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Research Article

A Perspective on Benzene Leukemogenesis

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Pages 177-209 | Published online: 25 Sep 2008

References

  • Santesson C. G. Uber chronische Vergiftung mit Steinkohlen-teerbenzin, vier Todesfalle. Arch. Hyg. Bed. 1897; 31: 336
  • Selling L. A preliminary report of some cases of purpura haemorrhagica due to benzol poisoning. Bull. Johns Hopkins Hosp. 1910; 21: 33
  • Selling L. Benzol as a leukotoxin. Studies on degeneration regeneration of blood and hematopoietic organs. Johns Hopkins Hosp. Rep. 1916; 17: 83
  • Synder R., Kocsis J. J. Current concepts of chronic benzene toxicity. Crit. Rev. Toxicol. 1975; 3: 265
  • Synder R., Longacre S. L., Witmer C. M., Kocsis J. J. Biochemical toxicity of benzene. Reviews in Biochemical Toxicology, E. Hodgson, J. R. Bend, R. ML Philpot. Elsevier, New York 1981; Vol. 3: 123
  • Synder R. The benzene problem in historical perspective. Fundam. Appl. Toxicol. 1984; 4: 692
  • Kalf G. F. Recent advances in the metabolism and toxicity of benzene. Crit. Rev. Toxicol. 1987; 18: 141
  • Kalf G. F., Post G., Snyder R. Solvent toxicology: recent advances in the toxicology of benzene, the glycol ethers, and carbon tetrachloride. Annu. Rev. Pharmacol. Toxicol. 1987; 27: 399
  • Le Noir C. Sur un cas de purpura attributé a l'intoxication par le benzène. Bull. Mem. Soc. Med. Hosp. Paris 1987; 14: 1251
  • Delore P., Borgomano C. Leucemie aigue au cours d'intoxication benzenique. Sur l'origine toxique de certaines leucemies aigues et leur relations avec les anemies graves. J. Med. Lyon. 1928; 9: 227
  • Mallory T. B., Gall E. A., Brickley W. J. Chronic exposure to benzene (benzol). III. The pathologic results. J. Ind. Hyg. Toxicol. 1939; 21: 355
  • Lignac G. O. E. Benzene induced leukemia in humans and white mice. Klin. Wochenschr. 1932; 12: 109
  • Uyeki E. M., Askar A. E., Shoeman D. W., Bisel T. U. Acute toxicity of benzene inhalation to hemopoietic precursor cells. Toxicol. Appl. Pharmacol. 1977; 40: 49
  • Gill D., Jenkins V., Kemper R., Ellis S. The importance of pluripotent stem cells in benzene toxicity. Toxicology 1980; 16: 163
  • Green J. D., Snyder C. A., Lobue J., Goldstein B. D., Albert R. E. Acute and chronic dose/response effects of inhaled benzene on multipotential hemopoietic stem, CFU-S and granulocyte/macrophage progenitor, GM-CFU-C cells in CD-1 mice. Toxicol. Appl. Pharmacol. 1981; 58: 492
  • Harigaya K., Miller M. E., Cronkite E. P., Drew R. T. The detection ofin vivo hematotoxicity of benzene by in vitro liquid bone marrow cultures. Toxicol. Appl. Pharmacol. 1981; 60: 346
  • Toft K., Olofsson T., Tunek A., Berlin M. Toxic effects on mouse bone marrow caused by inhalation of benzene. Arch. Toxicol. 1982; 51: 295
  • Baarson K., Snyder C. A., Albert R. E. Repeated exposures of C57B16 mice to 10 ppm inhaled benzene markedly depressed erythropoietic colony formation. Toxicol. Lett. 1984; 20: 337
  • Seidel H. J., Barthel E., Zinser D. The hematopoietic stem cell compartments in mice during and after long term inhalation of three doses of benzene. Exp. Hematol. 1989; 17: 300
  • Anon. Benzene, 1ARC Monogr. Eval. Carcinog. Risks Hum. 1982; 29: 93
  • Snyder C. A. Benzene, in Ethel Browning's Toxicity and Metabolism of Industrial Solvents. Hydrocarbons, 2nd ed., R. Synder. Elsevier, Amsterdam 1986; Vol. 1: 3
  • Bagby G. C., Jr. The concept of preleukemia: clinical and laboratory studies. Crit. Rev. Oncol./Hematol. 1986; 4: 203
  • Tricot G. J. K. The myelodysplastic syndromes. Hematology, Basic Principles and Practice, R. Hoffman, E. J. Benz, Jr., S. J. Shattil, B. Furie, H. J. Cohen. Churchill Livingstone, New York 1991; 805
  • Galton D. A. The myelodysplastic syndromes. Scand. J. Haematol. 1986; 36: 11
  • Janssen J. W. G., Buschle M., Layton M., Drexler H. G., Lyons J., van den Burghe H., Heimpel H., Kubanek B., Kleihauer E., Mufti G. J., Bartram C. R. Clonal analysis of myelodysplastic syndrome. Evidence of multipotent stem cell origin. Blood 1989; 73: 248
  • Tefferi A., Thibodeau S. N., Solberg L. S. Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms. Blood 1990; 52: 285
  • Irons R. D. Studies on the mechanisms of chemically induced leukemia/lymphoma. Chem. Ind. Inst. Activities 1988; 8: 1
  • Vigliani E., Forni A. Benzene and leukemia. Environ. Res. 1976; 11: 122
  • Aksoy M. Benzene hematotoxicity. Benzene Carcinogenicity, M. Aksoy. CRC Press, Boca Raton, FL 1988; 59
  • Goldwater L. J. Disturbances in the blood following exposure to benzol. J. Lab. Clin. Med. 1940; 26: 957
  • Hamilton-Patterson J. L., Browning E. Toxic effects in women exposed to industrial rubber solutions. Br. Med. J. 1944; 4340: 11
  • Helmer K. J. Accumulated cases of chronic benzene poisoning in the rubber industry. Acta Med. Scand. 1944; 118: 254
  • Savilahti M. More than 100 cases of benzene intoxication in a shoe factory. Observations on hematological symptoms and course of the process in one year. Arch. Gewerbepath. Gewerbehyg. 1956; 15: 147
  • Aksoy M., Dincol K., Akgun T., Erdem S., Dincol G. Haematological effects of chronic benzene poisoning in 217 workers. Br. J. Ind. Med. 1971; 28: 296
  • Aksoy M., Dincol K., Erdem S., Akgun T., Dincol G. Details of blood changes in 32 patients with pancytopenia associated with long-term exposure to benzene. Br. J. Industr. Med. 1972; 29: 56
  • Aksoy M., Erdem S., Erdogan G., Dincol G. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. Hum. Hered. 1976; 26: 149
  • Aksoy M. Benzene and leukemia. Lancet 1978; i: 441
  • Aksoy M., Erdem S. Follow-up study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. Blood 1978; 52: 285
  • Aksoy M. Malignancies due to occupational exposure to benzene. Am. J. Ind. Med. 1985; 7: 395
  • Yin S. N., Li G. L., Tain F. D., Fu N. I., Jin C., Chen Y. J., Luo S. J., Ye P. Z., Zhang J. Z., Wang G. C., Zhang X. C., Wu H. N., Zhong Q. C. Leukaemia in benzene workers, a retrospective cohort study. Br. J. Ind. Med. 1987; 44: 124
  • Yin S.-N., Li Q., Tian F., Du C., Jin C. Occupational exposure to benzene in China. Br. J. Ind. Med. 1987; 44: 192
  • Austin H., Delzell E., Cole P. Benzene and leukemia. A review of the literature and a risk assessment. Am. J. Epidemiol. 1988; 127: 419
  • Girard R., Revol L. Frequency of benzene exposure in the course of serious blood diseases. Nouv. Rev. Fr. d'Hemat. 1970; 10: 477
  • Ishimaru T., Okada H., Tomiyasu T., Tschuioto T., Hoshino T., Ichmaru M. Occupational factors in the epidemiology of leukemia in Hiroshima and Nagasaki. Am. J. Epidemiol. 1971; 93: 157
  • Thorpe J. J. Epidemiological survey of leukemia in persons potentially exposed to benzene. J. Occup. Med. 1974; 17: 375
  • Infante P., Rinsky R., Wagoner J., Young R. Leukemia in benzene workers. Lancet 1977; ii: 76
  • Rinsky R. A., Smith A. B., Hornung R., Filloon T. G., Young R. J., Okun A. K., Landrigan P. J. Benzene and leukemia, an epidemiological risk assessment. N. Engl. J. Med. 1987; 316: 1044
  • Rinsky R. A., Young R. J., Smith A. Leukemia in benzene workers. Am. J. Ind. Med. 1981; 2: 217
  • Ott M. G., Townsend J. C., Fishbeck W. A., Langner R. A. Mortality among individuals occupationally exposed to benzene. Arch. Environ. Health 1978; 33: 3
  • Bond G. G., McLaren E. A., Baldwin C. L., Cook R. R. An update of mortality among chemical workers exposed to benzene. Br. J. Ind. Med. 1986; 43: 685
  • Linos A., Kyle R. A., O'Fallon W. M., Kurland L. T. A case control study of occupational exposures and leukemia. Int. J. Epidemiol. 1980; 9: 131
  • Rushton L., Alderson M. R. A case-control study to investigate the association between exposure to benzene and deaths from leukaemia in oil refinery workers. Br. J. Cancer 1981; 43: 77
  • Decouflé P., Blattner W. A., Blair A. Mortality among chemical workers exposed to benzene and other agents. Environ. Res. 1983; 30: 16
  • Wong O. An industry wide mortality study of chemical workers occupationally exposed to benzene. I. General results. Br. J. Ind. Med. 1987; 44: 365
  • Wong O. An industry wide mortality study of chemical workers occupationally exposed to benzene. II. Dose response analyses. Br. J. Ind. Med. 1987; 44: 382
  • Tsai S. P., Wen C. P., Weiss N. S., Wong O., McClellan W. A., Gibson R. L. Retrospective mortality and medical surveillance studies of workers in benzene areas of refineries. J. Occup. Med. 1983; 25: 685
  • ACGIH. Notice of intended changes: benzene. Appl. Occup. Environ. Hyg. 1990; 7: 453
  • White M. C., Infante P., Chu K. C. A quantitative estimate of leukemia mortality associated with occupational exposure to benzene. Risk Analysis 1982; 2: 195
  • Albert R. E. Carcinogen Assessment Group's final report on population risk to ambient benzene exposures. Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Research Triangle Park, NC 1979, Publ. No. EPA-450/5–80–004
  • Crump K. S., Allen B. C. Quantitative estimates of risk of leukemia from occupational exposure to benzene. Occupational Safety and Health Administration. May, 1984, Docket H-059B, Exhibit 152
  • Rinsky R. A., Hornung R. W., Landrigan P. J. Re: Benzene and leukemia. A review of the literature and a risk assessment. Am. J. Epidemiol. 1989; 129: 1084
  • Austin H., Delzell E., Cole P. The authors reply. Am. J. Epidemiol. 1989; 129: 1085
  • Kipen H. M., Cody R. P., Crump K. S., Allen B., Goldstein B. D. Hematologic effects of benzene. A thirty-five year longitudinal study of rubber workers. Toxicol. Ind. Health 1988; 4: 411
  • Kipen H. M., Cody R. P., Goldstein B. D. Use of longitudinal analysis of peripheral blood counts to validate historical reconstruction of benzene exposure. Environ. Health Perspect. 1989; 82: 199
  • Paustenbach D. J., Price P. S., Ollison W., Blank C., Jernigan J. D., Bass R. D., Peterson H. D. Reevaluation of benzene exposure for the pliofilm, rubberworker cohort, 1936–1976. J. Toxicol. Environ. Health 1992; 36: 177
  • Snyder R., Lee E. W., Kocsis J. J., Witmer C. M. Bone marrow depressant and leukemogenic actions of benzene. Life Sci. 1977; 21: 1709
  • Goldstein B. D., Snyder C. A., Laskin S., Bromberg I., Albert R. E., Nelson N. Myelogenous leukemia in rodents inhaling benzene. Toxicol. Lett. 1982; 13: 169
  • Cronkite E., Bullis J., Inoe T., Drew R. Benzene inhalation produces leukemia in mice. Toxicol. Appl. Pharmacol. 1984; 75: 358
  • Snyder C. A., Goldstein B. D., Sellakumar A. R., Bromberg I., Laskin S., Albert R. E. The inhalation toxicology of benzene, incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57B1/6J mice. Toxicol. Appl. Pharmacol. 1980; 54: 323
  • Farris G. M., Everitt J. I., Irons R., Popp J. A. Carcinogenicity of inhaled benzene in CBA mice. Fundam. Appl. Toxicol. 1993; 20: 503
  • Maltoni C., Scarnato C. First experimental demonstration of the carcinogenic effects of benzene. Long-term bioassays on Sprague-Dawley rats by oral administration. Med. Law 1979; 70: 352
  • Huff J. E., Haseman J. K., DeMarini D. M. Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6 C3F1 mice. Environ. Health Perspect. 1989; 82: 125
  • Maltoni C., Conti B., Cotti G. Benzene: a multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology. Am. J. Ind. Med. 1983; 4: 589
  • Maltoni C., Ciliberti A., Cotti G., Conti B., Belpoggi F. Benzene: an experimental multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology. Environ. Health Perspect. 1989; 82: 109
  • Porteous J. W., Williams R. T. Studies in detoxication. The isolation of phenol, catechol, quinol and hydroxyquinol from the ethereal sulfate fraction of the urine of rabbits receiving benzene orally. Biochem. J. 1949; 44: 56
  • Parke D. V., Williams R. T. Studies in detoxication: 49. The metabolism of benzene containing14C1 benzene. Biochem. J. 1953; 54: 231
  • Henderson R. F., Sabourin P. J., Bechtold W. E., Griffith W. C., Medinsky M. A., Birnbaum L. S., Lucier G. W. The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. Environ. Health Perspect. 1989; 82: 9
  • Synder R., Pirozzi-Chatterjee S. Benzene metabolism. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, E. Arinc, I. B. Schenckman, E. Hodgson. Plenum Press, New York 1991; 375
  • Yardley-Jones A., Anderson D., Parke D. V. The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br. J. Ind. Med. 1991; 48: 437
  • Andrews L. S., Sasame H. A., Gillette J. R. 3H-benzene metabolism in rabbit bone marrow. Life Sci. 1979; 25: 567
  • Irons R., Dent J., Baker T., Rickert D. Benzene is metabolized and covalently bound in bone marrow in situ. Chem. Biol. Interact. 1980; 30: 241
  • Sammett D., Lee E. W., Kocsis J. J., Snyder R. Partial hepatectomy reduces both metabolism and toxicity of benzene. J. Toxicol. Environ. Health 1979; 5: 785
  • Andrews L. S., Lee E. W., Witmer C. M., Kocsis J. J., Snyder R. Effects of toluene on the metabolism, disposition, and hemopoietic toxicity of3H benzene. Biochem. Pharmacol. 1977; 26: 293
  • Smart R. C., Zannoni V. G. DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene. Mol. Pharmacol. 1984; 26: 105
  • Johansson I., Ingelman-Sundberg M. Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver. J. Biol. Chem. 1983; 258: 7311
  • Koop D. R., Laethem C. L., Schnier G. G. Identification of ethanol-inducible P450 isozyme 3a, P45011E1, as a benzene and phenol hydroxylase. Toxicol. Appl. Pharmacol. 1989; 98: 278
  • Chepiga T. A., Yang C. S., Snyder R. Benzene metabolism by two purified, reconstituted rat hepatic mixed function oxidase systems. Biological Reactive Intermediates. IV. Molecular and Cellular Effects and Their Impact on Human Health, C. M. Witmer, R. Snyder, D. J. Jollow, G. F. Kalf, J. J. Kocsis, I. G. Sipes. Plenum Press, New York 1991; 261
  • Gorsky L. D., Coon M. J. Evaluation of the role of free hydroxyl radicals in the cytochrome P-450 catalyzed oxidation of benzene and cyclohexanol. Drug Metab. Disp. Biol. Fate Chem. 1985; 13: 169
  • Jerina D., Daley J., Witkop B., Zaltzman-Nirenberg P., Udenfriend S. Role of arene oxide-oxepin system in the metabolism of aromatic substrates. I.In vitro conversion of benzene oxide to premercapturic acid and dihydrodiol. Arch. Biochem. Biophys. 1968; 128: 176
  • Latriano L., Goldstein B. D., Witz G. Formation of muconaldehyde, an open-ring metabolite of benzene in mouse liver microsomes, a novel pathway for toxic metabolites. Proc. Natl. Acad. Sci. U.S.A. 1986; 83: 8356
  • Bolcsak L. E., Nerland D. E. Inhibition of erythropoiesis by benzene and benzene metabolites. Toxicol. Appl. Pharmacol. 1983; 69: 363
  • Snyder R., Dimitriadis E., Guy R., Hu P., Cooper K. R., Bauer H., Witz G., Goldstein B. D. Studies on the mechanism of benzene toxicity. Environ. Health Perspect. 1989; 82: 31
  • Witz G., Rao G. S., Goldstein B. D. Short-term toxicity oftrans, trans-muconaldehyde. Toxicol. Appl. Pharmacol. 1985; 80: 511
  • Twerdok L. E., Trush M. A. Differences in quinone reductase activity in primary bone marrow stromal cells derived from C57BL/6 and DBA/2 mice. Res. Commun. Chem. Pathol. Pharmacol. 1990; 67: 375
  • Lee E. W., Kocsis J. J., Snyder R. Acute effect of benzene on [59Fe] incorporation into circulating erythrocytes. Toxicol. Appl. Pharmacol. 1974; 27: 431
  • Lee E. W., Kocsis J. J., Snyder R. The use of ferrokinetics in the study of experimental anemia. Environ. Health Perspect. 1981; 39: 29
  • Eastmond D. A., Smith M. T., Irons R. D. An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure. Toxicol. Appl. Pharmacol. 1987; 91: 85
  • Guy R. L., Dimitriadis E., Hu P., Cooper K. R., Snyder R. Interactive inhibition of erythroid [59Fe] utilization by benzene metabolites in female mice. Chem. Biol. Interact. 1990; 74: 55
  • Guy R. L., Hu P., Witz G., Goldstein B. D. Depression of iron uptake into erythrocytes in mice by treatment with the combined benzene metabolites p-benzoquinone, muconaldehyde, and hydroquinone. J. Appl. Toxicol. 1991; 11: 443
  • Barale R., Marrazzini A., Betti C., Vangelisti V., Loprieno N., Barrai I. Genotoxicity of two metabolites of benzene: phenol and hydroquinone show strong synergistic effects in vivo. Mutat. Res. 1990; 244: 15
  • Kolanchana P., Subrahmanyam V. V., Meyer K. B., Zhang L., Smith M. T. Benzene and its phenolic metabolites produce oxidative damage in HL-60 cellsin vitro and in bone marrow in vivo. Cancer Res. 1993; 53: 1023
  • Longacre S., Kocsis J. J., Snyder R. Influence of strain differences in mice on the metabolism and toxicity of benzene. Toxicol. Appl. Pharmacol. 1981; 60: 398
  • Neun D. J., Penn A., Snyder C. A. Evidence for strain-specific differences in benzene toxicity as a function of host target cell susceptibility. Arch. Toxicol. 1992; 66: 11
  • Sabourin P. J., Chen B. T., Lucier G., Birnbaum S., Fisher E., Henderson R. F. Effect of dose on the absorption and excretion of [14C]benzene administered orally or by inhalation in rats and mice. Toxicol. Appl. Pharmacol. 1987; 87: 325
  • Sabourin P. J., Bechtold W. E., Birnbaum L. S., Lucier G., Henderson R. F. Differences in the metabolism and disposition of inhaled [3H]benzene by F344/N rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 1988; 94: 128
  • Snyder R., Orzechowski A., Schrenk D., Schwarz L. R. Benzene metabolism in rat and mouse hepatocytes. Toxicologist 1993; 13: 327
  • Lutz W., Schlatter C. Mechanism of the carcinogenic action of benzene: irreversible binding to rat liver DNA. Chem. Biol. Interact. 1977; 18: 214
  • Snyder R., Lee E. W., Kocsis J. J. Binding of labeled benzene metabolites to mouse liver and bone marrow. Res. Commun. Chem. Pathol. Pharmacol. 1978; 20: 191
  • Schwartz C. S., Snyder R., Kalf G. F. The inhibition of mitochondrial DNA replicationin vitro by the metabolites of benzene, hydroquinone and p-benzoquinone. Chem. Biol. Interact. 1985; 53: 327
  • Wallin H., Melin P., Schelin C., Jergil B. Evidence that covalent binding of metabolically activated phenol to microsomal proteins is caused by oxidized products of hydroquinone and catechol. Chem. Biol Interact. 1985; 55: 335
  • Schlosser M. J., Kalf G. F. Metabolic activation of hydroquinone by macrophage peroxidase. Chem. Biol Interact. 1989; 72: 191
  • Bhat R. V., Subrahmanyam V. V., Sadler A., Ross D. Bioactivation of catechol in rat and human bone marrow cells. Toxicol. Appl. Pharmacol. 1988; 94: 297
  • Lee E. W., Garner C. D. Effects of benzene on DNA strand breaksin vivo versus benzene metabolite-induced DNA strand breaksin vitro in mouse bone marrow cells. Toxicol. Appl. Pharmacol. 1991; 108: 497
  • Kawanishi S., Inoue S., Kawanishi M. Human DNA damage induced by 1,2,4-benzenetriol, a benzene metabolite. Cancer Res. 1989; 49: 164
  • Sabourin P. J., Muggenburg B. A., Couch R. C., Lefler D., Lucier G., Birnbaum L. S., Henderson R. F. Metabolism of [14C]benzene by cynomolgus monkeys and chimpanzees. Toxicol. Appl. Pharmacol. 1992; 114: 277
  • Medinsky M. A., Sabourin P., Lucier G., Birnbaum L. S., Henderson R. F. A physiological model for simulation of benzene metabolism by rats and mice. Toxicol. Appl Pharmacol. 1989; 99: 193
  • Travis C., Quillen J., Arms A. D. Pharmacokinetics of benzene. Toxicol. Appl. Pharmacol. 1990; 102: 400
  • Beliles R. P., Totman L. C. Pharmacokinetically based risk assessment of workplace exposure to benzene. Regul. Toxicol. Pharmacol. 1989; 9: 186
  • Bois F. Y., Smith M. T., Spear R. C. Mechanisms of benzene carcinogenesis. Application of a physiological model of benzene pharmacokinetics and metabolism. Toxicol. Lett. 1991; 56: 283
  • Spear R. C., Bois F. Y., Woodruff T., Auslander D., Parker J., Selvin S. Modeling benzene pharmacokinetics across three sets of animal data. Parametric sensitivity and risk implications. Risk Anal. 1991; 11: 641
  • Cox L. A., Ricci P. F. Reassessing benzene cancer risks using internal doses. Risk Anal. 1992; 12: 401
  • Scheding S., Loeffler M., Schmitz S., Seidel H. J., Wichmann H. E. Hematotoxic effects of benzene analyzed by mathematical modeling. Toxicology 1992; 72: 265
  • Cronkite E. P., Drew R. T., Inoue T., Hirayabashi Y., Bullis J. E. Hematotoxicity and carcinogenicity of inhaled benzene. Environ. Health Perspect. 1988; 82: 97
  • Green J. D., Snyder C., Lobue J., Goldstein B. D., Albert R. E. Acute and chronic dose/response effect of benzene inhalation on the peripheral blood, bone marrow and spleen cells of CD-1 male mice. Toxicol. Appl. Pharmacol. 1981; 159: 204
  • Dean B. J. Recent findings on the genetic toxicology of benzene, toluene, xylenes, and phenols. Mutat. Res. 1985; 154: 153
  • Eastmond D. A. Induction of micronucleus and aneuploidy by the quinone-forming agents benzene ando-phenylphenol. Toxicol. Lett. 1993; 67: 105
  • Pollini G., Colombi R. II danno cromosomico midollare nell'anemia aplastica benzolica. Med. J. Lav. 1964; 55: 241
  • Pollini G., Colombi R. Chromosomal damage in lymphocytes during benzene hemopathy. Med. J. Lav. 1964; 55: 641
  • Forni A., Moreo L. Cytogenetic studies in a case of benzene leukemia. Eur. J. Cancer 1967; 3: 251
  • Forni A., Moreo L. Chromosome studies in a case of benzene-induced erythroleukemia. Eur. J. Cancer 1969; 5: 459
  • Forni A., Pacifico E., Limonta A. Chromosome studies in workers exposed to benzene or toluene or both. Arch. Environ. Health 1971; 22: 373
  • Forni A., Cappellini A., Pacifico E., Vagliani E. Chromosome changes and their evolution with past exposure to benzene. Arch. Environ. Health 1971; 23: 385
  • Hartwich G., Schwanitz G., Becker J. Chromosomen aberrationen bei einen benzol-leukamie. Dtsch. Med. Wochenschr. 1969; 94: 1228
  • Tough I. M., Smith P. G., Court Brown W. M., Harnden D. G. Chromosome studies on workers exposed to atmospheric benzene. The possible influence of age. Eur. J. Cancer 1970; 6: 49
  • Sellyei M., Kelemen E. Chromosome study in a case of granulocytic leukemia with “pelgerisation” 7 years after benzene pancytopenia. Eur. J. Cancer 1971; 7: 83
  • Erdogan G., Aksoy M. Cytogenetic studies in thirteen patients with pancytopenia and leukemia associated with long-term exposure to benzene. N. Istanbul Contrib. Clin. Sci. 1973; 10: 230
  • Kahn H., Kahn M. H. Cytogenetic studies following chronic exposure to benzene. Arch. Toxicol. 1973; 31: 39
  • Picciano D. Cytogenetic studies of workers exposed to benzene. Environ. Res. 1979; 19: 33
  • Sasiadek M. Non-random distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene. Environ. Health Perspect. 1992; 97: 255
  • Rothman N., Haas R., Hayes R. B., Yin S.-N., Wiemls J., Campelman S., Compton-Qintana P. J. E., Dosemeci M., Wang Y. Z., Li G.-L., Blot W., Smith M. T. Hematotoxicity and glycophorin A mutation frequency in workers exposed to benzene. Proc. Am. Assoc. Cancer Res. 1994; 35: 286
  • Le Beau M. M., Larson R. A. Cytogenetics and neoplasia. Hematology Basic Principles and Practice, R. Hoffman, E. J. Benz, S. J. Shattil, B. Furie, H. J. Cohen. Churchill Livingstone, New York 1991; 638
  • van den Berghe H., Louwagie A., Broechaert-van Orshoven A., David G., Verwilhen R. Chromosome analysis in two unusual malignant blood disorders presumably induced by benzene. Blood 1979; 53: 558
  • Kissling M., Speck B. Chromosome aberrations in experimental benzene intoxication. Helv. Med. Acta 1971; 36: 59
  • Siou G., Conan L., el Haitem M. Evaluation of the clastogenic action of benzene by oral administration with 2 cytogenetic techniques in mouse and Chinese hamster. Mutat. Res. 1981; 90: 273
  • Styles J. A., Richardson C. R. Cytogenetic effects of benzene. Dosimetric studies on rats exposed to benzene vapour. Mutat. Res. 1984; 135: 203
  • Fujie K., Ito Y., Maeda S. Acute cytogenetic effect of benzene on rat bone marrow cellsin vivo and the effect of inducers or inhibitors of drug-metabolizing enzymes. Mutat. Res. 1992; 298: 81
  • Tunek A., Hogstedt G., Olofsson T. Mechanism of benzene toxicity. Effects of benzene and benzene metabolites on bone marrow cellularity, number of granulopoietic stem cells and frequency of micronuclei in mice. Chem. Biol. Interact. 1982; 39: 129
  • Hite M., Pecharo M., Smith I., Thornton S. The effect of benzene in micronucleus test. Mutat. Res. 1980; 77: 149
  • Choy W. N., MacGregor J. T., Shelby M. D., Maronpot R. R. Induction of micronuclei by benzene in B6C3F1 mice. Retrospective analysis of blood smears from NTP carcinogenesis bioassay. Mutat. Res. 1985; 143: 55
  • Gad-El Karim M. M., Ramanujam S., Legator M. S. Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in the urine by CD-1 mice. Toxicol. Appl. Pharmacol. 1986; 85: 464
  • Anwar W. A., Au W. W., Legator M., Sadagopa R. V. M. Effect of dimethyl sulfoxide on the genotoxicity and metabolism of benzene in vivo. Carcinogenesis 1989; 10: 441
  • Harper B. L., Ramanujam V. M. S., Gad-El-Karim M. M., Legator M. S. The influence of simple aromatics on benzene clastogenicity. Mutat. Res. 1984; 128: 105
  • Ciranni R., Barale R., Marrazzini A., Loprieno N. Benzene and the genotoxicity of its metabolites. I. Transplacental activity in mouse fetuses and in their dams. Mutat. Res. 1988; 208: 61
  • Ciranni R., Barale R., Ghelardini G., Loprieno N. Benzene and the genotoxicity of its metabolites. II. The effect of the route of administration on the micronuclei and bone marrow depression in mouse bone marrow cells. Mutat. Res. 1988; 209: 23
  • Adler I.-D., Kliesch U. Comparison of single and multiple treatment regimens in the mouse bone marrow micronucleus assay for hydroquinone, HQ and cyclophosphamide, CP. Mutat. Res. 1990; 234: 115
  • Pirozzi S. J., Renz J. F., Kalf G. F. The prevention of benzene-induced genotoxicity in mice by indomethacin. Mutat. Res. 1989; 222: 291
  • Tice R. R., Costa D. L., Drew R. T. Cytogenetic effects of inhaled benzene in murine bone marrow, induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 2148
  • Morimoto K., Wolff S. Increase in sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites. Cancer Res. 1980; 40: 1189
  • Morimoto K. Induction of sister chromatid exchanges and cell division delays in human lymphocytes by microsomal activation of benzene. Cancer Res. 1983; 43: 1330
  • Morimoto K., Wolff S., Koizumi A. Induction of sister chromatid exchanges in human lymphocytes by microsomal activation of benzene metabolites. Mutat. Res. 1983; 119: 355
  • Erexson G. L., Wilmer J. L., Kligerman A. D. Sister chromatid exchange induction in human lymphocytes exposed to benzene and its metabolites in vitro. Cancer Res. 1985; 45: 2471
  • Witz G., Gad S. C., Tice R. R., Oshiro Y., Piper C. E., Goldstein B. D. Genetic toxicity of the benzene metabolitetrans, trans-muconaldehyde in mammalian and bacterial cells. Mutat. Res. 1990; 240: 295
  • McCarroll N. E., Piper C. E., Keech B. H. Bacterial microsuspension assays with benzene and other organic solvents. Environ. Mutagen. 1980; 2: 281
  • Jacobs R. H., Cornbleet M. A., Vardiman J. W., et al. Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes. Blood 1765; 67: 1986
  • Gold E. J., Conjalka M., Pelus L. M., et al. Marrow cytogenetic and cell-culture analyses of the myelodysplastic syndromes: insights into pathophysiology and prognosis. J. Clin. Oncol. 1983; 1: 627
  • Third MIC Cooperative Study Group (1987). Morphologic, immunologic, and cytogenetic (MIC) working classification of the primary myelodysplastic syndromes and therapy-related myelodysplasias and leukemias. Cancer Genet. Cytogenet. 1988; 32: 1
  • Mitelman F., Brandt L., Nilsson P. G. Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia. Blood 1978; 52: 1229
  • Mitelman G., Nilsson P. G., Brandt L., et al. Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet. Cytogenet. 1981; 4: 197
  • Golomb H. M., Alimena G., Rowley J. D., et al. Correlation of occupation and karyotype in adults with acute nonlymphocytic leukemia. Blood 1982; 60: 404
  • Sasiadek M. Nonrandom distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene. Environ. Health Perspect. 1992; 97: 255
  • Aksoy M. Leukemia in workers due to occupational exposure to benzene. N. Istanbul Contrib. Clin. Sci. 1977; 12: 3
  • Koeffler H. F., Rowley J. D. Therapy-related acute nonlymphocytic leukemia. Neoplastic Diseases of the Blood, P. H. Wiernik, G. P. Canelloe, R. A. Kyle, C. A. Schiffer. Churchill Livingstone, New York 1984; 357
  • Rowley J. D., Golomb H. M., Vardiman J. W. Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndrome in patients with previously treated malignant disease. Blood 1981; 58: 759
  • DeBraekeleer M., Lin C. C. 4;11 Translocation-associated acute leukemia: a comprehensive analysis. Cancer Genet. Cytogenet. 1986; 21: 53
  • Sole F., Caballin M. R., Coll M. D., Woessner S., Egozcue J. Acute lymphoblastic leukemia with t(4;11) in a patient previously exposed to a carcinogen. Cancer Genet. Cytogenet. 1990; 49: 133
  • Miazzo M., Sozzi G., Castellano M., Calderone C., Orazi A., Pierotti M. A., Viviani S., Delia Porta G. Cytogenetic study of 14 patients therapy-related nonlymphocytic leukemia (t-ANLL) and myelodysplastic syndromes (t-MDS). Book of Abstracts of the 21st European Society of Human Genetics, GroningenThe Netherlands. 48
  • Le Beau M. M., Albain K. S., Larson R. A., et al. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute non-lymphocytic leukemia. Further evidence for characteristic abnormalities of chromosomes Nos. 5 and 7. J. Clin. Oncol. 1986; 4: 325
  • Groopman J. E., Molina J.-M., Scadden D. T. Hematopoietic growth factors: biology and clinical applications. N. Engl. J. Med. 1989; 321: 1449
  • Willman C. L., Sever C., Pallavicini M., Harada H., Tanaka N., Slovak M., Yamamoto H., Harada K., Meeker T. C., List A., Taniguchi T. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 1993; 259: 968
  • Harada H., Kitagawa M., Tanaka B., Yamamoto H., Harada K., Ishihara M., Taniguchi T. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 1993; 259: 971
  • Goyert S. M., Ferraro R., Rettig W. J., et al. The CD 14 monocyte differentiation antigen maps to a region encoding growth factors and receptors. Science 1988; 239: 497
  • Sukhatme V. P., Cao X., Chang L. D., et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation and after cellular depolarization. Cell 1988; 53: 37
  • Kere J., Ruutu T., Lahtimen R., de la Chapelle A. Molecular characterization of chromosome 7 long arm abnormalities in myeloid disorders. Blood 1987; 70: 1349
  • Shannon K. M., Turham A. G., Chang S. S. Y., et al. Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7. J. Clin. Invest. 1989; 84: 984
  • Tenth International Workshop on Human Gene Mapping. Human gene mapping 10. Cytogenet. Cell Genet. 1989; 51: 1
  • Ludwig L., Schultz A. S., Janssen J. W., Grunewald K., Bertram C. R. p53 Mutations in the myelodysplastic syndromes. Leukemia 1992; 6: 1302
  • Jonveaux P., Fenaux P., Quiqandon I., Pignon J. M., Lai J., Loucheaux-Lefebvre M. H., Goossens M., Bauters F., Berger R. Mutations in the p53 gene in myelodysplastic syndromes. Oncogene 1991; 6: 2234
  • Slingerland J. M., Minden M., Benchimoi S. Mutations in the p53 gene in acute myelogenous leukemia. Blood 1991; 77: 1500
  • Fenaux P., Preudhomme C., Quiquandon J., Jonveaux P., Lai J. I., Vanrumbke M., Loucheux-Lefbvre M. H., Bauter F., Berger R., Kerckaert J. P. Mutations of the p53 gene in acute myeloid leukemia. Br. J. Haematol. 1992; 80: 178
  • Ganser A., Seipelt G., Lindemann A., Ottmann I. G., Galk S., Eder M., Herrmann F., Becher R., Hoffken K., Buchner T., Klausmann M., Frisch J., Schultz G., Mertelsman R., Hoelzer D. Effects of recombinant human interleukin-3 in patients with myelodysplastic syndromes. Blood 1990; 76: 455
  • Borrow J., Goddard A. D., Sheer D., Solomon E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990; 249: 1577
  • de The H., Chomienne C., Lanotte M., Degos L., Dejean A. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 1990; 347: 558
  • Longo L., Pandolfi P. P., Biondi A., Rambaldi A., Mencarelli A., LoCoco F., Diverio D., Pagoraro L., Avanzi G., Tabilio A., Zangrilli D., Alcalay M., Donti E., Grignani F., Pelicci P. G. Rearrangements and aberrant expression of the RARα gene in acute promyelocytic leukemias. J. Exp. Med. 1990; 172: 1571
  • Evans R. M. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889
  • Meng-Er H., Yu-Chen T., Shu-Rong C., Jin-Ren C., Jia-Xiang L., Long-Jun G., Zhen-Yi W. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72: 567
  • Breitman T. R., Collins S. J., Keene B. R. Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood 1981; 57: 1000
  • Lewin B. Oncogenic conversion by regulatory changes in transcription factors. Cell 1991; 64: 303
  • Metcalf D., Nowell P. C., Rowley J. D., Sachs L. Chromosomal and growth factor abnormalities in leukemia. Cancer Res. 1991; 51: 2494
  • Rowley J. D., Testa J. R. Chromosome abnormalities in malignant hematologic diseases. Adv. Cancer Res. 1982; 36: 103
  • Miyoshi H., Shimizu K., Kozu T., Maseki N., Kaneko Y., Ohki M L. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. U.S.A. 1991; 88: 10, 431
  • Berger R., Bernheim A., Flandrin G. Absence d'anomalie chromosomique et leucemie aigue. C. R. Acad. Sci. III 1980; 290: 1557
  • Dubreuil P., Torres H., Courcoul M.-A., Birg F., Mannoni P. c-fms expression is a molecular marker of human acute myeloid leukemias. Blood 1988; 72: 1081
  • Tobal K., Pagliuca A., Bhatt B., Bailey N., Layton D. M., Mufti G. J. Mutation of the human fms gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 1990; 4: 486
  • Ridge S. A., Worwood M., Oscier D., Jacobs A., Padua R. A. FMS mutations in myelodysplasia, leukemia and normal subjects. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 1377
  • Bartram C. R. Mutations inras genes in myelocytic leukemias and myelodysplastic syndromes. Blood Cells 1988; 14: 533
  • Bos J. L., Toksoz D., Marshall C. J., et al. Amino-acid substitutions at codon 13 of theN-ras oncogene in human acute myeloid leukemia. Nature 1985; 315: 726
  • Hirai H., Okada M., Mizoguchi H., et al. Relationship between an activatedN-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome. Blood 1988; 71: 256
  • Edison L., Brian H., Rodman M., et al. The role of mutantras genes in preleukemic states. Blood 1987; 70(Suppl.)282a
  • Bashey A., Gill R., Levi C. J., Farr R., Clutterbuck J. L., Millar J. L., Pragnell I. B., Marshall C. J. Mutational activation of theN-ras oncogene assessed in primary clonogenic cultures of acute myeloid leukemia (AML): implications for the role ofN-ras mutation in AML pathogenesis. Blood 1992; 79: 981
  • Taylor J. A., Sandler D. P., Bloomfield C. D., Shore D. L., Ball E. D., Neubauer A., McIntyre O. R., Liu E. ras oncogene activation and occupational exposures in acute myeloid leukemia. J. Natl. Cancer Inst. 1992; 84: 1626
  • Morishita K., Paraganas E., William C. L., Whittaker M. H., Drabkin H., Oval J., Taetle R., Valentine M. B., Ihle J. N. Activation ofEvi-1 gene expression in human acute myelogenous leuke-mias by translocations spanning 300 to 400 kilobases on chromosome band 3q26. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 3937
  • Blatt C., Aberdam D., Schwartz R., Sacks L. DNA rearrangement of a homeobox gene in myeloid leukemia cells. EMBO J. 1988; 7: 4283
  • Perkins A., Kongsuwan K., Visvader J., Adams J. M., Cory S. Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 8398
  • Frash V. N., Yushkov B. G., Karaulov A. V., Skuratov V. Mechanism of action of benzene on hematopoiesis. Investigation of hematopoietic stem cells. Bull. Exp. Biol. Med. 1976; 82: 985
  • Speck B., Cornu P., Nissen C., Groff P., Weber W., Jeannet M. On the pathogenesis and treatment of aplastic anemia. Experimental Hematology Today, S. J. Baum, G. D. Ledney. Springer-Verlag, New York 1978; 43
  • Cronkite E. P., Inoue T., Carsten A. L., Miller M. E., Bullis J. E., et al. Effects of benzene inhalation on murine pleuripotential stem cells. J. Toxicol. Environ. Health 1982; 9: 411
  • Keller K. A., Snyder C. A. Mice exposed in utero to low concentrations of benzene exhibit enduring changes in their colony forming hematopoietic cells. Toxicology 1986; 42: 171
  • Keller K. A., Snyder C. A. Mice exposed in utero to 20 ppm benzene exhibit altered numbers of recognizable hematopoietic cells up to seven weeks after exposure. Fundam. Appl. Toxicol. 1988; 10: 224
  • Tunek A., Olofsson T., Berlin M. Toxic effects of benzene and benzene metabolites on granulopoietic stem cells and bone marrow cellularity in mice. Toxicol. Appl. Pharmacol. 1981; 59: 149
  • Dempster A. M., Snyder C. A. Effect of low-level benzene exposure on murine hemopoietic precursor cells. Toxicologist 1986; 6: 285
  • Pirozzi S. J., Schlosser M. J., Kalf G. F. Prevention of benzene-induced myelotoxicity and prostaglandin synthesis in bone marrow of mice by inhibitors of prostaglandin H synthase. Immunopharmacology 1989; 18: 39
  • Seidel H., Barthel E., Zinser D. The hematopoietic stem cell compartments in mice during and after long term inhalation of three doses of benzene. Exp. Hematol. 1989; 17: 300
  • Dempster A. M., Snyder C. A. Short-term benzene exposure provides a growth advantage for granulopoietic progenitor cells over erythroid progenitor cells. Arch. Toxicol. 1990; 64: 539
  • Kalf G. F., O'Connor A. The effects of benzene and hydroquinone on myeloid differentiation of HL-60 promyelocytic leukemia cells. Leuk. Lymph. 1993; 11: 331
  • Fontana J. A., Colbert D. A., Deisseroth A. B. Identification of a population of bipotent stem cells in the HL-60 human promyelocytic leukemia cell line. Proc. Natl. Acad. Sci. U.S.A. 1981; 78: 3838
  • Collins S. J. The HL-60 promyelocytic leukemia cell line. Proliferation differentiation and oncogene expression. Blood 1987; 70: 1233
  • Rovera G., Santoli D., Damsky G. Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with phorbol diesters. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 2779
  • Huberman E., Callahan M. F. Induction of terminal differentiation in human promyelocytic leukemia cells by tumor promoting agents. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 1293
  • Murao S., Gemmell M. A., Callahan M. F., Anderson N. L., Huberman E. Control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1α, 25-dihydroxyvitamin D3 and phorbol-12-myristate-13-acetate. Cancer Res. 1983; 43: 4989
  • Tanaka H., Abe E., Miyaura C., Shiina Y., Suda T. 1α,25-Dihydroxyvitamin D3 induces differentiation of human promyelocytic cells (HL-60) into monocyte-macrophages, but not into granulocytes. Biochem. Biophys. Res. Commun. 1983; 117: 86
  • McCarthy D. M., San Miguel J. F., Freake H. C., Green P. M., Zola H., Catovsky D., Goldman J. M. 1α,25-Dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukemia (HL-60) cells and induces monocyte-macrophages in HL-60. Leuk. Res. 1983; 7: 51
  • Breitman J. R., Selonick S. E., Collins S. J. Induction of differentiation of the human promyelocytic cell line HL-60 by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 2936
  • Collins S. J., Ruscetti F. W., Gallagher R. E., Gallo R. C. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide (DMSO) and other polar solvents. Proc. Natl. Acad. Sci. U.S.A. 1978; 75: 2458
  • Valtieri M., Tweardy J., Caracciolo D., Johnson K., Mavilio F., Altmann S., Santoli D., Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 1987; 138: 3829
  • Irons R. D., Stillman W. S., Colagiovanni D. B., Henry V. A. Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 3691
  • Oliveira N. L., Kalf G. F. Induced differentiation of HL-60 promyelocytic leukemia cells to monocyte/macrophages is inhibited by hydroquinone, a hematotoxic metabolite of benzene. Blood 1992; 79: 627
  • Tavassoli M., Friedenstein A. Hemopoietic stromal microenvironment. Am. J. Hematol. 1983; 15: 195
  • Dexter T. M., Allen T. D., Lajtha L. G. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell Physiol. 1977; 91: 335
  • Dexter T. M. Hemopoiesis in long-term bone marrow cultures. Acta Haematol. 1979; 62: 299
  • Garnett H., Cronkite E. P., Drew R. T. Effect of in vivo exposure to benzene on the characteristics of bone marrow adherent cells. Leuk. Res. 1983; 7: 803
  • Chertkov J. L., Lutton J. D., Jiang S., daSilva J.-L., Abraham N. G. Hematopoietic effects of benzene inhalation assessed by murine long-term bone marrow culture. J. Lab. Clin. Med. 1992; 119: 412
  • Gaido K. W., Wierda D. In vitro effects of benzene metabolites on mouse bone marrow stromal cells. Toxicol. Appl. Pharmacol. 1984; 76: 45
  • Gaido K. W., Wierda D. Modulation of stromal cell function in DBA/2 and B6C3F1 mice exposed to benzene or phenol. Toxicol. Appl. Pharmacol. 1985; 81: 469
  • Gaido K. W., Wierda D. Suppression of bone marrow stromal cell function by benzene and hydroquinone is ameliorated by indomethacin. Toxicol. Appl. Pharmacol. 1987; 89: 378
  • MacEachern L., Synder R., Laskin D. L. Alterations in the morphology and functional activity of bone marrow phagocytes following benzene treatment of mice. Toxicol. Appl. Pharmacol. 1992; 117: 147
  • Thomas D. J., Reasor M. J., Wierda D. Macrophage regulation of myelopoiesis is altered by exposure to the benzene metabolite hydroquinone. Toxicol. Appl. Pharmacol. 1989; 97: 440
  • Thomas D. J., Sadler A., Subrahmanyam V. V., Siegel D., Reasor M. J., Wierda D., Ross D. Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone. Comparison of macrophages and fibroblastoid cells. Mol. Pharmacol. 1990; 37: 255
  • Renz J. F., Kalf G. F. Role for interleukin-1 (IL-1) in benzene-induced hematotoxicity. Inhibition of conversion of pre-IL-1α to mature cytokine in murine macrophages by hydroquinone and prevention of benzene-induced hematoxicity in mice by IL-1α. Blood 1991; 78: 938
  • Moore M. A. S. Regulatory role of the macrophage in hemopoiesis. Stem Cells and Tissue Homeostasis, B. I. Lord, C. S. Potten, R. J. Cole. Cambridge University Press, London 1978; 187
  • Post G. B., Snyder R., Kalf G. F. Metabolism of benzene and phenol in macrophagesin vitro and the inhibition of RNA synthesis by benzene metabolites. Cell Biol. Toxicol. 1986; 2: 231
  • Ido M., Harada M., Furuichi H., Matsuoka N., Nakano K., Sohmura Y. Interleukin-1-induced sequential myelorestoration. Dynamic relation between granulopoiesis and progenitor cell recovery in myelosuppressed mice. Exp. Hematol. 1992; 20: 161
  • Gascon P., Scala G. Decreased interleukin-1 production in aplastic anemia. JAMA 1988; 85: 668
  • Nakao N., Matsushima K., Yoiung N. Decreased interleukin-1 production in aplastic anemia. Br. J. Haematol. 1989; 71: 431
  • Katayama N., Nishikawa M., Minami N., Shirakawa S. Putative involvement of protein kinase c in proliferation of human myeloid progenitor cells. Blood 1989; 73: 123
  • Whetton A. D., Heyworth C. M., Dexter T. M. Phorbol esters activate protein kinase c and glucose transport and can replace the requirement for growth factor in interleukin-3-dependent multipotent stem cells. J. Cell Sci. 1986; 84: 93
  • Weinstein I. B. Nonmutagenic mechanisms in carcinogenesis. Role of protein kinase c in signal transduction and growth control. Environ. Health Perspect. 1991; 93: 175
  • Hsiao W.-L. W., Housey G. M., Johnson M. D., Weinstein I. B. Cells that overproduce protein kinase c are more susceptible to transformation by an activatedH-ras oncogene. Mol. Cell. Biol. 1989; 9: 2641
  • Housey G. M., Johnson M. D., Hsiao W.-L. W., O'Brian C. A., Murphy J. P., Kirschmeier P., Weinstein I. B. Overproduction of protein kinase c causes disordered growth control in rat fibroblasts. Cell 1988; 52: 343
  • Krauss R. S., Housey G. M., Johnson M. D., Weinstein I. B. Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase c. Oncogene 1989; 4: 991
  • Yarden Y., Kuang W. J., Yang F. T., Coussens L., Munemitsu S., Dull T. J., Chen E., Schlessinger L. J., Francke U., Ullrich A. Human photo-oncogenec-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987; 6: 3341
  • Huang E., Nocka K., Beier D. R., Chu T. Y., Buck J., Lahm H. W., Wellner D., Leder P., Besmer P. The hematopoietic growth factor KL is encoded by the S1 locus and is the ligand of thec-kit receptor, the gene product of the W locus. Cell 1990; 63: 225
  • Witte O. N. Steel locus defines new multipotent growth factor. Cell 1990; 63: 5
  • Ikeda H., Kanakura Y., Tamaki T., Kuriu A., Kitayama H., Ishikawa J., Kanayama Y., Yonezawa T., Tarui S., Griffin J. Expression and functional role of the proto-oncogenec-kit in acute myeloblasts leukemia. Blood 1991; 78: 2962
  • Cheng K. C., Cahill D. S., Kasai H., Nishimura S., Loeb L. 8-OH Deoxyguanosine, an abundant form of oxidative DNA damage causes G-T and A-C substitutions. J. Biol. Chem. 1992; 267: 167
  • Fenaux P., Jonveaux P., Quiquandon I., Lai J. L., Pignon J. M., Loucheux-Lefebvre M. H., Bauters F., Berger R., Kerckaert J. P. p53 gene mutations in acute myeloid leukemia with 17p monosomy. Blood 1991; 78: 1652
  • Fenaux P., Preudhomme C., Quiquandon I., Jonveaux P., Lai J. L., Vanrumbeke M., Loucheux-Lefebvre M. H., Bauters F., Berger R., Kerckaert J. P. Mutations of the p53 gene in acute myeloid leukemia. Br. J. Haematol. 1992; 80: 178
  • Irons R. D., Neptun D. A. Effects of the principal hydroxymetabolites of benzene on microtubule polymerization. Arch. Toxicol. 1980; 45: 297
  • Irons R. D., Neptun D. A., Pfeiffer R. W. Inhibition of lymphocyte transformation and microtubule assembly by quinone metabolites of benzene. Evidence for a common mechanism. J. Reticuloendothelial. Soc. 1981; 30: 359
  • Bernal S. D., Chen L. B. Induction of cytoskeleton-associated proteins during differentiation of human myeloid leukemic cell lines. Cancer Res. 1982; 42: 5106
  • Bernal S. D., Stahel R. A. Cytoskeleton-associated proteins. Their role as cellular integrators in neoplastic processes. Crit. Rev. Oncol. Hematol. 1985; 3: 191
  • Brown W. J., Norwood C. F., Smith R. G., Snell W. J. Development of capping ability during differentiation of HL-60 human promyelocytic leukemia cells. J. Cell Physiol. 1981; 106: 127
  • Leung M., Sokoloski J. A., Sartorelli A. C. Changes in microtubules, microtubule-associated proteins and intermediate filaments during the differentiation of HL-60 leukemia cells. Cancer Res. 1992; 52: 949
  • Leung M., Sartorelli A. C. The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells. Leukemia Res. 1992; 16: 929
  • Miller A. M., Weiner R. S., Ziboh V. A. Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation. Exp. Hematol. 1986; 14: 760
  • Ziboh V. A., Wong T., Wu M. C., Yunis A. A. Modulation of colony stimulating factor-induced murine myeloid colony formation byS-peptidolipoxygenase products. Cancer Res. 1986; 46: 600
  • Snyder D. S., Castro R., Desforges J. F. 5-Lipoxygenase metabolites of arachidonic acid modulate proliferation of malignant hematopoietic cell lines. Blood 1986; 70: 185a
  • Miller A. M., Cullen M. K., Kobb S. M., Weiner R. S. Effects of lipoxygenase and glutathione pathway inhibitors on leukemic cell line growth. J. Lab. Clin. Med. 1989; 113: 355
  • Jensen P. K. A., Junien C., Despoisse S., et al. Inverted tandem duplication of the short arm of chromosome 8. A non-random de novo structural aberration in man. Localization of the gene for glutathionine reductase in subband 8p21.1. Ann. Genet. 1982; 25: 207
  • Silverstein D. L., Shows T. B. Gene for glutathioneS-transferase-1 (GST1) is on human chromosome 11. Somatic Cell Genet. 1982; 8: 667
  • Rowley J. D. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res. 1984; 44: 3159
  • Fearon E. R., Vogelstein B. A genetic model for colon tumorigenesis. Cell 1990; 61: 759

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