilson W. P. Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterans and matched controls. JAMA 1988; 259: 1661
   PubMed Web of Science ®Google Scholar
• Kamimura H., Koga N., Oguri K., Yoshimura H., Honda Y., Nakano M. Enhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads. Xenobiotica 1988; 18: 585
   PubMed Web of Science ®Google Scholar
• Hutzinger O., Vanden Berg M., Olie K., Opperhuizen A., Safe S. Dioxins and furans in the environment: evaluating toxicological risk from different sources by multi-criteria analysis. Dioxins in the Environment, M. A. Kamrin, P. W. Rodgers. Hemisphere Publishing, Washington, DC 1985; 9
   Google Scholar
• Kedderis L. B., Mills J. J., Andersen M. E., Birnbaum L. S. A physiologically-based pharmacokinetic model for 2,3,7,8-Tetrabromodibenzo-p-dioxin (TBDD) in the rat. Organohalogen Compounds 1992; 10: 113
   Google Scholar
• Kennedy S. W., Lorenzen A., James C. A. A rapid and sensitive method for measuring ethoxyresorufin-O-dethylase (EROD) activity in cultured hepatocytes exposed to dioxins, PCBs, and related compounds. Organohalogen compounds 1992; 10: 117
   Google Scholar
• Kimbrough R. D., Grandjean P. Occupational exposure in Halogenated Biphenyls, Terphenyls, Naphthalenes. Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 485
   Google Scholar
• King F. G., Dedrick R. L., Collins J. M., Matthews H. B., Birnbaum L. S. Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-furan in several species. Toxicol. Appl. Pharmacol. 1983; 67: 390
   PubMed Web of Science ®Google Scholar
• Kissel J. C., Robarge G. M. Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic models. Chemosphere 1988; 17: 2017
   Google Scholar
• Kleeman J. M., Olson J. R., Chen S. M., Peterson R. E. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout. Toxicol. Appl. Pharmacol. 1986; 83: 391
   PubMed Web of Science ®Google Scholar
• Kleeman J. M., Olson J. R., Chen S. M., Peterson R. E. 2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Toxicol. Appl. Pharmacol. 1986; 83: 402
   PubMedGoogle Scholar
• Kleeman J. M., Olson J. R., Peterson R. E. Special differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish. Fundam. Appl. Toxicol. 1988; 10: 206
   PubMedGoogle Scholar
• Kociba R. J., Keyes D. G., Beyer J. E., Carreon R. M., Wade C. E. Results of a two year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-o-dioxin in rats. Toxicol. Appl. Pharmacol. 1978; 46: 279
   PubMed Web of Science ®Google Scholar
• Kociba R. J., Cabey O. Comparative toxicity and biologic activity of chlorinated dibenzo-p-dioxins and furans relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemosphere 1985; 14: 649
   Web of Science ®Google Scholar
• Koga N., Kuroki J., Nakashima H., Hokama-Kuroki Y., Yoshimura H., Kuroki H., Masuda Y. Acute toxicity, inductive effects of liver enzymes and distribution in the liver of 1,2,3,7,8-pentachlorodibenzo-p-dioxin in rats. Fukuoka Igaku Zasshi 1991; 82: 197
   PubMedGoogle Scholar
• Korte M., Stahlman R., Neubert D. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD tissue concentrations after single treatment during pregnancy. Chemosphere 1990; 20: 1193
   Google Scholar
• Koshakji R. P., Harbison R. D., Bush M. T. Studies on the metabolic fate of [14C]2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) in the mouse. Toxicol. Appl. Pharmacol. 1984; 73: 69
   PubMedGoogle Scholar
• Krowke R., Chahoud I., Baumann-Wilschke I., Neubert D. Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. II. Pharmacokinetics in rats using a loading-dose/maintenance-dose regime with high doses. Arch. Toxicol. 1989; 63: 356
   PubMedGoogle Scholar
• Krowke R., Neubert D. Comparison of cleft palate frequency and TCDD concentration in mice at different stages of development. Chemosphere 1990; 20: 1177
   Google Scholar
• Krowke R., Abraham K., Wiesmuller T., Hagenmaier H., Neubert D. Transfer of various PCDDs and PCDFs via the placenta and mothers milk to Marmoset offspring. Chemosphere 1990; 20: 1065
   Web of Science ®Google Scholar
• Kubiak T. J., Harris H. J., Smith L. M., Schwartz T. R., Stalling D. L., Trick J. A., Sileo L., Docherty D. E., Erdmann T. C. Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan. Arch. Environ. Contam. Toxicol. 1989; 18: 727
   Google Scholar
• Kuehl D. W., Cook P. M., Batterman A. R., Lothenbach D. B. Bioavailability of 2,3,7,8-tetra-chlorodibenzo-p-dioxin from municipal incinerator fly ash to freshwater fish. Chemosphere 1985; 14: 427
   Google Scholar
• Kuehl D. W., Cook P. M., Batterman A. R. Uptake and depuration studies of PCDDs and PCDFs in freshwater fish. Chemosphere 1986; 15: 2023
   Google Scholar
• Kuehl D. W., Cook P. M., Batterman A. R., Butterworth B. C. Isomer dependent bioavailability of polychlorinated dibenzo-p-dioxins and dibenzo-furans from municipal incinerator fly ash to carp. Chemosphere 1987; 16: 657
   Web of Science ®Google Scholar
• Kuehl D. W., Cook P. M., Batterman A. R. Studies on the bioavailability of 2,3,7,8-TCDD from municipal incinerator fly ash to freshwater fish. Chemosphere 1985; 14: 871
   Google Scholar
• Kumaki K., Jensen N. M., Shire J. G. M., Nebert D. W. Genetic differences in induction of cytosol reduced-NAD(P)H: menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J. Biol. Chem. 1977; 252: 157
   PubMed Web of Science ®Google Scholar
• Kuratsune M. Yusho, with reference to Yu-Cheng. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 381
   Google Scholar
• Kuroki H., Masuda Y. Determination of polychlorinated dibenzofuran isomers retained in patients with Yusho. Chemosphere 1978; 10: 771
   Web of Science ®Google Scholar
• Kuroki H., Masuda Y., Yoshihara S., Yoshimura H. Accumulation of polychlorinated dibenzofurans in the livers of monkeys and rats. Food Cosmet. Toxicol. 1980; 18: 387
   PubMedGoogle Scholar
• Kuroki J., Koga N., Yoshimura H. High affinity of 2,3,4,7,8-pentachlorodibenzofuran to cytochrome P-450 in the hepatic microsomes of rats. Chemosphere 1986; 15: 731
   Google Scholar
• Kuroki H., Haraguchi K., Masuda Y. Polychlorinated dibenzofuran (PCDF) congeners in the tissues of patients with yusho and normal Japanese. Chemosphere 1987; 16: 2039
   Web of Science ®Google Scholar
• Kuroki H., Hattori R., Haraguchi K., Masuda Y. Metabolism of 2,8-dichlorodibenzofuran in rats. Chemosphere 1989; 19: 803
   Google Scholar
• Kuroki H., Haraguchi K., Masuda Y. Metabolism of polychlorinated dibenzofurans (PCDFs) in rats. Chemosphere 1990; 20: 1065
   Google Scholar
• Lakshmanan M. R., Campbell B. S., Chirtel S. J., Ekarohita N., Ezekiel M. Studies on the mechanism of absorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. J. Pharmacol Exp. Ther. 1986; 239: 673
   PubMedGoogle Scholar
• Landers J. P., Birse L. M., Nakai J. S., Winhall M. J., Bunce N. J. Chemically induced hepatic cytosol from the Sprague-Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-di-oxin to components kinetically distinct from the Ah receptor. Toxicol. Lett. 1990; 51: 295
   PubMedGoogle Scholar
• Lans M. C., Brouwer A., Koppe J. G., Vanden Berg M. Enzyme induction and alterations in thyroid hormone, vitamine A and K levels by TCDD in neonatal and maternal rats. Chemosphere 1990; 20: 1129
   Web of Science ®Google Scholar
• Lans M., DeWinden P., Safe S., Brouwer A. Effects of hydroxy-dioxins on thyroidhormone binding to transthyretin and thyroidhormone type 1 deiodinase activity in vitro and in vivo. Proc. 11th Int. Symp. on Dioxins and Related Compounds, Research Triangle Park. NC, 1991; 129
   Google Scholar
• Leece B., Denomme M. A., Towner R., Li A., Landers J., Safe S. Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3.7,8-tetrachlorodibenzo-p-dioxin receptor. Can. J. Physiol. Pharmacol. 1987; 65: 1908
   PubMed Web of Science ®Google Scholar
• Leung H. W., Ku R. H., Paustenbach D. J., Andersen M. E. A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Toxicol. Lett. 1988; 42: 15
   PubMed Web of Science ®Google Scholar
• Leung H. W., Poland A., Paustenbach D. J., Murray F. J., Andersen M. E. Pharmacokinetics of [125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach. Toxicol. Appl. Pharmacol. 1990; 103: 411
   PubMed Web of Science ®Google Scholar
• Leung H. W., Paustenbach D. J., Murray F. J., Andersen M. E. A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol. Appl. Pharmacol. 1990; 103: 399
   PubMed Web of Science ®Google Scholar
• Leung H. W., Wendling J. M., Orth R., Hileman F., Paustenbach D. J. Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatic and adipose tissues. Toxicol. Lett. 1990; 50: 275
   PubMedGoogle Scholar
• Lower W. R., Yanders A. F., Orazio C. E., Puri R. K., Hancock J., Kapila S. A survey of 2,3,7,8-tetrachlorodibenzo-p-dioxin residues in selected animal species from Times Beach, Missouri. Chemosphere 1989; 18: 1079
   Google Scholar
• Lucier G. W., Sonawane B. R., Mc Daniel O. S., Hook G. E. R. Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats. Chem. Biol. Interact 1975; 11: 15
   PubMed Web of Science ®Google Scholar
• Lucier G. W., Rumbaugh R. C., Mc Coy Z., Hass R., Harvan D., Albro P. Ingestion of soil contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic enzyme activities in rats. Fundam. Appl. Toxicol. 1986; 6: 364
   PubMedGoogle Scholar
• Lyakhovich V. V., Chasovnikova O. B., Tsyrlov I. B. Effect of TCDD and comparable inducers upon synthesis of monooxygenase forms P-450 sub(c) and P-450 sub(d) in rats. Chemosphere 1989; 18: 715
   Google Scholar
• Manara L., Coccia P., Croci T. Prevention of TCDD toxicity in laboratory rodents by addition of charcoal or cholic acids to chow. Food Chem. Toxicol. 1984; 22: 815
   PubMedGoogle Scholar
• Marinovich M., Sirtori C. R., Galli C. L., Paoletti R. The binding of 2,3,7,8-tetrachloro-dibenzodioxin to plasma lipoproteins may delay toxicity in experimental hyperlipidemia. Chem. Biol. Interact 1983; 45: 393
   PubMedGoogle Scholar
• Maslanka R., Steward A. R., Subodh Kumar, Sikka H. C. Disposition and metabolism of 2,3,7,8-tetrachlorodibenzofuran in Rainbow trout. Mar. Environ. Res., in press
   Google Scholar
• Mason G., Sawyer T., Keys B., Bandiera S., Romkes M., Piskorska-Pliszczynska J., Zmudzka B., Safe S. Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-acitvity relationships. Toxicology 1985; 37: 1
   PubMed Web of Science ®Google Scholar
• Mason G., Farrell K., Keys B., Piskorska-Pliszczynska J., Safe L., Safe S. Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships. Toxicology 1986; 41: 21
   PubMed Web of Science ®Google Scholar
• Mason G., Safe S. Synthesis, biologic and toxic effects of the major 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites in the rat. Toxicology 1986; 41: 153
   PubMed Web of Science ®Google Scholar
• Mason G. G., Wilhelmsson A., Cuthill S., Gillner M., Poellinger L., Gustafsson J. A. The dioxin receptor: characterization of its DNA-binding properties. J. Steroid. Biochem. 1988; 30: 307
   PubMedGoogle Scholar
• McConnell E. E., Lucier G. W., Rumbaugh R. C., Albro P. W., Harvan D. J., Hass J. R., Harris M. W. Dioxin in soil: bioavailability after ingestion by rats and guinea pigs. Science 1984; 223: 1077
   PubMed Web of Science ®Google Scholar
• McConnell E. E. Acute and chronic toxicity and carcinogenesis in animals. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 161
   Google Scholar
• McKinley M. K., Diliberto J. J., Birnbaum L. S. 2,3,7,8-Tetrachlorodibenzofuran (TCDF) pre-treatment of male fisher rats alters the hepatic metabolism of a subsequent dose. Proc. 11th Int. Symp. on Dioxins and Related Compounds, Research Triangle Park, NC, 1991; 144
   Google Scholar
• McKinney J. D., Chae K., Oatley S. J., Blake C. C. Molecular interactions of toxic chlorinated dibenzo-p-dioxins and dibenzofurans with thyroxine binding prealbumin. J. Med. Chem. 1985; 28: 375
   PubMed Web of Science ®Google Scholar
• McKinney J. D., Fawkes J., Jordan S., Chae K., Oatley S., Coleman R. E., Briner W. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity. Environ. Health Perspect 1985; 61: 41
   PubMedGoogle Scholar
• McKinney J., Fannin R., Jordan S., Chae K., Rickenbacher U., Pedersen L. Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts. J. Med. Chem. 1987; 30: 79
   PubMed Web of Science ®Google Scholar
• McKinney J. D. Multifunctional receptor model for dioxin and related compound toxic action: possible thyroid hormone-responsive effector-linked site. Environ. Health Perspect 1989; 82: 323
   PubMed Web of Science ®Google Scholar
• McLachlan M. S., Thoma H., Reissinger M., Hutzinger O. PCDD/F in an agricultural foodchain. I. PCDD/F mass balance of a lactating cow. Chemosphere 1990; 20: 1013
   Web of Science ®Google Scholar
• McNulty W. P. Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques. (Macaca mulatta), Environ. Health Perspect 1985; 60: 77
   PubMed Web of Science ®Google Scholar
• McPhail M. E., Green C. E., Mc Garrigle B. P., Petrelli N., Rodriguez M. A., Olson J. R. Metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in rat and human liver. Toxicologist 1993; 13: 193
   Google Scholar
• Merchant M., Morrison V., Santostefano M., Safe S. Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Arch. Biochem. Biophys 1992; 298: 389
   PubMedGoogle Scholar
• Millis C. D., Mills R. A., Sleight S. D., Aust S. D. Toxicity of 3,4,5,3′,4′,5′-hexabrominated bi-phenyl and 3,4,3′,4′-tetrabrominated biphenyl. Toxicol. Appl. Pharmacol. 1985; 78: 88
   PubMedGoogle Scholar
• Miyata H., Takayama K., Mimura M., Kashimoto T., Fukushima S. Specific congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in blue mussel in Osaka Bay in Japan: aqueous solubilities of PCDDs and PCDFs. Bull. Environ. Contam. Toxicol. 1989; 43: 342
   PubMedGoogle Scholar
• Moore J. A., Harris M. W., Albro P. W. Tissue distribution of [14C]tetrachlorodibenzo-p-dioxin in pregnant and neonatal rats. Toxicol. Appl. Pharmacol. 1976; 37: 146
   Web of Science ®Google Scholar
• Moore J. A., Mc Connell E. E., Dalgard D. W., Harris M. W. Comparative toxicity of three halogenated dibenzofurans in guinea pigs, mice and rhesus monkeys. Ann. N.Y. Acad. Sci. 1979; 32: 150
   Google Scholar
• Morita M., Oishi S. Clearance and tissue distribution of polychlorinated dibenzofurans in mice. Bull Environ. Contam. Toxicol. 1977; 188: 61
   Google Scholar
• Morita M., Yasuhara A., Seki H., Ohi G. Chlorodibenzo-p-dioxins in the feral pigeon. Chemosphere 1987; 16: 1749
   Google Scholar
• Morrissey R. E., Schwetz B. A. Reproductive and developmental toxicity in animals. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzo-dioxins and Related Products 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 195
   Google Scholar
• Morrissey R. E., Harris M. W., Diliberto J. J., Birnbaum L. S. Limited PCB antagonism of TCDD-induced malformations in mice. Toxicol. Lett. 1992; 60: 19
   PubMed Web of Science ®Google Scholar
• Morse D. C., De Bie A., Van Bladeren P. J., Brouwer A. Excretion kinetics of a combined dose of 3,4,3′,4′-tetrachlorobiphenyl and 2,4,5,2′,4′,5′-hexachlorobiphenyl in female rats. Organohalogen Compounds 1990; 1: 39
   Google Scholar
• Muir D. C. G., Marshall W. K., Webster G. R. B. Bioconcentration of PCDDs by fish: effects of molecular structure and water chemistry. Chemosphere 1985; 14: 829
   Google Scholar
• Muir D. C. G., Yarechewski A. L., Knoll A., Webster G. R. B. Bioconcentration and disposition of 1,3,6,8-tetrachlorodibenzo-p-dioxin and octachloro-dibenzo-p-dioxin by Rainbow trout and Fathead minnow. Environ. Toxicol. Chem. 1986; 5: 261
   Google Scholar
• Muir D. C. G., Yarechewksi A. L. Dietary accumulation of four chlorinated dioxin congeners by Rainbow trout and Fathead minnows. Environ. Toxicol Chem. 1988; 7: 227
   Google Scholar
• Muir D. C. G., Yarechewksi A. L., Metner D. A., Lockhart W. L., Webster G. R. B., Friesen K. J. Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8-pentachlorodibenzofuran in rainbow trout. Environ. Toxicol. Chem. 1990; 9: 1463
   Web of Science ®Google Scholar
• Muller M. D., Buser H. R. Halogenated aromatic compounds in automotive emissions from leaded gasoline additives. Environ. Sci. Technol. 1986; 10: 1151
   Google Scholar
• Nagayama J., Masuda Y., Kuratsune M. Determination of polychlorinated dibenzofurans in tissues of patients with Yusho. Food Cosmet. Toxicol. 1977; 15: 195
   PubMedGoogle Scholar
• Nagayama J., Tokudome S., Kuratsune M., Masuda Y. Transfer of polychlorinated dibenzofurans to the foetuses and offspring of mice. Food Cosmet. Toxicol. 1980; 18: 153
   PubMedGoogle Scholar
• Nagayama J., Kiyohara C., Masuda Y., Kuratsune M. Inducing potency of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells and mice by polychlorinated dibenzofuran congeners. Environ. Health Perspect 1985; 59: 107
   PubMedGoogle Scholar
• Nagayama J., Kiyohara C., Handa S., Masuda Y., Kuratsune M. Effects of chlorinated dibenzofuran and dioxin on concentration and pattern of chlorobiphenyls and activity of benzo(a)pyrene hydroxylation in mice. Fukuoka Igaku Zasshi 1985; 76: 175
   PubMedGoogle Scholar
• Nagayama J., Kiyohara C., Handa S., Horie A. Comparative toxicologic study of 2,3,4,7,8-penta-chlorodibenzofuran in Ah responsive and nonresponsive strains of mice. Chemosphere 1990; 20: 1165
   Google Scholar
• Nau H., Bass R. Transfer of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) to the mouse embryo and fetus. Toxicology 1981; 20: 299
   PubMed Web of Science ®Google Scholar
• Nau H., Bass R., Neubert D. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via placenta and milk, and postnatal toxicity in the mouse. Arch. Toxicol. 1986; 59: 36
   PubMed Web of Science ®Google Scholar
• Neal R. A., Olson J. R., Gasiewicz T. A., Geiger L. E. The toxicokinetics of 2,3,7,8-tetra-chlorodibenzo-p-dioxin in mammalian systems. Drug Metab. Rev. 1982; 13: 355
   PubMed Web of Science ®Google Scholar
• Neal R. A. Mechanisms of the biological effects of PCBs, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in experimental animals. Environ. Health Perspect 1985; 60: 41
   PubMed Web of Science ®Google Scholar
• Nebert D. W. The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. Crit. Rev. Toxicol. 1989; 20: 153
   PubMed Web of Science ®Google Scholar
• Nessel C. S., Amoruso M. A., Umbreit T. H., Gallo M. A. Hepatic aryl hydrocarbon hydroxylase and cytochrome P450 induction following the trans-pulmonary absorption of TCDD from intratracheally instilled particles. Fundam. Appl. Toxicol. 1990; 15: 500
   PubMedGoogle Scholar
• Neubert D., Wiesmuller T., Abraham K., Krowke R., Hagenmaier H. Persistence of various poly-chlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in hepatic and adipose tissue of marmoset monkeys. Arch. Toxicol. 1990; 64: 431
   PubMed Web of Science ®Google Scholar
• Newsome W. H., Iverson F., Ryan J. J., Lau P. Y., Mc Leod H. A. Chlorinated compounds in tissues of chickens raised on pentachlorophenol-contaminated litter. Food Addit. Contam. 1984; 1: 3
   PubMedGoogle Scholar
• Niimi A. J., Oliver B. G. Biological half-lives of chlorinated dibenzo-p-dioxins and dibenzofurans in Rainbow trout. (Salmo gairdneri). Environ. Toxicol. Chem. 1986; 5: 49
   Google Scholar
• Niimi A. J., Oliver B. G. Assessment of relative toxicity of chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in Lake Ontario salmonids to mammalian systems using toxic equivalent factors (TEF). Chemosphere. 1989; 18: 1413
   Web of Science ®Google Scholar
• Nolan R. J., Smith F. A., Hefner J. G. Elimination and tissue distribution of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) in female guinea pigs following a single oral dose. Toxicol. Appl. Pharmacol. 1979; 48: A162
   Google Scholar
• Norback D. H., Engblom J. F., Allen J. R. Tissue distribution and excretion of octachlorodibenzo-p-dioxin in the rat. Toxicol. Appl. Pharmacol. 1975; 32: 330
   PubMedGoogle Scholar
• Norstrom R. J., Simon M., Muir D. C. G., Schweinberg R. E. Organochlorine contaminants in arctic food chains: identification, geographical distribution, and temporal trends in polar bears. Environ. Sci. Technol. 1988; 22: 1063
   PubMed Web of Science ®Google Scholar
• Norstrom R. J., Simon M L, Muir D. C. G. Polychlorinated dibenzo-p-dioxins and dibenzofurans in marine mammals in the Canadian North. Environ. Pollut. 1990; 66: 1
   PubMed Web of Science ®Google Scholar
• O'Keefe P. W., Hilker D. R., Smith R. M., Aldous K. M., Donnelly R. J., Long D., Pope D. H. Nonaccumulation of chlorinated dioxins and furans by goldfish exposed to contaminated sediment and flyash. Bull. Environ. Contam. Toxicol. 1986; 36: 452
   PubMedGoogle Scholar
• O'Keefe P. W., Smith R. M. PCB capacitor/transformer accident. Halogenated Biphenyls, Terphenyls. Naphthalenes, Dibenzodioxins and Related Products. 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 417
   Google Scholar
• Ogaki J., Takayama K., Miyata H., Kashimoto T. Levels of PCDDS and PCDFs in human tissues and various foodstuffs in Japan. Chemosphere 1987; 16: 2047
   Web of Science ®Google Scholar
• Olie K., Vermeulen P., Hutzinger O. Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in The Netherlands. Chemosphere 1977; 6: 455
   Google Scholar
• Oiling M., Derks H. J. G.M., Berende P. L. M., Liem A. K. D., Dejong A. P. J.M. Toxicokinetics of eight 13C-labelled polychlorinated dibenzo-p-dioxins and furans in lactating cows. Organohalogen Compounds 1990; 1: 485
   Google Scholar
• Olson J. R., Gasiewicz T. A., Neal R. A. Tissue distribution, excretion and metabolism of 2,3,7,8-tetrachior-p-dioxin (TCDD) in the Golden Syrian hamster. Toxicol. Appl. Pharmacol. 1980; 56: 78
   PubMed Web of Science ®Google Scholar
• Olson J. R., Wroblewski V. J. Metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated hepatocytes from guinea pigs and rats. Chemosphere 1985; 14: 979
   Google Scholar
• Olson J. R. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs. Toxicol. Appl. Pharmacol. 1986; 85: 263
   PubMed Web of Science ®Google Scholar
• Olson J. R., Gutman S. I., Shen E. S. Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD. Chemosphere 1989; 18: 363
   Google Scholar
• Olson J. R., McReynolds J. H., Kumar S., McGarrigle B. P., Gigliotti B. P. Uptake and metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in rat hepatocytes and liver slices. Proc. 11th Int. Symp. on Dioxins and Related Compounds, Research Triangle Park, NC, 1991; 145
   Google Scholar
• Ono M., Kannan N., Wakimoto T., Tatsukawa R. Dibenzofurans a greater global pollutant than dioxins? Evidence from analyses of open ocean killer whale. Mar. Pollut. Bull. 1987; 18: 640
   Web of Science ®Google Scholar
• Opperhuizen A., Wagenaar W. J., Vander Wielen F. W. M., Vanden Berg M., Olie K., Gobas F. A. P.C. Uptake and elimination of PCDD/PCDF congeners by fish after aqueous exposure to a fly-ash extract from a municipal incinerator. Chemosphere 1986; 15: 2049
   Web of Science ®Google Scholar
• Opperhuizen A., Sijm D. T. H.M. Bioaccumulation and biotransformation of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish. Environ. Toxicol. Chem. 1990; 9: 175
   Web of Science ®Google Scholar
• Owens I. D. Genetic regulation of UDP-gluceronyl-transferase induction by polycyclic aromatic hydrocarbon compounds in mice. J. Biol. Chem. 1977; 252: 2827
   PubMed Web of Science ®Google Scholar
• Paasivirta J., Tarhane J., Juvonen B., Vuorinen P. Dioxin and related aromatic chloroethers in Baltic wildlife. Chemosphere 1987; 16: 1787
   Google Scholar
• Papke O., Ball M., Lis Z. A., Scheunert K. PCDD/PCDF in whole blood samples of unexposed persons. Chemosphere 1989; 19: 941
   Web of Science ®Google Scholar
• Papke O., Ball M., Lis Z. A., Scheunert K. Determination of PCDD/PCDF in whole blood from persons involved in fire incidents. Chemosphere 1990; 20: 959
   Google Scholar
• Patterson D. G., Hoffman R. E., Needham L. L., Roberts D. W., Bagby J. R., Pirkle J. L., Falk H., Sampson E. J., Houk V. N. 2,3,7,8-Tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report. JAMA 1986; 256: 2683
   PubMed Web of Science ®Google Scholar
• Patterson D. G., Furst P., Henderson L. O., Isaacs S. G., Alexander L. R., Turner W. E., Needham L. L., Hannon H. Partitioning of in vivo bound PCDD/PCDFs among various compartments in whole blood. Chemosphere 1989; 19: 135
   Google Scholar
• Patterson D. G., Turner W. E., Isaacs S. G., Alexander L. R. A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). Chemosphere 1990; 20: 829
   Google Scholar
• Pedersen L. G., Darden T. A., Oatley S. J., Mc Kinney J. D. A theoretical study of the binding of polychlorinated biphenyls (PCBs) dibenzodioxins, and dibenzofuran to human plasma prealbumin. J. Med. Chem. 1986; 29: 2451
   PubMedGoogle Scholar
• Philippe M., Krasnobagew V., Zeyer J., Huetter R. Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in microbial cultures and soil under laboratory conditions. FEMS Symp. 1981; 12: 2210
   Google Scholar
• Phillips D. L. Propagation of error and bias in half-life estimates based on two measurements. Arch. Environ. Contam. Toxicol. 1989; 18: 508
   PubMed Web of Science ®Google Scholar
• Picket C. B., Lu A. Y. H. Glutathione S-transferases: gene structure, regulation, and biological function. Annu. Rev. Biochem. 1989; 58: 743
   PubMedGoogle Scholar
• Piper W. N., Rose J. Q., Gehring P. J. Excretion and tissue distribution of 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the rat. Environ. Health Perspect 1973; 5: 241
   PubMedGoogle Scholar
• Pirkle J. L., Wolfe W. H., Patterson D. G., Needham L. L., Michalek J. E., Miner J. C., Peterson M. R., Phillips D. L. Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. J. Toxicol. Environ. Health 1989; 27: 165
   PubMed Web of Science ®Google Scholar
• Pluess N., Poiger H., Schlatter C., Buser H. R. The metabolism of some pentachlorodibenzo-furans in the rat. Xenobiotica 1987; 17: 209
   PubMed Web of Science ®Google Scholar
• Pluess N., Poiger H., Hohbach C., Suter M., Schlatter C. Subchronic toxicity of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in rats. Chemosphere 1988; 17: 1099
   Web of Science ®Google Scholar
• Pleuss N., Poiger H., Hohbach C., Schlatter C. Subchronic toxicity of some chlorinated dibenzofurans (PCDFs) and a mixture of PCDFs and chlorinated dibenzodioxins (PCDDs) in rats. Chemosphere 1988; 17: 973
   Google Scholar
• Pohjanvirta R., Tuomisto J., Vartiainen T., Rozman K. Han/Wistar rats are exceptionally resistant to TCDD. I. Pharmacol. Toxicol. 1987; 60: 145
   PubMedGoogle Scholar
• Pohjanvirta R., Tuomisto J. Han/Wistar rats are exceptionally resistant to TCDD. II. Arch. Toxicol. Suppl. 1987; 11: 344
   PubMedGoogle Scholar
• Pohjanvirta R., Juvonen R., Karenlampi S., Raunio H., Tuomisto J. Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD-susceptible and -resistant rat strain. Toxicol. Appl. Pharmacol. 1988; 92: 131
   PubMed Web of Science ®Google Scholar
• Pohjanvirta R., Hakansson H., Juvonen R., Tuomisto J. Effects of TCDD on vitamin A status and liver microsomal enzyme activities in a TCDD-susceptible and a TCDD-resistant rat strain. Food Chem. Toxicol. 1990; 28: 197
   PubMedGoogle Scholar
• Pohjanvirta R., Vartiainen T., Uusi-Rauva A., Monkkonen J., Tuomisto J. Tissue distribution, metabolism, and excretion of 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain. Pharmacol. Toxicol. 1990; 66: 93
   PubMedGoogle Scholar
• Poiger H., Schlatter C. Biological degradation of TCDD in rats. Nature 1979; 281: 706
   PubMed Web of Science ®Google Scholar
• Poiger H., Schlatter C. Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD. Food Cosmet. Toxicol. 1980; 18: 477
   PubMedGoogle Scholar
• Poiger H., Buser H. R. The metabolism of TCDD in the dog and rat, Banbury Rep. Biol. Mechanisms Dioxin Action 1984; 18: 39
   Google Scholar
• Poiger H., Buser H. R., Schlatter C. The metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat. Chemosphere 1984; 13: 351
   Google Scholar
• Poiger H., Schlatter C. Influence of pheno-barbital and TCDD on the hepatic metabolism of TCDD in the dog. Experientia 1985; 41: 376
   PubMedGoogle Scholar
• Poiger H., Schlatter C. Pharmacokinetics of 2,3,7,8-TCDD in man. Chemosphere 1986; 15: 1489
   Web of Science ®Google Scholar
• Poiger H., Pluess N., Schlatter C. Subchronic toxicity of some chlorinated dibenzofurans in rats. Chemosphere 1989; 18: 265
   Google Scholar
• Poiger H., Pluess N., Buser H. R. The metabolism of selected PCDFs in the rat. Chemosphere 1989; 18: 259
   Google Scholar
• Poland A., Glover E. Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachloro-dibenzo-p-dioxin: evidence for a receptor mutation in genetically non-responsive mice. Mol. Pharmacol. 1975; 11: 389
   Web of Science ®Google Scholar
• Poland A., Glover E., Kende A. S. Stereospecific, high affinity binding of 2,3,7,8-tetrachloro-dibenzo-p-dioxin by hepatic cytosol. J. Biol. Chem. 1976; 251: 4936
   PubMed Web of Science ®Google Scholar
• Poland A., Glover E. An estimate of the maximumin vivo covalent binding of 2,3,7,8-tetrachloro-dibenzo-p-dioxin to rat liver protein, robosomal RN A and DNA. Cancer Res. 1979; 39: 3341
   PubMed Web of Science ®Google Scholar
• Poland A., Glover E. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin: segregation of toxicity with the Ah-locus. Mol. Pharmacol. 1980; 17: 86
   PubMed Web of Science ®Google Scholar
• Poland A., Knutson J. C. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. 1982; 22: 517
   Google Scholar
• Poland A., Teitelbaum P., Glover E., Kende A. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [1251]-2-iodo-3,7,8-trichloro-dibenzo-p-dioxin by the administration of agonist for the Ah receptor. Mol. Pharmacol. 1989; 36: 121
   PubMed Web of Science ®Google Scholar
• Puhvel S. M., Sakamoto M., Reisner R. M. Localization of TCDD in hairless mouse skin. Chemosphere. 1986; 15: 2065
   Google Scholar
• Ramsey J. C., Hefner J. G., Karbowski R. J., Braun R. J., Gehring P. J. The in vivo biotransformation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat. Toxicol. Appl. Pharmacol. 1982; 65: 180
   PubMedGoogle Scholar
• Randerath K., Putman K. L., Randerath E., Mason G., Kelley M., Safe S. Organ-specific effects of long term feeding of 2,3,7,8-tetrachloro-dibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DN A of female Sprague-Dawley rats. Carcinogenesis 1988; 9: 2285
   PubMed Web of Science ®Google Scholar
• Randerath K., Putman K. L., Randerath E., Zacharewski T., Harris M., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships. Toxicol. Appl. Pharmacol. 1990; 103: 271
   PubMed Web of Science ®Google Scholar
• Rappe C., Buser H. R., Kuroki H., Masuda Y. Identification of polychlorinated dibenzofurans (PCDFs) retained in patients with Yusho. Chemo-sphere 1979; 4: 259
   Google Scholar
• Rappe C., Andersson R., Bergqvist P. A., Brohede C., Hansson M., Kjeller L. O., Lindstroem G., Marklund S., Nygren M. Overview on environmental fate of chlorinated dioxins and dibenzofurans, sources, levels and isomeric pattern in various matrices. Chemosphere 1987; 16: 1603
   Web of Science ®Google Scholar
• Rappe C., Buser H. R. Chemical and physical properties, analytical methods, sources and environmental levels of halogenated dibenzodioxins and dibenzofurans. Halogenated Biphenyls, Terphenyls. Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 71
   Google Scholar
• Rappe C., Bergqvist P. A., Kjeller L. O. Levels, trends and patterns of PCDDs and PCDFs in Scandinavian environmental samples. Chemosphere 1989; 18: 651
   Web of Science ®Google Scholar
• Rappe C., Bergqvist P. A., Kjeller L. O., Swanson S., Belton T., Ruppel B., Lockwood K., Kahn P. Levels and patterns of PCDD and PCDF contamination in fish, crabs, and lobsters from Newark Bay and the New York Bight. Chemosphere 1991; 22: 239
   Google Scholar
• Reggiani G. M. The Seveso accidents; medical survey of a TCDD exposure. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 445
   Google Scholar
• Reinecke A. J., Nash R. G. Toxicity of 2,3,7,8-TCDD and short-term bioaccumulation by earthworms (Oligochaeta). Soil Biol. Biochem. 1984; 16: 45
   Google Scholar
• Rogan W. J., Cheng Yu. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., R. D. Kimbrough, A. A. Jensen. Elsevier/North-Holland, Amsterdam 1989; 401
   Google Scholar
• Romkes M., Piskorska-Pliszczynska J., Keys B., Safe S., Fujita T. Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor. Cancer Res. 1987; 47: 5108
   PubMed Web of Science ®Google Scholar
• Rose J. Q., Ramsey J. C., Wentzler T. H., Hummel R. A., Gehring P. J. The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol. 1976; 36: 209
   PubMed Web of Science ®Google Scholar
• Rozman K., Hazelton G. A., Klaassen C. D., Arlotto M. P., Parkinson A. Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 1985; 37: 51
   PubMed Web of Science ®Google Scholar
• Rozman K., Gorski J. R., Dutton D., Parkinson A. Effects of vitamin A and/or thyroidectomy on liver microsomal enzymes and their induction in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats. Toxicology 1987; 46: 107
   PubMedGoogle Scholar
• Rushmore T. H., Pickett C. B. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. J. Biol. Chem. 1990; 265: 146
   Google Scholar
• Ryan J. J., Lizotte R., Lau B. P. Y. Chlorinated dibenzo-p-dioxins and chlorinated dibenzofurans in Canadian human adipose tissue. Chemosphere 1985; 14: 697
   Web of Science ®Google Scholar
• Ryan J. J., Lau B. P. Y., Hardy J. A., Stone W. B., O'Keefe P., Gierthy J. F. 2,3,7,8 Tetra-chlorodibenzo-p-dioxin and related dioxins and furans in snapping turtle (Chelydra serpentina) tissues from the upper St. Lawrence River. Chemosphere 1986; 15: 537
   Google Scholar
• Ryan J. J., Lizotte R., Lewis D. Human tissue levels of PCDDs and PCDFs from a fatal pentachloro-phenol poisoning. Chemosphere 1987; 16: 1989
   Google Scholar
• Ryan J. J., Masuda Y., Lizotte R., Panopio L. G., Lau B. P. Y. The effect of strong alkali on the determination of polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs). Chemosphere 1989; 18: 149
   Web of Science ®Google Scholar
• Ryan J. J., Gasiewicz T. A., Brown J. F. Human body burden of polychlorinated dibenzofurans associated with toxicity based on the Yusho and Yucheng incidents. Fundam. Appl. Toxicol. 1990; 15: 722
   PubMedGoogle Scholar
• Ryan J. J., Masuda Y. Elimination of polychlorinated dibenzofurans (PCDFs) in humans from the Yusho and Yucheng rice oil poisonings. Proc. 11th Int. Symp. on Dioxins and Related Compounds, Research Triangle Park, NC, 1991; 70
   Google Scholar
• Safe S. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 1986; 26: 371
   PubMed Web of Science ®Google Scholar
• Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit. Rev. Toxicol. 1990; 21: 51
   PubMed Web of Science ®Google Scholar
• Safe S., Astroff B., Harris M., Zacharewski T., Dickerson R., Romkes M., Biegel L. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds as antioestrogens: characterization and mechanism of action. Pharmacol. Toxicol. 1991; 69: 400
   PubMedGoogle Scholar
• Sawahata T., Olson J. R., Neal R. A. Identification of metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin formed on incubation with isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 1982; 105: 341
   PubMedGoogle Scholar
• Sawyer T. W., Safe S. In vitro AHH induction by polychlorinated biphenyl and dibenzofuran mixtures: additive effects. Chemosphere 1985; 14: 79
   Web of Science ®Google Scholar
• Schecter A., Ryan J. J., Constable J. D. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran levels in human breast milk from Vietnam compared with cow's milk and human breast milk from the North American Continent. Chemosphere 1987; 16: 2003
   Web of Science ®Google Scholar
• Schecter A., Ryan J. J., Kostyniak P. J. Decrease over a six year period of dioxin and dibenzofuran tissue levels in a single patient following exposure. Chemosphere 1990; 20: 911
   Google Scholar
• Schecter A., Ryan J. J., Constable J. D., Baughman R., Bangert J., Furst P., Wilmers K., Oates R. D. Partitioning of 2,3,7,8-chlorinated dibenzo-p-dioxins and dibenzofurans between adipose tissue and plasma lipid of 20 Massachusetts Vietnam veterans. Chemosphere 1990; 20: 951
   Web of Science ®Google Scholar
• Schlatter C. Data on kinetics of PCDDs and PCDFs as a prerequisite for human risk assessment Banbury Rep. Biol. Basis Risk Assessments Dioxins Related Compounds, 35, in press
   Google Scholar
• Schulz-Schalge T., Koch E., Schwind K. H., Hutzinger O., Neubert D. Comparative study on the inductive potency of TCDD and TBrDD with three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Organohalogen Compounds 1990; 1: 321
   Google Scholar
• Shen E. S., Olson J. R. Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab. Dispos. 1987; 15: 653
   PubMedGoogle Scholar
• Shireman R. B., Wei C. Uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin from plasma lipoproteins by cultured human fibroblasts. Chem. Biol. Interact 1986; 58: 1
   PubMedGoogle Scholar
• Shu H., Paustenbach D., Murray F. J., Marple L., Brunck B., Dei-Rossi D., Teitelbaum P. Bioavailability of soil-bound TCDD: oral bioavailability in the rat. Fundam. Appl. Toxicol. 1988; 10: 648
   PubMedGoogle Scholar
• Shu H., Teitelbaum P., Webb A. S., Marple L., Brunck B., Dei Rossi D., Murray F. J., Paustenbach D. Availability of soilbound TCDD: dermal bioavailability in the rat. Fundam. Appl. Toxicol. 1988; 10: 335
   PubMedGoogle Scholar
• Sielken R. L. Statistical evaluations reflecting the skewness in the distribution of TCDD levels in humans adipose tissue. Chemosphere 1987; 16: 2135
   Web of Science ®Google Scholar
• Sijm D. T. H.M., Opperhuizen A. Biotransformation, bioaccumulation and lethality of 2,8-dichlorodibenzo-p-dioxin: a proposal to explain the biotic fate and toxicity of PCDD's and PCDF's. Chemosphere 1988; 17: 83
   Web of Science ®Google Scholar
• Sijm D. T. H.M., Wever H., Opperhuizen A. Influence of biotransformation on the accumulation of PCDDs from fly-ash in fish. Chemosphere 1989; 19: 475
   Google Scholar
• Sijm D. T. H.M., Yarechewski A. L., Muir D. C. G., Webster G. R. B., Seinen W., Opperhuizen A. Biotransformation and tissue distribution of 1,2,3,7-tetrachlorodibenzo-p-dioxin, 1,2,3,4,7-pentachlorodibenzo-p-dioxin and 2,3,4,7,8-penta-chlorodibenzofuran in Rainbow trout. Chemosphere 1990; 21: 845
   Web of Science ®Google Scholar
• Soues S., Fernandez N., Souverain P., Lesca P. Intracellular lipoproteins as carriers for 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene in rat and mouse liver. Biochem. Pharmacol. 1989; 38: 2841
   PubMedGoogle Scholar
• Spencer C. B., Rifkind A. B. NAD(P)H: quinone oxidoreductase (DT-diaphorase) in chick embryo liver. Comparison to activity in rat and guinea pig liver and differences in co-induction with 7-ethoxyresorufin deethylase by 2,3,7,8-tetrachlorodibenzo-p-dioxine. Biochem. Pharmacol. 1990; 39: 327
   PubMedGoogle Scholar
• Spitsbergen J. M., Kleeman J. M., Peterson R. E. Morphologic lesions and acute toxicity in rainbow trout (Salmo gairdner) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Toxicol. Environ. Health 1988; 23: 333
   PubMed Web of Science ®Google Scholar
• Spitsbergen J. M., Kleeman J. M., Peterson R. E. 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in yellow perch. (Perca flavescens), J. Toxicol. Environ. Health 1988; 23: 359
   PubMed Web of Science ®Google Scholar
• Stegeman J. J., Lech J. J. Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure. Environ. Health Perspect 1991; 90: 101
   PubMed Web of Science ®Google Scholar
• Tai H. L., Mc Reynolds J. H., Goldstein J. A., Eugster H. P., Senstag C., Alworth W. L., Olson J. R. Cytochrome P-450 1A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in the rat and human. Toxicol. Appl. Pharmacol., in press.
   Google Scholar
• Tai H. L., Goldstein J. A., Alworth W. L., Olson J. R. Cytochrome P-450 1A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in the rat. Toxicologist 1993; 13: 193
   Google Scholar
• Takizawa Y., Muto H. PCDDs and PCDFs carried to the human body from the diet. Chemosphere 1987; 16: 1971
   Google Scholar
• Tanabe S., Kannan N., Subramanian A., Watannabe S., Tatsukawa R. Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans. Environ. Pollut. 1987; 47: 147
   PubMed Web of Science ®Google Scholar
• Tarhanen J., Koistinen J., Paasivirta J., Vuorinen P. J., Koivusaari J., Nuuja I., Kannan T., Tatsukawa R. Toxic significance of planar aromatic compounds in Baltic ecosystem — new studies on extremely toxic coplanar PCBs. Chemosphere 1989; 18: 1067
   Web of Science ®Google Scholar
• Theelen R. M. C., Van Laar A. Bioretention of 2,3,7,8-chlorine substituted dioxins and furans from flue ash and flue ash extract in rat liver. Chemosphere, in press
   Google Scholar
• Thoma H., Mucke W., Kretschmer E. Concentrations of PCDD and PCDF in human fat and liver samples. Chemosphere 1989; 18: 491
   Google Scholar
• Thoma H., Mucke W., Kauert G. Comparison of the polychlorinated dibenzo-p-dioxin and dibenzofuran in human tissue and human liver. Chemosphere 1990; 20: 433
   Google Scholar
• Thompson T. N., Watkins J. B., Gregus Z., Klaassen C. D. Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation. Toxicol. Appl. Pharmacol. 1982; 66: 400
   PubMed Web of Science ®Google Scholar
• Tillit D. E., Ankley G. T., Giesy J. P. Planar chlorinated hydrocarbons (PCHs) in colonial fish-eating waterbird eggs from the Great Lakes. Mar. Environ. Res. 1989; 28: 505
   Google Scholar
• Tillit D. E., Giesy J. P., Ankley G. T. Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halo-genated hydrocarbons in environmental samples. Environ. Sci. Technol. 1991; 25: 87
   Web of Science ®Google Scholar
• Tillit D. E., Ankley G. T., Giesy J. P., Ludwig J. P., Kurita-Matsuba H., Weseloh D. V., Ross P. S., Bishop C., Sileo L., Stromberg K. L., Larson J., Kubiak T. J. Polychlorinated biphenyl residues and egg mortality in double-crested comorants from the Great Lakes. Environ. Toxicol. Chem., in press
   Google Scholar
• Tritscher A., Clark G., Mc Coy Z., Portier C., Greenlee W., Goldstein J., Lucier G. Dose response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a rat tumor promotion model. II. Quantification and immunolocalization of cytochromes P450c(1A1) and P450d(1A2) in the liver. Proc. 11th Int. Symp. on Dioxins and Related Compounds, Research Triangle Park, NC, 1991; 148
   Google Scholar
• Tulp M. T. M., Hutzinger O. Rat metabolism of polychlorinated dibenzo-p-dioxins. Chemosphere 1978; 9: 761
   Google Scholar
• Umbreit T. H., Hesse E. J., Gallo M. A. Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site. Science 1986; 232: 497
   PubMed Web of Science ®Google Scholar
• Umbreit T. H., Gallo M. A. Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Lett 1988; 42: 5
   PubMed Web of Science ®Google Scholar
• Umbreit T. H., Hesse E. J., Gallo M. A. Bioavailability and cytochrome P-450 induction from 2,3,7,8-tetrachlorodibenzo-p-dioxin contaminated soils from Times Beach, Missouri, and Newark, New Jersey. Drug. Chem. Toxicol. 1988; 11: 405
   PubMed Web of Science ®Google Scholar
• Umbreit T. H., Hesse E. J., Macdonald G. J., Gallo M. A. Effects of TCDD-estradiol interactions in three strains of mice. Toxicol. Lett. 1988; 40: 1
   PubMed Web of Science ®Google Scholar
• Umbreit T. H., Engles D., Grossman A., Gallo M. A. Special comparison of steroid UDP-glucuronyl transferase: correlation to TCDD sensitivity. Toxicol. Lett. 1989; 48: 29
   PubMedGoogle Scholar
• Van Birgelen A., Vander Kolk J., Fase K., Poiger H., Brouwer A., Vanden Berg M. Toxicity and biochemical potencies of polychlorinated biphenyl congeners relative to 2,3,7,8-TCDD in three months feeding studies in the rat. Organohalogen Compounds 1992; 10: 373
   Google Scholar
• Vanden Berg M., Olie K., Hutzinger O. Uptake and selective retention in rats of orally administered dioxins and dibenzofurans from fly ash and fly ash extract. Chemosphere 1983; 12: 537
   Google Scholar
• Vanden Berg M., Olie K., Hutzinger O. Polychlorinated dibenzofurans (PCDFs) — environmental occurrence and physical, chemical and biological properties. Toxicol. Environ. Chem. 1985; 9: 171
   Google Scholar
• Vanden Berg M., VanGreevenbroek M., Olie K., Hutzinger O. Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by the rat. Chemosphere 1986; 15: 509
   Google Scholar
• Vanden Berg M., De Vroom E., Olie K., Hutzinger O. Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and Syrian golden hamsterm. Chemosphere 1986; 15: 519
   Google Scholar
• Vanden Berg M., Meerman L., Olie K., Hutzinger O. Retention of PCDDs and PCDFs in the liver of the rat and hamster after oral administration of a municipal incinerator fly ash extract. Toxicol. Environ. Chem. 1986; 12: 267
   Google Scholar
• Vanden Berg M., Vander Wielen F. W. M., Olie K., Boxtel C. J. The presence of PCDDs and PCDFs in human breast milk from The Netherlands. Chemosphere 1986; 15: 693
   Google Scholar
• Vanden Berg M., Blank F., Heeremans C., Wagenaar H., Olie K. Presence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in fish-eating birds and fish from The Netherlands. Arch. Environ. Contam. Toxicol. 1987; 16: 149
   Google Scholar
• Vanden Berg M., Sinke M., Wever H. Vehicle dependent bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs) and -dibenzofurans (PCDFs) in the rat. Chemosphere 1987; 16: 1193
   Google Scholar
• Vanden Berg M., Heeremans C., Veenhoven E., Olie K. Transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans to fetal and neonatal rats. Fundam. Appl. Toxicol. 1987; 9: 635
   PubMedGoogle Scholar
• Vanden Berg M., van-Wijnen J., Wever H., Seinen W. Selective retention of toxic polychlorinated dibenzo-p-dioxins and dibenzofurans in the liver of the rat after intravenous administration of a mixture. Toxicology 1989; 55: 173
   PubMedGoogle Scholar
• Vanden Berg M., De Jongh J., Eckhart P., Vander Wielen F. W. Disposition and elimination of three polychlorinated dibenzofurans in the liver of the rat. Fundam. Appl. Toxicol. 1989; 12: 738
   PubMedGoogle Scholar
• Vanden Berg M., Poiger H. Selective retention of PCDDs and PCDFs in mammals: a multiple cause problem. Chemosphere 1989; 18: 677
   Google Scholar
• Vanden Berg M., Bouwman C., Seinen W. Hepatic retention of PCDDs and PCDFs in C57BL/6 and DBA/2 mice. Chemosphere 1989; 19: 795
   Google Scholar
• Vanden Berg M., Poiger H. Toxicokinetic limitations in the present Toxic Equivalency (TEQ) concept. Organohalogen Compounds 1990; 1: 333
   Google Scholar
• Vander Kolk J., Van Birgelen A., Poiger H., Schlatter C. Interactions of 2,2,'4,4′,5,5′-hexachloro-biphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Chemosphere 1992; 25: 2023
   Google Scholar
• Vander Weiden M. E. J., Craane L. H. J., Evers E. H. G., Kooke R. M. M., Olie K., Seinen W., Vanden Berg M. Bioavailability of PCDDs and PCDFs from bottomsediment and some associated biological effects in the carp. (Cyprinus carpio), Chemosphere 1989; 19: 1009
   Google Scholar
• Vander Weiden M. E. J., Vander Kolk J., Kempeneers F. D., Seinen W., Vanden Berg M. Comparative toxicity and enzyme induction of 2,3,7,8-TCDD in the carp (Cyprinus carpio) and the rainbow trout. (Onchorhynchus mykiss), Organohalogen Compounds 1990; 1: 397
   Google Scholar
• Van Miller J. P., Marlar R. J., Allen J. R. Tissue distribution and excretion of tritiated tetra-chlorodibenzo-p-dioxin in non-human primates and rats. Food Cosmet. Toxicol. 1976; 14: 31
   PubMedGoogle Scholar
• Van Wijnen J., Van Bavel B., Lindstrom G., Koppe J. G., Olie K. Placental transport of PCDDs and PCDFs in humans. Organohalogen Compounds 1990; 1: 47
   Google Scholar
• Veerkamp W. Wever, Hutzinger O. The metabolism of some polychlorinated dibenzofurans by rats. Chemosphere 1981; 10: 397
   Google Scholar
• Veerkamp W., Serne P., Hutzinger O. Prediction of hydroxylated metabolites in polychloro-dibenzo-p-dioxins and polychlorodibenzofurans by Hückel Molecular Orbital calculations. J. Chem. Soc. Perkin Trans 1983; II: 353
   Google Scholar
• Villeneuve D. C., Chu I., Le Cavelier P., Feeley M., Kennedy S. Subchronic toxicity of PCB 126 in the rat. Toxicologist 1992; 12: 1677
   Google Scholar
• Voorman R., Aust S. Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity. Toxicol. Appl. Pharmacol. 1987; 90: 69
   PubMed Web of Science ®Google Scholar
• Voorman R., Aust S. D. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a tight binding inhibitor of cytochrome P-450d. J. Biochem. Toxicol. 1989; 4: 105
   PubMedGoogle Scholar
• Wacker R., Poiger H., Schlatter C. Pharmacokinetics and metabolism of 1,2,3,7,8-pentachloro-dibenzo-p-dioxin in the rat. Chemosphere 1986; 15: 1473
   Google Scholar
• Waern F., Han berg A., Manzoor E., Ahlborg U. G. TCDD and 2,3,4,7,8-PeCDF temporal interaction of vitamin A depletion and hepatic enzyme induction in the rat. Chemosphere 1990; 20: 1155
   Google Scholar
• Waern F., Flodström S., Busk L., Kronevi T., Nordgren I., Ahlborg U. G. Relative liver tumor promoting activity and toxicity of some polychlorinated dibenzo-p-dioxin- and dibenzofuran-congeners in female Sprague-Dawley rats. Pharmacol. Toxicol. 1991; 69: 450
   PubMedGoogle Scholar
• Walden R., Schiller C. M. Comparative toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in four (sub)strains of adult male rats. Toxicol. Appl Pharmacol. 1985; 77: 490
   PubMedGoogle Scholar
• Walker M. K., Peterson R. E. Potencies if polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachloro-dibenzo-p-dioxin, for producing early life stage mortality in rainbow trout. (Oncorhynchus mykiss), Aquat. Toxicol. 1991; 21: 219
   Web of Science ®Google Scholar
• Weber H., Poiger H., Schlatter C. Acute oral toxicity of TCDD metabolites. Toxicol. Lett. 1982; 14: 117
   PubMedGoogle Scholar
• Weber H., Poiger H., Schlatter C. Fate of 2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolites from dogs in rats. Xenobiotica 1982; 12: 353
   PubMed Web of Science ®Google Scholar
• Weber H., Poiger H., Schlatter C. Acute oral toxicity of TCDD-metabolites in male guinea pigs. Toxicol Lett. 1982; 14: 117
   PubMedGoogle Scholar
• Weber H., Birnbaum L. S. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachloro-dibenzofuran (TCDF) in pregnant C57BL/6N mice: distribution to the embryo and excretion. Arch. Toxicol. 1985; 57: 159
   PubMed Web of Science ®Google Scholar
• Webster T., Connett P. Estimating bioconcentration factors and halflives in humans using physiologically based pharmacokinetic modelling. 1,2,3,7,8-TCDD. Organohalogen Compounds 1990; 1: 611
   Google Scholar
• Weisiger R., Gollan J., Ockner R. Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances. Science 1981; 211: 1048
   PubMed Web of Science ®Google Scholar
• Wendling J., Hileman F., Orth R., Umbreit T., Hesse E., Gallo M. An analytical assessment of the bioavailability of dioxin contaminated soils to animals. Chemosphere 1989; 18: 925
   Web of Science ®Google Scholar
• Wendling J. M., Orth R. G., Poiger H. Determination of [3H]-2,3,7,8-tetrachlorodibenzo-p-di-oxin in human feces to ascertain its relative metabolism in man. Anal. Chem. 1990; 62: 796
   PubMedGoogle Scholar
• Wermerlinger M., Poiger H., Schlatter C. Absence of an effect of a nontoxic PCDF on the toxicity of 2,3,4,7,8-PnCDF. Organohalogen Compounds 1990; 4: 163
   Google Scholar
• Wermerlinger M., Poiger H., Schlatter C. Results of a 9 month feeding study with OCDD and OCDF in rats. Organohalogen Compounds 1990; 1: 221
   Google Scholar
• Whitelock J. P., Denison M. S., Durrin L. K., Fisher J. M., Galeazzi D. R., Jones P. B. Regulation of cytochrome P1-450 gene expression in mouse hepatoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab. Rev. 1989; 20: 839
   PubMedGoogle Scholar
• Whitelock J. P. The control of cytochrome P-450 gene expression by dioxin. Trends Pharmacol. Sci. 1989; 10: 285
   PubMedGoogle Scholar
• Whitelock J. P. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol. 1990; 30: 251
   PubMedGoogle Scholar
• Wilhelmsson A., Cuthilt S., Denis M., Wikstrom A. C., Gustafsson J. A., Poellinger L. The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. EMBO J 1990; 9: 69
   PubMed Web of Science ®Google Scholar
• World Health Organization-Regional Office for Europe. Assessment of Health Risks in infants associated with exposure to PCBs. PCDDs and PCDFs in breast milk, P. Granjean, S. Tarkowski, R. Kimbrough, E. J. Yrjänheikki, J. H. Rantanen. Environmental Health Series No. 29, 1988
   Google Scholar
• World Health Organization-Regional Office for Europe. Levels of PCBs. PCDDs, and PCDFs in breast milk. Environmental Health, E. J. Yrjänheikki. Series No. 34, 1989
   Google Scholar
• World Health Organization-Regional Office for Europe. Consultation on tolerable daily intake from food of PCDDs and PCDFs. The Netherlands, Bilthoven 1990
   Google Scholar
• Wroblewski V. J., Olson J. R. Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig. Toxicol. Appl. Pharmacol. 1985; 81: 231
   PubMed Web of Science ®Google Scholar
• Wroblewski V. J., Olson J. R. Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster. Drug Metab. Dispos. 1988; 16: 43
   PubMed Web of Science ®Google Scholar
• Wroblewski V. J., Gessner T., Olson J. R. Qualitative and quantitative differences in the induction and inhibition of hepatic benzo-a-pyrene metabolism in the rat and hamster. Biochem. Pharmacol. 1988; 37: 1509
   PubMedGoogle Scholar
• Yoshihara S., Ngata K., Yoshimura H., Kuroki H., Masuda Y. Inductive effect on hepatic enzymes and acute toxicity of individual polychlorinated dibenzofuran congeners in rats. Toxicol. Appl. Pharmacol. 1981; 59: 580
   PubMed Web of Science ®Google Scholar
• Yoshimura H., Kuroki J., Koga N., Kuroki H., Masuda Y., Fukasaku N., Hasegawa M. High accumulation of 2,3,4,7,8-pentachlorodibenzofuran to hepatic microsomes of rats. J. Pharmacohiodyn. 1984; 7: 414
   PubMedGoogle Scholar
• Yoshimura Y., Kamimura H., Oguri K., Honda Y., Nakano M. Stimulating effect of activated charcoal beads on fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats. Chemosphere 1986; 15: 219
   Web of Science ®Google Scholar
• Yoshimura H., Yonemoto Y., Yamada H., Koga N., Oguri K., Saeki S. Metabolismin vivo of 3,4,3′,4′-tetrachlorobiphenyl and toxicological assessment of the metabolites in rats. Xenobiotica 1987; 17: 897
   PubMed Web of Science ®Google Scholar
• Yoshimura H., Kuroki J., Koga N. Unique features of subcellular distribution of 2,3,4,7,8-penta-chlorodibenzofuran in rat liver. Chemosphere 1987; 16: 1695
   Google Scholar
• Young A. L., Cockerham L. G., Thalken C. E. A long-term study of ecosystem contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 1987; 16: 1791
   Google Scholar
• Wacker R. Einige Aspekte über Höher Chlorierte Dibenzo-p-Dioxine und Furane. Ph.D. thesis, Eidgenössischen Technische Hochschule, Zürich 1989
   Google Scholar
• Bol J., Vanden Berg M., Seinen W. Interactive effects of PCDDs, PCDFs and PCBs as assessed by the E.L.S.-bioassay. Chemosphere 1989; 19: 899
   Google Scholar