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Research Article

Organochlorine Compounds in Relation to Breast Cancer, Endometrial Cancer, and Endometriosis: An Assessment of the Biological and Epidemiological Evidence

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Pages 463-531 | Published online: 25 Sep 2008

References

  • Davis D. L., Bradlow H. L., Wolff M., Woodruff T., Hoel D. G., Anton-Culver H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ. Health Perspect 1993; 101: 372
  • Hunter D. J., Kelsey K. T. Pesticide residues and breast cancer: the harvest of a silent spring? (editorial). J. Natl. Cancer Inst 1993; 85: 598
  • Soto A. M., Chung K. L., Sonnenschein C. The pesticides endosulfan, tox-aphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ. Health Perspect 1994; 102: 380
  • Manske D. D., Corneliussen P. E. Pesticide residues in total diet samples (VII). Pest. Monit. J 1974; 8: 110
  • Kutz F. W., Wood P. H., Bottimore D. P. Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev. Environ. Contam. Toxicol 1991; 120: 1
  • Levine R. Recognized and possible effects of pesticides in humans. Handbook of Pesticide Toxicology, W. J. Hayes, E. R. Laws, Jr., 1991; Vol. 1, chap. 7
  • Kimbrough R. D. Human health effects of polychlorinated biphenyls (PCBs), and polybrominated biphenyls (PBBs). Annu. Rev. Pharmacol. Toxicol 1987; 27: 87
  • Hodgson E., Silver I. S., Butter L. E., Lawton M. P., Levi P. E. Metabolism. Handbook of Pesticide Toxicology, W J. Hayes, E. R. Laws, Jr., 1991; Vol. 1, chap. 3
  • Smith A. G. Chlorinated hydrocarbon insecticides. Handbook of Pesticide Toxicology, W. J. Hayes, E. R. Laws, Jr., 1991
  • Jones K. C., Bennett B. G. Human exposure to environmental polychlorinated dibenzo-p-dioxins and dibenzofurans: an exposure commitment assessment for 2,3,7,8-TCDD. Sci. Total Environ 1989; 78: 99
  • Jensen A. A. Chemical contaminants in human milk. Residue Reviews, F A. Gunther, J D. Gunther. Springer-Verlag, New York 1983; 1
  • Okey A. B., Riddick D. S., Harper P A. Molecular biology of the aromatic hydrocarbon (dioxin) receptor. TIPS 1994; 15: 226
  • Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors. Crit. Rev. Toxicol 1990; 21: 51
  • Ahlborg U. G., Brouwer A., Fingerhut M. A., Jacobson J. L., Jacobson S. W., Kennedy S. W., Kettrup A. A. F., Koeman J. H., Poiger H., Rappe C., Safe S. H., Seegal R. F., Tuomisto J., van den Berg M. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls on human and environmental health. with special emphasis on application of the toxic equivalency factor concept. Eur. J. Pharmacol 1992; 228: 179
  • NATO/CCMS (North Atlantic Treaty Organization). International toxicity equivalency factor (I-TEF) method of risk assessment for complex mixtures of dioxins and related compounds. NATO Rep. No. 176. 1988
  • Jensen A. A. Background levels in humans. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R. D. Kimbrough, A. A. Jensen. Elsevier, Amsterdam 1989; 345
  • Graham M. F., Hileman F. D., Kirk J., Wendling J., Wilson J. Background human exposure to 2,3,7,8-TCDD. Chemosphere 1985; 14: 925
  • Hutzinger O., Blumich M. J., van den Berg M., Olie K. Sources and fate of PCDDs and PCDFs: an overview. Chemosphere 1985; 14: 581
  • Reggiani G. Acute human exposure to TCDD in Seveso, Italy. J. Toxicol Environ. Health 1980; 6: 27
  • Kahn P. C., Gochfeld M., Nygren M., Hansson M., Rappe C., Velez H., Ghent-Guenther T., Wilson W. P. Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterans and matched controls. JAMA 1988; 259: 1661
  • Norén K. Contemporary and retrospective investigations of human milk in the trend studies of organochlorine contaminants in Sweden. Sci. Total Environ. 1993; 139/40: 347
  • Rappe C. Recent data on levels of dioxin and related compounds in breast milk in Europe. WHO EURO working paper 1986
  • Wolff M. S. Occupational exposure to polychlorinated biphenyls (PCBs). Environ. Health Perspect 1985; 60: 133
  • Silberhorn E. M., Glavert H. P., Robertson L. W. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit. Rev. Toxicol 1990; 20: 439
  • Hammond P. B., Nisbet I. C. T., Sarofim A. F., Drury W. H., Nelson N. PCBs-environmental impact. Environ. Res 1972; 5: 249
  • Fries G. P. Polychlorinated biphenyl residues in the milk of environmentally and experimentally contaminated cows. Environ. Health Perspect 1972; 10: 55
  • Anderson H. A. General population exposure to environmental concentrations of halogenated biphenyls. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R D. Kimbrough, A A. Jensen. Elsevier, Amsterdam 1989; 345
  • Ahlborg U. G., Becking G. C., Birnbaum L. S., Brouwer A., Derks H. J. G.M., Feeley M., Golor G., Hanberg A., Larsen J. C., Liem A. K. D., Safe S. H., Schlatter C., Wærn F., Younes M., Yrjänheikki E. Toxic equivalency factors for dioxin-like PCBs, Report on a WHO-ECEH and IPCS consultation, December 1993. Chemosphere 1994; 28: 1049
  • Kimbrough R. D., Grandjean P. Occupational exposure. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R D. Kimbrough, A A. Jensen. Elsevier, Amsterdam 1989; 485
  • Kreiss K. Studies on populations exposed to polychlorinated biphenyls. Environ. Health Perspect 1985; 60: 193
  • Corliss J. News. J. Natl. Cancer Inst 1993; 85: 602
  • WHO. Polychlorinated Biphenyls and Terphenyls, 2nd ed. World Health Organization, Geneva 1993, Environmental Health Criteria 140
  • Mes J. PCBs in human populations. PCBs and the Environment, J S. Waid. CRC, Boca Raton, FL 1991; 39
  • Gartrell M. J., Craun J. C., Podrebarac D. S., Gunderson E. L. Pesticides, selected elements, and other chemicals in adult total diet samples, October 1979-September 1980. J. Assoc. Off. Anal. Chem 1985; 68: 1184
  • Slorach S. A., Vaz R. PCB levels in breast milk: data from the UNEP/WHO pilot project on biological monitoring and some other recent studies. Environ. Health Perspect 1985; 60: 121
  • Bergman Å., Klasson-Wehler E., Kuroki H. Selective retention of hydroxylated PCB metabolites in blood. Environ. Health Perspect 1994; 102: 2
  • WHO. DDT And Its Derivatives—Environmental Aspects. World Health Organization, Geneva 1989
  • Roan C. C. They're eating DDT!. Farm. Chem 1970; 133: 44
  • Morgan D. P., Roan C. C. Loss of DDT from storage in human body fat. Nature 1972; 238: 221
  • Mes J., Davies D. J., Doucet J., Weber D., McMullen E. Levels of chlorinated hydrocarbon residues in Canadian human breast milk and their relationship to some characteristics of the donors. Food Addit. Contam. 1993; 10(4)429
  • Hoffman W. Relation of pesticide concentration in fat to pathological changes in tissue. Arch. Environ. Health 1967; 15: 758
  • Casarett L. J., Fryer G. C., Yauger W. L., Kelmmer H. W. Organochlorined pesticide and polychlorinated biphenyl residues in biopsied human adipose tissue—Hawaii. Arch. Environ. Health 1968; 17: 306
  • Davies J. E., Edmundson W. F., Macio A., Barquet A., Cassady J. An epidemiologic application of the study of DDE levels in whole blood. Am. J. Public Health 1969; 59: 435
  • Davies J. E., Edmundson W. F., Raffonelli A., Cassady J. C., Morgade C. The role of social class in human pesticide pollution. Am. J. Epidemiol 1972; 96: 334
  • Kutz F. W., Ybs A. R., Strassman S. C. Racial stratification of organochlorine insecticide residues in human adipose tissue. J. Occup. Med 1977; 19: 619
  • Sandifer S. H. A case-control study of persons with elevated blood levels of dieldrin. Arch. Environ. Contam. Toxicol 1981; 10: 35
  • Walker K. C., Goette M. B., Batchelor G. S. Pesticide residue in foods. Dichloro-diphenyltrichloroethane and dichlorodiphenyl-dichloroethylene content of prepared meals. J. Agric. Food Chem. 1034; 2: 1954
  • Spear R. Recognized and possible exposure to pesticides. Handbook of Pesticide Toxicology, W. J. Hayes, E. R. Laws, Jr., 1991, chap. 6
  • International Agency for Research on Cancer (IARC). DDT and associated compounds (review), Monographs on the evaluation of carcinogenic risks to humans. Occupational Exposures in Insecticide Application and Some Pesticides. IARC, LyonFrance 1991; Vol. 53
  • Murphy R. S., Kutz F. W., Strassman S. C. Selected pesticide residues or metabolites in blood and urine specimens from a general population survey. Environ. Health Perspect 1983; 48: 81
  • Howell D. E. A case of DDT in human fat. Proc. Okla. Acad. Sci 1948; 29: 31
  • Kashyap R., Iyer L. R., Singh M. M., Kashyap S. K. Evaluation of human exposure to the persistent insecticides DDT and HCH in Ahmedabad, India. J. Anal. Toxicol 1991; 17: 211
  • Murphy R., Harvey C. Residues and metabolites of selected persistent hydrocarbons in blood specimens from a general population survey. Environ. Health Perspect 1985; 60: 115
  • Kreiss K., Zack M. M., Kimbrough R. D., Needham L. L., Smrek A. L., Jones B. T. Cross-sectional study of a community with exceptional exposure to DDT. JAMA 1926; 245: 1981
  • Wassermann M., Tomatis L., Wassermann D., Day N. E., Groner Y., Lazarovici S., Rosenfeld D. Epidemiology of organochlorine insecticides in the adipose tissue of Israelis. Pest. Mon. J 1974; 8: 1
  • Laug E. P., Kunze F. M., Prickett C. S. Occurrence of DDT in human fat and milk. Arch. Ind. Hyg. Occup. Med 1951; 3: 245
  • WHO. Chlordane Health and Safety Guide. World Health Organization, Geneva 1988, Health and Safety Guide No. 13
  • IARC. Chlordane and heptachlor (review). Monographs on the evaluation of carcinogenic risks to humans. Occupational Exposures in Insecticide Application And Some Pesticides. IARC, LyonFrance 1991; Vol. 53: 115
  • Kutz F. W., Sovocool G. W., Strassman S., Lewis R. G. Transnonachlor residues in human adipose tissue. Bull. Environ. Contam. Toxicol 1976; 16: 9
  • Savage E. P., Keefe T. J., Tessari J. D., Wheeler H W., Applehans F. M., Goes E. A., Ford S. A. National study of chlorinated hydrocarbon insecticide residues in human milk. USA. Am. J. Epidemiol 1981; 113: 413
  • Kutz F. W., Strassman S. C., Stroup C. R., Carra J. S., Leininger C. C., Watts D. L., Sparacino C. M. The human body burden of mirex in the Southeastern United States. J. Toxicol. Environ. Health 1985; 15: 385
  • Öberg L. G., Rappe C. Biochemical formulation of PCDD/Fs from chlorophenols. Chemosphere 1992; 25: 49
  • Sundström G., Jensen S., Jansson B., Erne K. Chlorinated phenoxyacetic acid derivatives and tetraehlorodibenzo-p-dioxin in foliage after application of 2,4,5-trichlorophenoxyacetic acid ester. Arch. Environ. Contam. Toxicol 1979; 8: 441
  • Welch R. M., Levin W., Conney A. H. Estrogenic action of DDT and its analogs. Toxicol. Appl. Pharmacol 1969; 14: 358
  • Bitman J., Cecil H. C. Estrogenic activity of DDT analogs and polychlorinated biphenyls. J. Agric. Food Chem 1970; 18: 1108
  • Kupfer D. Studies on short and long-range estrogenic action of chlorinated hydrocarbon pesticides. Bunbury Report 1982; 11: 379
  • Nelson J. A., Struck R. F., James R. Estrogenic activities of chlorinated hydrocarbons. J. Toxicol. Environ. Health 1978; 4: 325
  • Robison A. K., Schmidt W. A., Stancel G. M. Estrogenic activity of DDT: estrogen-receptor profiles and the responses of individual uterine cell types followingo,p'-DDT administration. J. Toxicol. Environ. Health 1985; 16: 493
  • Galand P., Mairesse N., Degraef C., Rooryck J. o,p'-DDT (1,1,1-trichloro-2(p-chlorophenyl) 2-(o-chloro?henyl) ethane is a purely estrogenic agonist in the rat uterus in vivo and in vitro. Biochem. Pharmacol. 1987; 36: 397
  • Bustos S., Denegri J. C., Diaz F., Tchernitchin A. N. p,p'-DDT is an estrogenic compound. Bull. Environ. Contam. Toxicol. 1988; 41: 496
  • Robison A. K., Sirbasu D. A., Stancel G. M. DDT supports the growth of an estrogen-responsive tumor. Toxicol. Lett 1985; 27: 109
  • Bulger W. H., Kupfer D. Estrogenic action of DDT analogs. Am. J. Ind. Med 1983; 4: 163
  • Faber K. A., Basham K., Hughes C. L. J. The effect of neonatal exposure to DES ando,p'-DDT on pituitary responsiveness to GnRH in adult castrated rats. Reprod. Toxicol 1991; 5: 363
  • Uphouse L., Williams J. Sexual behavior of intact female rats after treatment witho,p'-DDT orp,p'-DDT. Reprod. Toxicol 1989; 3: 33
  • Mason R. R., Schulte G. J. Estrogenlike effects ofo,p'-DDT on the progesterone receptor of rat uterine cytosol. Res. Commun. Chem. Pathol. Pharmacol 1980; 29: 281
  • Bulger W. H., Kupfer D. Effect of xenobiotic estrogens and structurally related compounds on 2-hydroxylation of estradiol and on other monoxygenase activities in rat liver. Biochem. Pharmacol. 1005; 32: 1983
  • Forster M. S., Wilder E. L., LeRoy Heinrichs W. Estrogenic behavior of 2(O-chlorophenyl)-2-(P-chlorophenyl)-1,1,1-trichloroethane and its homologues. Biochem. Pharmacol 1975; 24: 1777
  • Stancel G. M., Ireland J. S., Mukku V. R., Robison A. K. The estrogenic activity of DDT: in vivo and in vitro induction of a specific estrogen inducible uterine protein byo,p'-DDT. Life Sci 1980; 27: 1111
  • Mason R. R., Schulte G. J. Interaction ofo,p'-DDT with the estrogen-binding protein (EBP) of DMBA-induced rat mammary tumors. Res. Commun. Chem. Pathol. Pharmacol 1981; 33: 119
  • Robison A. K., Mukku V. R., Spalding D. M., Stancel G. M. The estrogenic activity of DDT: the in vitro induction of an estrogen-inducible protein byo,p'-DDT. Toxicol. Appl. Pharmacol 1984; 76: 537
  • McBlain W. A. The levo enantiomer ofo,p'-DDT inhibits the binding of 17β-estradiol to the estrogen receptor. Life Sci 1987; 40: 215
  • Robison A. K., Stancel G. M. The estrogenic activity of DDT: correlation of estrogenic effect with nuclear level of estrogen receptor. Life Sci 1982; 31: 2479
  • Etgen A. M. 1-(o-Chlorophenyl)-l-(p-chlorophenyl)2,2,2-trichloroethane: a probe for studying estrogen and progestin receptor mediation of female sexual behavior and neuroendocrine responses. Endocrinology 1982; 111: 1498
  • Bitman J., Cecil H. C., Harris S. J., Feil V. J. Estrogenic activity ofo,p'-DDT metabolites and related compounds. J. Agric. Food Chem 1978; 26: 149
  • Johnson D. C., Kogo H., Dey S. K. Multiple estrogenic action ofo,p'-DDT: initiation and maintenance of pregnancy in the rat. Toxicology 1988; 53: 79
  • Johnson D. C., Sen M., Dey S. K. Differential effects of dichlorodiphenyl-trichloroethane analogs, chlordecone, and 2,3-7,8-tetrachlorodibenzo-p-dioxin on establishment of pregnancy in the hypophysectomized rat. Proc. Soc. Exp. Biol. Med 1992; 199: 42
  • Bulger W. H., Muccitelli R. M., Kupfer D. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol 1978; 27: 2417
  • Ousterhout J., Struck R. F., Nelson J. A. Estrogenic activities of methoxychlor metabolites. Biochem. Pharmacol 2869; 30: 1981
  • Williams J., Eckols K., Uphouse L. Estradiol and chlorodecone interactions with the estradiol receptor. Toxicol. Appl. Pharmacol 1989; 98: 413
  • Hammond P. B., Katzenellenbogen B. S., Krauthammer N., McConnell J. Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors. Proc. Natl. Acad. Sci. USA 1979; 76: 6641
  • Cochran R. C., Wiedow M. A. Chlordecone lacks estrogenic properties in the male rat. Toxicol. Appl. Pharmacol 1984; 76: 519
  • Foster W. G., McMahon A., Villeneuve D. C., Jarrel J. F. Hexachlorobenzene (HCB) suppresses circulating progesterone concentrations during the luteal phase in the cynomolgus monkey. J. Appl Toxicol 1992; 12: 13
  • Foster W. G., Pentick J. A., McMahon A., Lecavalier P R. Ovarian toxicity of hexachlorobenzene (HCB) in the superovulated female rat. J. Biochem. Toxicol 1992; 7: 1
  • McKinney J. D., Waller C. L. Polychlorinated biphenyls as hormonally active structural analogues. Environ. Health Perspect 1994; 102: 290
  • Jansen H. T., Cooke P. S., Porcelli J., Liu T. C., Hansen L. G. Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies. Reprod. Toxicol 1993; 7: 237
  • Ecobichon D. J., MacKenzie D. O. The uterotropic activity of commercial and isomerically pure chlorobiphenyls in the rat. Res. Commun. Chem. Pathol. Pharmacol 1974; 9: 85
  • Korach K. S., Sarver P., Chae K., McLachlan J. A., McKinney J. D. Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. Mol. Pharmacol 1988; 33: 120
  • Müller W. F., Hobson W., Fuller G. B., Knauf W., Coulston F., Korte F. Endocrine effects of chlorinated hydrocarbons in rhesus monkeys. Ecotoxicol. Environ. Safety 1978; 2: 161
  • Truelove J. F., Tanner J. R., Langlois I. A., Stapley R A., Arnold D. L., Mes J. C. Effect of polychlorinated biphenyls on several endocrine reproductive parameters in the female rhesus monkey. Arch. Environ. Contain. Toxicol 1990; 19: 939
  • Gellert R. J. Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environ. Res 1978; 16: 123
  • Vincent D. R., Bradshaw W. S., Booth G. M., Seegmiller R E., Alien S. D. Effect of PCB and DES on rat monoamine oxidase, acetylcholinesterase, testosterone. and estradiol ontogeny. Bull. Environ. Contain. Toxicol 1992; 48: 884
  • Lundkvist U., Kindahl H. Plasma concentrations of 15-keto-13,14-dihydro-PGF-2α. oestrone sulphate. oestradiol-17β and progesterone in pregnant guinea-pigs treated with polychlorinated biphenyls. J. Reprod. Fertil 1989; 87: 55
  • Kociba R. J., Keyes D. G., Beyer J. E., Carreon R. M., Wade C. E., Dittenber D. A., Kalnins R. P., Frauson L. E., Park C. N., Barnard S. D., Hummel R. A., Humiston C. G. Results of a two-year toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol 1978; 46: 279
  • Gierthy J. F., Bennett J. A., Bradley L. M., Cutler D. S. Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Res 1993; 53: 3149
  • Holcomb M., Safe S. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetra-ehlorodibenzo-p-dioxin. Cancer Lett 1994; 82: 43
  • Safe S., Harris M., Biegel L., Zacharewski T. Mechanism of action of TCDD as an antiestrogen in transformed human breast cancer and rodent cell lines. Banbury Report 35. Biological Basis for Risk Assessment of Dioxins and Related Compounds, M J. Gallo, R J. Scheuplein, K. A. van der Heijden. Cold Spring Harbor Laboratory Press, New York 1991; 367
  • Astroff B., Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochem. Pharmacol 1990; 39: 485
  • Astroff B., Rowlands C., Dickerson R., Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17β-estradiol-inducedincreases in rat uterine epidermal growth factor receptor binding activity and gene expression. Mol. Cell. Endocrinol 1990; 72: 247
  • Astroff B., Eldridge B., Safe S. Inhibition of the 17β-estradiol-induced and constitutive expression of the cellular proto-oncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus. Toxicol. Lett 1991; 56: 305
  • Gallo M. A., Hesse E. J., MacDonald G. J., Umbreit T. H. Interactive effects of estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic-cytochrome P-450 and mouse uterus. Toxicol Lett 1986; 32: 123
  • Safe S., Astroff B., Harris M., Zacharewski T., Dickerson R., Romkes M., Biegel L. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antiestrogens: characterization and mechanism of action. Pharmacol. Toxicol 1991; 69: 400
  • Goldstein J. A., Lin F. H., Stohs S. J., Graham M., Clarke G., Birnbaum L., Lucier G. The effects of TCDD on receptors for epidermal growth factor, glucocorticoid, and estrogen in Ah-responsive and Ah-nonresponsive congenic mice and the effects of TCDD on estradiol metabolism in a liver tumor promotion model in female rats. Mouse Liver Carcinog 1990; 331: 187
  • Lin F. H., Stohs S. J., Birnbaum L. S., Clark G., Lucier G. W., Goldstein J. A. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. Toxicol. Appl. Pharmacol 1991; 108: 129
  • DeVito M. J., Thomas T., Martin E., Umbreit T. H., Gallo M. A. Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice. Toxicol. Appl. Pharmacol 1992; 113: 284
  • Shiverick K. T., Muther T. F. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal steroid metabolism and serum estradiol of pregnant rats. Biochem. Pharmacol 1983; 32: 991
  • Gray L. E., Ostby J. S., Kelce W., Marshall R., Diliberto J. J., Birnbaum L. S. Perinatal TCDD exposure alters sex differentiation in both female and male LE hooded rats, in13th International Symposium on Chlorinated Dioxins and Related Compounds. Vienna 1993; 13: 337
  • Bookstaff R. C., Moore R. W., Peterson R. E. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the potency of androgens and estrogens as feedback inhibitors of luteinizing hormone secretion in male rats. Toxicol. Appl. Pharmacol 1990; 104: 212
  • Moore R. W., Bookstaff R. C., Mably T. A., Peterson R. E. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on responsiveness of male rats to androgens, 17β-estradiol, luteinizing hormone, gonadotropin-releasing hormone and progesterone;. Chemosphere 1992; 25: 91
  • Hruska R. E., Olson J. R. Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol. Lett 1989; 48: 289
  • Romkes M., Piskorska-Pliszczynska J., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. Toxicol. Appl. Pharmacol 1987; 87: 306
  • Romkes M., Piskorska-Pliszczynska J., Safe S. Role of the Ah receptor in mediating the down regulation of uterine and hepatic estrogen receptor levels in rats. Chemosphere 1987; 16: 1691
  • Astroff B., Safe S. Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in female rat. Toxicol. Appl. Pharmacol 1988; 95: 43
  • Astroff B., Romkes M., Safe S. Mechanism of action of 2,3,7,8-TCDD and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as antiestrogens in the female rat. Chemosphere 1989; 19: 785
  • Astroff B., Safe S. 6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats. Toxicology 1991; 69: 187
  • Dickerson R., Howie L., Safe S. The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus. Toxicol. Appl. Pharmacol 1992; 113: 55
  • Chadwick R. W., Cooper R. L., Chang J., Rehnberg G. L., McElroy W. K. Possible antiestrogenic activity of lindane in female rats. J. Biochem. Toxicol 1988; 3: 147
  • Wang X., Porter W., Krishnan V., Narasimhan T. R., Safe S. Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Mol Cell. Endocrinol 1993; 96: 159
  • Biegel L., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52-, and 160-kDa proteins in human breast cancer cells. J. Steroid Biochem. Mol. Biol 1990; 37: 725
  • Krishnan V., Narisimhan T. R., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in MCF-7-human breast cancer cells. Chemosphere 1992; 25: 947
  • Safe S., Biegel L., Harris M., Narasimhan T. R., Lui H., Fernandez P. Inhibition of estrogen-and growth factor-induced proliferation of human breast cancer cell lines by TCDD: characterization and mechanistic studies. Chemosphere 1992; 25: 83
  • Krishnan V., Safe S. Antiestrogenic activity of polychlorinated biphenyl (PCB) congeners and mixtures in MCF-7 human breast cancer cells. Toxicologist 1992; 12: 32
  • Chaloupka K., Krishnan V., Safe S. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor. Carcinogenesis 1992; 13: 2233
  • Gierthy J. F., Lincoln D. W., Gillespie M. B., Seeger J. L., Martinez H. L., Dickerman H. W., Kumar S. A. Suppression of estrogen-regulated extracellular plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Res 1988; 47: 6198
  • Liu H., Biegel L., Narasimhan T. R., Rowlands C., Safe S. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol. Cell. Endocrinol 1992; 87: 19
  • Krishnan V., Safe S. Polychlorinated biphenyls (PCBs). dibenzo-p-dioxins (PCDDs). and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol. Appl. Pharmacol 1993; 120: 55
  • Zacharewski T., Harris M., Biegel L., Morrison V., Merchant M., Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicol. Appl. Pharmacol 1992; 113: 311
  • Narasimhan T. R., Safe S., Williams H. J., Scott A. I. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-in-duced glucose metabolism in MCF-7 human breast cancer cells13C Nuclear magnetic resonance spectroscopy studies. Mol. Pharmacol. 1029; 40: 1991
  • Gierthy J. F., Lincoln I ID. W. Inhibition of postconfluent focus production in cultures of MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Breast Cancer Res. Treat 1988; 12: 227
  • Harris M., Zacharewski T., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Res 1990; 50: 3579
  • Zacharewski T., Harris M., Safe S. Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear-estrogen receptor levels in wild-type and mutant mouse hepa lclc7 cells. Biochem. Pharmacol 1931; 41: 1991
  • Graham M. J., Lucier G. W., Linko P., Maronpot R. R., Goldstein J. A. Increases in cytochrome P-450 mediated 17β-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a two-stage hepatocarcinogenesis model. Carcinogenesis 1935; 9: 1988
  • Goldstein J. A., Graham M. J., Sloop T., Maronpot R., Goodrow T., Lucier G. W. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on estradiol metabolism and enzyme-altered foci in a two stage hepatocarcinogenesis model in rats. Chemosphere 1989; 18: 695
  • Gierthy J. F., Lincoln I ID. W., Kampcik S. J., Dickerman H. W., Bradlow H. L., Niwa T., Swaneck G. E. Enhancement of 2 and 16α-estradiol hydroxylation in MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun 1988; 157: 515
  • Spink D. C., Lincoln D. W., Dickerman H. W., Gierthy J. F. 2,3,7,8-tetra chlorodibenzo-p-dioxin causes an extensive alteration of 17β-estradiol metabolism in MCF-7 breast tumor cells. Proc. Natl. Acad. Sci. U.S.A 1990; 87: 6917
  • Spink D. C., Lincoln D. W., II, Johnson J. A., Dickerman H. W., Gierthy J. F. Stimulation of 17β-estradiol metabolism in MCF-7 breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 1992; 25: 87
  • Spink D. C., Eugster H-P., Lincoln D. W., Schuetz J. D., Schuetz E. G., Johnson J. A., Kaminsky L. S., Gierthy J. F. 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch. Biochem. Biophys 1992; 293: 342
  • DeVito M. J., Ma X. F., Babish J. G., Menache M., Birnbaum L. S. Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation. Toxicol. Appl. Pharmacol 1994; 124: 82
  • Romkes M., Safe S. Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. Toxicol. Appl. Pharmacol 1988; 87: 306
  • Romkes M., Safe S. Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and progesterone on estrogenic responses in rats. Chemosphere 1989; 18: 745
  • DeVito M., Umbreit T. H., Thomas T., Gallo M. A. An analogy between the actions of the Ah receptor and the estrogen receptor for use in the biological basis for risk assessment of dioxin. Banbury Report 35. Biological Basis for Risk Assessment of Dioxins and Related Compounds, M A. Gallo, R. J. Scheuplein, K. A. van der Heijden. Cold Spring Harbor Laboratory Press, New York 1991; 427
  • White T. E. K., Gasiewicz T. A. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun 1993; 193: 956
  • Demirpence E., Balaguer P., Trousse F., Nicolas J. C., Pons M., Gagne D. Antiestrogenic effects of all-trans-retinoic acid and 1,25-dihydroxyvitamin D3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanisms. Cancer Res. 1994; 54: 1458
  • Poland A., Glover E. Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of structure activity relationship. Mol Pharmacol 1977; 13: 924
  • Sawyer T., Safe S. PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin Odeethylase enzyme activities in rat hepatoma cells. Toxicol. Lett 1982; 13: 87
  • International Agency for Research on Cancer (IARC). 1987; Vol. 1 to 42(Suppl. 7), Monographs on the evaluation of carcinogenic risks to humans Overall evaluations of carcinogenicity: an updating of IARC Monographs
  • Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Methoxychlor. U.S. Department of Health and Human Services. 1994; TP-93/11
  • International Programme on Chemical Safety (IPCS). Mirex. World Health Organization, Geneva 1984, Environmental Health Criteria 44
  • International Programme on Chemical Safety (IPCS). Chlordecone. World Health Organization, Geneva 1984, Environmental Health Criteria 43
  • Poland A., Knutson J. C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol 1982; 22: 517
  • Safe S. H. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol 1986; 26: 371
  • Goldstein J. A., Safe S. Mechanism of action and structure-activity relationship for the chlorinated dibenzo-p-dioxins and related compounds. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R D. Kimbrough, A A. Jensen. Elsevier, Amsterdam 1989; 239
  • Kociba R. J. Summary and critique of rodent carcinogenicity studies of chlorinated dibenzo-p-dioxins. Public Health Risks of the Dioxins, W W. Lowrance. Rockefeller University, New York 1984; 77
  • Kimbrough R. D., Buckley J., Fishbein L., Flamm G., Kasza L., Marcus W., Shibko S., Teske R. Animal toxicology. Environ. Health Perspect 1978; 24: 173
  • Van Miller J. P., LaLich J. J., Allen J. R. Increased incidence of neoplasms in rats exposed to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 1977; 9: 537
  • National Toxicology Program (NTP). Bioassay of 1,2,3,6,7,8-and 1,2,3,7,8,9-Hexachlorodibenzo-p-Dioxin for Possible Carcinogenicity. National Toxicology Program, Research Triangle Park, NC. 1980, DHHS Publication (NIH) 80-1754
  • National Toxicology Program (NTP). Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin for Possible Carcinogenicity, NTP-TR-201/209. National Toxicology Program, Research Triangle Park, NC 1982, DHHS Publication (NIH) 82-1765
  • Rao M. S., Subbarao V., Prasad J. D., Scarpelli D. G. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster. Carcinogenesis 1988; 9: 1677
  • U.S. EPA. Health Assessment Document for Polychlorinated Dibenzo-p-Dioxins, EPA/600/8-84/014F. Office of Health and Environmental Assessment, Washington, DC 1985
  • Nessel C. S., Gallo M. A. Dioxins and related compounds. Environmental Toxicants: Human Exposures and Their Health Effects, M Lippmann. Van Nostrand Reinhold, New York 1992; 163
  • Kimbrough R. D. Laboratory and human studies on polychlorinated biphenyls (PCBs) and related compounds. Environ. Health Perspect 1985; 59: 99
  • Shu H. P., Paustenbach D. J., Murray F. J. A critical evaluation of the use of mutagenesis, carcinogenesis, and tumor promotion data in a cancer risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Regul. Toxicol. Pharmacol 1987; 7: 57
  • Gold L. S., Slone T. H., Stern B. R., Manley N. B., Ames B. Rodent carcinogens: setting priorities. Science 1992; 258: 261
  • McConnell E. E. Acute and chronic toxicity and carcinogenesis in animals. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Compounds, R D. Kimbrough, A A. Jensen. Elsevier, Amsterdam 1989; 161
  • Ito N., Nagasaki H., Arai M., Makiura S., Sugihara S., Hirao K. Histopathologic studies on liver tumorigenesis induced in mice by technical polychlorinated biphenyls and its promoting effect on liver tumors induced by benzene hexachloride. J. Natl. Cancer Inst 1973; 51: 1637
  • Kimura N. T., Baba T. Neoplastic changes in the rat liver induced by polychlorinated biphenyls. Gann 1973; 64: 105
  • Kimbrough R. D., Linder R. E. Induction of adenofibrosis and hepatomas of the liver in BALB/cJ mice by polychlorinated biphenyls (Arochlor 1254). J. Natl. Cancer Inst 1974; 53: 547
  • Kimbrough R. D., Squire R. A., Linder R. E., Strandberg J. D., Montali R. J., Burse V. W. Induction of liver tumors in Sherman strain female rats by polychlorinated biphenyl Arochlor 1260. J. Natl. Cancer Inst 1975; 55: 1453
  • U.S. National Cancer Institute. Bioassay of Aroclor 1254 for Possible Carcinogenicity. U.S. Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, MD 1977, Carcinogenesis Technical report serial number 38), DHEW Publication number (NIH) 78-838
  • Norback D. H., Weltman R. H. Poly chlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ. Health Perspect 1985; 60: 97
  • Morgan R. W., Ward J. M., Hartman P. E. Aroclor 1254-induced intestinal metaplasia and adenocarcinoma in the glandular stomach of F344 rats. Cancer Res 1981; 41: 5052
  • Ward J. M. Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254. Environ. Health Perspect 1985; 60: 89
  • U.S. National Cancer Institute. Bioassays of DDT, TDE, andp,p'-DDE for Possible Carcinogenicity, (Tech. Rep. No. 131; PB-286367). U.S. Department of Health, Education, and Welfare, National Institutes of Health, Bethesda, MD 1978
  • Ward J. ML, Lynch P., Riggs C. Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital. Cancer Lett 1988; 39: 9
  • Schaeffer E., Greim H., Goessner W. Pathology of chronic polychlorinated bi-phenyl (PCB) feeding in rats. Toxicol. Appl. Pharmacol 1984; 75: 278
  • Moore J. A., Hardisty J. F., Banas D. A., Smith M. A. A comparison of liver tumor diagnoses from seven PCB studies in rats. Regul. Toxicol. Pharmacol 1994; 20: 362
  • Hayes M. A., Lee G., Tatematsu M L, Farber E. Influences of diethylnitrosamine on longevity of surrounding hepatocytes and progression of transplanted persistent nodules during phenobarbital promotion of hepatocarcinogenesis. Int. J. Cancer 1987; 40: 58
  • Kerkvliet N. I., Kimeldod D. J. Antitumor activity of a polychlorinated biphenyl mixture, Aroclor 1254, in rats inoculated with Walker 256 carcinosarcoma cells. J. Natl. Cancer Inst 1977; 59: 951
  • Kerkvliet N. I., Kimeldorf D. J. Inhibition of tumor growth in rats by feeding a polychlorinated biphenyl, Aroclor 1254. Bull. Environ. Contam. Toxicol 1977; 18: 243
  • Innes J. R.ML, Ulland B. ML, Valerio M. G., Petrucelli L., Fishbein L., Hart E. R., Pallotta A. J., Bates R. R., Falk H. L., Gart J. J., Klein M L, Mitchell I., Peters J. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice. A preliminary note. J. Natl. Cancer Inst 1969; 42: 1101
  • Tarjan R., Kemeny T. Multigeneration studies on DDT in mice. Food Cosmet. Toxicol 1969; 7: 215
  • Tomatis L., Turusov V., Day N., Charles R. T. The effect of longterm exposure to DDT on CF-1 mice. Int. J. Cancer 1972; 10: 489
  • Turusov V. S., Day N. E., Tomatis L., Gati E., Charles R. T. Tumors in CF-1 mice exposed for six consecutive generations to DDT. J. Natl. Cancer Inst 1973; 51: 983
  • Radomski J. L., Deichmann W. B., MacDonald W. E., Glass E. M. Synergism among oral carcinogens. I. Results of simultaneous feeding of four tumorigens to rats. Toxicol. Appl. Pharmacol 1965; 1: 652
  • Deichmann W. B., Keplinger M., Sala F., Glass E. Synergism among oral carcinogens. IV. Simultaneous feeding of four tumorigens to rats. Toxicol. Appl. Pharmacol 1967; 11: 88
  • Cabral J. R., Hall R. K., Rossi L., Bronczyk S. A., Shubik P. Effects of long-term intake of DDT on rats. Tumorigenesis 1982; 68: 5
  • Terracini B., Cabral J. R., Testa M. C. (1973) A multigeneration study on the effect of continuous administration of DDT to BALB/c mice. Proceedings of the 8th Inter-American Conference on Toxicology: Pesticides and the Environment, A Continuing Controversy, Miami, Florida, 1973, W B. Deichmann. Intercontinental Medical Book Corp, New York, 77
  • Terracini B., Testa M. C., Cabral J. R., Day N. The effects of longterm feeding of DDT to BALB/c mice. Int. J. Cancer 1973; 11: 747
  • Thorpe E., Walker A. I. T. The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, B-BHC, and γ-BHC. Food Cosmet. Toxicol 1973; 11: 433
  • Walker A. I. T., Thorpe E., Stevenson D. E. The toxicology of dieldrin (HEOD). I. Long-term oral toxicity studies in mice. Food Cosmet. Toxicol 1973; 11: 415
  • Kashyap R., Nigam S. K., Karnik A. B., Gupta R. C., Chatterjee S. K. Carcinogenicity of DDT (dichlorodiphenyl trichloroethane) in pure inbred Swiss mice. Int. J. Cancer 1977; 19: 725
  • Graillot C., Gak J. C., Lancret C., Truhaut R. On the modes and mechanisms of toxic activity of organochlorine insecticides. II. Study in hamster of long-term toxicity of DDT (Fr). Eur. J. Toxicol 1975; 8: 353
  • Cabral J. R. P., Hall R. K., Rossi L., Bronczyk S. A., Shubik P. Lack of carcinogenicity of DDT in hamsters. Tumorigenesis 1982; 68: 5
  • Scribner J. D., Mottet N. K. DDT acceleration of mammary gland tumors induced in the male Sprague-Dawley rat by 2-acetamidophenanthrene. Carcinogenesis 1981; 2: 1235
  • Silinskas K. C., Okey A. B. Protection by 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (DDT) against mammary tumors and leukemia during prolonged feeding of 7,12-dimethylbenz[a]anthracene to female rats. J. Natl. Cancer Inst. 1975; 55: 653
  • Kociba R. J., Schwetz B. A. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Drug Metab. Rev 1982; 13: 387
  • Burg R. V. Toxicology updated—TCDD. J. Appl. Toxicol 1988; 8: 145
  • Flodström S., Hemming H., Wärngård L., Ahlborg U. G. Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis 1990; 11: 1413
  • Pitot H. C., Goldsworthy T., Campbell H. A., Poland A. Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis, from dimethylnitrosamine. Cancer Res 1980; 40: 3616
  • DiGiovanni J. A., Viaje D. L., Berry T. J., Slaga T. J., Juchau M. R. Tumor-initiating ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Arochlor 1254 in the two-stage system of mouse skin carcinogenesis. Bull. Environ. Contain. Toxicol. 1977; 18: 552
  • Poland A., Glover E. An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein ribosomal RNA and DNA. Cancer-Res 1979; 39: 3341
  • Wærn F., Flodström S., Busk L., Kronevi T., Nordgren I., Ahlborg U. G. Relative liver tumor promoting activity and toxicity of some polychlorinated dibenzo-p-dioxin-and dibenzofuran-congeners in female Sprague-Dawley rats. Pharmacol. Toxicol 1991; 69: 450
  • Poland A., Glover E., Kende A. S. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J. Biol. Chem 1976; 251: 4936
  • Whitlock J. P., Jr. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol 1990; 30: 251
  • Rao M. S., Reddy J. K. Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis 1987; 8: 631
  • Bradfield C. A., Glover E., Poland A. Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol. Pharmacol 1991; 39: 13
  • Lambert G. H., Humphrey H. E. B., Schoeller D. The effects of polybrominated biphenyls (PBB) on the human cytochrome P-450 system. Pediatr. Res 1987; 21: 258
  • Kamrin M. A., Fischer L. J. Workshop on human health impacts of halogenated biphenyls and related compounds. Environ. Health Perspect 1991; 91: 157
  • Lucier G. W., Tritscher A., Goldsworthy T., Foley J., Clark G., Goldstein J., Maronpot R. Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res 1991; 51: 1391
  • Schoeny R. S., Smith C. C., Loper J. C. Nonmutagenicity for Salmonella of the chlorinated hydrocarbons Aroclor 1254, 1,2,4-trichlorobenzene, Mirex, and Kepone. Mutat. Res 1979; 68: 125
  • Probst G. S., McMahon R. E., Hill L. E., Thompson C. Z., Epp J. K., Neal S. B. Chemically induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds. Environ, Mutagen 1981; 3: 11
  • Ames B. N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity testing. Mutat. Res 1975; 31: 347
  • Odashima S. The cooperative development in Japan of methods for screening chemicals for carcinogenicity. Screening Tests in Chemical Carcinogenesis, R Montesano, H Bartsch, L Tomatis. International Agency for Research on Cancer, LyonFrance 1976, Sci. Pub. No. 12
  • Sina J. F., Bean C. L., Dysart G. R., Taylor V. L., Bradley M. O. Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutat. Res 1983; 113: 357
  • Sargent L., Roloff B., Meisner L. In vitro chromosome damage due to PCB interactions. Mutat. Res 1989; 224: 79
  • Nishizumi M. Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital. Cancer Lett 1976; 2: 11
  • Preston B. D., Van Miller J. P., Moore R. W., Allen J. R. Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat. J. Natl. Cancer Inst 1981; 66: 509
  • Buchmann A., Ziegler S., Wolf A., Robertson L. W., Durham S. K., Schwarz M. Effects of polychlorinated biphenyls in rat liver: correlation between primary subcellular effects and promoting activity. Toxicol. Appl. Pharmacol 1991; 111: 454
  • Tatematsu M., Nakanishi K., Murasaki G., Miyata Y., Hirose M., Ito N. Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules byN-2-fluorenylacetamide in rats. J. Natl. Cancer Inst 1979; 63: 1411
  • Kimura N. T., Kanematsu T., Baba T. Polychlorinated biphenyl(s) as a promoter in experimental hepatocarcinogenesis in rats, Z Krebsforsch. Klin. Onkol 1976; 87: 257
  • Anderson L. M., Ward J. M., Fox S. D., Isaaq H. J., Riggs C. W. Effects of a single dose of polychlorinated biphenyls to infant mice onN-nitrosodimethylamine-initiated lung and liver tumors. Int. J. Cancer 1986; 38: 109
  • Peraino C., Fry R. J. M., Staffeldt E., Christopher J. P. Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin and dichlorodiphenyl-trichloroethane on 2-acetylaminofluorene-in-duced hepatic tumorigenesis in the rat. Cancer Res. 2884; 35: 1975
  • Lto N., Tsuda H., Hasegawa R., Imaida K. Comparison of the promoting effect of various agents in induction of preneoplastic lesions in rat liver. Environ. Health Perspect 1983; 50: 131
  • Weisburger J. H., Williams G. M. Chemical carcinogens. Casarett and Doull's Toxicology: The Basic Science of Poisons, C D. Klaassen, M O. Amdur, J Doull. Macmillan, New York 1986; 99
  • Trosko J. E., Chang C. C. Non-genotoxic mechanisms in carcinogenesis: role of inhibited intercellular communication. Banbury Report, Vol. 31, New directions in Qualitative and Quantitative Aspects in Carcinogen Risk Assessment, R W. Hart, R B. Setlow. Cold Spring Harbor Press, Cold Spring Harbor, NY 1988; 139
  • Sugie S., Mori H., Takahashi M. Effect of in vivo exposure to the liver tumor promoters phenobarbital or DDT on the gap junctions of rat hepatocytes: a quantitative freeze-fracture analysis. Carcinogenesis 1987; 8: 45
  • Mesnil M., Fitzgerald D. J., Yamasaki H. Phenobarbital specifically reduces gap junction protein mRNA level in rat liver. Mol. Carcinog 1988; 1: 79
  • Greenland S., Robins J. Invited commentary: ecologic studies—biases, misconceptions and counterexamples. Am. J. Epidemiol 1994; 139: 747
  • Hankey B. F., Miller B., Curtis R., Kosary C. Trends in breast cancer in younger women in contrast to older women. J. Natl. Cancer Inst 1994; 16: 7
  • Miller B. A., Feuer E. J., Hankey B. F. Recent incidence trends for breast cancer in women and the relevance of early detection: an update. Cancer Stat 1993; 43: 27
  • Devesa S. S., Pollack E. S., Young J. L., Jr. Assessing the validity of observed cancer incidence trends. Am. J. Epidemiol 1984; 119: 274
  • Kessler L. G., Feuer E. J., Brown M. L. Projections of the breast cancer burden to US women: 1990to 2000. Prev. Med. 1991; 20: 170
  • Parkin D. M., Muir C. S., Whelan S. L., Gao Y. T., Ferlay J., Powell J. Cancer Incidence in Five Continents. IARC (World Health Organization), LyonFrance 1992, Vol. VI, IARC, Sci. Publ. No. 120
  • Buell P. Changing incidence of breast cancer in Japanese-American women. J. Natl. Cancer Inst 1973; 51: 1479
  • Waterhouse J., Muir C., Shanmugaratnam K., Powell J. Cancer Incidence in Five Continents. IARC (World Health Organization), LyonFrance 1982; Vol. IV., IARC Sci. Publ. No. 42
  • Kelsey J. L. A review of the epidemiology of human breast cancer. Epidemiol. Rev 1979; 1: 74
  • Bertazzi P. A., Zocchetti C., Pesatori A. C., Guercilena S., Sanarico M., Radice L. Ten-year mortality study of the population involved in the Seveso Incident in 1976. Am. Z Epidemiol. 1989; 129: 1187
  • Bertazzi P. A., Pesatori A. C., Consonni D., Tironi A., Landi M. T., Zocchetti C. Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiology 1993; 4: 398
  • Westin J. B., Richter E. The Israeli breast-cancer anomaly. Ann. NY Acad. Sci 1990; 609: 269
  • Centers for Disease Control (CDC). Breast Cancer on Long Island, New York. Prepared for the New York State Department of Health. 1992, December
  • Melius J. M., Lewis-Michl E. L., Kallenbach L. R., Ju C. L., Talbot T. O., Orr M. F., Lauridsen P. E. Residence Near Industries and High Traffic Areas and the Risk of Breast Cancer on Long Island. 1994, Report from the NY State Department of Health
  • Modan B., Barell V., Lubin F., Modan M. Dietary factors and cancer in Israel. Cancer Res 1975; 35: 3503
  • Steinetz R., Parkin D. M., Young J. L., Bieber C. A., Katz L. Cancer Incidence in Jewish Migrants to Israel 1961-1981. IARC, LyonFrance 1989, IARC Sci. Publ. No. 98
  • Shames L. S., Munekata M. T., Pike M. C. Re: Blood levels of organochlorine residues and risk of breast cancer (correspondence). J. Natl. Cancer Inst 1994; 86: 1642
  • Hardell L., Sandström A. Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br. J. Cancer 1979; 39: 711
  • Eriksson M., Hardell L., Berg N. O., Moller T., Axelson O. Soft-tissue sarcomas and exposure to chemical substances: a case-referent study. Br. J. Ind. Med 1981; 38: 27
  • Balarajan R., Acheson E. Soft tissue sarcomas in agriculture and forestry workers. J. Epidemiol. Community Health 1984; 38: 113
  • Smith A. H., Pearce N. E., Fisher D. O., Giles H. J., Teague C. A., Howard J. K. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J. Natl. Cancer Inst 1984; 73: 1111
  • Hoar S. K., Blair A., Holmes F. F., Boysen C. D., Robel R. J., Hoover R., Fraumeni J. F., Jr. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 1986; 256: 1141
  • Vineis P., Terracini B., Ciccone G., Cignetti A., Colombo E., Donna A., Mafti L., Pisa R., Ricci P., Zanini E., Compa P. Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. Scand. J. Environ. Health 1986; 13: 9
  • Fingerhut M. A., Halperin W. E., Marlow D. A., Piacitelli L. A., Honchar P. A., Sweeney M. H., Greife A. L., Dill P. A., Steenland K., Suruda A. J. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N. Engl. J. Med 1991; 324: 212
  • Wasserman M., Nogueira D. P., Tomatis L., Mirra A. P., Shibata H., Arie G., Cucos S., Wasserman D. Organochlorine compounds in neoplastic and adjacent apparently normal breast tissue. Bull. Environ. Contam. Toxicol 1976; 15: 478
  • Unger M., Kiaer H., Blichert-Toft M., Olsen J., Clausen J. Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery. Environ. Res 1984; 34: 24
  • Mussalo-Rauhamaa H., Hasanen E., Pyysalo H., Antervo K., Kauppila R., Pantzar P. Occurrence of β-hexachlorocyclohexane in breast cancer patients. Cancer 1990; 66: 2124
  • Falck F., Ricci A., Jr., Wolff M. S., Godbold J., Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch. Environ. Health 1992; 47: 143
  • Wolff M. S., Toniolo P. G., Lee E. W., Rivera M., Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J. Natl. Cancer Inst 1993; 85: 648
  • Dewailly E., Dodin S., Verreault R., Ayotte P., Sauve L., Morin J., Brisson J. High organochlorine body burden in women with estrogen receptor positive breast cancer. J. Natl. Cancer Inst 1994; 86: 232
  • Krieger N., Wolff M. S., Hiatt R. A., Rivera M., Vogelman J., Orentreich N. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J. Natl. Cancer Inst 1994; 86: 589
  • Lynge E. A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark. Br. J. Cancer 1985; 52: 259
  • Manz A., Berger J., Dwyer J. H., Flesch-Janys D., Nagel S., Waltsgott H. Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet 1991; 338: 959
  • Saracci R., Kogevinas M., Bertazzi P.-A, Bueno de Mesquita B. H., Coggon D., Green L. M., Kauppinen T., L'Abbe K. A., Littorin M., Lynge E., Mathews J. D., Neuberger M., Osman J., Pearce N., Winkelman R. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenyls. Lancet 1027; 338: 1991
  • Flesch-Janys D., Berger J., Manz A., Nagel S., Ollroge L. Exposure to polychlorinated dibenzo-p-dioxins and-furans and breast cancer in a cohort of female workers of a herbicide producing plant in Hamburg, FRG. Organohalogen Compounds, Vol. 13, Human Exposure, Toxicology, Epidemiology, H Fiedler, H Frank, O Hutzinger, W Parzefall, A Riss, S Safe, Vienna 1993, 13th International on Chlorinated Dioxins and Related Compounds
  • Kogevinas M., Saracci R., Bertazzi P. A., Bueno de Mesquita B. H., Coggon D., Green L. M., Kauppinen T., Littorin M., Lynge M., Mathews J. D., Neuberger M., Osman J., Pearce N., Winkelmann R. Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols. Chemosphere 1992; 25: 1071
  • Brown D. P. Mortality of workers exposed to polychlorinated biphenyls—an update. Arch. Environ. Health 1987; 42: 333
  • Industrial Disease Standards Panel (IDSP). Report to the workers' compensation board on occupational exposure to PCBs and various cancers. Toronto, Ontario 1987, IDSP Rep. No. 2
  • Lynge E. Cancer in phenoxy herbicide manufacturing workers in Denmark, 1947-87—an update. Cancer Causes Control 1993; 4: 261
  • Sinks T., Steele G., Smith A. B., Watkins K., Shults R. A. Mortality among workers exposed to polychlorinated biphenyls. Am. J. Epidemiol 1992; 136: 389
  • Bertazzi P. A., Riboldi L., Pesatori A., Radice L., Zocchetti C. Cancer mortality of capacitor manufacturing workers. Am. J. Ind. Med 1987; 11: 165
  • Kelsey J. L., Thompson W. D., Evans A. S. Methods in Observational Epidemiology. Oxford University Press, New York 1986
  • Toniolo P. G., Pasternack B. S., Shore R. E., Sonnenschein E., Koenig K. L., Rosenberg C., Strax P., Strax S. Endogenous hormones and breast cancer: a prospective cohort study. Breast Cancer Res. Treat. 1991; 18: S23
  • Adami H. O., Lipworth L., Titus-Ernstoff L., Hsieh C. C., Hanberg A., Ahlborg U., Baron J., Trichopoulos D. Organochlorine compounds and estrogen-related cancers in women. Cancer Causes Control., in press
  • Rothman K. J., Boice J. D. Epidemiologic Analysis with a Programmable Calculator. Epidemiology Resources Inc., Chestnut Hill, MA. 1982; 29
  • Key T., Reeves G. Organochlorines in the environment and breast cancer. Br. Med. J 1994; 308: 1520
  • MaJone K. E., Daling J. R., Weiss N. R. Oral contraceptives in relation to breast cancer. Epidemiol Rev 1993; 15: 80
  • Brinton L. A., Schairer C. Estrogen replacement therapy and breast cancer risk. Epidemiol. Rev 1993; 15: 66
  • Ames B. N., Magaw R., Gold L. S. Ranking possible carcinogenic hazards. Science 1987; 236: 271
  • MacMahon B. Pesticide residues and breast cancer? (editorial). J. Natl. Cancer Inst. 1994; 86: 572
  • Wolff M. S., Toniolo P. G. Re: DDT and hreast cancer (correspondence). J. Natl. Cancer Inst. 1095; 86: 1994
  • Kelsey J. L. Breast cancer. Epidemiol. Rev 1993; 15: 1
  • Lipworth L. Epidemiology of breast cancer. Eur. J. Cancer Prev 1995; 4: 7
  • Kelsey J. L. Breast cancer epidemiology: Summary and future directions. Epidemiol. Rev 1993; 15: 156
  • Adami H. O., Persson O., Ekbom A., Wolk A., Pontén J., Trichopoulos D. The aetiology and pathogenesis of human breast cancer. Mutat. Res., in press
  • Adami H. O., Persson I. Hormone replacement and breast cancer—a remaining controversy? (Editorial). JAMA 1995; 274: 178
  • Parazzini F., La Vecchia C., Bocciolone L., Franceschi S. Review. The epidemiology of endometrial cancer. Gynecol. Oncol 1991; 41: 1
  • Herrington L. J., Weiss N. S. Postmenopausal unopposed estrogens. Characteristics of use in relation to the risk of endometrial carcinoma, Ann. Epidemiol 1993; 3: 308
  • Steinberg K. K., Smith S. J., Thacker S. B., Stroup D. F. Breast cancer risk and duration of estrogen use: the role of study design in metaanalysis. Epidemiology 1994; 5: 415
  • Coleman M. P., Esteve J., Damiecki P., Arslan A., Renard H. Trends in Cancer Incidence and Mortality. IARC, LyonFrance 1993, IARC Sci. Publ. No. 121
  • Persson L., Schmidt M., Adami H. O., Bergström R., Pettersson B., Sparen P. Trends in endometrial cancer incidence and mortality in Sweden, 1960-1984. Cancer Causes Control 1990; 1: 201
  • Jick H., Walker A. M., Rothman K. J. The epidemic of endometrial cancer: a commentary. Am. J. Public Health 1980; 70: 264
  • Austin D. F., Roe K. M. The decreasing incidence of endometrial cancer: public health implications. Am. J. Public Health 1982; 72: 65
  • Goldman M. B., Cramer D. W. The epidemiology of endometriosis. Current Concepts in Endometriosis. Alan R. Liss Inc., New York 1990; 15
  • Wheeler J. M. Epidemiology and prevalence of endometriosis. Infertil. Reprod. Med. Clin. N. Am 1992; 3: 545
  • Dizerega G. S., Barber D. L., Hodgen G. D. Endometriosis: role of ovarian steroids in initiation, maintenance, and suppression. Fertil. Steril 1980; 33: 649
  • Dmowski W. P., Steele R. W., Baker G. F. Deficient cellular immunity in endometriosis. Am. J. Obstet. Gynecol 1981; 141: 377
  • Dmowski W. P., Braun D., Gebel H. The immune system in endometriosis. Modern Approaches to Endometriosis, E J. Thomas, J A. Rock. Kluwer Academic, Boston 1991; 97
  • Hill J. A. Immunologic factors in endometriosis and endometriosis-associated reproductive failure. Infertil. Reprod. Med. Clin. N. Am 1992; 3: 583
  • Rier S. E., Martin D. C., Bowman R. E., Dmowski P., Becker J. L. Endometriosis in Rhesus monkeys (Macaca mulatto) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam. Appl. Toxicol 1993; 21: 433
  • Jones M. K., Weisenburger W. P., Sipes I. G., Russel D. H. Circadian alteration in prolactin, corticosterone, and thyroid hormone levels and downregulation of prolactin receptor activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol 1987; 87: 337
  • Allen J. R., Barsotti D. A., Lambrecht L. K., Van Miller J. P. Reproductive effects of halogenated aromatic hydrocarbons on nonhuman primates. Ann. NY Acad. Sci 1979; 320: 419
  • Bowman R. E., Schantz S. L., Weerasinghe M. C. A., Gross M. L., Barsotti D. A. Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimates of reproductive toxicity. Chemosphere 1989; 18: 243
  • Faith R. E., Luster M. L. Investigations on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on parameters of various immune functions. Ann. NY Acad. Sci 1979; 320: 564
  • Neubert R., Jacob-Muller U., Helge H., Stahlmann R., Neubert D. Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. Arch. Toxicol 1991; 65: 213
  • Tomar R. S., Kerkvliet N. I. Reduced T-helper cell function in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD). Toxicol. Lett 1991; 57: 55
  • Campbell J. S., Wong J., Tryphonas L., Arnold D. L., Nera E., Cross B., LaBossiere E. Is Simian Endometriosis an Effect of Immunotoxicity?. Paper presented at the Ontario Association of Pathologists 48th Annual Meeting, London, Ontario, 1985
  • Gerhard L., Runnebaum B. Fertility disorders may result from heavy metal and pesticide contamination which limits effectiveness of hormone therapy (German). Zent. bl Gynakol 1992; 114: 593
  • Vaz R. Organochlorine Contaminants in Swedish Foods of Animal Origin and in Human Milk 1973-1992. Ph.D. thesis, Swedish University of Agricultural Science, UppsalaSweden 1993
  • U. S. FDA. Food and Drug Administration Pesticide Program, Residues in Foods 1990. Food and Drug Administration, Washington, DC 1990
  • Safe S. H. Environmental and dietary estrogens and human health: is there a problem?. Environ. Health Perspect 1995; 103: 346
  • McCarthy M. Dioxin's health effects (News). Lancet 1994; 344: 876

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