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Research Article

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

Pages 87-149 | Published online: 25 Sep 2008

References

  • Addison R. F., Zinck M. E., Willis D. E., Darrow D. C. Induction of hepatic mixed function oxidases in trout by polychlorinated biphenyls and butylated monochlorodiphenyl ethers. Toxicol. Appl. Pharmacol. 1979; 49: 245
  • Ahlborg U. G. Nordic risk assessment of PCDDs and PCDFs. Chemosphere 1989; 19: 603
  • Ahlborg U. G., Brouwer A., Fingerhut M. A., Jacobson J. L., Jacobson S. W., Kennedy S. W., Kettrup A. A. F., Koeman J. H., Poiger H., Rappe C., Safe S. H., Seega R. F., Tuomisto J., Van den Berg M. Impact of polychlorinated dibenzo-P-dioxins, dibenzofurans, and biphenyls on human and environmental health with special emphasis on application of the toxic equivalence factor concept. Eur. J. Pharmacol 1992; 228: 179
  • Ahlborg U. G., Hanberg A., Kenne K. Risk Assessment of Polychlorinated Biphenyls (PCBs). Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden 1992
  • Ahlborg U. G., Håkansson H., Warn F., Hanberg A. Nordisk dioxinriskbedömning. Rapport fran en nordisk expertgrupp. Nordisk Ministerrådet, Miljorapport 1988
  • Ahotupa M. Enhancement of epoxide-metabolizing enzyme activities by pure PCB isomers. Biochem. Pharmacol. 1981; 30: 1866
  • Albrecht W. N. Central nervous system toxicity of some common environmental residues in the mouse. J. Toxicol. Environ. Health 1987; 21: 405
  • Albro P. W., Corbett J. T., Schroeder J. L. Quantitative characterization of polychlorinated bi phenyl mixtures (Aroclors 1248, 1254 and 1260) by gas chromatography using capillary columns. J. Chromatogr. 1981; 205: 103
  • Albro P. W., Parker C. E. Comparison of the composition of Aroclor 1242 and Aroclor 1016. J. Chromatogr. 1979; 169: 161
  • Allen J. R. Response of the nonhuman primate to polychlorinated biphenyl exposure. Fed. Proc 1975; 34: 1675
  • Allen J. R., Abrahamson L. J. Morphological and biochemical changes in the liver of rats fed polychlorinated biphenyls. Arch. Environ. Contain. Toxicol. 1973; 1: 265
  • Allen J. R., Abrahamson L. J. Responses of rats exposed to polychlorinated biphenyls for 52 weeks. II. Composition and enzymic changes in the liver. Arch. Environ. Contam. Toxicol. 1979; 8: 191
  • Allen J. R., Carstens L. A., Abrahamson L. J. Responses of rats exposed to polychlorinated biphenyls for 52 weeks. I. Comparison of ti levels of PCB and biological changes. Arch. Environ. Contam. Toxicol. 1976; 4: 404
  • Allen J. R., Carstens L. A., Barsotti D. A. Residual effects of short-term, low-level exposure of non-human primates to polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 1974; 30: 440
  • Alvares A. P. Stimulatory effects of polychlorinated biphenyls (PCB) on cytochromes P-450 and P-448 mediated microsomal oxidations. Microsomes and Drug Oxidations, V. Ullrich, A. Hildebrandt, I. Roots, R. W. Estabrook, A. H. Conney. Pergamon Press, Oxford 1977; 476
  • Alvares A. P., Bickers D. R., Kappas A. Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. Proc. Natl. Acad. Sci. USA. 1973; 70: 1321
  • Alvares A. P., Fischbein A., Anderson K. E., Kappas A. Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin. Pharmacol. Ther. 1977; 22: 140
  • Alvares A. P., Kappas A. The inducing properties of polychlorinated biphenyls on hepatic monoxygenases. Clin. Pharmacol. Ther. 1977; 22: 809
  • Alvares A. P., Kappas A. Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls. J. Biol. Chem. 1977; 252: 6373
  • Alvares A. P., Kappas A. Lead and polychlorinated biphenyls: effects on heme and drug metabolism. Drug Metab. Rev. 1979; 10: 91
  • Alvares A. P., Ueng T.-H., Eiseman J. L. Polychlorinated biphenyls (PCBs) inducible mono oxygenases in rabbits and mice: species and organ specificities. Life Sci. 1982; 30: 747
  • Anderson L. M., Beebe L. E., Fox S. D., Issaq H. J., Kovatch R. M. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. Exp. Lung Res. 1991; 17: 455
  • Anderson L. M., Van Havere K., Budinger J. M. Effects of polychlorinated biphenyls on lung and liver tumors initiated in suckling mice byN-nitrosodimethylamine. J. Natl. Cancer Inst. 1983; 71: 157
  • Anderson R. S. Aryl hydrocarbon hydroxylase induction in an insect,Spodoptera eridania (Cramer), by polychlorinated biphenyls (PCBs). Comp. Biochem. Physiol. 1978; 60: 51
  • Andersson L., Nikolaidis E., Brunström B., Bergman Å., Dencker L. Effects of polychlorinated biphenyls with Ah receptor affinity on lym phoid development in the thymus and the bursa of Fabricius of chick embryosin ovo and in mouse thymus anlagen in vitro. Toxicol. Appl. Pharmacol. 1991; 107: 183
  • Anon. Report of a new chemical hazard. New Sci. 1966; 32: 621
  • Aoki Y., Satoh K., Sato K., Suzuki K. T. Induction of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by co-planar polychlorinated biphenyl congeners. Biochem. J. 1992; 281: 539
  • Argus M. F., Bryan G. M., Pastor K. M., Arcos J. C. Effect of polychlorinated biphenyls (Aroclor 1254) on inducible and repressible microso malN-demethylases in the mouse and rat. Cancer Res. 1975; 35: 1574
  • Arnold D. L., Mes J., Bryce F., Karpinski K., Bickis M. G., Zawidzka Z. Z., Stapley R. A pilot study on the effects of Aroclor 1254 ingestion by rhesus and cynomolgus monkeys as a model for human ingestion of PCBs. Food Chem. Toxicol. 1990; 28: 847
  • Asplund L., Grafström A.-K., Haglund P., Jansson B., Järnberg U., Mace D., Strandell M., De Wit C. Analysis of non-ortho polychlorinated biphenyls and polychlorinated naphthalenes in Swedish dioxin survey samples. Chemosphere 1990; 20: 1481
  • Atlas E., Giam C. S. Global transport of organic pollutants: ambient concentrations in the remote marine atmosphere. Science 1981; 211: 163
  • Aulerich R. J., Ringer R. K. Current status of PCB toxicity to mink, and effect on their reproduction. Arch. Environ. Contam. Toxicol. 1977; 6: 279
  • Aulerich R. J., Ringer R. K., Safronoff J. Assessment of primary vs. secondary toxicity of Aroclor 1254 to mink. Arch. Environ. Contam. Toxicol. 1986; 15: 393
  • Ax R. L., Hansen L. G. Effects of purified PCB analogs on chicken reproduction. Poult. Sci. 1975; 54: 895
  • Azais V., Arand M., Rauch P., Schramm H., Bellenand P., Narbonne J.-F., Oesch F., Pascal G., Robertson L. W. A time-course investigation of vitamin A levels and drug metabolizing enzyme activities in rats following a single treatment with prototypical polychlorinated biphenyls and DDT. Toxicology 1987; 44: 341
  • Azais V., Pascal G. Effects of congeneric polychlorinated biphenyls on liver and kidney retinoid levels. Chemosphere 1986; 15: 1905
  • Bacon C. E., Jarman W. M., Costa D. P. Organochlorine and polychlorinated biphenyl levels in pinniped milk from the Arctic, the Antarctic, California and Australia. Chemosphere 1992; 24: 779
  • Bahn A. K., Grover P., Rosenwaike I., O'Leary K., Stellman J. PCB and melanoma. N. Engl. J. Med. 1977; 296: 108
  • Bahn A. K., Rosenwaike I., Herrmann N., Grover P., Stellman J., O'Leary K. Melanoma after exposure to PCBs. N. Engl. J. Med. 1976; 295: 450
  • Baker F. D., Bush B., Tumasonis C. F., Lo F. C. Toxicity and persistence of low-level PCB in adult Wistar rats, fetuses, and young. Arch. Environ. Contam. Toxicol. 1977; 5: 143
  • Bakke J. E., Feil V. J., Bergman Å. Metabolites of 2,4′,5-trichlorobiphenyl in rats. Zenobiotica 1983; 13: 555
  • Ballschmiter K. Global distribution of organic compounds. Environ. Carcinogen. Rev. 1991; 9: 1
  • Ballschmiter K., Buchert H., Bihler S. Baseline studies of global pollution. Fresenius Z. Anal. Chem. 1981; 306: 323
  • Ballschmiter K., Rappe C., Buser H. R. Chemical properties, analytical and environmental levels of PCBs, PCTs, PCNs and PCBs. Haloge nated Biphenyls, Terphenyls, Naphthalenes, Dibenzo dioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier-North Holland, Amsterdam 1989; 47
  • Ballschmiter K., Scholz Ch., Buchert H., Zell M., Figge K., Polzhofer K., Hoerschelmann H. Studies of the global baseline pollution. Fresenius Z. Anal. Chem. 1981; 309: 1
  • Ballschmiter K., Zell M. Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chro matography. Composition of technical Aroclor- and Clophen-PCB mixtures. Fresenius Z. Anal. Chem. 1980; 302: 20
  • Bandiera S., Farrell K., Mason G., Kelley M., Romkes M., Bannister R., Safe S. Comparative toxicities of the polychlorinated dibenzofuran (PCDF) and biphenyl (PCB) mixtures which persist in Yusho victims. Chemosphere 1984; 13: 507
  • Bandiera S., Safe S., Okey A. B. Binding of polychlorinated biphenyls classified as either pheno barbitone-, 3-methylcholanthrene-, or mixed-type in ducers to cytosolic Ah receptor. Chem.-Biol. Interact. 1982; 39: 259
  • Bannister R., Davis D., Zacharewski T., Tizard I., Safe S. Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme activity and immunotoxicity. Toxicology 1987; 46: 29
  • Bannister R., Safe S. Synergistic interactions of 2,3,7,8-TCDD and 2,2′,4,4′,5,5′-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor. Toxicology 1987; 44: 159
  • Barnes D. G. Toxicity equivalents and EPA's risk assessment of 2,3,7,8-TCDD. Sci. Total Environ. 1991; 104: 73
  • Barsotti D. A., Allen J. R. Effects of polychlo rinated biphenyls on reproduction in the primate. Fed. Proc. 1975; 34: 338
  • Barsotti D. A., Marlar R. J., Allen J. R. Reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aroclor 1248). Food Cosmet. Toxicol. 1976; 14: 99
  • Bastomsky C. H. Effects of a polychlorinated biphenyls mixture (Aroclor 1254) and DDT on biliary thyroxin excretion in rats. Endocrinology 1974; 95: 1150
  • Baumann M., Demi E., Schäffer E., Greim H. Effects of polychlorinated biphenyls at low dose levels in rats. Arch. Environ. Contain. Toxicol. 1983; 12: 509
  • Bäcklin B.-M., Bergman A. Morphological aspects on the reproductive organs in female mink (Mustela vison) exposed to polychlorinated biphenyls and fractions thereof. Ambio 1992; 21: 596
  • Beck H., Dross A., Mathar W. PCDDs, PCDFs, and related contaminants in the German food supply. Chemosphere 1992; 25: 1539
  • Becker G. M., McNulty W. P., Bell M. Polychlorinated biphenyl-induced morphologic changes in the gastric mucosa of the rhesus monkey. Lab. Invest. 1979; 40: 373
  • Becker M. M., Gamble W. Determination of the binding of 2,4,5,2′,4′,5′-hexachlorobiphenyl by low density lipoprotein and bovine serum albumin. J. Toxicol. Environ. Health 1982; 9: 225
  • Beebe L. E., Fox S. D., Issaq H. J., Anderson L. M. Biological and biochemical effects of retained polyhalogenated hydrocarbons. Environ. Toxicol. Chem. 1991; 10: 757
  • Beebe L. E., Fox S. D., Riggs C. W., Park S. S., Gelboin H. V., Issaq H. J., Anderson L. M. Persistent effects of a single dose of Aroclor 1254 on cytochromes P450IA1 and IIB1 in mouse lung. Toxicol. Appl. Pharmacol. 1992; 114: 16
  • Bellin J. S., Barnes D. G. Interim Procedures for Estimating Risks Associated with Exposures to Mixtures of Chlorinated Dibenzo-p-Dioxins and -Dibenzofurans (CDDs and CDFs). United States Environmental Protection Agency, Washington, DC 1989
  • Bergman Å., Athanasiadou M., Bergek S., Haraguchi K., Jensen S., Klasson-Wehler E. PCB and PCB methyl sulphones in mink treated with PCB and various PCB fractions. Ambio 1992; 21: 570
  • Bergman Å., Bäcklin B.-M., Järplid B., Grimelius L., Wilander E. Influence of commercial polychlorinated biphenyls and fractions thereof on liver histology in female mink (Mustela vison). Ambio 1992; 21: 591
  • Bergman Å., Biessmann A., Brandt I., Rafter J. Metabolism of 2,4,5-trichlorobiphenyl: role of the intestinal microflora in the formation of bronchial-seeking methylsulphone metabolites in mice. Chem. Biol. Interact. 1982; 40: 123
  • Bergman A., Brandt I., Darnerud P. O., Wachtmeister C. A. Metabolism of 2,2′,5,5′-tetrachlorobiphenyl: formation of mono- and bis-me thyl sulphone metabolites with a selective affinity for the lung and kidney tis in mice. Xenobiotica 1982; 12: 1
  • Bergman A., Brandt I., Jansson B. Accumulation of methylsulfonyl derivatives of some bronchial-seeking polychlorinated biphenyls in the respiratory tract of mice. Toxicol. Appl. Pharmacol. 1979; 48: 213
  • Berry D. L., DiGiovanni J., Juchau M. R., Bracken W. M., Gleason G. L., Slaga T. J. Lack of tumor-promoting ability of certain environmental chemicals in a two-stage mouse skin tu morigenesis assay. Res. Commun. Chem. Pathol. Pharmacol. 1978; 20: 101
  • Berry D. L., Slaga T. J., DiGiovanni J., Juchau M. R. Studies with chlorinated dibenzo-p-dioxins, polybrominated biphenyls, and polychlorinated biphenyls in a two-stage system of mouse skin tumorigenesis: potent anticarcinogenic effects. Ann. N.Y. Acad. Sci. 1979; 320: 405
  • Bertazzi P. A., Ribaldi L., Pesatori A., Radice L., Zocchetti C. Cancer mortality of capacitor manufacturing workers. Am. J. Ind. Med. 1987; 11: 165
  • Biegel L., Harris M., Davis D., Rosengren R., Safe L., Safe S. 2,2′,4,4′,5,5′-Hexachloro-biphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol. Appl. Pharmacol. 1989; 97: 561
  • Biocca M., Gupta B. N., Chae K., McKinney J. D., Moore J. A. Toxicity of selected symmetrical hexachlorobiphenyl isomers in the mouse. Toxicol. Appl. Pharmacol. 1981; 58: 461
  • Birnbaum L. S. EPA's reassessment of dioxin risk: directed health effects. Organohalogen Compounds, Dioxin 1992 1992; 10: 287
  • Birnbaum L. S., Baird M. B. Induction of hepatic mixed function oxidases in senescent rodents. Exp. Gerontol 1978; 13: 299
  • Birnbaum L. S., Harris M. W., Crawford D. D., Morrissey R. E. Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/ 6N mice. Toxicol. Appl. Pharmacol. 1987; 91: 246
  • Bleavins M. R., Aulerich R. J., Ringer R. K. Polychlorinated biphenyls (Aroclors 1016 and 1242): effects on survival and reproduction in mink and ferrets. Arch. Environ. Contam. Toxicol. 1980; 9: 627
  • Blomkvist G., Roos A., Jensen J., Bignert A., Olsson M. Concentrations of sDDT and PCB in seals from Swedish and Scottish waters. Ambio 1992; 21: 539
  • Boobis A. R., Nebert D. W., Pelkonen O. Effects of microsomal enzyme inducersin vivo and inhibitorsin vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonre-sponsive mice. Biochem. Pharmacol 1979; 28: 111
  • Borlakoglu J. T., Clarke S., Huang S.-W., Kils R. R., Haegele K. D., Gibson G. G. Lacta tional transfer of 3,3′,4,4′-tetrachloro- and 2,2′,4,4′,5,5′-hexachlorobiphenyl induces cytochrome P450IVA1 in neonates: evidence for a potential syn ergistic mechanism. Biochem. Pharmacol. 1992; 43: 153
  • Borlakoglu J. T., Edwards-Webb J. D., Dils R. R. Polychlorinated biphenyls increase fatty acid desaturation in the proliferating endoplasmic reticu lum of pigeon and rat livers. Eur. J. Biochem. 1990; 188: 327
  • Borlakoglu J. T., Edwards-Webb J. D., Dils R. R., Wilkins J. P. G., Robertson L. W. Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls. FEBS Lett. 1989; 247: 327
  • Borlakoglu J. T., Wilkins J. P. G., Walker C. H., Dils R. R. Polychlorinated biphenyls (PCBs) in fish-eating sea birds. I. Molecular features of PCB isomers and congeners in adipose ti of male and female razorbills (Alca tarda) of British and Irish coastal waters. Comp. Biochem. Physiol. 1990; 97: 151
  • Borlakoglu J. T., Wilkins J. P. G., Walker C. H., Dils R. R. Polychlorinated biphenyls (PCBs) in fish-eating sea birds. III. Molecular features and metabolic interpretations of PCB isomers and congeners in adipose tis. Comp. Biochem. Physiol. 1990; 97: 173
  • Borlakoglu J. T., Wilkins J. P. G., Walker C. H., Dils R. R. Polychlorinated biphenyls (PCBs) in fish-eating sea birds. II. Molecular features of PCB isomers and congeners in adipose ti of male and female puffins (Fratercula arctica), guillemots (Uria aalga), shags (Phalacrocorax aristotelis) and cormorants (Phalacrocorax carbo) of British and Irish coastal waters. Comp. Biochem. Physiol. 1990; 97: 161
  • Bosveld B. A. T.C., Van den Berg M., Theelen R. M. C. Assessment of the EROD inducing potency of eleven 2,3,7,8-substituted PCDD/Fs and three co planar PCBs in the chick embryo. Chemosphere 1992; 25: 911
  • Botelho L. H., Ryan D. E., Levin W. Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholan threne. J. Biol. Chem. 1979; 254: 5635
  • Bowes G. W., Mulvihill M. J., DeCamp M. R., Kende A. S. Gas chromatographic characteristics of authentic chlorinated dibenzofurans: identification of two isomers in American and Japanese polychlorinated biphenyls. J. Agric. Food Chem. 1975; 23: 1222
  • Bowes G. W., Mulvihill M. J., Simoneit B. R. T., Burlingame A. L., Risebrough R. W. Identification of chlorinated dibenzofurans in American polychlorinated biphenyls. Nature 1975; 256: 305
  • Bowman R. E., Heironimus M. P., Allen J. R. Correlation of PCB body burden with behavioral toxicology in monkeys. Pharmacol. Biochem. Behav. 1978; 9: 49
  • Bowman R. E., Heironimus M. P., Barsotti D. A. Locomotor hyperactivity in PCB-exposed rhesus monkeys. Neurotoxicology 1981; 2: 251
  • Bradlaw J. A., Casterline J. L., Jr. Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds. J. Assoc. Off. Anal. Chem. 1979; 62: 904
  • Brandt I., Bergman Å. Bronchial mucosal and kidney cortex affinity of 4- and 4,4′-substituted sulphur-containing derivatives of 2,2′,5,5′-tetrachloro-biphenyl in mice. Chem.-Biol. Interact. 1981; 34: 47
  • Brandt I., Darnerud P. O., Bergman A., Larsson Y. Metabolism of 2,4′,5-trichlorobiphenyl: enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal field of pregnant mice. Chem.-Biol. Interact. 1982; 40: 45
  • Brandt I., Klasson-Wehler E., Rafter J., Bergman A. Metabolism of 2,4′,5-trichlorobiphenyl: ti concentrations of methylsulphonyI-2,4′,5-trichlorobiphenyl in germfree and conventional mice. Toxicol. Lett. 1982; 12: 273
  • Brandt I., Lund J., Bergman A., Klasson-Wehler E., Poellinger L., Gustafsson J.-Å. Target cells for the polychlorinated biphenyl metabolites 4,4′-bis(methylsulfonyl)-2,2′,5,5′-tetrachlorobiphenyl in lung and kidney. Drug Metab. Dispos. 1985; 13: 490
  • Brouwer A., Klasson-Wehler E., Bokdam M., Morse D. C., Traag W. A. Competitive inhibition of thyroxin binding to transthyretin by mono hydroxy metabolites of 3,4,3′,4′-tetrachlorobiphenyl. Chemosphere 1990; 20: 1257
  • Brouwer A., Kukler A., Van den Berg K. J. Alterations in retinoid concentrations in several extra-hepatic organs of rats by 3,4,3′,4′-tetrachlorobiphenyl. Toxicology 1988; 50: 317
  • Brouwer A., Van den Berg K. J. Early and differential decrease in natural retinoid levels in C57BL/Rij and DBA/2 mice by 3,4,3′,4′-tetrachloro-biphenyl. Toxicol. Appl. Pharmacol. 1984; 73: 204
  • Brouwer A., Van den Berg K. J. Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Toxicol. Appl. Pharmacol. 1986; 85: 301
  • Brouwer A., Van den Berg K. J., Kukler A. Time and dose responses of the reduction in retinoid concentrations in C57BL/Rij and DNA/2 mice induced by 3,4,3′,4′-tetrachlorobiphenyl. Toxicol. Appl. Pharmacol. 1985; 78: 180
  • Brown D. P. Mortality of workers exposed to poly-chlorinated biphenyls — an update. Arch. Environ. Health 1987; 42: 333
  • Brown D. P., Jones M. Mortality and industrial hygiene study of workers exposed to polychlorinated biphenyls. Arch. Environ. Health 1981; 36: 120
  • Brown J. R., Jr., Bedard D. L., Brennan M. J., Carnahan J. C., Feng H., Wagner R. E. Polychlorinated biphenyl dechlorination in aquatic sediments. Science 1987; 236: 709
  • Bruckner J. V., Jiang W.-D., Brown J. M., Putcha L., Chu C. K., Stella V. J. The influence of ingestion of environmentally encountered levels of a commercial polychlorinated biphenyl mixture (Aroclor 1254) on drug metabolism in the rat. J. Pharmacol. Exp. Ther. 1977; 202: 22
  • Bruckner J. V., Khanna K. L., Cornish H. H. Biological responses of the rat to polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 1973; 24: 434
  • Bruckner J. V., Khanna K. L., Cornish H. H. Polychlorinated biphenyl-induced alteration of biologic parameters in the rat. Toxicol. Appl. Pharmacol. 1974; 28: 189
  • Bruckner J. V., Khanna K. L., Cornish H. H. Effect of prolonged ingestion of polychlorinated biphenyls on the rat. Food Cosmet. Toxicol. 1974; 12: 323
  • Brunn H., Schmidt E., Reinacher M., Manz D., Eigenbrodt E. Histology and histochemistry of the liver of chickens after DENA induced hepatocar cinogenesis and ingestion of low chlorinated biphenyls. Arch. Toxicol. 1987; 60: 337
  • Brunström B. Activities in chick embryos of 7-ethoxycoumarinO-deethylase and aryl hydrocarbon (benzo[a]pyrene) hydroxylase and their induction by 3,3′,4,4′-tetrachlorobiphenyl in early embryos. Xenobiotica 1986; 16: 865
  • Brunström B. Mono-ortho-chlorinated chloro biphenyls: toxicity and induction of 7-ethoxyresorufinO-deethylase (EROD) activity in chick embryos. Arch. Toxicol. 1990; 64: 188
  • Brunström B. Induction of cytochrome P-450-de-pendent enzyme activities in female mink (Mustela vison) and their kits by technical PCB preparations and fractions thereof. Ambio 1992; 21: 585
  • Brunström B. Embryolethality and induction of 7-ethoxyresorufinO-deethylase in chick embryos by polychlorinated biphenyls and polycyclic aromatic hydrocarbons having Ah receptor affinity. Chem.-Biol. Interact. 1992; 81: 69
  • Brunström B., Andersson L., Nikolaidis E., Dencker L. Non-ortho- and mono-ortho-chlorine substituted polychlorinated biphenyls — embryo toxicity and inhibition of lymphoid development. Chemosphere 1990; 20: 1125
  • Brunström B., Darnerud P. O. Toxicity and distribution in chick embryos of 3,3′,4,4′-tetrachloro-biphenyl injected into the eggs. Toxicology 1983; 27: 103
  • Brunström B., Hakansson H., Lundberg K. Effects of a technical PCB preparation and fractions thereof on ethoxyresorufin O-deethylase activity, vi tamin-A levels and thymic development in the mink (Mustela vison). Pharmacol. Toxicol. 1991; 69: 421
  • Brunström B., Kihlstrom I., Lundkvist U. Studies of fetal death and fetal weight in guinea pigs fed polychlorinated biphenyls (PCB). Acta Pharmacol. Toxicol. 1982; 50: 100
  • Buchmann A., Kunz W., Wolf C. R., Oesch F., Robertson L. W. Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholan-threne-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initi ated rats. Cancer Lett. 1986; 32: 243
  • Buchmann A., Ziegler S., Wolf A., Robertson L. W., Durham S. K., Schwarz M. Effects of polychlorinated biphenyls in rat liver: correlation between primary subcellular effects and promoting activity. Toxicol. Appl. Pharmacol. 1991; 111: 454
  • Bunyan P. J., Page J. M. J. Polychlorinated biphenyls. The effect of structure on the induction of quail hepatic microsomal enzymes. Toxicol. Appl. Pharmacol. 1978; 43: 507
  • Buser H. R., Rappe C., Gara A. Polychlorinated dibenzofurans (PCDFs) found in Yusho oil and in used Japanese PCB. Chemosphere 1978; 5: 439
  • Bush B., Streeter R. W., Sloan R. J. Polychlorobiphenyl (PCB) congeners in striped bass (Morone saxatilis) from marine and estuarine waters of New York State determined by capillary gas chro matography. Arch. Environ. Contam. Toxicol. 1989; 19: 49
  • Byrne J. J., Carbone J. P., Hanson E. A. Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybromi nated biphenyl. Endocrinology 1987; 21: 520
  • Byrne J. J., Carbone J. P., Pepe M. G. Suppression of serum adrenal cortex hormones by chronic low-dose polychlorobiphenyl or polybromo biphenyl treatments. Arch. Environ. Contam. Toxicol. 1988; 17: 47
  • Carter J. W., Mercer L. P. Prediction of food intake, weight gain and organ weights in rats as a formulation of dietary Aroclor 1254 (PCBs) by the saturation kinetics model for physiological responses. Nutr. Rep. Int. 1983; 27: 561
  • Chase K. H., Wong O., Thomas D., Stal B. W., Berney B. W., Simon R. K. Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls. J. Occup. Med. 1982; 24: 109
  • Chen L.-C, Berberian I., Koch B., Mercier M., Azais-Braesco V., Glauert H. P., Chow C. K., Robertson L. W. Polychlorinated and polybro minated biphenyl congeners and retinoid levels in rat tis: structure-activity relationships. Toxicol. Appl. Pharmacol. 1992; 114: 47
  • Chen P. H., Chang K. T., Lu Y. D. Polychlorinated biphenyls and polychlorinated dibenzofurans in the toxic rice-bran oil that caused PCB poisoning in Taichung. Bull. Environ. Contam. Toxicol. 1981; 26: 489
  • Chen P. H., Lu Y. D., Yang M. H., Chen J. S. Toxic compounds in the cooking oil which caused PCB poisoning in Taiwan. II. The presence of poly-chlorinated quarterphenyls and polychlorinated terphenyls (in Chinese). Clin. Med. 1981; 7: 77
  • Chen Y.-C. J., Guo Y.-L., Hsu C.-C, Rogan W. J. Cognitive development of Yu-Cheng (“oil disease”) children prenatally exposed to heat-degraded PCBs. JAMA 1992; 268: 3213
  • Chou S. M., Miike T., Payne W. M., Davis G. J. Neuropathology of “spinning syndrome” induced by prenatal intoxication with a PCB in mice. Ann. NY. Acad. Sci. 1979; 320: 373
  • Chu C. K., Stella V. J., Bruckner J. V., Jiang W. D. Effects of long-term exposure to environmental levels of polychlorinated biphenyls on phar macokinetics of pentobarbital in rast. J. Pharm. Sci. 1977; 66: 238
  • Clark D. A., Sweeney G., Safe S., Hancock E., Kilburn D. G., Gauldie J. Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons. Immunopharmacology 1983; 6: 143
  • Collins W. T., Capen C. C. Biliary excretion of thyroxine-1–125 and fine structural alterations in the thyroid glands of Gunn-rats fed PCBs. Lab. Invest. 1980; 43: 158
  • Collins W. T., Capen C. C. Ultrastructural and functional alterations of the rat thyroid gland produced by polychlorinated biphenyls compared with iodide excess and deficiency, and thyrotropin and thyroxine administration. Virchows Arch. 1980; 33: 213
  • Collins W. T., Capen C. C., Kasza L., Carter C., Dailey R. E. Effect of polychlorinated biphenyls (PCB) on the thyroid gland of rats. Am. J. Pathol. 1977; 89: 119
  • Conney A. H. Pharmacological implications of mi crosomal enzyme induction. Pharmacol. Rev. 1967; 19: 317
  • Conney A. H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res. 1982; 42: 4875
  • Corbett J., Albro P. W., Chae K., Jordan S. The relationship between metabolism of 2,3,4,5,3′,4′,5′-heptachlorobiphenyl and its ability to induce both cytochromes P-448 and P-450. Chem. Biol. Interact. 1982; 39: 331
  • Davidorf F. H., Knupp J. A. Epidemiology of ocular melanoma, incidence and geographical relationship in Ohio (1967–1977). Ohio St. Med. J. 1979; 75: 561
  • Davis D., Safe S. Dose-response immuno toxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetra chlorodibenzo-p-dioxin. Toxicol. Lett. 1989; 48: 35
  • Davis D., Safe S. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6 mice: structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology 1990; 63: 97
  • De Jongh J., Wondergem F., Seinen W., Van den Berg M. Absence of interactions on hepatic retention and 7-ethoxyresorufin-O-deethylation activity after co-administration of 1,2,3,7,8-pentachloro dibenzo-p-dioxin and 2,4,5,2′,4′,5′-hexachloro-biphenyl. Toxicology 1992; 75: 21
  • De Voogt P., Brinkman U. A. T. Production, properties and usage of polychlorinated biphenyls. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier-North Holland, Amsterdam 1989; 3
  • Deml E., Oesterle D. Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver. Carcinogenesis 1982; 3: 1449
  • Deml E., Oesterle D., Wiebel F. J. Benzo[a]pyrene initiates enzyme-altered islands in the liver of adult rats following single pretreatment and promotion with polychlorinated biphenyls. Cancer Lett. 1983; 19: 301
  • Denomme M. A., Bandiera S., Lambert I., Copp L., Safe L., Safe S. Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes — structure activity relationships for a series of 2,4-dichloro-substituted congeners. Biochem. Pharmacol. 1983; 32: 2955
  • Denomme M. A., Leece B., Li A., Towner R., Safe S. Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls: structure-activity relationships for a series of 2,4-dichloro-substituted congeners. Biochem. Pharmacol. 1986; 35: 277
  • De Vito M. J., Maier W. E., Diliberto J. J., Birnbaum L. S. Comparative ability of various PCBs, PCDFs and TCDD to induce cytochrome P4501A1 and 1A2 activity following weeks of treatment. Fundam. Appl. Toxicol. 1993; 20: 125
  • Dewailly E., Weber J. P., Gingras S., Laliberte C. Coplanar PCBs in human milk in the province of Quebec, Canada — are they more toxic than dioxin for breast fed infants. Bull. Environ. Contam. Toxicol. 1991; 47: 491
  • Dogra S., Filser J. G., Cojocel C., Greim H., Regel U., Oesch R., Robertson L. W. Long term effects of commercial and congeneric polychlorinated biphenyls on ethane production and malondialdehyde levels, indicators inin vivo lipid peroxidation. Arch. Toxicol. 1988; 62: 369
  • Duarte-Davidson R., Burnett V., Waterhouse K. S., Jones K. C. A congener specific method for the analysis of polychlorinated biphenyls (PCBs) in human milk. Chemosphere 1991; 23: 119
  • Eadon G., Kaminsky L., Silkworth J., Aldous K., Hilker D., O'Keefe P., Smith R., Gierthy J. F., Hawley J., Kim N., DeCaprio A. Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures. Environ. Health Perspect. 1986; 70: 221
  • Ebner K. V., Braselton W. E. Structural and chemical requirements of hydroxylated polychlori nated biphenyls (PCBOH) for inhibition of energy dependent swelling of rat liver mitochondria. Chem. Biol. Interact. 1987; 63: 139
  • Ecobichon D. J. The influence of polychlorinated biphenyl compounds on the hepatic function in the rat. Environ. Sci. Res. 1975; 7: 207
  • Ecobichon D. J., Mackenzie D. O. The uterotropic activity of commercial and isomerically pure chlorobiphenyls in the rat. Res. Commun. Chem. Pathol. Pharmacol. 1974; 9: 85
  • Edqvist L.-E., Madej A., Forsberg M. Biochemical blood parameters in pregnant mink fed PCB and fractions of PCB. Ambio 1992; 21: 577
  • Egaas E., Varanasi U. Effects of polychlorinated biphenyls and environmental temperature onin vitro formation of benzo[a]pyrene metabolites by liver of trout (Salmo gairdneri). Biochem. Pharmacol. 1982; 31: 561
  • Elcombe C. R., Lech J. J. Induction and characterization of hemoprotein(s) P-450 and monoxy genation in rainbow trout (Salmo gairdneri). Toxicol. Appl. Pharmacol. 1979; 49: 437
  • Elliott J. E., Kennedy S. W., Jeffrey D., Shutt L. Polychlorinated biphenyl (PCB) effects on hepatic mixed function oxidases and porphyria in birds. II. American kestrel. Comp Biochem. Physiol. 1991; 99: 141
  • Emmett E. A. Polychlorinated biphenyl exposure and effect in transformer repair workers. Environ. Health Perspect. 1985; 60: 185
  • Emmett E. A., Maroni M., Jefferies J., Schmith J., Levin B. K., Alvares A. Studies of transformer repair workers exposed to PCBs. II. Results of clinical laboratory investigations. Am. J. Ind. Med. 1988; 14: 47
  • Eriksson P. Effects of 3,3′,4,4′-tetrachlorobiphenyl in the brain of the neonatal mouse. Toxicology 1988; 49: 43
  • Eriksson P., Lundkvist U., Fredriksson A. Neonatal exposure to 3,3′,4.4′-tetrachlorobiphenyl: changes in spontaneous behaviour and cholinergic muscarinic receptors in the adult mouse. Toxicology 1991; 69: 27
  • Evans M. S., Noguchi G. E., Rice C. P. The biomagnification of polychlorinated biphenyls, tox aphene, and DDT compounds in a Lake Michigan offshore food web. Arch. Environ. Contam. Toxicol. 1991; 20: 87
  • Exon J. H., Talcott P. A., Roller L. D. Effect of lead, polychlorinated biphenyls, and cyclophos phamide on rat natural killer cells, interleukin 2, and antibody synthesis. Fundam. Appl. Toxicol. 1985; 5: 158
  • Fait A., Grossman E., Self S., Jeffries J., Pellizzari E. D., Emmett E. A. Polychlorinated biphenyl congeners in adipose ti lipid and serum of past and present transformer repair workers and a comparison group. Fundam. Appl. Toxicol. 1989; 12: 42
  • Falck F., Ricci A., Wolff M. S., Godbold J., Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch. Environ. Health 1992; 47: 143
  • Farland W. H., Schaum J. L. EPA's reassessment of dioxin health effects and approaches to estimating exposure. Organohalogen Compounds, Dioxin 1992 1992; 10: 311
  • Fein G. G., Jacobson J. L., Jacobson S. W., Schwartz P. M., Dowler J. K. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J. Pediatr. 1984; 105: 315
  • Fischbein A., Wolff M. S., Lilis R., Thornton J., Selikoff I. J. Clinical findings among PCB exposed capacitor manufacturing workers. Ann. N.Y. Acad. Sci. 1979; 320: 703
  • Fishbein L. Chromatographic and biological aspects of polychlorinated biphenyls. J. Chromatogr. 1972; 68: 345
  • Fitzgerald E. F., Weinstein A. L., Youngblood L. G., Standfast S. J., Melius J. M. Health effects three years after potential exposure to the toxic contaminants of an electrical transformer fire. Arch. Environ. Health 1989; 44: 214
  • Flodström S., Ahlborg U. G. Relative liver tumor promoting activity of some polychlorinated dibenzo-p-dioxin-, dibenzofuran- and biphenyl-con geners in female rats. Chemosphere 1992; 25: 169
  • Fossi C., Leonzio C., Focardi S., Renzoni A. Seasonal variations in aldrin epoxidase (MFO) activity of yellow-legged herring gulls: the relationship to breeding and PCB residues. Bull. Environ. Contam. Toxicol. 1988; 41: 365
  • Förlin L. Effects of Clophen A50, 3-methylcholan threne, pregnenolone-16α-carbonitrile, and pheno barbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout,Salmo gairdneri, of different age and sex. Toxicol. Appl. Pharmacol. 1980; 54: 420
  • Förlin L., Lidman U. Effects of Clophen A50, 4-, 2,5,2′,5′-tetra- and 2,4,5,2′,4′,5′-hexachlorobiphenyl on the mixed-function oxidase system of rainbow trout (Salmo gairdnerii Rich.) liver. Comp. Biochem. Physiol. 1978; 60: 193
  • Fysh J. M., Okey A. B. Aryl hydrocarbon (benzo[a]pyrene) hydroxylase development in rat mammary ti. Biochem. Pharmacol. 1978; 27: 2968
  • Garthoff L. H., Friedman L., Farber T. M., Locke K. K., Sobotka T. J., Green S., Hurley N. E., Peters E. L., Story G. E., Moreland F. M., Graham C. H., Keys J. E., Taylor M. J., Scalera J. V., Rothlein J. E., Marks E. M., Cerra F. E., Rodi S. B., Sporn E. M. Biochemical and cytogenetic effects in rats caused by short-term inges tion of Aroclor 1254 or Firemaster BP6. J. Toxicol. Environ. Health 1977; 3: 769
  • Gellert R. J. Uterotrophic activity of polychlori nated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environ. Res. 1978; 16: 123
  • Ghazarian J. G., Martinez J. E., Gallardo A. C., Kulkoski J. A., Peterson B. L. Induction of renal cytochrome P-450 by the polychlorinated biphe-nyl Aroclor-1254. J. Biol. Chem. 1980; 255: 8275
  • Gillette D. M., Corey R. D., Helferich W. G., McFarland J. M., Lowenstine L. J., Moody D. E., Hammock B. D., Shull L. R. Comparative toxicology of tetrachlorobiphenyls in mink and rats. I. Changes in hepatic enzyme activity and smooth endo plasmic reticulum volume. Fundam. Appl. Toxicol. 1987; 8: 5
  • Gillner M., Lund J., Cambillau C., Alexandersson M., Hurtig U., Bergman Å., Klasson-Wehler E., Gustafsson J. The binding of methylsulfonyl polychlorobiphenyls to uteroglobin. J. Steroid Biochem. 1988; 31: 27
  • Gladen B. C., Rogan W. J. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J. Pediatr. 1991; 119: 58
  • Gladen B. C., Rogan W. J., Hardy P., Thulen J., Tingelstad J., Tully M. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J. Pediatr. 1988; 113: 991
  • Goldman D., Yawetz A. The interference of Aroclor 1254 with progesterone metabolism in guinea pig adrenal and testes microsomes. J. Biochem. Toxicol. 1990; 5: 99
  • Goldman D., Yawetz A. Cytochrome P-450 mediated metabolism of progesterone by adrenal microsomes of PCB-treated and untreated barn owl (Tyto alba) and marsh turtle (Mauremys caspica) in comparison with the guinea-pig. Comp. Biochem. Physiol. 1991; 99: 251
  • Goldman D., Yawetz A. The interference of polychlorinated biphenyls (Aroclor 1254) with membrane regulation of the activities of cytochrome-P-450c21 and cytochrome-P-45017α,lyase in guinea-pig adrenal microsomes. J. Steroid Biochem. Mol. Biol. 1992; 42: 37
  • Goldstein J., Linko P., McKinney J. D., Albro P. W. Marked differences in the inductive effects of two symmetrical hexachlorobiphenyls and the corresponding unsymmetrical isomers on hepatic mono oxygenases. Biochem. Pharmacol. 1981; 30: 1008
  • Goldstein J. A., Haas J. R., Linko P., Harvan D. J. 2,3,7,8-Tetrachlorodibenzofuran in a commercially available 99% pure polychlorinated biphenyl isomer identified as the inducer of hepatic cytochrome P-448 and aryl hydrocarbon hydroxylase in the rat. Drug Metab. Dispos. 1978; 6: 258
  • Goldstein J. A., Hickman P., Bergman H., McKinney J. D., Walker M. P. Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448. Chem.-Biol Interact. 1977; 17: 69
  • Goldstein J. A., Hickman P., Burse V. W., Bergman H. A comparative study of two polychlorinated biphenyl mixtures (Aroclors 1242 and 1016) containing 42% chlorine on induction of hepatic porphyria and drug metabolizing enzymes. Toxicol. Appl. Pharmacol. 1975; 32: 461
  • Goldstein J. A., Linko P., Luster M. I., Sundheimer D. W. Purification and characterization of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomers. J. Biol. Chem. 1982; 257: 2702
  • Goldstein J. A., McKinney J. D., Lucier G. W., Hickman P., Bergman H., Moore J. A. Toxi cological assessment of hexachlorobiphenyl isomers and 2,3,7,8-tetrachlorodibenzofuran in chicks. II. Effects on drug metabolism and porphyrin accumulation. Toxicol. Appl. Pharmacol. 1976; 36: 81
  • Goldstein J. A., Safe S. Mechanism of action and structure-activity relationships for the chlorinated dibenzo-p-dioxins and related compounds. Haloge nated Biphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R. D. Kimbrough, A. A. Jensen. Elsevier-North Holland, Amsterdam 1989; 239
  • Golub M. S., Donald J. M., Reyes J. A. Reproductive toxicity of commercial PCB mixtures — LOAELs and NOAELs from animal studies. Environ. Health Perspect. 1991; 94: 245
  • Gonzalez F. J., Nebert D. W. Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse cytochrome P1-450 gene. Nucleic Acids Res. 1985; 13: 7269
  • Gooch J. W., Elskus A. A., Kloepper-Sams P. J., Hahn M. E., Stegeman J. J. Effects ofortho-and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops). Toxicol. Appl. Pharmacol. 1989; 98: 422
  • Graham M. J., Lucier G. W., Linko P., Maronpot R. R., Goldstein J. A. Increases in cytochrome P-450 mediated 17β-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachloro-dibenzo-P-dioxin in a two-stage hepatocarcinogenesis model. Carcinogenesis 1988; 9: 1935
  • Grant D. L., Phillips W. E. J. The effect of age and sex on the toxicity of Aroclor 1254, a polychlorinated biphenyl, in the rat. Bull. Environ. Contam. Toxicol. 1974; 12: 145
  • Graves P. E., Elhag G. A., Ciaccio P. J., Bourque D. P., Halpert J. R. cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2′,4,4′,5,5′-hexa-chlorobiphenyl. Arch. Biochem. Biophys. 1990; 281: 106
  • Gray L. E., Jr., Ostby J., Marshall R., Andrews J. Endocrine effects of a polychlorinated biphenyl mixture (Aroclor 1254): repressed sex accessory glands in hypothyroid rats with normal levels of serum and testicular testosterone. Organohalogen Compounds, Dioxin 1992 1992; 10: 73, (Abstr.)
  • Gregor D. J., Gummer W. D. Evidence of atmospheric transport and deposition of organochlo rine pesticides and polychlorinated biphenyls in Canadian Arctic snow. Environ. Sci. Technol. 1989; 23: 561
  • Griffin H., Windsor D., Boriakoglu J. Changes in plasma lipoprotein metabolism in chicks in response to polychlorinated biphenyls (PCBs). Biochem. Pharmacol. 1991; 42: 1493
  • Grote W., Schmoldt A., Benthe H. F. Hepatic porphyrin synthesis in rats after pretreatment with polychlorinated biphenyls (PCBs). Acta Pharmacol. Toxicol. 1975; 36: 215
  • Grote W., Schmoldt A., Dammann H. G. The metabolism of foreign compounds in rats after treatment with polychlorinated biphenyls (PCBs). Biochem. Pharmacol. 1975; 24: 1121
  • Gruger E. H., Jr., Wekell M. M., Numoto P. T., Craddock D. R. Induction of hepatic aryl hydrocarbon hydroxylase in salmon exposed to petroleum dissolved in seawater and to petroleum and polychlorinated biphenyls, separate and together, in food. Bull. Environ. Contam. Toxicol. 1977; 17: 512
  • Gustavsson P., Hogstedt C., Rappe C. Short term mortality and cancer incidence in capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Am. J. Ind. Med. 1986; 10: 341
  • Gyorkos J., Denomme M. A., Leece B., Homonko K., Valli V. E., Safe S. Reconstituted haloge nated hydrocarbon pesticide and pollutant mixtures found in human tis: effects on the immature male Wistar rat after short-term exposure. Can. J. Physiol. Pharmacol. 1985; 63: 36
  • Haake J. ML, Safe S., Mayura K., Phillips T. D. Aroclor 1254 as an antagonist of the teratoge nicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Lett. 1987; 38: 299
  • Haake-McMillan J. M., Safe S. Neonatal modulation of adult rat hepatic microsomal benzo[a] pyrene hydroxylase activities by Aroclor 1254 or phenobarbital. J. Biochem. Toxicol. 1991; 5: 203
  • Hansen L. Environmental toxicology of polychlorinated biphenyls. Polychlorinated Biphenyls (PCBs) : Mammalian and Environmental Toxicology, Environmental Toxin Series, S. Safe, O. Hutzinger. Springer-Verlag, Heidelberg 1987; 15
  • Hansson T., Rafter J., Gustafsson J.-Å. Effects of some common inducers on the hepatic microsomal metabolism of androstenedione in rainbow trout with special reference to cytochrome P-450-de pendent enzymes. Biochem. Pharmacol. 1980; 29: 583
  • Hara I. Health status and PCBs in blood of workers exposed to PCBs and of their children. Environ. Health Perspect. 1985; 59: 85
  • Haraguchi H., Kuroki K., Masuda Y., Shigematsu N. Determination of methylthio and methylsulphone polychlorinated biphenyls in tis of patients with “Yusho”. Food Chem. Toxicol. 1984; 22: 283
  • Haraguchi K., Athanasiadou M., Bergman Å., Hovander L., Jensen S. PCB and PCB methyl sulfones in selected groups of seals from the Swedish waters. Ambio 1992; 21: 546
  • Hardwick J. P., Linko P., Goldstein J. A. Dose response for induction of two cytochrome P-450 isozymes and their mRNAs by 3,4,5,3′,4′,5′-hexa-chlorobiphenyl indicating coordinate regulation in rat liver. Mol. Pharmacol. 1985; 27: 676
  • Harper N., Connor K., Safe S. Comparative immunotoxic potencies of selected polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzop-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice. Toxicology 1993; 80: 217
  • Harrad S. J., Sewart A. S., Boumphrey R., Duarte-Davidson R., Jones K. C. A method for the determination of PCB congeners 77, 126 and 169 in biotic and abiotic matrices. Chemosphere 1992; 24: 1147
  • Harris M., Zacharewski T., Safe S. Comparative potencies of Aroclors 1232,1242,1248,1254 and 1260 in male Wistar rats — assessment of toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundam. Appl. Toxicol. 1993; 20: 456
  • Harvey G. R., Steinhauer W. G. Atmospheric transport of polychlorobiphenyls to the North Atlantic. Atmos. Environ. 1974; 8: 777
  • Hayes M. A., Roberts E., Safe S., Farber E., Cameron R. G. Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities ofN-2-fluorenylacetamide in rat liver. J. Natl. Cancer Inst. 1986; 76: 683
  • Hayes M. A., Safe S. H., Armstrong D., Cameron R. G. Influence of cell proliferation on initiating activity of pure polychlorinated biphenyls and complex mixtures in resistant hepatocytein vivo assays for carcinogenicity. J. Natl. Cancer Inst. 1985; 71: 1037
  • Håkansson H., Manzoor E., Ahlborg U. G. Effects of technical PCB preparations and fractions thereof on vitamin A levels in the mink (Mustela vison). Ambio 1992; 21: 588
  • Hill D. W., Hejtmancik E., Camp B. J. Induction of hepatic microsomal enzymes by Aroclor 1254 inIctalurus punctatus (Channel catfish). Bull. Environ. Contam. Toxicol. 1976; 16: 495
  • Hinton D. E., Glaumann H., Trump B. F. Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver — a morphological and biochemical study. Virchows Arch. 1978; 27: 279
  • Hong C.-S., Bush B., Xiao J. Isolation and determination of mono-ortho and non-ortho substituted PCBs (coplanar PCBs) in human milk by HPLC porous graphite carbon and GC/ECD. Chemosphere 1992; 24: 465
  • Hori S., Obana H., Kashimoto T., Otaki T., Nishimura H., Ikegami M., Kunita N., Uda H. Effect of polychlorinated quaterphenyls in cyno-molgus monkey (Macaca fascicularis). Toxicology 1982; 24: 123
  • Hornshaw T. C., Safronoff J., Ringer R. K., Aulerich R. J. LC50 test results in polychlorinated biphenyl-fed mink: age, season, and diet comparisons. Arch. Environ. Contam. Toxicol. 1986; 15: 717
  • Hsu S.-T., Ma C.-I, Kwo-Hsiung S., Wu S. S., Hsu N. H.M., Yeh C. C., Wu S. B. Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup. Environ. Health Perspect. 1985; 59: 5
  • Huang S., Gibson G. G. Differential induction of cytochromes P450 and cytochrome P450-depen dent arachidonic acid metabolism by 3,4,5,3′,4′ pentachlorobiphenyl in the rat and the guinea pig. Toxicol. Appl. Pharmacol. 1991; 108: 86
  • Huckins J. N., Schwartz T. R., Petty J. D., Smith L. M. Determination, fate, and potential significance of PCBs in fish and sediment samples with emphasis on selected AHH-inducing congeners. Chemosphere 1995; 17: 1988
  • Hutton J. J., Meier J., Hackney C. Comparison of thein vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tis from inbred mice treated with phenobarbital, 3-meth ylcholanthrene or polychlorinated biphenyls. Mutat. Res. 1979; 66: 75
  • Hutzinger O., Safe S., Zitko V. The Chemistry of PCBs. CRC Press, Boca Raton, FL 1974
  • Imaida K., Furihata C., Tatematsu M., Yoon C. H., Furukawa F., Uneyama C., Takahashi M., Ito N., Hayashi Y. Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: induction by polychlorinated biphenyls. Toxicol. Pathol. 1991; 19: 230
  • Inoue K., Takanaka A., Mizokami K., Fujimori K., Sunouchi M., Kasuya Y., Omori Y. Effects of polychlorinated biphenyls on the mono oxygenase systems in fetal livers of rats. Toxicol. Appl. Pharmacol. 1981; 59: 540
  • International Joint Commission, IJC Great Lakes Water Quality — Appendix E. 1977, Status Report on the Persistent Toxic Pollutants in the Lake Ontario Basin
  • Ito N., Nagasaki H., Arai M., Makiura S., Sugihara S., Hirao K. Histopathologic studies on liver tumorigenesis induced in mice by technical polychlorinated biphenyls and its promoting effect on liver tumors induced by benzene hexachloride. J. Natl. Cancer Inst. 1973; 51: 1637
  • Ito N., Nagasaki H., Makiura S., Arai M. Histopathological studies on liver tumorigenesis in rats treated with polychlorinated biphenyls. Gann 1974; 65: 545
  • Iverson F., Truelove J., Hierlihy S. L. Hepatic microsomal enzyme induction by Aroclors 1248 and 1254 in cynomolgus monkeys. Food Chem. Toxicol. 1982; 20: 307
  • Jacob J., Grimmer G., Raab G., Schmoldt A. The metabolism of pyrene by rat liver microsomes and the influence of various mono-oxygenase induc ers. Xenobiotica 1982; 12: 45
  • Jacob J., Grimmer G., Schmoldt A. The influence of polycyclic aromatic hydrocarbons as in ducers of monooxygenases on the metabolite profile of benz[a]anthracene in rat liver microsomes. Cancer Lett. 1981; 14: 175
  • Jacob J., Schmoldt A., Grimmer G. Time course of oxidative benz[a]anthracene metabolism by liver microsomes of normal and PCB-treated rats. Carcinogenesis 1981; 2: 395
  • Jacob J., Schmoldt A., Grimmer G. Influence of monooxygenase inducers on the metabolic profile of phenanthrene in rat liver microsomes. Toxicology 1982; 25: 333
  • Jacob J., Schmoldt A., Grimmer G. Formation of carcinogenic and inactive chrysene metabolites by rat liver microsomes of various monooxygenase activities. Arch. Toxicol. 1982; 51: 255
  • Jacob J., Schmoldt A., Grimmer G. Benzo[a]pyrene metabolism in rat liver microsomes: dependence of the metabolite profile on the pretreat ment of rats with various monooxygenase inducers. Carcinogenesis 1983; 4: 905
  • Jacobson J. L., Fein G. G., Jacobson S. W., Schwartz P. M., Dowler J. K. The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk. Am. J. Public Health 1984; 74: 378
  • Jacobson J. L., Humphrey H. E. B., Jacobson S. W., Schantz S. L., Mullin M. D., Welch R. Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichloro diphenyl trichloroethane (DDT) levels in the sera of young children. Am. J. Public Health 1989; 79: 1401
  • Jacobson J. L., Jacobson S. W. New methodologies for assessing the effects of prenatal toxic exposure on cognitive functioning in humans. Toxic Contaminants and Ecosystem Health: A Great Lakes Focus, M. Evans. John Wiley & Sons, New York 1988
  • Jacobson J. L., Jacobson S. W., Fein G. G., Schwartz P. M., Dowler J. K. Prenatal exposure to an environmental toxin: a test of the multiple effects model. Dev. Psychol. 1984; 20: 523
  • Jacobson J. L., Jacobson S. W., Humphrey H. E. B. Effects ofin utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J. Pediatr. 1990; 116: 38
  • Jacobson J. L., Jacobson S. W., Humphrey H. E. B. Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol. Teratol. 1990; 12: 319
  • Jacobson S. W., Fein G. G., Jacobson J. L., Schwartz P. M., Dowler J. K. The effect of PCB exposure on visual recognition memory. Child Dev. 1985; 56: 853
  • James M. O., Little P. J. Polyhalogenated biphenyls and phenobarbital: evaluation as inducers of drug metabolizing enzymes in the sheepshead. Archosargus probatocephalus, Chem.-Biol. Interact. 1981; 36: 229
  • Jan J., Tratnik M., Kenda A. Atmospheric contamination with polychlorinated biphenyls in Bela Krajina (Yugoslavia): emissions from industrial plant, landfill, and river areas. Chemosphere 1988; 17: 809
  • Jannetti R. A., Anderson L. M. Dimethyl nitrosamine demethylase activity in fetal, suckling, and maternal mouse liver and its transplacental and transmammary induction by polychlorinated biphenyls. J. Natl. Cancer Inst. 1981; 67: 461
  • Janz D. M., Metcalfe C. D. Nonadditive interactions of mixtures of 2,3,7,8-TCDD and 3,3′,4,4′-tetrachlorobiphenyl on aryl hydrocarbon hydroxylase induction in rainbow trout (Oncorhynchus mykiss). Chemosphere 1991; 23: 467
  • Jefferies D. J., Parslow J. L. F. Thyroid changes in PCB-dosed guillemots and their indication of one of the mechanisms of action of these materials. Environ. Pollut. 1976; 10: 293
  • Jenke H.-S. Polychlorinated biphenyls interfere with the regulation of hydroxymethylglutaryl-coenzyme A reductase activity in rat liver via enzyme-lipid interaction and at the transcriptional level. Biochim. Biophys. Acta 1985; 837: 85
  • Jenke H.-S., Lowel M., Berndt J. Modes of action and combination effects of gamma-hexachloro cyclohexane on the regulation of rat liver 3-hydroxy-3-methylglutaryl coenzymeA reductase. Chem.-Biol. Interact. 1988; 65: 175
  • Jenke H.-S., Michel G., Hornhardt S., Berndt J. Protooncogene expression in rat liver by polychlorinated biphenyls (PCB). Xenobiotica 1991; 21: 945
  • Jensen A. A. Background levels in humans. Ha logenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier Science, Amsterdam 1989; 345
  • Jensen R. K., Sleight S. D., Aust S. D., Goodman J. I., Trosko J. E. Hepatic tumor-promoting ability of 3,3′,4,4′,5,5′-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor promoting ability. Toxicol. Appl. Pharmacol. 1983; 71: 163
  • Jensen S., Jansson B. Anthropogenic substances in seal from the Baltic: methylsulphone metabolites of PCB and DDE. Ambio 1976; 5: 257
  • Jensen S., Sundström G. Structures and levels of most chlorobiphenyls in the technical PCB products and in human adipose ti. Ambio 1974; 3: 70
  • Johansson B. Lack of effects of polychlorinated biphenyls on testosterone synthesis in mice. Pharmacol. Toxicol. 1987; 61: 220
  • Jonsson H. T., Jr., Walker E. M., Jr., Greene W. B., Hughson M. D., Hennigar G. R. Ef fects of prolonged exposure to dietary DDT and PCB on rat liver morphology. Arch. Environ. Contam. Toxicol. 1981; 10: 171
  • Kamataki T., Ando M., Ishii K., Kato R. Inhibition of SKF 525-A of 7-ethoxycoumarinO-de-ethylation in microsomal and the reconstituted monooxygenase systems from PCB-treated rat livers. Jpn. J. Pharmacol. 1980; 30: 841
  • Kamohara K., Yagi N., Hokawa Y. Mechanism of lipid peroxide formation in polychlorinated biphenyls (PCB) and dichlorodiphenyltri chloroethane (DDT)-poisoned rats. Environ. Res. 1984; 34: 18
  • Kannan N., Tanabe S., Ono M., Tatsukawa R. Critical evaluation of polychlorinated biphenyl toxicity in terrestrial and marine mammals: increasing impact of non-ortho and mono-ortho coplanar polychlorinated biphenyls from land to ocean. Arch. Environ. Contam. Toxicol. 1989; 18: 850
  • Kannan N., Tanabe S., Tatsukawa R. Potentially hazardous residues of non-ortho chlorine substituted coplanar PCBs in human adipose ti. Arch. Environ. Health 1988; 43: 11
  • Kannan N., Tanabe S., Tatsukawa R. Toxic potential of non-ortho and mono-ortho coplanar PCBs in commercial PCB preparations: 2,3,7,8-T4CDD toxicity equivalence factors approach. Bull. Environ. Contam. Toxicol. 1988; 41: 267
  • Kannan N., Tanabe S., Wakimoto T., Tatsukawa R. Coplanar polychlorinated biphenyls in Aroclor and Kanechlor mixtures. J. Assoc. Off. Anal. Chem. 1987; 70: 451
  • Kashimoto T., Miyata H., Kunita S., Tung T. C., Hsu S. T., Chang K. J., Tang S. Y., Ohi G., Nakagawa J., Yamamoto S. I. Role of polychlorinated dibenzofuran in Yusho (PCB poisoning). Arch. Environ. Health 1981; 32: 321
  • Kasza L., Collins W. T., Capen C. C., Garthoff L. H., Friedman L. Comparative toxicity of polychlorinated biphenyls and polybrominated biphenyl in the rat thyroid gland: light and electron microscopic alterations after subacute dietary exposure. J. Environ. Pathol. Toxicol. 1978; 1: 587
  • Kasza L., Weinberger M. A., Hinton D. E., Trump B. F., Patel C., Friedman L., Garthoff L. H. Comparative toxicity of polychlorinated biphenyls and polybrominated biphenyl in the rat liver: light and electron microscopic alterations after sub acute dietary exposure. J. Environ. Pathol. Toxicol. 1978; 1: 241
  • Kawanishi S., Seki Y., Sano S. Polychloro biphenyls that induce O-aminolevulinic acid syn thetase inhibit uroporphyrinogen decarboxylase in cultured chick embryo liver cells. FEBS Lett. 1981; 129: 93
  • Kawanishi S., Seki Y., Sano S. Uropor phyrinogen decarboxylase: purification, properties, and inhibition by polychlorinated biphenyl isomers. J. Biol. Chem. 1983; 258: 4285
  • Kerkvliet N. I., Baecher-Steppan L. Suppression of allograft immunity by 3,4,5,3′,4′,5′-hexachloro-biphenyl. II. Effects of exposure on mixed lymphocyte reactivity and induction of suppressor cell activity in vitro. Immunopharmacology 1988; 16: 13
  • Kerkvliet N. I., Baecher-Steppan L. Suppression of allograft immunity by 3,4,5,3′,4′,5′-hexachloro-biphenyl. I. Effects of exposure on tumor rejection and cytotoxic T cell activityin vivo. Immunopharmacology 1988; 16: 1
  • Kerkvliet N. I., Kimeldorf D. J. Antitumor activity of a polychlorinated biphenyl mixture, Aroclor 1254, in rats inoculated with Walker 256 carcinosarcoma cells. J. Natl. Cancer Inst. 1977; 59: 951
  • Kihlstrom J. E., Olsson M., Jensen S., Johansson Å., Ahlbom J., Bergman A. Effects of PCB and different fractions of PCB on the reproduction of the mink (Mustela vison). Ambio 1992; 21: 563
  • Kilburn K. H., Warsaw R. H., Shields M. G. Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs): possible improvement after detoxification. Arch. Environ. Health 1989; 44: 345
  • Kimbrough R., Buckley J., Fishbein L., et al. Animal toxicology. Environ. Health Perspect. 1978; 24: 173
  • Kimbrough R. D. Laboratory and human studies on polychlorinated biphenyls (PCBs) and related compounds. Environ. Health Perspect. 1985; 59: 99
  • Kimbrough R. D., Grandjean P. Occupational exposure. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier, Amsterdam 1989; 485
  • Kimbrough R. D., Linder R. E., Gaines T. B. Morphological changes in livers of rats fed polychlorinated biphenyls. Arch. Environ. Health 1972; 25: 354
  • Kimbrough R. D., Squire R. A., Linder R. E., Strandberg J. L., Montali R. J., Burse V. W. Induction of liver tumors in Sherman strain female rats by PCB Aroclor 1260. J. Natl. Cancer Inst. 1975; 55: 1453
  • Kimura N. T., Baba T. Neoplastic changes in the rat liver induced by polychlorinated biphenyls. Gann 1973; 64: 105
  • Kimura N. T., Kanematsu T., Baba T. Polychlorinated biphenyl(s) as a promoter in experimental hepatocarcinogenesis in rats. Z. Krebsforsch. 1976; 87: 257
  • Kiyohara C., Hirohata T., Mohri N. Effects of 3-methylsulphonyl-4,5,3′,4′-tetrachlorobiphenyland 3,8-benzoflavone on mouse liver aryl hydrocarbon hydroxylase activity in vitro. Toxicol. In Vitro 1990; 4: 103
  • Kiyohara C., Mohri N., Hirohata T., Haraguchi K., Masuda Y. In vitro effects of methylsulfonyl polychlorinated biphenyls and 3,8-benzoflavone on aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells. Pharmacol. Toxicol. 1990; 66: 273
  • Kiyohara C., Omura M., Hirohata T., Masuda Y. Comparison of suppression of mutage nicity of benzo(a)pyrene among methylsulfonyl polychlorinated biphenyl isomers. Bull. Environ. Contam. Toxicol. 1992; 48: 877
  • Klasson-Wehler E., Kuroki H., Athanasiadou M., Bergman A. Selective retention of hydroxy lated PCBs in blood. Organohalogen Compounds, Dioxin 1992 1992; 10: 121, (Abstr.)
  • Klasson-Wehler E., Brunstöm B., Rannug U., Bergman Å. 3,3′,4,4′-Tetrachlorobiphenyl: metabolism by the chick embryoin ovo and toxicity of hydroxylated metabolites. Chem.-Biol. Interact. 1990; 73: 121
  • Kling D., Gamble W. in vivo inhibition of citrate cleavage enzyme by polychlorinated biphenyls. Experientia 1991; 37: 1258
  • Kling D., Kunkle J., Roller A. S., Gamble W. Polychlorinated biphenyls:in vivo andin vitro modifications of cholesterol and fatty acid biosynthesis. J. Environ. Pathol. Toxicol. 1978; 1: 813
  • Kociba R. J., Keyes D. G., Beger J. E., Carreon R. M., Wade C. E., Dittenber D. A., Kalnins R. P., Frauson L. E., Park C. L., Barnard S. D., Hummel R. A., Humiston C. G. Results of a 2-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachloridibenzo-p-dioxin (TCDD) in rats. Toxicol. Appl. Pharmacol. 1978; 46: 279
  • Koga N., Beppu M., Yoshimura H. Metabolismin vivo of 3,4,5,3′,4′-pentachlorobiphenyI and toxicological assessment of the metabolite in rats. J. Pharmacobio-Dyn. 1990; 13: 497
  • Kohli K. K., Gupta B. N., Albro P. W., McKinney J. D. Effects of inducers of drug metabolism enzymes on triglyceride and phospholipid biosynthesis. Chem.-Biol. Interact. 1981; 36: 117
  • Kohli K. K., Gupta B. N., Albro P. W., Mukhtar H., McKinney J. D. Biochemical effects of pure isomers of hexachlorobiphenyl: fatty livers and cell structure. Chem.-Biol. Interact. 1979; 25: 139
  • Kohli K. K., Linko P., Goldstein J. A. Multiple forms of solubilized and partially resolved cyto chrome P-450 from rats induced by 2,3,5,2′,3′,5′- and 3,4,5,3′,4′,5′-hexachlorobiphenyls. Biochem. Biophys. Res. Commun. 1981; 100: 483
  • Kohli K. K., Mukhtar H., Bend J. R., Albro P. W., McKinney J. D. Biochemical effects of pure isomers of hexachlorobiphenyl hepatic microso mal epoxide hydrase and cytosolic glutathione S-trans ferase activities in the rat. Biochem. Pharmacol. 1979; 28: 1444
  • Kohli K. K., Philpot R. M., Albro P. W., McKinney J. D. Induction of different species of cytochrome P-450 by coplanar and non-coplanar isomers of hexachlorobiphenyl. Life Sci. 1980; 26: 945
  • Koller L. D. Enhanced polychlorinated biphenyls lesions in Moloney leukemia virus-infected mice. Clin. Toxicol. 1977; 11: 107
  • Koller L. D., Zinkl J. G. Pathology of polychlorinated biphenyls in rabbits. Am. J. Pathol. 1973; 70: 363
  • Korach K. S., Sarver P., Chae K., McLachlan J. A., McKinney J. D. Estrogen receptor-binding activity of polychlorinated hydroxy biphenyls: con formationally restricted structural probes. Mol. Pharmacol. 1988; 33: 120
  • Koval P. J., Peterle T. J., Harder J. D. Ef fects of polychlorinated biphenyls on mourning dove reproduction and circulating progesterone levels. Bull. Environ. Contam. Toxico. 1987; 39: 663
  • Krauss P. P., Suns K., Buckley E. H. Moni toring of PCBs in water, sediments and biota of the Great Lakes — some recent examples. Physical Behavior of PCBs in the Great Lakes, D. Mackay, S. Paterson, S. J. Eisenreich, M. S. Simmons. Ann Arbor Science, Ann Arbor, MI 1983; 385
  • Kreiss K. Studies on populations exposed to polychlorinated biphenyls. Environ. Health Perspect. 1985; 60: 193
  • Krishnan V., Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzo furans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. ToxicoL Appl. Pharmacol. 1993; 120: 55
  • Kunita N., Kashimoto T., Miyata H., Fukushima S., Hori S., Obana H. Causal agents of Yusho. Am. J. Ind. Med. 1984; 5: 45
  • Kuratsune M. Yusho. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough. Elsevier/North Holland, Amsterdam 1980; 287
  • Kuratsune M. Yusho, with reference to Yu-Cheng. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier, Amsterdam 1989; 381
  • Kuratsune M., Shapiro R. E. PCB Poisoning in Japan and Taiwan. Alan R. Liss, New York 1984
  • Kuroki H., Masuda Y. Structures and concentrations of the main components of polychlorinated biphenyls retained in patients with Yusho. Chemo sphere 1977; 6: 469
  • Kutz F. W., Barnes D. G., Bretthauer E. W., Bottimore D. P., Greim H. The international toxicity equivalency factor (I-TEF) method for estimating risks associated with exposures to complex mixtures of dioxins and related compounds. Toxicol. Environ. Chem. 1990; 26: 99
  • Laib R. M., Rose N., Bunn H. Hepato carcinogenicity of PCB congeners. Toxicol. Environ. Chem. 1991; 34: 19
  • Lake B. G., Collins M. A., Harris R. A., Gangolli S. D. The induction of hepatic and extrahepatic xenobiotic metabolism in the rat and ferret by a polychlorinated biphenyl mixture (Aroclor 1254). Xenobiotica 1979; 9: 723
  • Lambrecht R. W., Jacobs J. M., Sinclair P. R., Sinclair J. F. Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P 450-mediated uroporphyrinogen oxidation. Biochem. J. 1990; 269: 437
  • Larsen G. L., Huwe J. K., Bergman Å., Klasson-Wehler E., Hargis P. Methylsulfonyl metabolites of xenobiotics can serve as ligands for fatty acid binding proteins in chicken liver and intestinal mu cosa. Chemosphere 1992; 25: 1189
  • Lawton R. W., Ross M. R., Feingold J., Brown J. F. Effects of PCB exposure on biochemical and hematological findings in capacitor workers. Environ. Health Perspect. 1985; 60: 165
  • Leece B., Denomme M. A., Towner R., Li Å., Landers J. P., Safe S. Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Can. J. Physiol. Pharmacol. 1987; 65: 1908
  • Leece B., Denomme M. A., Towner R., Li S. M. A. Polychlorinated biphenyls: correlation betweenin vivo and in vitro quantitative structure-activity relationships (QSARs). J. Toxicol. Environ. Health 1985; 16: 379
  • Levin E. D., Schantz S. L., Bowman R. E. Delayed spatial alteration deficits resulting from perinatal PCB exposure in monkeys. Arch. Toxicol. 1988; 62: 267
  • Lewin C., McBlain W. A., Wolfe F. H. Acute intraperitoneal toxicity of DDT and PCBs in mice using two solvents. Bull. Environ. Contam. Toxico. 1972; 8: 245
  • Lilienthal H., Neuf M., Munoz C., Winneke G. Behavioral effects of pre- and postnatal exposure to a mixture of low chlorinated PCBs in rats. Fundam. Appl. Toxicol. 1990; 15: 457
  • Lilienthal H., Winneke G. Sensitive periods for behavioral toxicity of polychlorinated biphenyls: determination by cross-fostering in rats. Fundam. Appl. Toxicol. 1991; 17: 368
  • Lillie R. J., Cecil H. C., Bitman J., Fries G. F. Differences in response of caged white leghorn layers to various polychlorinated biphenyls (PCBs) in the diet. Poult. Sci. 1974; 53: 726
  • Linder R. E., Gaines T. B., Kimbrough R. D. The effect of polychlorinated biphenyls on rat reproduction. Food Cosmet. Toxicol. 1974; 12: 63
  • Linzey A. V. Effects of chronic polychlorinated biphenyls exposure on growth and reproduction of second generation white-footed mice (Peromyscus leucopus). Arch. Environ. Contam. Toxicol. 1988; 17: 39
  • Loo J. C. K., Tryphonas H., Jordan N., Brien R., Karpinski K. R., Arnold D. L. Effects of Aroclor 1254 on hydrocortisone levels in adult rhesus monkeys (Macaca mulatto). Bull. Environ. Contam. Toxico. 1989; 43: 667
  • Loose L. D., Pittman K. A., Benitz K.-F., Silkworth J. B., Mueller W., Coulston F. Environmental chemical-induced immune dysfunction. Ecotoxicol. Environ. Safety 1978; 2: 173
  • Loose L. D., Silkworth J. B., Pittman K. A., Benitz K.-F., Mueller W. Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl and hexachlorobenzene-treated mice. Infect. Immun. 1978; 20: 30
  • Lubet R. A., Jones C. R., Stockus D. L., Fox S. D., Nims R. W. Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254. Toxicol. Appl. Pharmacol. 1991; 108: 355
  • Lubet R. A., Lemaire B. N., Avery D., Kouri R. E. Induction of immunotoxicity in mice by polyhalogenated biphenyls. Arch. Toxicol. 1986; 59: 71
  • Lubet R. A., Nims R. W., Beebe L. E., Fox S. D., Issaq H. J., McBee K. Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor-1254 in feral rodents. Arch. Environ. Contam. Toxicol. 1992; 22: 339
  • Luebeck E. G., Moolgavkar S. H., Buchmann Å., Schwarz M. Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci. Toxicol. Appl. Pharmacol. 1991; 111: 469
  • Lund B. O., Bergman Å., Brandt I. Decreased pulmonary drug metabolism in mice treated with the PCB metabolite 4-methylsulphonyl-2,2′,5,5′-tetrachlorobiphenyl. Toxicol. Lett. 1986; 32: 261
  • Lund J., Andersson O., Ripe E. Characterization of a binding protein for the PCB metabolite 4,4′-bis-(methylsulfonyl)-2,2′,5,5′-tetrachlorobiphenyl present in bronchoalveolar lavage from healthy smokers and non-smokers. Toxicol. Appl. Pharmacol. 1986; 83: 486
  • Lund J., Brandt I., Poellinger L., Bergman Å., Klasson-Wehler E., Gustafsson J.-Å. Target cells for the polychlorinated biphenyl metabolite 4,4′-bis(methylsulfonyl)-2,2′,5,5′-tetrachloro biphenyl: characterization of high affinity binding in rat and mouse lung cytosol. Mol. Pharmacol. 1985; 27: 314
  • Lundkvist U. Clinical and reproductive effects of Clophen A50 (PCB) administered during gestation on pregnant guinea pigs and their offspring. Toxicology 1990; 61: 249
  • Luster M. I., Lawson L. D., Linko P., Goldstein J. A. Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure. Mol. Pharmacol. 1983; 23: 252
  • Madej Å., Forsberg M., Edqvist L.-E. Urinary excretion of cortisol and oestrone sulfate in pregnant mink fed PCB and fractions of PCB. Ambio 1992; 21: 582
  • Manis J., Kim G. Effects of polyhalogenated aromatic hydrocarbons on benzo(a)pyrene hydroxy lase activity in the intestine and liver. Life Sci. 1980; 26: 1431
  • Marks T. A., Kimmel G. L., Staples R. E. Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. I. Teratogenicity of 3,3′,4,4′,5,5′-hexachlorobiphenyl. Toxicol. Appl. Pharmacol. 1981; 61: 269
  • Marks T. A., Kimmel G. L., Staples R. E. Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. II. Comparison of 4,4′-dichlorobiphenyl, 3,3′,4,4′-tetrachlorobiphenyl, 3,3′,5,5′-tetrachlorobiphenyI, and 3,3′,4,4′-tetramethylbiphenyl. Fundam. Appl. Toxicol. 1989; 13: 681
  • Maroni M., Columbi Å., Arbosti G., Cantoni S., Foa V. Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects. Br. J. Ind. Med. 1981; 38: 55
  • Mayura C., Spainhour C. B., Howie L., Safe S., Phillips T. D. Teratogenicity and immunotoxicity of 3,3′,4,4′-5-pentachlorobiphenyl in C57BL/6 mice. Toxicology 1993; 77: 123
  • McArthur M. L. B., Fox G. A., Peakall D. B., Philogène B. J. R. Ecological significance of behavioral and hormonal abnormalities in breeding ring doves fed an organochlorine chemical mixture. Arch. Environ. Contam. Toxicol. 1983; 12: 343
  • McFarland V. A., Clarke J. U. Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: considerations for a congener-specific analysis. Environ. Health Perspect. 1989; 81: 225
  • McKinney J. D., Chae K., Gupta B. N., Moore J. A., Goldstein J. A. Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8-tetrachlorodibenzofuran in chicks. I. Relationship of chemical parameters. Toxicol. Appl. Pharmacol. 1976; 36: 65
  • McNulty W. P., Becker G. M., Cory H. T. Chronic toxicity of 3,4,3′,4′- and 2,5,2′,5′-tetrachloro biphenyls in rhesus macaques. Toxicol. Appl. Pharmacol. 1980; 56: 182
  • Melancon M. J., Elcombe C. R., Vodicnik M. J., Lech J. J. Induction of cytochromes P450 and mixed-function oxidase activity by polychlorinated biphenyls and β-naphthoflavone in carp (Cyprinus carpio). Comp. Biochem. Physiol. 1981; 69: 219
  • Mes J., Weber D. Non-ortho-chlorine substituted coplanar polychlorinated biphenyl congeners in Canadian adipose ti, breast milk and fatty foods. Chemosphere 1989; 19: 1357
  • Meserve L. A., Murray B. A., Landis J. A. Influence of maternal ingestion of Aroclor- 1254(PCB) or Firemaster BP-6 (PBB) on unstimulated and stimulated corticosterone levels in young rats. Bull. Environ. Contam. Toxico. 1992; 48: 715
  • Miniats O. P., Platonow N. S., Geissinger H. D. Experimental polychlorinated biphenyl toxicosis in germfree pigs. Can. J. Comp. Med. 1978; 42: 192
  • Mio T., Sumino K., Mizutani T. Sulfur-containing metabolites of 2,2′,5,5′-tetrachlorobiphenyl, a major component of commercial PCBs. Chem. Pharm. Bull. 1976; 24: 1958
  • Miranda C. L., Henderson M. C., Wang J.-L., Nakaue H. S., Buhler D. R. Effects of poly chlorinated biphenyls on porphyrin synthesis and cy tochrome P-450-dependent monooxygenases in small intestine and liver of Japanese quail. J. Toxicol. Environ. Health 1987; 20: 27
  • Miranda C. L., Henderson M. C., Wang J.-L., Nakaue H. S., Buhler D. R. Comparative effects of the polychlorinated biphenyl mixture, Aroclor 1242, on porphyrin and xenobiotic metabolism in kidney of Japanese quail and rat. Comp. Biochem. Physiol. 1992; 103: 149
  • Miranda C. L., Wang J.-L., Chang H.-S., Buhler D. R. Multiple effects of 3,4,5,3′,4′,5′-hexachlorobiphenyl administration on hepatic cyto chrome P450 isozymes and associated mixed-function oxidase activities in rainbow trout. Biochem. Pharmacol. 1990; 39: 388
  • Miyata H., Fukushima S., Kashimoto T., Kunita N. PCBs, PCQs and PCDFs in the tis of Yusho and Yu-Cheng patients. Environ. Health Perspect. 1985; 59: 67
  • Miyata H., Kashimoto T. The finding of poly ehlorodibenzofurans in commercial PCBs (Aroclor, Phenoclor and Clophen) (in Japanese). J. Food Hyg. Soc. Jpn. 1976; 17: 434
  • Miyata H., Kashimoto T., Kunita N. Detection and determination of polychlorodibenzofurans in normal human tis and Kanemi rice oils caused “Kanemi Yusho” (in Japanese). J. Food Hyg. Soc. Jpn. 1977; 19: 260
  • Miyata H., Nakamura A., Kahimoto T. Separation of polychlorodibenzofurans (PCDFs) in Japanese commercial PCBs (Kanechlors) and their heated preparation. J. Food Hyg. Soc. Jpn. 1976; 17: 227
  • Monosson E., Stegeman J. J. Cytochrome P450E (P450IA) induction and inhibition in winter flounder by 3,3′,4,4′-tetrachlorobiphenyl: comparison of response in fish from Georges Bank and Narra gansett Bay. Environ. Toxicol. Chem. 1991; 10: 765
  • Morales N. M., Matthews H. B. in vivo binding of 2,3,6,2′,3′,6′-hexachlorobiphenyl and 2′,4′,5′-hexachlorobiphenyl to mouse liver macromolecules. Chem.-Biol. Interact. 1979; 27: 94
  • Morgan R. W., Ward J. M., Hartman P. E. Aroclor 1254-induced intestinal metaplasia and adeno carcinoma in the glandular stomach of F344 rats. Cancer Res. 1981; 41: 5052
  • Morita M., Nakagawa J., Akiyama K., Mimura S., Isono N. Detailed examination of polychlorinated dibenzofurans in PCB preparations and Kanemi Yusho oil. Bull. Environ. Contam. Toxicol. 1977; 18: 67
  • Morrissey R. E., Harris M. W., Diliberto J. J., Birnbaum L. S. Limited PCB antagonism of TCDD-induced malformations in mice. Toxicol. Lett. 1992; 60: 19
  • Muller W. F., Hobson W., Fuller G. B., Knauf W., Coulston F., Korte F. Endocrine effects of chlorinated hydrocarbons in rhesus monkeys. Eco-toxicol. Environ. Safety 1978; 2: 161
  • Mullin M., Sawka G., Safe L., McCrindle S., Safe S. Synthesis of octa- and nonachlorobiphenyl isomers and congeners and their quantitation in commercial polychlorinated biphenyls and identification in human breast milk. J. Anal. Toxicol. 1981; 5: 138
  • Mullin M. D., Filkins J. C. Analysis of polychlorinated biphenyls by glass capillary and packed column gas chromatography. Advances in the Identification and Analysis of Organic Pollutants in Water, L. W. Keith. Ann Arbor Science, Ann Arbor, MI 1981; 187
  • Mullin M. D., Pochini C. M., McCrindle S., Romkes M., Safe S., Safe L. High-resolution PCB analysis: the synthesis and chromatographic properties of all 209 PCB congeners. Environ. Sci. Technol. 1984; 18: 468
  • Murphy T. J., Pokojowczyk J. C., Mullin M. D. Vapor exchange of PCBs with Lake Michigan: the atmosphere as a sink for PCBs. Physical Behavior of PCBs in the Great Lakes, D. Mackay, S. Paterson, S. J. Eisenreich, M. S. Simmons. Ann Arbor Science, Ann Arbor, MI 1983; 49
  • Nagaoka S., Miyazaki H., Aoyama Y., Yoshida Å. Effects of dietary polychlorinated biphenyls on cholesterol catabolism in rats. Br. J. Nutr. 1990; 64: 161
  • Nagata K., Matsunaga T., Buppodom P., Ishmatsu M., Yamato H., Yoshihara S., Yoshimura H. Unique induction of cytochrome P-450 isozymes in rat liver microsomes by treatment with 3,4,5,3′,4′-pentachlorobiphenyl and its effect on testosterone metabolism. J. Pharmacobio-Dyn. 1985; 8: 948
  • Narasimhan T. R., Kim H. L., Safe S. Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation. J. Biochem. Toxicol. 1991; 6: 229
  • Narbonne J.-F., Grolier P., Aibrecht R., Azais V., Oesch F., Robertson L. W. A time course investigation of vitamin A level and lipid composition of the liver endoplasmic reticulum in rats following treatment with congeneric polychlorobiphenyls. Toxicology 1990; 60: 253
  • Narbonne J. F. Effect of age and sex on liver response to Phenoclor DP6, a polychlorinated biphenyl, in the rat. Bull. Environ. Contam. Toxicol. 1978; 20: 662
  • Narbonne J. F. Effects of polychlorinated biphenyls (Phenoclor DP6) onin vivo protein and RNA synthesis in rat liver. Bull. Environ. Contam. Toxicol. 1979; 23: 36
  • Narbonne J. F. In vitro effects of Phenoclor DP6 on drug metabolism in rat liver. Bull. Environ. Contam. Toxicol. 1979; 23: 344
  • Narbonne J. F. Time course of induction of microso mal enzymes following dietary administration of a polychlorinated biphenyl (Phenoclor DP6). Toxicol. Appl. Pharmacol. 1980; 56: 1
  • Narbonne J. F., Suteau P., Daubeze M., Audy C. Polycyclic aromatic hydrocarbon metabolism in mullets,Chelon labrosus, treated by polychlorinated biphenyls. Bull. Environ. Contam. Toxicol. 1987; 38: 53
  • Nath R. G., Randerath E., Randerath K. Short-term effects of the tumor promoting polychlorinated biphenyl mixture, Aroclor 1254, on I-compounds in liver, kidney and lung DNA of male Sprague-Dawley rats. Toxicology 1991; 68: 275
  • 1988, NATO/CCMS, North Atlantic Treaty (NATO/Committee on the Challenges of Modern Society (CCMS), Report Number 176
  • 1978, National Cancer Institute, Bioassay of Aroclor 1254 for possible carcinogenicity, CAS No. 27323–18–8, NCI Carcinogenesis Tech. Rep. Ser. No. 38
  • Nelson N. N., Hammon P. B., Nisbet I. C. T., Saroflm A. F., Drury W. H. Polychlorinated biphenyls — environmental impact. Environ. Res. 1972; 5: 249
  • Nikolaidis E., Brunström B., Dencker L. Effects of the TCDD congeners 3,3′,4,4′-tetrachloro-biphenyl and 3,3′,4,4′-tetrachloroazoxybenzene on lymphoid development in the bursa of fabricius of the chick embryo. Toxicol. Appl. Pharmacol. 1988; 92: 315
  • Nikolaidis E., Brunström B., Dencker L. Effects of TCDD and its congeners 3,3′,4,4′-tetra chloroazoxybenzene and 3,3′,4,4′-tetrachlorobiphenyl on lymphoid development in the thymus of avian embryos. Pharmacol. Toxicol. 1988; 63: 333
  • Nishihara Y. Comparative toxicity of 4-chloro biphenyl and its metabolite 4-chloro-4′-biphenylol in isolated rat liver mitochondria. Biochem. Pharmacol. 1988; 37: 2915
  • Nishihara Y., Utsumi K. 4-Chloro-4′-biphenylol as an uncoupler and an inhibitor of mitochondrial oxida tive phosphorylation. Biochem. Pharmacol. 1987; 36: 3453
  • Nishizumi M. Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital. Cancer Lett. 1976; 2: 11
  • Nishizumi M. Effects of phenobarbital, dichloro diphenyltrichlorethane and polychlorinated biphenyls on diethylnitrosamine-induced hepatocarcinogenesis. Gann 1979; 70: 835
  • Norback D. H., Weltman R. H. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ. Health Perspect. 1985; 60: 97
  • Nordqvist M., Thakker D. R., Levin W., Yagi H., Ryan D. E., Thomas P. E., Conney A. H., Jerina D. M. The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes. Mol. Pharmacol. 1979; 16: 643
  • O'Keefe P. W., Smith R. M. PCB capacitor/transformer accidents. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier, Amsterdam 1989; 417
  • Oesterle D., Deml E. Promoting effect of polychlorinated biphenyls on development of enzyme-altered islands in livers of weanling and adult rats. J. Cancer Res. Clin. Oncol. 1983; 105: 141
  • Oesterle D., Deml E. Dose-dependent promoting effect of polychlorinated biphenyls on enzyme altered islands in livers of adult and weanling rats. Carcinogenesis 1984; 5: 351
  • Orberg J., Kihlstrom J. E. Effects of long term feeding of polychlorinated biphenyls (PCB, Clophen A60) on the length of the oestrous cycle and on the frequency of implanted ova in the mouse. Environ. Res. 1973; 66: 176
  • Orberg J., Lundberg C. Some effects of DDT and PCB on the hormonal system in the male mouse. Environ. Physiol. Biochem. 1974; 4: 116
  • Ouw H. K., Simpson G. R., Siyali D. S. Use and health effects of Aroclor 1242, a polychlorinated biphenyl in an electrical industry. Arch. Environ. Health 1976; 31: 189
  • Overmann S. R., Kostas J., Wilson L. R., Shain W., Bush B. Neurobehavioral and somatic effects of perinatal PCB exposure in rats. Environ. Res. 1987; 44: 56
  • Ozawa N., Yoshihara S., Kawano K., Okada Y., Yoshimura H. 3,4,5,3′,5′-Pentachlorobiphenyl as a useful inducer for purification of rat liver mi crosomal cytochrome P448. Biochem. Biophys. Res. Commun. 1979; 91: 1140
  • Ozawa N., Yoshihara S., Yoshimura H. Selective induction of rat liver microsomal cytochrome P-448 by 3,4,5,3′,5′-pentachlorobiphenyl and its effect on liver microsomal drug metabolism. J. Pharm. Dyn. 1979; 2: 309
  • Paivi K., Erkki M., Sirpa K. Induction of aryl hydrocarbon hydroxylase AHH by two previously un characterized pentachlorinated biphenyls in a mouse and a rat hepatoma cell line. Chemosphere 1992; 24: 201
  • Pantaleoni G.-C, Fanini D., Sponta A. M., Palumbo G., Giorgi R., Adams P. M. Effects of maternal exposure to polychlorobiphenyls (PCBs) on Fl generation behavior in the rat. Fundam. Appl. Toxicol. 1988; 11: 440
  • Parkinson A., Cockerline R., Safe S. Polychlorinated biphenyl isomers and congeners as induc ers of both 3-methylcholanthrene- and phenobarbitone type microsomal enzyme activity. Chem.-Biol. Interact. 1980; 29: 277
  • Parkinson A., Cockerline R., Safe S. Induction of both 2-methylcholanthrene- and pheno barbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer. Biochem. Pharmacol. 1980; 29: 259
  • Parkinson A., Robertson L., Safe L., Safe S. Polychlorinated biphenyls as inducers of hepatic mi crosomal enzymes: effects ofdiortho substitution. Chem.-Biol. Interact. 1981; 31: 1
  • Parkinson A., Robertson L., Safe L., Safe S. Polychlorinated biphenyls as inducers of hepatic mi crosomal enzymes: structure-activity rules. Chem. Biol. Interact. 1981; 30: 271
  • Parkinson A., Robertson L., Safe S. Hepatic microsomal enzyme induction by 2,2′,3,3′,4,4′- and 2,2′,3′,4,4′,5-hexachlorobiphenyl. Life Sci. 1980; 27: 2333
  • Parkinson A., Robertson L., Uhlig L., Campbell M. A., Safe S. 2,3,4,4′,5-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice. Biochem. Pharmacol. 1982; 31: 2830
  • Parkinson A., Safe S., Robertson L., Thomas P. E., Ryan D. E., Levin W. Immunochemical quantitation of cytochrome P-450 isozymes and ep oxide hydrolase in liver microsomes from polychlorinated and polybrominated biphenyls: a study of structure activity relationships. J. Biol. Chem. 1983; 258: 5967
  • Parkki M. G., Marniemi J., Vainio H. Long term effects of single and combined doses of DDT and PCB on drug-metabolizing enzymes in rat liver. J. Toxicol. Environ. Health 1977; 3: 903
  • Paustenbach D. J., Wenning R. J., Lau V., Harrington N. W., Rennix D. K., Parsons A. H. Recent developments on the hazards posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin in soil: implications for setting risk-based cleanup levels at residential and industrial sites. J. Toxicol. Environ. Health 1992; 36: 103
  • Pelissier M. A., Frayssinet C., Boisset M., Albrecht R. Effect of Phenoclor DP6 on enzyme-altered foci and lipid peroxidation in livers of afla toxin Bl-initiated rats. Food Chem. Toxicol. 1992; 30: 133
  • Pelissier M. A., Miladi N., Atteba S., Narbonne J. F., Albrecht R. Polychlorobiphenyle (Phenoclor DP6) et metabolisme des xenobiotiques: effets d'un regime hyperlipyque. Food Chem. Toxicol. 1985; 23: 805
  • Pellizzari E., Moseley M. A., Cooper S. D. Recent advances in the analysis of polychlorinated biphenyls in environmental and biological media. J. Chromatogr. 1985; 334: 277
  • Pereira M. A., Herren S. L., Britt A. L., Khoury M. M. Promotion by polychlorinated biphenyls of enzyme-altered foci in rat liver. Cancer Lett. 1982; 15: 185
  • Pitot H. C., Goldsworthy T., Campbell H. A., Poland A. Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepato-carcinogenesis from diethylnitrosamine. Cancer Res. 1980; 40: 3616
  • Poland A., Glover E. Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure activity relationship. Mol. Pharmacol. 1977; 13: 924
  • Poland A., Greenlee W. F., Kende A. S. Studies on the mechanism of action of the chlorinated dibenzo-p-dioxins and related compounds. Ann. N.Y. Acad. Sci. 1979; 320: 214
  • Poland A., Knutson J. C. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 1982; 22: 517
  • Poland A., Palen D., Glover E. Tumour promotion by TCDD in skin of HRS/J hairless mice. Nature 1982; 300: 271
  • Powers R. H., Gilbert L. C., Aust S. D. The effect of 3,4,3′,4′-tetrachlorobiphenyl on plasma ret inol and hepatic retinyl palmitate hydrolase activity in female Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 1987; 89: 370
  • Preston B. D., Miller J. D., Miller E. C. Reactions of 2,2′,5,5′-tetrachlorobiphenyl 3,4-oxide with methionine, cysteine and glutathione in relation to the formation of methylthio-metabolites of 2,2′,5,5′-tetrachlorobiphenyl in the rat and mouse. Chem.-Biol. Interact. 1984; 50: 289
  • Preston B. D., Van Miller J. P., Moore R. W., Allen J. R. Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated diben zofuran-free Aroclor 1254 on diethylnitrosamine-in-duced tumorigenesis in the rat. J. Natl. Cancer Inst. 1981; 66: 509
  • Rao C. V., Banerjee A. S. Induction of liver tumors in male Wistar rats by feeding polychlorinated biphenyls (Aroclor 1260). Cancer Lett. 1988; 39: 59
  • Rao M. S., Subbarao V., Prasad J. D., Scarpelli D. G. Carcinogenicity of 2,3,7,8-tetra chlorodibenzo-p-dioxin in the Syrian golden hamster. Carcinogenesis 1988; 9: 1677
  • Rickenbacher U., McKinney J. D., Oatley S. J., Blake C. C. F. Structurally specific binding of halogenated biphenyls to thyroxine transport protein. J. Med. Chem. 1986; 29: 641
  • Rinzky A., Perry A. S. Induction of the mixed-function oxidase system in the liver of the barn owl Tyto alba by PCBs. Pestic. Biochem. Physiol. 1981; 16: 72
  • Rinzky A., Perry A. S. Postnatal development of the mixed function oxidase system in nestling barn owls and baby chicks and induction of this system in the mature forms by Aroclor 1254. Comp. Biochem. Physiol. 1983; 75: 51
  • Risebrough R. W., Rieche P., Herman S. G., Peakall D. B., Kirven M. N. Polychlorinated biphenyls in the global ecosystem. Nature 1968; 220: 1098
  • Riviere J. L., De Lavaur E., Grolleau G. Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny. Toxicology 1978; 11: 329
  • Robertson L. W., Parkinson A., Bandiera S., Lambert I., Merrill J., Safe S. PCBs and PBBs — biologic and toxic effects on C57BL/6J and DBA/2J inbred mice. Toxicology 1984; 31: 191
  • Rodman L. E., Shedlofsky S. I., Mannschreck A., Puttmann M., Swim A. I., Robertson L. W. Differential potency of atropisomers of polychlori nated biphenyls on cytochrome P450 induction and uroporphyrin accumulation in the chick embryo hepa-tocyte culture. Biochem. Pharmacol. 1991; 41: 915
  • Rodman L. E., Shedlofsky S. I., Swim A. T., Robertson L. W. Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture. Arch. Biochem. Biophys. 1989; 275: 252
  • Rogan W. J., Yu-Cheng. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, R. D. Kimbrough, A. A. Jensen. Elsevier, Amsterdam 1989; 401
  • Rogan W. J., Gladen B. C., Hung K., Koong S., Shih L., Taylor J. S., Wu Y., Yang D., Ragan N. B., Hsu C. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 1988; 241: 334
  • Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am. J. Public Health 1986; 76: 172
  • Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J. Pediatr. 1986; 109: 335
  • Rogan W. J., Gladen B. C., Wilcox A. J. Potential reproductive and postnatal morbidity from exposure to polychlorinated biphenyls: epidemiologic considerations. Environ. Health Perspect. 1985; 60: 233
  • Rumsby P. C., Evans J. G., Phillimore H. E., Carthew P., Smith A. G. Search for Ha-ras codon 61 mutations in liver tumours caused by hexa-chlorobenzene and Aroclor 1254 in C57BL/10ScSn mice with iron overload. Carcinogenesis 1992; 13: 1917
  • Ryan D. E., Thomas P. E., Korzeniowski D., Levin W. Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. J. Biol. Chem. 1979; 254: 1365
  • Ryan D. E., Thomas P. E., Levin W. Properties of purified liver microsomal cytochrome P-450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254. Mol. Pharmacol. 1977; 13: 521
  • Ryan D. E., Thomas P. E., Reik L. M., Levin W. Purification characterization and regulation of five rat hepatic cytochrome P-450 isozymes. Xeno biotica 1982; 12: 727
  • Safe S. Polychlorinated biphenyls (PCBs) and poly brominated biphenyls (PBBs): biochemistry, toxicology and mechanism of action. CRC Crit. Rev. Toxicol. 1984; 12: 319
  • Safe S. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 1986; 26: 371
  • Safe S. PCBs and human health. Polychlorinated Biphenyls (PCBs):Mammalian and Environmental Toxicology, S. Safe, O. Hutzinger. Environmental Toxin Series, Vol. 1, Springer-Verlag, Heidelberg 1987; 133
  • Safe S. Polychlorinated biphenyls: human health effects. Hazards, Decontamination and Replacement of PCBs, J. P. Crin. Plenum Press, New York 1988; 51
  • Safe S. Polyhalogenated aromatics: uptake, disposition and metabolism. Halogenated Biphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R. D. Kimbrough, A. A. Jensen. Elsevier-North Holland, Amsterdam 1989; 51
  • Safe S. Polychlorinated biphenyls (PCBs): mutage nicity and carcinogenicity. Mutat. Res. 1989; 220: 31
  • Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). CRC Crit. Rev. Toxicol. 1990; 21: 51
  • Safe S. Polychlorinated dibenzo-p-dioxins and related compounds: sources, environmental distribution and risk assessment. Environ. Carcinogen. Ecotoxicol. Rev. 1991; C9: 261
  • Safe S. Toxicology, structure-function relationships, human and environmental health impacts of polychlorinated biphenyls (PCBs): progress and problems. Environ. Health Perspect. 1992; 100: 259
  • Safe S., Bandiera S., Sawyer T., Robertson L., Parkinson A., Thomas P. E., Ryan D. E., Reik L. M., Levin W., Denomme M. A., Fujita T. PCBs: structure-function relationships and mechanism of action. Environ. Health Perspect. 1985; 60: 47
  • Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology, S. Safe, O. Hutzinger. Environmental Toxin Series, Springer-Verlag, Heidelberg 1987; Vol. 1
  • Safe S., Mason G., Sawyer T., Zacharewski T., Harris M., Yao C., Keyes B., Farrell K., Holcomb M., Davis D., Safe L., Piskorska-Pliszczynska J., Leece B., Denomme M. A., Hutzinger O., Thoma H., Chittim B., Madge J. Development and validation ofin vitro induction assays for toxic halogenated mixtures. Toxicol. Ind. Health 1989; 5: 757
  • Safe S., Mullin M., Safe L., Pochini C., McCrindle S., Romkes M. High resolution PCB analysis. Physical Behavior of PCBs in the Great Lakes, D. Mackay, S. Paterson, S. J. Eisenreich, M. S. Simons. Ann Arbor Science, Ann Arbor, MI 1983; 1
  • Safe S., Robertson L. W., Safe L., Parkinson A., Bandiera S., Sawyer T., Campbell M. A. Halogenated biphenyls: molecular toxicology. Can. J. Physiol. Pharmacol. 1982; 60: 1057
  • Safe S., Safe L., Mullin M. Polychlorinated biphenyls (PCBs) — congener-specific analysis of a commercial mixture and a human milk extract. J. Agric. Food Chem. 1985; 33: 24
  • Safe S., Safe L., Mullin M L. Polychiorinated biphenyls: environmental occurrence and analysis. Polychlorinated Biphenyls(PCBs): Mammalian and Environmental Toxicology. Environmental Toxin Series, Springer-Verlag, Heidelberg 1987; 1
  • Sager D. B. Effect of postnatal exposure to polychlorinated biphenyis on adult male reproductive function. Environ. Res. 1983; 31: 76
  • Sager D. B., Girard D., Nelson D. Early postnatal exposure to PCBs: sperm function in rats. Environ. Toxicol. Chem. 1991; 10: 737
  • Sanders O. T., Kirkpatrick R. L. Effects of a polychlorinated biphenyl (PCB) on sleeping times, plasma corticosteroids, and testicular activity of white-footed mice. Environ. Physiol. Biochem. 1975; 5: 308
  • Sanders O. T., Zepp R. L., Kirkpatrick R. L. Effect of PCB ingestion on sleeping times, organ weights, food consumption, serum corticosterone and survival of albino mice. Bull. Environ. Contam. Toxicol. 1974; 12: 394
  • Sangalang G. B., Freeman H. C., Crowell R. Testicular abnormalities in cod (Gadus morhua) fed Aroclor 1254. Arch. Environ. Contam. Toxicol. 1981; 10: 617
  • Sargent L., Dragan Y. P., Erickson C., Laufer C. J., Pitot H. C. Study of the separate and combined effects of the non-planar 2,5,2′,5′- and the planar 3,4,3′,4′-tetrachlorobiphenyl in liver and lymphocytesin vivo. Carcinogenesis 1991; 12: 793
  • Sargent L. M., Sattler G. L., Roloff B., Xu Y.-H., Sattler C. A., Meisner L., Pitot H. C. Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2′,5′-tetrachlorobiphenyl and/or 3,4,3′,4′-tetrachlorobiphenyl in rat liver. Cancer Res. 1992; 52: 955
  • Sassa S., Sugita O., Ohnuma N., Imajo S., Okumura T., Noguchi T., Kappas A. Studies of the influence of chloro-substituent sites and confor mational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures. Biochem. J. 1986; 235: 291
  • Sawyer T., Safe S. PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufinO-deethylase enzyme activities in rat hepatoma cells. Toxicol. Lett. 1982; 13: 87
  • Sawyer T. W., Vatcher A. D., Safe S. Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture. Chemosphere 1984; 13: 695
  • Schaeffer E., Greim H., Goessner W. Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats. Toxicol. Appl. Pharmacol. 1984; 75: 278
  • Schantz S. L., Levin E. D., Bowman R. E. Long-term neurobehavioral effects of perinatal polychlorinated biphenyl (PCB) exposure in monkeys. Environ. Toxicol. Chem. 1991; 10: 747
  • Schantz S. L., Levin E. D., Bowman R. E., Heironimus M. P., Laughlin N. K. Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys. Neurotoxicol. Teratol. 1989; 11: 243
  • Scheutz E. G., Wrighton S. A., Safe S. H., Guzelian P. S. Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture andin vivo. Biochemistry 1986; 25: 1124
  • Schmidt L. J., Hesselberg R. J. A mass spec troscopic method for analysis of AHH-inducing and other polychlorinated biphenyl congeners and selected pesticides in fish. Arch. Environ. Contam. Toxicol. 1992; 23: 37
  • Schmoldt A., Altenähr E., Grote W., Dammann H. G., Sidau B., Benthe H. F. Rat liver changes after subchronic exposition to polychlorinated biphenyls (PCB) of low chlorine content. Arch. Toxicol. 1977; 37: 203
  • Schmoldt A., Herzberg W., Benthe H. F. On the inhibition of microsomal drug metabolism by polychlorinated biphenyls (PCBs) and related phenolic compounds. Chem.-Biol. Interact. 1977; 16: 191
  • Sehnellmann R. G., Vickers E. M., Sipes I. G. Metabolism and disposition of polychlorinated biphenyls. Reviews in Biochemical Toxicology, E. Hodgson, J. R. Bend, R. M. Philpot. Elsevier, Amsterdam 1985; Vol. 7: 247
  • Schulte-Hermann R. Tumor promotion in the liver. Arch. Toxicol. 1985; 57: 147
  • Schulz D. E., Petrick G., Duinker J. C. Complete characterization of polychlorinated biphenyl congeners in commercial Aroclor and Clophen mixtures by multidimensional gas chromatography-elec tron capture detection. Environ. Sci. Technol. 1989; 23: 852
  • Seegal R. F., Brosch K. O., Bush B. Polychlorinated biphenyls produce regional alterations of dopamine metabolism in rat brain. Toxicol Lett. 1986; 30: 197
  • Seegal R. F., Brosch K. O., Bush B. Regional alterations in serotonin metabolism induced by oral exposure of rats to polychlorinated biphenyls. Neurotoxicology 1986; 7: 155
  • Seegal R. F., Bush B., Brosch K. O. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Toxicology 1991; 66: 145
  • Seegal R. F., Bush B., Shain W. Lightly chlorinatedortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in ti culture. Toxicol. Appl. Pharmacol. 1990; 106: 136
  • Sepkovic D. W., Bryne J. J. Kinetic parameters of L-[125I]triiodothyronine degradation in rats pretreated with polyhalogenated biphenyls. Food Chem. Toxicol. 1984; 22: 743
  • Serabjit-Singh C. J., Albro P. W., Robertson I. G. C., Philpot R. M. Interactions between xenobiotics that increase or decrease the levels of cytochrome P-450 isozymes in rabbit lung and liver. J. Biol. Chem. 1983; 258: 12827
  • Shain W., Bush B., Seegal R. Neurotoxicity of polychlorinated biphenyls: structure-activity relationship of individual congeners. Toxicol. Appl. Pharmacol. 1991; 111: 33
  • Shelton D. W., Goeger D. E., Hendricks J. D., Bailey G. S. Mechanisms of anti-carcinogene sis: the distribution and metabolism of aflatoxin B1 in rainbow trout fed Aroclor 1254. Carcinogenesis 1986; 7: 1065
  • Shelton D. W., Hendricks J. D., Coulombe R. A., Bailey G. S. Effect of dose on the inhibition of carcinogenesis/mutagenesis by Aroclor 1254 in rainbow trout fed aflatoxin B1. J. Toxicol. Environ. Health 1984; 13: 649
  • Shimada T. Metabolic activation of [14C]poly chlorinated biphenyl mixtures by rat liver microsomes. Bull. Environ. Contam. Toxicol. 1976; 16: 25
  • Shimada T., Sato R. Covalent bindingin vitro of polychlorinated biphenyls to microsomal macro molecules. Biochem. Pharmacol. 1978; 27: 585
  • Shu H. P., Paustenbach D. J., Murray F. J. A critical evaluation of the use of mutagenesis,Carcinogenesis, and tumor promotion data in a cancer risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Regul. Toxicol. Pharmacol. 1987; 7: 57
  • Silberhorn E. M., Glauert M. P., Robertson L. W. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. CRC Crit. Rev. Toxicol. 1990; 20: 439
  • Silkworth J. B., Antrim L., Kaminsky L. S. Correlations between polychlorinated biphenyl immu notoxicity, the aromatic hydrocarbon locus and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice. Toxicol. Appl. Pharmacol. 1984; 75: 156
  • Silkworth J. B., Grabstein E. M. Polychlorinated biphenyl immunotoxicity: dependence on iso mer planarity and Ah gene complex. Toxicol. Appl. Pharmacol. 1982; 65: 109
  • Silkworth J. B., Loose L. D. Cell-mediated immunity in mice fed either Aroclor 1016 or hexachlorobenzene. Toxicol. Appl. Pharmacol. 1978; 45: 326
  • Sinclair P. R., Bement W. J., Bonkovsky H. L., Lambrecht R. W., Frezza J. E., Sinclair J. F., Urquhart A. J., Elder G. H. Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Biochem. J. 1986; 237: 63
  • Sinclair P. R., Bement W. J., Bonkovsky H. L., Sinclair J. F. Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepa tocyte cultures: essential role for induction of cytochrome P-448. Biochem. J. 1984; 222: 737
  • Sinclair P. R., Bement W. J., Lambrecht R. W., Gorman N., Sinclair J. F. Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytes. Arch. Biochem. Biophys. 1990; 281: 225
  • Sipes I. G., Schnellmann R. G. Biotransforma tion of PCBs: metabolic pathways and mechanisms. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology, S. Safe, O. Hutzinger. Springer-Verlag, Heidelberg 1987; 97
  • Sissons D., Welti D. Structural identification of polychlorinated biphenyls in commercial mixtures by gas liquid chromatography, nuclear magnetic resonance and mass spectrometry. J. Chromatogr. 1971; 60: 15
  • Skaare J. U., Jensen E. G., Goksoyr A., Egaas E. Response of xenobiotic metabolizing enzymes of rainbow trout (Oncorhynchus mykiss) to the mono ortho substituted polychlorinated PCB congener, 2,3′,4,4′5,-pentachlorobiphenyl, PCB-118, detected by enzyme activities and immunochemical methods. Arch. Environ. Contam. Toxicol. 1991; 20: 349
  • Smialowicz R. J., Andrews J. E., Riddle M. M., Rogers R. R., Luebke R. W., Copeland C. B. Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology 1989; 56: 197
  • Smith A. G., Francis J. E., Carthew P. Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls inAh-responsive C57BL/ l0ScSn mice. Carcinogenesis 1990; 11: 437
  • Smith A. G., Francis J. E., Green J. A., Greig J. B., Wolf C. R., Manson M. M. Sex-linked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenyls. Biochem. Pharmacol. 1990; 40: 2059
  • Smith J. A. B., Schloemer J., Lowry L. K., Smallwood A. W., Ligo R. N., Tanaka S., Stringer W., Jones M., Hervin R., Glueck C. J. Metabolic and health consequences of occupational exposure to polychlorinated biphenyls (PCBs). Br. J. Ind. Med. 1982; 39: 361
  • Snyder R., Remmer H. Classes of hepatic microsomal mixed function oxidase inducers. Pharmacol. Ther. 1979; 7: 203
  • Solt D. B., Farber E. New principle for the analysis of chemicalCarcinogenesis. Nature 1976; 263: 702
  • Sonzogni W., Maack L., Gibson T., Lawrence J. Toxic polychlorinated biphenyl congeners in Sheboygan River (USA) sediments. Bull. Environ. Contam. Toxico. 1991; 47: 398
  • Spear P. A., Bourbonnais D. H., Peakall D. B., Moon T. W. Dove reproduction and retinoid (Vitamin A) dynamics in adult females and their eggs following exposure to 3,3′,4,4′-tetrachlorobiphenyl. Can. J. Zool. 1989; 67: 908
  • Spear P. A., Moon T. W. Low dietary iodine and thyroid anomalies in ring doves,Streptopelia risoria, exposed to 3,4,3′,4′-tetrachlorobiphenyl. Arch. Environ. Contam. Toxicol. 1985; 14: 547
  • Spear P. A., Moon T. W., Peakall D. B. Liver retinoid concentrations in natural populations of herring gulls (Larus argentatus) contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin and in ring doves (Streptopelia risoia) injected with a dioxin analogue. Can. J. Zool. 1986; 64: 204
  • Spencer F. An assessment of the reproductive toxic potential of Aroclor 1254 in female Sprague-Dawley rats. Bull. Environ. Contam. Toxicol. 1982; 28: 290
  • Stadnicki S., Lin F. S. D., Allen J. R. DNA single strand breaks caused by 2,2′,5,5′-tetrachloro-biphenyl and its metabolites. Res. Commun. Chem. Pathol. Pharmacol. 1979; 24: 313
  • Stadnicki S. S., Allen J. R. Toxicity of 2,2′,5,5′-tetrachlorobiphenyl and its metabolites, 2,2′,5,5′-tetra-chlorobiphenyl-3,4-oxide and 2,2′,5,5′-tetrachloro-biphenyl-4-ol to cultured cellsin vitro. Bull. Environ. Contam. Toxicol. 1979; 23: 788
  • Stegeman J. J., Smolowitz R. M., Hahn M. E. Immunohistochemical localization of environmentally-induced cytochrome P450IA1 in multiple organs of the marine teleostStenotomus chrysops (Scup). Toxicol. Appl. Pharmacol. 1991; 110: 486
  • Stehr-Green P. A., Burse V. W., Welty E. Human exposure to polychlorinated biphenyls at toxic waste sites: investigations in the United States. Arch. Environ. Health 1988; 43: 420
  • Stehr-Green P. A., Ross D., Liddle J., Welty E., Steele G. A pilot study of serum polychlorinated biphenyl levels in persons at high risk of exposure in residential and occupational environments. Arch. Environ. Health 1986; 41: 240
  • Steinberg K. K., Freni-Titulaer L. W. J., Rogers T. N., Burse V. W., Mueller P. W., Stohr P. A., Miller D. T. Effects of polychlorinated biphenyls and lipemia on serum analytes. J. Toxicol. Environ. Health 1986; 19: 369
  • Stonard M. D., Grieg J. B. Different patterns of hepatic microsomal enzyme activity produced by administration of pure hexachlorobiphenyl isomers and hexachlorobenzene. Chem.-Biol. Interact. 1976; 15: 365
  • Storr-Hansen E., Cederberg T. Determination of coplanar polychlorinated biphenyl (CB) congeners in seal tis by chromatography on active carbon, dual-column high resolution GC/ECD and high resolution GC/high resolution MS. Chemosphere 1992; 24: 1181
  • Stratton C. L., Sosebee J. B., Jr. PCT and PCT contamination of the environment near sites of manufacture and use. Bull. Environ. Contam. Toxicol. 1976; 10: 1229
  • Street J. C., Sharma R. P. Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, Aroclor 1254, carbaryl, carbofuran, and methyl par athion. Toxicol. Appl. Pharmacol. 1975; 32: 587
  • Sundheimer D. W., Caveness M. B., Goldstein J. A. Differential metabolism of actanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methyl cholanthrene-inducible forms of rat liver cytochrome P-450. Arch. Biochem. Biophys. 1983; 226: 548
  • Sundström G., Hutzinger O., Safe S. The metabolism of chlorobiphenyls — a review. Chemosphere 1976; 5: 267
  • Swain M. G., Follows S. B., Marks G. S. Inhibition of uroporphyrinogen decarboxylase by 3,3′,4,4′-tetrachlorobiphenyl in chick embryo liver cell culture. Can. J. Physiol. Pharmacol. 1983; 61: 105
  • Takabatake E., Fujita M., Sawa Y. Combined effects of polychlorinated biphenyls and methyl mercury on hepatic microsomal monooxygenases and the hepatotoxic action of bromobenzene. J. Pharm. Dyn. 1980; 3: 463
  • Takagi Y., Aburada S., Otake T., Ikegami N. Effect of polychlorinated biphenyls (PCBs) accumulated in the dam's body on mouse filial immuno competence. Arch. Environ. Contam. Toxicol. 1987; 16: 375
  • Tanabe S. A need for reevaluation of PCB toxicity. Mar. Pollut. Bull. 1989; 20: 247
  • Tanabe S., Hidaka H., Tatsukawa R. PCBs and chlorinated hydrocarbon pesticides in Antarctic atmosphere and hydrosphere. Chemosphere 1983; 12: 277
  • Tanabe S., Kannan N., Ono M., Tatsukawa R. Toxic threat to marine mammals: increasing toxic potential of non-ortho and mono-ortho coplanar PCBs from land to ocean. Chemosphere 1989; 18: 485
  • Tanabe S., Kannan N., Subramanian A., Watanabe S., Ono M., Tatsukawa R. Occurrence and distribution of toxic coplanar PCBs in the biota. Chemosphere 1987; 16: 1965
  • Tanabe S., Kannan N., Subramanian A., Watanabe S., Tatsukawa R. Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans. Environ. Pollut. 1987; 47: 147
  • Tanabe S., Kannan N., Wakimoto T., Tatsukawa R. Method for the determination of three toxic non-ortftochlorine substituted coplanar PCBs in environmental samples at part-per-trillion levels. Int. J. Environ. Anal. Chem. 1987; 29: 199
  • Tanabe S., Kannan N., Wakimoto T., Tatsukawa R. Isomer-specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tis of “Yusho” PCB poisoning victim and in the causal oil. Toxicol. Environ. Chem. 1989; 24: 215
  • Tanimura T., Ema M., Kihara T. Effects of combined treatment with methylmercury and poly chlorinated biphenyls (PCBs) on the development of mouse offspring. Sch. Med. 1980; 4: 163
  • Tarhanen J., Koistinen J., Paasivirta J., Vuorinen P. J., Koivusaari J., Nuuja I., Kannan N., Tatsukawa R. Toxic significance of planar aromatic compounds in Baltic ecosystem — new studies on extremely toxic coplanar PCBs. Chemosphere 1989; 18: 1067
  • Tatematsu K., Nakanishi K., Murasaki G., Miyata Y., Hirose M., Ito N. Enhancing effect of induc ers of liver microsomal enzymes on induction of hyperplastic liver nodules byN-2-fluorenylacetamide in rats. J. Natl. Cancer Inst. 1979; 63: 1411
  • Taylor P. R., Lawrence C. E., Hwang H.-L., Paulson A. S. Polychlorinated biphenyls: influence on birthweight and gestation. Am. J. Public Health 1984; 74: 1153
  • Taylor P. R., Stelma J. M., Lawrence C. E. The relation of polychlorinated biphenyls to birth weight and gestational age in the offspring of occupa tionally exposed mothers. Am. J. Epidemiol. 1989; 129: 395
  • Thomas P. E., Korzeniowski D., Ryan D. E., Levin W. Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these two antigens in microsomes. Arch. Biochem. Biophys. 1979; 192: 524
  • Thomas P. E., Reik L. M., Ryan D. E., Levin W. Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes: effects of age, sex and induction. J. Biol. Chem. 1981; 256: 1044
  • Thomas P. E., Reik L. M., Ryan D. E., Levin W. Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. J. Biol. Chem. 1983; 258: 4590
  • Thomas P. T., Hinsdill R. D. Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and mice. Toxicol. Appl. Pharmacol. 1978; 44: 41
  • Tillitt D. E., Ankley G. T., Giesy J. P., Ludwig J. P., Kurita-Matsuba H., Weseloh D. V., Ross P. S., Bishop C. A., Sileo L., Stromborg K. L., Larson J., Kubiak T. J. Polychlorinated bi phenyl residues and egg mortality in double crested cormorants from the Great Lakes. Environ. Toxicol. Chem. 1992; 11: 1281
  • Tillitt D. E., Giesy J. P., Ankley G. T. Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar haloge nated hydrocarbons in environmental samples. Environ. Sci. Technol. 1991; 25: 87
  • Tilson H. A., Davis G. J., McLachlan J. A., Lucier G. W. The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice. Environ. Res. 1979; 18: 466
  • Tilson H. A., Jacobson J. L., Rogan W. J. Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol. Teratol. 1990; 12: 239
  • Traber P. G., Chianale J., Florence R., Kim K., Wojcik E., Gumucio J. J. Expression of cytochrome P450b and P450e benes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides. J. Biol. Chem. 1988; 263: 9449
  • Trotter W. J., Young S. J. V., Casterline J. L., Jr., Bradlaw J. A., Kamps L. R. Induction of aryl hydrocarbon hydroxylase activity in cell cultures by Aroclors, residues from Yusho oil samples, and polychlorinated biphenyl residues from fish samples. J. Assoc. Off. Anal. Chem. 1982; 65: 838
  • Truelove J., Grant D., Mes J., Tryphonas H., Tryphonas L., Zawidzka Z. Polychlorinated biphenyl toxicity in the pregnant cynomolgus monkey: a pilot study. Arch. Environ. Contain. Toxicol. 1982; 11: 583
  • Tryphonas H., Hayward S., O'Grady L., Loo J. C. K., Arnold D. L., Bryce F., Zawidzka Z. Z. Immunotoxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatto) monkey — preliminary report. Int. J. Immunopharmacol. 1989; 11: 199
  • Tryphonas H., Luster M. I., Schiffman G., Dawson L.-L., Hodgen M., Germolec D., Hayward S., Bryce F., Loo J. C. K., Mandy F., Arnold D. L. Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatto) monkey. Fundam. Appl. Toxicol. 1991; 16: 773
  • Tryphonas H., Luster M. I., White K. L., Naylor P. H., Erdos M. R., Burleson G. R., Germolec D., Hodgen M., Hayward S., Arnold D. L. Effects of PCB (Aroclor-1254) on non-specific immune parameters in rhesus (Macaca mulatto) monkeys. Int. J. Immunopharmacol. 1991; 13: 639
  • Tryphonas L., Arnold D. L., Zawidzka Z., Mes J., Charbonneau S., Wong J. A pilot study in adult rhesus monkeys (M. mulatto) treated with Aroclor 1254 for two years. Toxicol. Pathol. 1986; 14: 1
  • Tryphonas L., Charbonneau S., Tryphonas H., Zawidzka Z., Mes J., Wong J., Arnold D. L. Comparative aspects of Aroclor 1254 toxicity in adult cynomolgus and rhesus monkeys: a pilot study. Arch. Environ. Contam. Toxicol. 1986; 15: 159
  • Ueng T.-H., Alvares A. P. Selective loss of pulmonary cytochrome P-450I, in rabbits pretreated with polychlorinated biphenyls. J. Biol. Chem. 1981; 256: 7536
  • Ueng T.-H., Alvares A. P. Selective induction and inhibition of liver and lung cytochrome P-450-dependent monooxygenases by the PCBs mixture, Aroclor 1016. Toxicology 1985; 35: 83
  • Ueng T.-H., Eiseman J. L., Alvares A. P. Inhibition of pulmonary cytochrome P-450 and benzo(a)pyrene hydroxylase in rabbits by polychlori-nated biphenyls (PCBs). Biochem. Biophys. Res. Commun. 1980; 95: 1743
  • United States Environmental Protection Agency. 1991, Workshop Report on Toxicity Equivalency Factors for Polychlorinated Biphenyl Congeners, Risk Assessment Forum, EPA/625/3–91/020
  • Van Birgelen A., Van der Kolk J., Fase K., Poiger H., Brouwer A., Van den Berg M. Toxicity and biochemical potencies of polychlorinated biphenyl congeners relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin in three month feeding studies in the rat. Organohalogen Compounds, Dioxin 1992 1992; 10: 373, (Abstr.)
  • Van den Berg K. J., Zurcher C., Brouwer A. Effects of 3,4,3′,4′-tetrachlorobiphenyl on thyroid function and histology in marmoset monkeys. Toxicol. Lett. 1988; 41: 17
  • Villeneuve D. C., Grant D. L., Khera K., Clegg D. J., Baer H., Phillips W. E. J. The fetotoxicity of a polychlorinated biphenyl mixture (Aroclor 1254) in the rabbit and in the rat. Environ. Physiol. 1971; 1: 67
  • Villeneuve D. C., Grant D. L., Phillips W. E. J., Clark M. L., Clegg D. J. Effects of PCB administration on microsomal enzyme activity in pregnant rabbits. Bull. Environ. Contam. Toxicol. 1971; 6: 120
  • Vos J. G., Beems R. B. Dermal toxicity studies of technical polychlorinated biphenyls and fractions thereof in rabbits. Toxicol. Appl. Pharmacol. 1971; 19: 617
  • Vos J. G., DeRoij T. Immunosuppressive activity of a polychlorinated biphenyl preparation on the humoral immune response in guinea pigs. Toxicol. Appl. Pharmacol. 1972; 21: 549
  • Vos J. G., Van Genderen H. Toxicological aspects of immunosuppression. Pesticides in the Environment. A Continuing Controversy, W. B. Deichman. Intercontinental Medical Book Co., New York 1973; 527
  • Voss S. D., Shelton D. W., Hendricks J. D. Effects of dietary Aroclor 1254 and cyclopropene fatty acids on hepatic enzymes in rainbow trout. Arch. Environ. Contam. Toxicol. 1982; 11: 87
  • Walker M. K., Peterson R. E. Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachloro-dibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 1991; 21: 219
  • Ward J. M. Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254. Environ. Health Perspect. 1985; 60: 89
  • Ward J. M., Tsuda H., Tatematsu M., Hagiwara A., Ito N. Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioas say. Fundam. Appl. Toxicol. 1989; 12: 163
  • Warshaw R., Fischbein A., Thornton J., Miller A., Selikoff I. J. Decrease in vital capacity in PCB-exposed workers in a capacitor manufacturing facility. Ann. N.Y. Acad. Sci. 1979; 320: 277
  • Wasserman M., Wasserman D., Cucos S., Miller H. J. World PCBs map: storage and effects in man and his biologic environment in the 1970s. Ann. N.Y. Acad. Sci. 1979; 320: 69
  • Watanabe M., Sugahara T. Experimental formation of cleft palate in mice with polychlorinated biphenyls (PCBs). Toxicology 1981; 19: 49
  • Webb R. G., McCall A. C. Quantitative PCB standards for electron capture gas chromatography. J. Chromatogr. Sci. 1973; 11: 366
  • Whitlock J. P., Jr. The regulation of cytochrome P-450 gene expression. Anna. Rev. Pharmacol. Toxicol. 1986; 26: 333
  • Whitlock J. P., Jr. The regulation of gene expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Pharmacol. Rev. 1987; 39: 147
  • Whitlock J. P., Jr. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol Toxicol. 1990; 30: 251
  • Williams D. T., LeBel G. L. Coplanar polychlorinated biphenyl residues in human adipose ti samples from Ontario municipalities. Chemosphere 1991; 22: 1019
  • Williams L. L., Giesy J. P. Relationships among concentrations of individual polychlorinated biphenyl (PCB) congeners, 2,3,7,8-tetrachloro dibenzo-p-dioxin equivalents (TCDD-EQ) and rearing mortality of chinook salmon (Oncorhynchus tshawytscha) eggs from Lake Michigan. J. Great Lakes Res. 1992; 18: 108
  • Williams L. L., Giesy J. P., DeGalan N., Verbrugge D. A., Tillitt D. E., Ankley G. T., Welch R. L. Prediction of concentrations of 2,3,7,8 tetrachlorodibenzo-p-dioxin equivalents from total concentrations of polychlorinated biphenyls in fish fillets. Environ. Sci. Technol. 1992; 26: 1151
  • Wolff M. S. Occupational exposure to polychlorinated biphenyls (PCBs). Environ. Health Perspect. 1985; 60: 133
  • Wolff M. S., Fischbein A., Thornton J., Rice C., Lilis R., Selikoff I. J. Body burden of polychlorinated biphenyls among persons employed in capacitor manufacturing. Int. Arch. Occup. Environ. Health 1982; 49: 199
  • Wong A., Basrur P. K., Safe S. The metaboli cally mediated DNA damage and subsequent repair by 4-chlorobiphenyl in Chinese hamster ovary cells. Res. Commun. Chem. Pathol. Pharmacol. 1979; 24: 543
  • Wong T. K., Chiu P. L., Fu P. P., Yang S. K. Metabolic study of 7-methylbenzo[a]pyrene with rat liver microsomes: separation by reversed-phase and normal-phase high performance liquid chromatography and characterization of metabolites. Chem. Biol. Interact. 1981; 36: 153
  • Wyndham C., Safe S. in vitro metabolism of 4-chlorobiphenyl by control and induced rat liver mi crosomes. Biochemistry 1978; 17: 208
  • Yamamoto H., Yoshimura H. Metabolic studies on polychlorinated biphenyl. III. Complete structure and acute toxicity of the metabolites of 2,4,3,4′-tetrachlorobiphenyl. Chem. Pharm. Bull. 1973; 21: 2237
  • Yamamoto H., Yoshimura H., Fujita M., Yamamoto T. Metabolic and toxicologic evaluation of 2,3,3′,4,4′-pentachlorobiphenyl in rats and mice. Chem. Pharm. Bull. 1976; 24: 2168
  • Yao C., Panigrahy B., Safe S. Utilization of cultured chick embryo hepatocytes asin vitro bioas says for polychlorinated biphenyls (PCBs): quantitative structure-induction relationships. Chemosphere 1990; 21: 1007
  • Yeowell H. N., Waxman D. J., LeBlanc G. A., Linko P., Goldstein J. A. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Arch. Biochem. Biophys. 1989; 271: 508
  • Yeowell H. N., Waxman D. J., Wadhera A., Goldstein J. A. Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl and 3-methyl cholanthrene. Mol. Pharmacol. 1987; 32: 340
  • Yoshihara S., Kawano K., Yoshimura H., Kuroki H., Masuda Y. Toxicological assessment of highly chlorinated biphenyl congeners retained in the Yusho patients. Chemosphere 1979; 8: 531
  • Yoshihara S., Nagata K., Wada I., Yoshimura H., Kuroki H., Masuda Y. A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF). J. Pharm. Dyn. 1982; 5: 994
  • Yoshihara S., Nagata K., Yoshimura H. Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital type and 3-methylcholanthrene-type polychlorinated biphenyls in rats. J. Pharm. Dyn. 1983; 6: 954
  • Yoshimura H., Ozawa N., Saeki S. Inductive effect of polychlorinated biphenyls mixture and individual isomers on the hepatic microsomal enzymes. Chem. Pharm. Bull. 1978; 26: 1215
  • Yoshimura H., Yonemoto Y., Yamada H., Koga N., Oguri K., Saeki S. Metabolismin vivo of 3,4,3′,4′-tetrachlorobiphenyl and toxicological assessment of the metabolites in rats. Xenobiotica 1987; 17: 897
  • Yoshimura H., Yoshihara S., Ozawa N., Miki M. Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats. Ann. NY. Acad. Sci. 1979; 320: 179
  • Yu M.-L., Hsu C.-C., Gladen B. C., Rogan W. J. In utero PCB/PCDF exposure: relation of developmental delay to dysmorphology and dose. Neurotoxicol. Teratol. 1991; 13: 195
  • Zack T. A., Musch D. C. Mortality of PCB Workers at the Monsanto Plant in Sanget. 1979, Illinois, Monsanto Internal Report, St. Louis
  • Zinkl J. G. Skin and liver lesions in rats fed a polychlorinated biphenyl mixture. Arch. Environ. Contam. Toxicol. 1977; 5: 217

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