2,888
Views
169
CrossRef citations to date
0
Altmetric
Review Article

NF-Y and the transcriptional activation of CCAAT promoters

, &
Pages 29-49 | Received 16 Jun 2011, Accepted 29 Sep 2011, Published online: 03 Nov 2011

References

  • Abnizova I, Walter K, Te Boekhorst R, Elgar G, Gilks WR. 2007. Statistical information characterization of conserved non-coding elements in vertebrates. J Bioinform Comput Biol 5:533–547.
  • Alabert C, Rogers L, Kahn L, Niellez S, Fafet P, Cerulis S, Blanchard JM, Hipskind RA, Vignais ML. 2006. Cell type-dependent control of NF-Y activity by TGF-beta. Oncogene 25:3387–3396.
  • Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty AH, Okazaki H, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N. 2000. Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. J Biol Chem 275:31078–31085.
  • Attwooll C, Lazzerini Denchi E, Helin K. 2004. The E2F family: Specific functions and overlapping interests. EMBO J 23:4709–4716.
  • Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T. 2010. A human MAP kinase interactome. Nat Methods 7:801–805.
  • Baxevanis AD, Arents G, Moudrianakis EN, Landsman D. 1995. A variety of DNA-binding and multimeric proteins contain the histone fold motif. Nucleic Acids Res 23:2685–2691.
  • Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R. 1997. CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues. Nucleic Acids Res 25:2174–2181.
  • Benatti P, Basile V, Merico D, Fantoni LI, Tagliafico E, Imbriano C. 2008. A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response. Nucleic Acids Res 36:1415–1428.
  • Benatti P, Dolfini D, Viganò A, Ravo M, Weisz A, Imbriano C. 2011. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res 39:5356–5368.
  • Bernadt CT, Nowling T, Wiebe MS, Rizzino A. 2005. NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner. Gene Expr 12:193–212.
  • Bevilacqua MA, Faniello MC, Iovine B, Russo T, Cimino F, Costanzo F. 2002. Transcription factor NF-Y regulates differentiation of CaCo-2 cells. Arch Biochem Biophys 407:39–44.
  • Bhattacharya A, Deng JM, Zhang Z, Behringer R, de Crombrugghe B, Maity SN. 2003. The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation. Cancer Res 63:8167–8172.
  • Bi W, Wu L, Coustry F, de Crombrugghe B, Maity SN. 1997. DNA binding specificity of the CCAAT-binding factor CBF/NF-Y. J Biol Chem 272:26562–26572.
  • Bieda M, Xu X, Singer MA, Green R, Farnham PJ. 2006. Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res 16:595–605.
  • Blais A, Dynlacht BD. 2004. Hitting their targets: An emerging picture of E2F and cell cycle control. Curr Opin Genet Dev 14:527–532.
  • Blum R, Elkon R, Yaari S, Zundelevich A, Jacob-Hirsch J, Rechavi G, Shamir R, Kloog Y. 2007. Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). Cancer Res 67:3320–3328.
  • Blum R, Gupta R, Burger PE, Ontiveros CS, Salm SN, Xiong X, Kamb A, Wesche H, Marshall L, Cutler G, Wang X, Zavadil J, Moscatelli D, Wilson EL. 2009. Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. PLoS ONE 4:e5722.
  • Bolognese F, Imbriano C, Caretti G, Mantovani R. 2000. Cloning and characterization of the histone-fold proteins YBL1 and YCL1. Nucleic Acids Res 28:3830–3838.
  • Bonander N, Ferndahl C, Mostad P, Wilks MD, Chang C, Showe L, Gustafsson L, Larsson C, Bill RM. 2008. Transcriptome analysis of a respiratory Saccharomyces cerevisiae strain suggests the expression of its phenotype is glucose insensitive and predominantly controlled by Hap4, Cat8 and Mig1. BMC Genomics 9:365.
  • Bouatia-Naji N, Bonnefond A, Baerenwald DA, Marchand M, Bugliani M, Marchetti P, Pattou F, Printz RL, Flemming BP, Umunakwe OC, Conley NL, Vaxillaire M, Lantieri O, Balkau B, Marre M, Lévy-Marchal C, Elliott P, Jarvelin MR, Meyre D, Dina C, Oeser JK, Froguel P, O’Brien RM. 2010. Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes 59:2662–2671.
  • Boucher PD, Piechocki MP, Hines RN. 1995. Partial characterization of the human CYP1A1 negatively acting transcription factor and mutational analysis of its cognate DNA recognition sequence. Mol Cell Biol 15:5144–5151.
  • Bourgarel D, Nguyen CC, Bolotin-Fukuhara M. 1999. HAP4, the glucose-repressed regulated subunit of the HAP transcriptional complex involved in the fermentation-respiration shift, has a functional homologue in the respiratory yeast Kluyveromyces lactis. Mol Microbiol 31:1205–1215.
  • Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S. 2009. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci USA 106:22480–22485.
  • Buchmueller KL, Taherbhai Z, Howard CM, Bailey SL, Nguyen B, O’Hare C, Hochhauser D, Hartley JA, Wilson WD, Lee M. 2005. Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene. Chembiochem 6:2305–2311.
  • Buschlen S, Amillet JM, Guiard B, Fournier A, Marcireau C, Bolotin-Fukuhara M. 2003. The S. Cerevisiae HAP complex, a key regulator of mitochondrial function, coordinates nuclear and mitochondrial gene expression. Comp Funct Genomics 4:37–46.
  • Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM. 2002. The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci USA 99:11700–11705.
  • Cagen LM, Deng X, Wilcox HG, Park EA, Raghow R, Elam MB. 2005. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem J 385:207–216.
  • Calvo A, Perez-Stable C, Segura V, Catena R, Guruceaga E, Nguewa P, Blanco D, Parada L, Reiner T, Green JE. 2010. Molecular characterization of the Ggamma-globin-Tag transgenic mouse model of hormone refractory prostate cancer: Comparison to human prostate cancer. Prostate 70:630–645.
  • Campanero MR, Herrero A, Calvo V. 2008. The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. Oncogene 27:1263–1272.
  • Cao AR, Rabinovich R, Xu M, Xu X, Jin VX, Farnham PJ. 2011. Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem 286:11985–11996.
  • Caretti G, Cocchiarella F, Sidoli C, Villard J, Peretti M, Reith W, Mantovani R. 2000. Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter. J Mol Biol 302:539–552.
  • Caretti G, Motta MC, Mantovani R. 1999. NF-Y associates with H3-H4 tetramers and octamers by multiple mechanisms. Mol Cell Biol 19:8591–8603.
  • Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R. 2003. Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters. J Biol Chem 278:30435–30440.
  • Ceribelli M, Alcalay M, Viganò MA, Mantovani R. 2006. Repression of new p53 targets revealed by ChIP on chip experiments. Cell Cycle 5:1102–1110.
  • Ceribelli M, Benatti P, Imbriano C, Mantovani R. 2009. NF-YC complexity is generated by dual promoters and alternative splicing. J Biol Chem 284:34189–34200.
  • Ceribelli M, Dolfini D, Merico D, Gatta R, Viganò AM, Pavesi G, Mantovani R. 2008. The histone-like NF-Y is a bifunctional transcription factor. Mol Cell Biol 28:2047–2058.
  • Chae HD, Yun J, Bang YJ, Shin DY. 2004. Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions. Oncogene 23:4084–4088.
  • Chalmel F, Rolland AD, Niederhauser-Wiederkehr C, Chung SS, Demougin P, Gattiker A, Moore J, Patard JJ, Wolgemuth DJ, Jégou B, Primig M. 2007. The conserved transcriptome in human and rodent male gametogenesis. Proc Natl Acad Sci USA 104:8346–8351.
  • Chan QK, Lam HM, Ng CF, Lee AY, Chan ES, Ng HK, Ho SM, Lau KM. 2010. Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ 17:1511–1523.
  • Chassanidis C, Kalamaras A, Phylactides M, Pourfarzad F, Likousi S, Maroulis V, Papadakis MN, Vamvakopoulos NK, Aleporou-Marinou V, Patrinos GP, Kollia P. 2009. The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter. Ann Hematol 88:549–555.
  • Chattopadhyay C, Hawke D, Kobayashi R, Maity SN. 2004. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res 32:3632–3641.
  • Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT. 2011. Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIa and drug responsiveness. Mol Pharmacol 79:735–741.
  • Chen F, Ogawa K, Liu X, Stringfield TM, Chen Y. 2002. Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit. Biochem J 364:571–577.
  • Chen XW, Mo QH, Li Q, Zeng R, Xu XM. 2007. A novel mutation of -73(A–>T) in the CCAAT box of the beta-globin gene identified in a patient with the mild beta-thalassemia intermedia. Ann Hematol 86:653–657.
  • Chen YH, Lin YT, Lee GH. 2009. Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. Bone 44:777–784.
  • Chen-Plotkin AS, Sadri-Vakili G, Yohrling GJ, Braveman MW, Benn CL, Glajch KE, DiRocco DP, Farrell LA, Krainc D, Gines S, MacDonald ME, Cha JH. 2006. Decreased association of the transcription factor Sp1 with genes downregulated in Huntington’s disease. Neurobiol Dis 22:233–241.
  • Chodosh LA, Olesen J, Hahn S, Baldwin AS, Guarente L, Sharp PA. 1988. A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53:25–35.
  • Corona DF, Eberharter A, Budde A, Deuring R, Ferrari S, Varga-Weisz P, Wilm M, Tamkun J, Becker PB. 2000. Two histone fold proteins, CHRAC-14 and CHRAC-16, are developmentally regulated subunits of chromatin accessibility complex (CHRAC). EMBO J 19:3049–3059.
  • Coustry F, Maity SN, Sinha S, de Crombrugghe B. 1996. The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit. J Biol Chem 271:14485–14491.
  • Currie RA. 1998. NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF. J Biol Chem 273:1430–1434.
  • Deng H, Sun Y, Zhang Y, Luo X, Hou W, Yan L, Chen Y, Tian E, Han J, Zhang H. 2007. Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5. Dev Biol 308:583–592.
  • DeRisi JL, Iyer VR, Brown PO. 1997. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680–686.
  • Dervan PB, Edelson BS. 2003. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol 13:284–299.
  • de Silvio A, Imbriano C, Mantovani R. 1999. Dissection of the NF-Y transcriptional activation potential. Nucleic Acids Res 27:2578–2584.
  • Dolfini D, Zambelli F, Pavesi G, Mantovani R. 2009. A perspective of promoter architecture from the CCAAT box. Cell Cycle 8:4127–4137.
  • Domashenko AD, Danet-Desnoyers G, Aron A, Carroll MP, Emerson SG. 2010. TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells. Blood 116:2676–2683.
  • Donati G, Gatta R, Dolfini D, Fossati A, Ceribelli M, Mantovani R. 2008. An NF-Y-dependent switch of positive and negative histone methyl marks on CCAAT promoters. PLoS ONE 3:e2066.
  • Donati G, Imbriano C, Mantovani R. 2006. Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters. Nucleic Acids Res 34:3116–3127.
  • Dorn A, Bollekens J, Staub A, Benoist C, Mathis D. 1987. A multiplicity of CCAAT box-binding proteins. Cell 50:863–872.
  • Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG. 2006. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13:713–719.
  • Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D. 2002. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington’s disease. Science 296:2238–2243.
  • Eggen BJ, Benus GF, Folkertsma S, Jonk LJ, Kruijer W. 2001. TAK1 activation of the mouse JunB promoter is mediated through a CCAAT box and NF-Y. FEBS Lett 506:267–271.
  • Elkon R, Linhart C, Sharan R, Shamir R, Shiloh Y. 2003. Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. Genome Res 13:773–780.
  • Ericsson J, Jackson SM, Lee BC, Edwards PA. 1996. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc Natl Acad Sci USA 93:945–950.
  • Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q. 2002. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. J Biol Chem 277:8061–8067.
  • Fang X, Han H, Stamatoyannopoulos G, Li Q. 2004. Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. J Biol Chem 279:5444–5449.
  • Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F. 1999. The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300. J Biol Chem 274:7623–7626.
  • Faniello MC, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua MA, Baudi F, Colantuoni V, Cimino F, Venuta S, Avvedimento VE, Costanzo F. 2002. An alternative model of H ferritin promoter transactivation by c-Jun. Biochem J 363:53–58.
  • Faniello MC, Fregola A, Nisticò A, Quaresima B, Crugliano T, Faraonio R, Puzzonia P, Baudi F, Parlato G, Cuda G, Morrone G, Venuta S, Costanzo F. 2006. Detection and functional analysis of an SNP in the promoter of the human ferritin H gene that modulates the gene expression. Gene 377:1–5.
  • Farina A, Manni I, Fontemaggi G, Tiainen M, Cenciarelli C, Bellorini M, Mantovani R, Sacchi A, Piaggio G. 1999. Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex. Oncogene 18:2818–2827.
  • Farsetti A, Narducci M, Moretti F, Nanni S, Mantovani R, Sacchi A, Pontecorvi A. 2001. Inhibition of ERalpha-mediated trans-activation of human coagulation factor XII gene by heteromeric transcription factor NF-Y. Endocrinology 142:3380–3388.
  • Finch JS, Rosenberger SF, Martinez JD, Bowden GT. 2001. Okadaic acid induces transcription of junB through a CCAAT box and NF-Y. Gene 267:135–144.
  • FitzGerald PC, Shlyakhtenko A, Mir AA, Vinson C. 2004. Clustering of DNA sequences in human promoters. Genome Res 14:1562–1574.
  • Fontanesi F, Jin C, Tzagoloff A, Barrientos A. 2008. Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells. Hum Mol Genet 17:775–788.
  • Forget BG. 1998. Molecular basis of hereditary persistence of fetal hemoglobin. Ann N Y Acad Sci 850:38–44.
  • Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. 2010. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS ONE 5:e8785.
  • Forsburg SL, Guarente L. 1989. Identification and characterization of HAP4: A third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev 3:1166–1178.
  • Fossati A, Dolfini D, Donati G, Mantovani R. 2011. NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters. PLoS ONE 6:e17220.
  • Franks A, Tronrud C, Kiakos K, Kluza J, Munde M, Brown T, Mackay H, Wilson WD, Hochhauser D, Hartley JA, Lee M. 2010. Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide. Bioorg Med Chem 18:5553–5561.
  • Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW. 2002. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res 62:3377–3381.
  • Frontini M, Imbriano C, diSilvio A, Bell B, Bogni A, Romier C, Moras D, Tora L, Davidson I, Mantovani R. 2002. NF-Y recruitment of TFIID, multiple interactions with histone fold TAF(II)s. J Biol Chem 277:5841–5848.
  • Frontini M, Imbriano C, Manni I, Mantovani R. 2004. Cell cycle regulation of NF-YC nuclear localization. Cell Cycle 3:217–222.
  • Gangloff YG, Romier C, Thuault S, Werten S, Davidson I. 2001. The histone fold is a key structural motif of transcription factor TFIID. Trends Biochem Sci 26:250–257.
  • Gatta R, Mantovani R. 2008. NF-Y substitutes H2A-H2B on active cell-cycle promoters: Recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res 36:6592–6607.
  • Gatta R, Mantovani R. 2010. Single nucleosome ChIPs identify an extensive switch of acetyl marks on cell cycle promoters. Cell Cycle 9:2149–2159.
  • Gatta R, Mantovani R. 2011. NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters. Epigenetics 6:526–534.
  • Ge Y, Jensen TL, Matherly LH, Taub JW. 2002. Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1. Biochim Biophys Acta 1579:73–80.
  • Ge Y, Matherly LH, Taub JW. 2001. Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter. J Biol Chem 276:43570–43579.
  • Gilthorpe J, Vandromme M, Brend T, Gutman A, Summerbell D, Totty N, Rigby PW. 2002. Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY. Development 129:3887–3899.
  • Goda H, Nagase T, Tanoue S, Sugiyama J, Steidl S, Tüncher A, Kobayashi T, Tsukagoshi N, Brakhage AA, Kato M. 2005. Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunit. Arch Microbiol 184:93–100.
  • Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA. 2011. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene 30:3745–3754.
  • Goodarzi H, Elemento O, Tavazoie S. 2009. Revealing global regulatory perturbations across human cancers. Mol Cell 36:900–911.
  • Gorshkova EV, Kaledin VI, Kobzev VF, Merkulova TI. 2006. Lung cancer-associated SNP at the beginning of mouse k-ras gene intron 2 is essential for transcription factor binding. Bull Exp Biol Med 141:731–733.
  • Gowri PM, Yu JH, Shaufl A, Sperling MA, Menon RK. 2003. Recruitment of a repressosome complex at the growth hormone receptor promoter and its potential role in diabetic nephropathy. Mol Cell Biol 23:815–825.
  • Grindlay GJ, Campo MS, O’Brien V. 2005. Transactivation of the cyclin A promoter by bovine papillomavirus type 4 E5 protein. Virus Res 108:29–38.
  • Grskovic M, Chaivorapol C, Gaspar-Maia A, Li H, Ramalho-Santos M. 2007. Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells. PLoS Genet 3:e145.
  • Gurtner A, Fuschi P, Magi F, Colussi C, Gaetano C, Dobbelstein M, Sacchi A, Piaggio G. 2008. NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue. PLoS ONE 3:e2047.
  • Gurtner A, Fuschi P, Martelli F, Manni I, Artuso S, Simonte G, Ambrosino V, Antonini A, Folgiero V, Falcioni R, Sacchi A, Piaggio G. 2010. Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation. Cancer Res 70:9711–9720.
  • Gurtner A, Manni I, Fuschi P, Mantovani R, Guadagni F, Sacchi A, Piaggio G. 2003. Requirement for down-regulation of the CCAAT-binding activity of the NF-Y transcription factor during skeletal muscle differentiation. Mol Biol Cell 14:2706–2715.
  • Habib SL, Riley DJ, Mahimainathan L, Bhandari B, Choudhury GG, Abboud HE. 2008. Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 294:F281–F290.
  • Habib SL. 2009. Molecular mechanism of regulation of OGG1: Tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA. J Mol Signal 4:8.
  • Hackzell A, Uramoto H, Izumi H, Kohno K, Funa K. 2002. p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y. J Biol Chem 277:39769–39776.
  • Hahn S, Pinkham J, Wei R, Miller R, Guarente L. 1988. The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Mol Cell Biol 8:655–663.
  • Häkkinen A, Healy S, Jacobs HT, Ribeiro AS. 2011. Genome wide study of NF-Y type CCAAT boxes in unidirectional and bidirectional promoters in human and mouse. J Theor Biol 281:74–83.
  • Halperin Y, Linhart C, Ulitsky I, Shamir R. 2009. Allegro: Analyzing expression and sequence in concert to discover regulatory programs. Nucleic Acids Res 37:1566–1579.
  • Harari O, Liao JK. 2004. Inhibition of MHC II gene transcription by nitric oxide and antioxidants. Curr Pharm Des 10:893–898.
  • Hartlepp KF, Fernández-Tornero C, Eberharter A, Grüne T, Müller CW, Becker PB. 2005. The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions. Mol Cell Biol 25:9886–9896.
  • Hatamochi A, Golumbek PT, Van Schaftingen E, de Crombrugghe B. 1988. A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem 263:5940–5947.
  • Henry JA, Le NM, Nguyen B, Howard CM, Bailey SL, Horick SM, Buchmueller KL, Kotecha M, Hochhauser D, Hartley JA, Wilson WD, Lee M. 2004. Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: Design, synthesis, molecular biology, and biophysical studies. Biochemistry 43:12249–12257.
  • Hewetson A, Chilton BS. 2003. An Sp1-NF-Y/progesterone receptor DNA binding-dependent mechanism regulates progesterone-induced transcriptional activation of the rabbit RUSH/SMARCA3 gene. J Biol Chem 278:40177–40185.
  • Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, Kajitani T, Sekiguchi T, Yoshino M, Shigematsu Y, Mayumi M, Miyamoto K. 2002. Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Gene 290:107–114.
  • Hirose T, Sowa Y, Takahashi S, Saito S, Yasuda C, Shindo N, Furuichi K, Sakai T. 2003. p53-independent induction of Gadd45 by histone deacetylase inhibitor: Coordinate regulation by transcription factors Oct-1 and NF-Y. Oncogene 22:7762–7773.
  • Hochhauser D, Kotecha M, O’hare C, Morris PJ, Hartley JM, Taherbhai Z, Harris D, Forni C, Mantovani R, Lee M, Hartley JA. 2007. Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide. Mol Cancer Ther 6:346–354.
  • Hooft van Huijsduijnen RA, Bollekens J, Dorn A, Benoist C, Mathis D. 1987. Properties of a CCAAT box-binding protein. Nucleic Acids Res 15:7265–7282.
  • Huang W, Zhao S, Ammanamanchi S, Brattain M, Venkatasubbarao K, Freeman JW. 2005. Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. J Biol Chem 280:10047–10054.
  • Huang Y, Chuang AY, Romano RA, Liégeois NJ, Sinha S, Trink B, Ratovitski E, Sidransky D. 2010a. Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure. Cell Cycle 9:328–338.
  • Huang Y, Ratovitski EA. 2010b. Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation. J Biol Chem 285:41422–41431.
  • Huang S, Ling JJ, Yang S, Li XJ, Li S. 2011. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain 134:1943–1958.
  • Huo H, Magro PG, Pietsch EC, Patel BB, Scotto KW. 2010. Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance. Cancer Res 70:8726–8735.
  • Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R. 2001. HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes. J Biol Chem 276:26332–26339.
  • Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R. 2005. Direct p53 transcriptional repression: In vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol 25:3737–3751.
  • Ito Y, Zhang Y, Dangaria S, Luan X, Diekwisch TG. 2011. NF-Y and USF1 transcription factor binding to CCAAT-box and E-box elements activates the CP27 promoter. Gene 473:92–99.
  • Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K. 2001. Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. J Cell Sci 114:1533–1544.
  • Jääskeläinen T, Huhtakangas J, Mäenpää PH. 2005. Negative regulation of human parathyroid hormone gene promoter by vitamin D3 through nuclear factor Y. Biochem Biophys Res Commun 328:831–837.
  • Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ. 2009. Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 106:73–82.
  • Jin S, Gorfajn B, Faircloth G, Scotto KW. 2000. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. Proc Natl Acad Sci USA 97:6775–6779.
  • Jin S, Scotto KW. 1998. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol Cell Biol 18:4377–4384.
  • Jung MS, Yun J, Chae HD, Kim JM, Kim SC, Choi TS, Shin DY. 2001. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene 20:5818–5825.
  • Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kielbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling S, Sers C, Royer HD, Herzel H, Schäfer R. 2010. Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. PLoS Genet 6:e1001231.
  • Kabe Y, Yamada J, Uga H, Yamaguchi Y, Wada T, Handa H. 2005. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol 25:512–522.
  • Kaczynski J, Cook T, Urrutia R. 2003. Sp1- and Krüppel-like transcription factors. Genome Biol 4:206.
  • Kahle J, Baake M, Doenecke D, Albig W. 2005. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol 25:5339–5354.
  • Kahle J, Piaia E, Neimanis S, Meisterernst M, Doenecke D. 2009. Regulation of nuclear import and export of negative cofactor 2. J Biol Chem 284:9382–9393.
  • Kamada K, Shu F, Chen H, Malik S, Stelzer G, Roeder RG, Meisterernst M, Burley SK. 2001. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. Cell 106:71–81.
  • Kang JH, Kim MJ, Chang SY, Sim SS, Kim MS, Jo YH. 2008. CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. J Cell Biochem 104:1192–1203.
  • Kato M. 2005. An overview of the CCAAT-box binding factor in filamentous fungi: Assembly, nuclear translocation, and transcriptional enhancement. Biosci Biotechnol Biochem 69:663–672.
  • Kato T, Shimono Y, Hasegawa M, Jijiwa M, Enomoto A, Asai N, Murakumo Y, Takahashi M. 2009. Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. Cancer Res 69:3597–3604.
  • Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G. 2011. Transforming growth factor-ß signaling in motor neuron diseases. Curr Mol Med 11:48–56.
  • Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G. 2010. Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. J Neurosci 30:5702–5712.
  • Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K. 2003. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Biochem J 373:747–757.
  • Kel AE, Kel-Margoulis OV, Farnham PJ, Bartley SM, Wingender E, Zhang MQ. 2001. Computer-assisted identification of cell cycle-related genes: New targets for E2F transcription factors. J Mol Biol 309:99–120.
  • Kim CG, Sheffery M. 1990. Physical characterization of the purified CCAAT transcription factor, alpha-CP1. J Biol Chem 265:13362–13369.
  • Kim DS, Takai H, Arai M, Araki S, Mezawa M, Kawai Y, Murota K, Terao J, Ogata Y. 2007. Effects of quercetin and quercetin 3-glucuronide on the expression of bone sialoprotein gene. J Cell Biochem 101:790–800.
  • Kim IS, Sinha S, de Crombrugghe B, Maity SN. 1996. Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Mol Cell Biol 16:4003–4013.
  • Kim JH, Lee JN, Paik YK. 2001. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. J Biol Chem 276:18153–18160.
  • Koehler AN, Shamji AF, Schreiber SL. 2003. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. J Am Chem Soc 125:8420–8421.
  • Koszewski NJ, Alimov AP, Park-Sarge OK, Malluche HH. 2004. Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element. J Biol Chem 279:42431–42437.
  • Kotecha M, Kluza J, Wells G, O’Hare CC, Forni C, Mantovani R, Howard PW, Morris P, Thurston DE, Hartley JA, Hochhauser D. 2008. Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Mol Cancer Ther 7:1319–1328.
  • Kwon HS, Huang B, Ho Jeoung N, Wu P, Steussy CN, Harris RA. 2006. Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta 1759:141–151.
  • Lagor WR, de Groh ED, Ness GC. 2005. Diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter. J Biol Chem 280:36601–36608.
  • Landsberger N, Wolffe AP. 1995. Role of chromatin and Xenopus laevis heat shock transcription factor in regulation of transcription from the X. laevis hsp70 promoter in vivo. Mol Cell Biol 15:6013–6024.
  • Le NM, Sielaff AM, Cooper AJ, Mackay H, Brown T, Kotecha M, O’Hare C, Hochhauser D, Lee M, Hartley JA. 2006. Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells. Bioorg Med Chem Lett 16:6161–6164.
  • Leclerc GJ, Mou C, Leclerc GM, Mian AM, Barredo JC. 2010. Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: Implications for combination therapy. Leukemia 24:552–562.
  • Lee J, Li Z, Brower-Sinning R, John B. 2007. Regulatory circuit of human microRNA biogenesis. PLoS Comput Biol 3:e67.
  • Lee MR, Kim SH, Cho HJ, Lee KY, Moon AR, Jeong HG, Lee JS, Hyun JW, Chung MH, You HJ. 2004. Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment. J Biol Chem 279:9857–9866.
  • Lee SR, Park JH, Park EK, Chung CH, Kang SS, Bang OS. 2005. Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells. J Cell Physiol 205:270–277.
  • Leimgruber E, Seguín-Estévez Q, Dunand-Sauthier I, Rybtsova N, Schmid CD, Ambrosini G, Bucher P, Reith W. 2009. Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site. Nucleic Acids Res 37:2514–2528.
  • Li Q, Herrler M, Landsberger N, Kaludov N, Ogryzko VV, Nakatani Y, Wolffe AP. 1998. Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO J 17:6300–6315.
  • Li T, Huang H, Huang B, Huang B, Lu J. 2009. Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG). J Genet Genomics 36:335–342.
  • Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D. 1992. Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain. J Biol Chem 267:8984–8990.
  • Liang F, Schaufele F, Gardner DG. 2001. Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. J Biol Chem 276:1516–1522.
  • Liberati C, Cera MR, Secco P, Santoro C, Mantovani R, Ottolenghi S, Ronchi A. 2001. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. J Biol Chem 276:41700–41709.
  • Lindahl GE, Chambers RC, Papakrivopoulou J, Dawson SJ, Jacobsen MC, Bishop JE, Laurent GJ. 2002. Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. J Biol Chem 277:6153–6161.
  • Linhart C, Elkon R, Shiloh Y, Shamir R. 2005. Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis. Cell Cycle 4:1788–1797.
  • Liu X, Zhou B, Xue L, Qiu W, Shih J, Zheng S, Yen Y. 2004. Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. Biochem Pharmacol 67:1499–1511.
  • Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y. 2009. Preventing oxidative stress: A new role for XBP1. Cell Death Differ 16:847–857.
  • Louneva N, Huaman G, Fertala J, Jiménez SA. 2006. Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum 54:1298–1308.
  • Lucibello FC, Truss M, Zwicker J, Ehlert F, Beato M, Müller R. 1995. Periodic cdc25C transcription is mediated by a novel cell cycle-regulated repressor element (CDE). EMBO J 14:132–142.
  • Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ. 1997. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:251–260.
  • Luo R, Lu JF, Hu Q, Maity SN. 2008. CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP. J Cell Biochem 104:1708–1723.
  • Ma Y, Brewer JW, Diehl JA, Hendershot LM. 2002. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318:1351–1365.
  • Mackay H, Brown T, Sexton JS, Kotecha M, Nguyen B, Wilson WD, Kluza J, Savic B, O’Hare C, Hochhauser D, Lee M, Hartley JA. 2008. Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer. Bioorg Med Chem 16:2093–2102.
  • Mangino M, Brouilette S, Braund P, Tirmizi N, Vasa-Nicotera M, Thompson JR, Samani NJ. 2008. A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet 17:2518–2523.
  • Mannefeld M, Klassen E, Gaubatz S. 2009. B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells. Cancer Res 69:4073–4080.
  • Manni I, Caretti G, Artuso S, Gurtner A, Emiliozzi V, Sacchi A, Mantovani R, Piaggio G. 2008. Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity. Mol Biol Cell 19:5203–5213.
  • Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D. 1994. Dominant negative analogs of NF-YA. J Biol Chem 269:20340–20346.
  • Mariño-Ramírez L, Spouge JL, Kanga GC, Landsman D. 2004. Statistical analysis of over-represented words in human promoter sequences. Nucleic Acids Res 32:949–958.
  • Marinova Z, Leng Y, Leeds P, Chuang DM. 2011. Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Neuropharmacology 60:1109–1115.
  • Marziali G, Perrotti E, Ilari R, Coccia EM, Mantovani R, Testa U, Battistini A. 1999. The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: Regulation of tissue-specific genes through a ubiquitous transcription factor. Blood 93:519–526.
  • Matuoka K, Chen KY. 2002. Transcriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y. Ageing Res Rev 1:639–651.
  • McNabb DS, Pinto I. 2005. Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA complex in Saccharomyces cerevisiae. Eukaryotic Cell 4:1829–1839.
  • McNabb DS, Xing Y, Guarente L. 1995. Cloning of yeast HAP5: A novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9:47–58.
  • Mercier A, Pelletier B, Labbé S. 2006. A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell 5:1866–1881.
  • Minuzzo M, Ceribelli M, Pitarque-Martì M, Borrelli S, Erba E, DiSilvio A, D’Incalci M, Mantovani R. 2005. Selective effects of the anticancer drug Yondelis (ET-743) on cell-cycle promoters. Mol Pharmacol 68:1496–1503.
  • Minuzzo M, Marchini S, Broggini M, Faircloth G, D’Incalci M, Mantovani R. 2000. Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743. Proc Natl Acad Sci USA 97:6780–6784.
  • Montano X. 2009. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. Oncogene 28:3787–3800.
  • Moon YA, Lee JJ, Park SW, Ahn YH, Kim KS. 2000. The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter. J Biol Chem 275:30280–30286.
  • Morey M, Yee SK, Herman T, Nern A, Blanco E, Zipursky SL. 2008. Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons. Nature 456:795–799.
  • Morin CL, Schlaepfer IR, Eckel RH. 1995. Tumor necrosis factor-alpha eliminates binding of NF-Y and an octamer-binding protein to the lipoprotein lipase promoter in 3T3-L1 adipocytes. J Clin Invest 95:1684–1689.
  • Müller GA, Engeland K. 2010. The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription. FEBS J 277:877–893.
  • Murai-Takeda A, Shibata H, Kurihara I, Kobayashi S, Yokota K, Suda N, Mitsuishi Y, Jo R, Kitagawa H, Kato S, Saruta T, Itoh H. 2010. NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. J Biol Chem 285:8084–8093.
  • Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T. 2002. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Biochem Biophys Res Commun 295:74–80.
  • Nagy Z, Tora L. 2007. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene 26:5341–5357.
  • Nakshatri H, Bhat-Nakshatri P, Currie RA. 1996. Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. J Biol Chem 271:28784–28791.
  • Nassiri M, Liu J, Kulak S, Uwiera RR, Aird WC, Ballermann BJ, Jahroudi N. 2010. Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Arterioscler Thromb Vasc Biol 30:1423–1429.
  • Niida A, Smith AD, Imoto S, Tsutsumi S, Aburatani H, Zhang MQ, Akiyama T. 2008. Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells. BMC Bioinformatics 9:404.
  • Ocampo A, Zambrano A, Barrientos A. 2010. Suppression of polyglutamine-induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis. FASEB J 24:1431–1441.
  • Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M. 2010. Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PLoS ONE 5:e8773.
  • Park AM, Nagase H, Liu L, Vinod Kumar S, Szwergold N, Wong CM, Suzuki YJ. 2011. Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart. Cardiovasc Res 90:97–104.
  • Park SH, Lee SR, Kim BC, Cho EA, Patel SP, Kang HB, Sausville EA, Nakanishi O, Trepel JB, Lee BI, Kim SJ. 2002. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. J Biol Chem 277:5168–5174.
  • Peng Y, Jahroudi N. 2002. The NFY transcription factor functions as a repressor and activator of the von Willebrand factor promoter. Blood 99:2408–2417.
  • Peng Y, Jahroudi N. 2003. The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases. J Biol Chem 278:8385–8394.
  • Peng Y, Stewart D, Li W, Hawkins M, Kulak S, Ballermann B, Jahroudi N. 2007. Irradiation modulates association of NF-Y with histone-modifying cofactors PCAF and HDAC. Oncogene 26:7576–7583.
  • Pinkham JL, Olesen JT, Guarente LP. 1987. Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator. Mol Cell Biol 7:578–585.
  • Pise-Masison CA, Dittmer J, Clemens KE, Brady JN. 1997. Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. Mol Cell Biol 17:1236–1243.
  • Poch MT, Al-Kassim L, Smolinski SM, Hines RN. 2004. Two distinct classes of CCAAT box elements that bind nuclear factor-Y/alpha-actinin-4: Potential role in human CYP1A1 regulation. Toxicol Appl Pharmacol 199:239–250.
  • Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD. 2000. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. EMBO J 19:3377–3387.
  • Qureshi IA, Gokhan S, Mehler MF. 2010. REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell Cycle 9:4477–4486.
  • Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y. 2010. An atlas of combinatorial transcriptional regulation in mouse and man. Cell 140:744–752.
  • Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M. 2008. Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genet 4:e1000133.
  • Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Barrette TR, Ghosh D, Chinnaiyan AM. 2005. Mining for regulatory programs in the cancer transcriptome. Nat Genet 37:579–583.
  • Robu ME, Larson JD, Nasevicius A, Beiraghi S, Brenner C, Farber SA, Ekker SC. 2007. p53 activation by knockdown technologies. PLoS Genet 3:e78.
  • Roder K, Wolf SS, Larkin KJ, Schweizer M. 1999. Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Gene 234:61–69.
  • Rodrigues AC, Curi R, Hirata MH, Hirata RD. 2009. Decreased ABCB1 mRNA expression induced by atorvastatin results from enhanced mRNA degradation in HepG2 cells. Eur J Pharm Sci 37:486–491.
  • Romano RA, Birkaya B, Sinha S. 2006. Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: Potential roles for Sp1/Sp3, NF-Y, and p63. J Invest Dermatol 126:1469–1479.
  • Romier C, Cocchiarella F, Mantovani R, Moras D. 2003. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. J Biol Chem 278:1336–1345.
  • Salvatore G, Nappi TC, Salerno P, Jiang Y, Garbi C, Ugolini C, Miccoli P, Basolo F, Castellone MD, Cirafici AM, Melillo RM, Fusco A, Bittner ML, Santoro M. 2007. A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res 67:10148–10158.
  • Sato R, Inoue J, Kawabe Y, Kodama T, Takano T, Maeda M. 1996. Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. J Biol Chem 271:26461–26464.
  • Sato R, Okamoto A, Inoue J, Miyamoto W, Sakai Y, Emoto N, Shimano H, Maeda M. 2000. Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins. J Biol Chem 275:12497–12502.
  • Scafoglio C, Ambrosino C, Cicatiello L, Altucci L, Ardovino M, Bontempo P, Medici N, Molinari AM, Nebbioso A, Facchiano A, Calogero RA, Elkon R, Menini N, Ponzone R, Biglia N, Sismondi P, De Bortoli M, Weisz A. 2006. Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem 98:1163–1184.
  • Schmit F, Korenjak M, Mannefeld M, Schmitt K, Franke C, von Eyss B, Gagrica S, Hänel F, Brehm A, Gaubatz S. 2007. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle 6:1903–1913.
  • Schöffski P. 2009. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist 14:559–570.
  • Schüller HJ. 2003. Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43:139–160.
  • Schweizer M, Roder K, Zhang L, Wolf SS. 2002. Transcription factors acting on the promoter of the rat fatty acid synthase gene. Biochem Soc Trans 30:1070–1072.
  • Segal E, Fondufe-Mittendorf Y, Chen L, Thåström A, Field Y, Moore IK, Wang JP, Widom J. 2006. A genomic code for nucleosome positioning. Nature 442:772–778.
  • Sharina IG, Martin E, Thomas A, Uray KL, Murad F. 2003. CCAAT-binding factor regulates expression of the beta1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line. Proc Natl Acad Sci USA 100:11523–11528.
  • Shimizu E, Ogata Y. 2002. Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells. J Cell Biochem 86:35–44.
  • Sinha S, Adler AS, Field Y, Chang HY, Segal E. 2008. Systematic functional characterization of cis-regulatory motifs in human core promoters. Genome Res 18:477–488.
  • Sinha S, Kim IS, Sohn KY, de Crombrugghe B, Maity SN. 1996. Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex. Mol Cell Biol 16:328–337.
  • Stathopoulos A, Van Drenth M, Erives A, Markstein M, Levine M. 2002. Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Cell 111:687–701.
  • Steidl S, Tüncher A, Goda H, Guder C, Papadopoulou N, Kobayashi T, Tsukagoshi N, Kato M, Brakhage AA. 2004. A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: Piggy back transport of the pre-assembled complex to the nucleus. J Mol Biol 342:515–524.
  • Suganuma T, Gutiérrez JL, Li B, Florens L, Swanson SK, Washburn MP, Abmayr SM, Workman JL. 2008. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Nat Struct Mol Biol 15:364–372.
  • Suganuma T, Workman JL. 2011. Signals and combinatorial functions of histone modifications. Annu Rev Biochem 80:473–499.
  • Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S. 2001. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res 11:677–684.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S. 2004. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Genome Res 14:1711–1718.
  • Tabach Y, Milyavsky M, Shats I, Brosh R, Zuk O, Yitzhaky A, Mantovani R, Domany E, Rotter V, Pilpel Y. 2005. The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation. Mol Syst Biol 1: 2005.0022.
  • Tabe Y, Konopleva M, Contractor R, Munsell M, Schober WD, Jin L, Tsutsumi-Ishii Y, Nagaoka I, Igari J, Andreeff M. 2006. Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood 107:1546–1554.
  • Tanaka H, Ohshima N, Hidaka H. 1999. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: Drug-western. Mol Pharmacol 55:356–363.
  • Tanaka H, Ohshima N, Ikenoya M, Komori K, Katoh F, Hidaka H. 2003. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res 63:6942–6947.
  • Testa A, Donati G, Yan P, Romani F, Huang TH, Viganò MA, Mantovani R. 2005. Chromatin immunoprecipitation (ChIP) on chip experiments uncover a widespread distribution of NF-Y binding CCAAT sites outside of core promoters. J Biol Chem 280:13606–13615.
  • Testoni B, Mantovani R. 2006. Mechanisms of transcriptional repression of cell-cycle G2/M promoters by p63. Nucleic Acids Res 34:928–938.
  • Thomassen M, Tan Q, Kruse TA. 2008. Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer. BMC Cancer 8:394.
  • Thön M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA. 2010. The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38:1098–1113.
  • Tüncher A, Spröte P, Gehrke A, Brakhage AA. 2005. The CCAAT-binding complex of eukaryotes: Evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human. J Mol Biol 352:517–533.
  • Ueda A, Takeshita F, Yamashiro S, Yoshimura T. 1998. Positive regulation of the human macrophage stimulating protein gene transcription. Identification of a new hepatocyte nuclear factor-4 (HNF-4) binding element and evidence that indicates direct association between NF-Y and HNF-4. J Biol Chem 273:19339–19347.
  • Uramoto H, Wetterskog D, Hackzell A, Matsumoto Y, Funa K. 2004. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. J Cell Sci 117:5323–5331.
  • van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. 1997. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem 272:18367–18374.
  • van Wageningen S, Breems-de Ridder MC, Nigten J, Nikoloski G, Erpelinck-Verschueren CA, Löwenberg B, de Witte T, Tenen DG, van der Reijden BA, Jansen JH. 2008. Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha. Blood 111:1634–1643.
  • Van bokhoven H, Melino G, Candi E, Declercq W. 2011. p63, a story of mice and men. J Invest Dermatol 131:1196–1207.
  • Villard J, Peretti M, Masternak K, Barras E, Caretti G, Mantovani R, Reith W. 2000. A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. Mol Cell Biol 20:3364–3376.
  • von Richter O, Pitarque M, Rodríguez-Antona C, Testa A, Mantovani R, Oscarson M, Ingelman-Sundberg M. 2004. Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6). Pharmacogenetics 14:369–379.
  • Walker P, Doenecke D, Kahle J. 2009. Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers. J Biol Chem 284:11652–11662.
  • Wang S, Yan-Neale Y, Fischer D, Zeremski M, Cai R, Zhu J, Asselbergs F, Hampton G, Cohen D. 2003. Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. Oncogene 22:6204–6213.
  • Wang W, Di X, Torti SV, Torti FM. 2010. Ferritin H induction by histone deacetylase inhibitors. Biochem Pharmacol 80:316–324.
  • Wang W, Dong L, Saville B, Safe S. 1999. Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Mol Endocrinol 13:1373–1387.
  • Wang Y, Stary JM, Wilhelm JE, Newmark PA. 2010. A functional genomic screen in planarians identifies novel regulators of germ cell development. Genes Dev 24:2081–2092.
  • Wang YL, Faiola F, Xu M, Pan S, Martinez E. 2008. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem 283:33808–33815.
  • Węsierska-Gądek J, Maurer M, Zulehner N, Komina O. 2011. Whether to target single or multiple CDKs for therapy? That is the question. J Cell Physiol 226:341–349.
  • Wienk H, Lammers I, Hotze A, Wu J, Wechselberger RW, Owens R, Stammers DK, Stuart D, Kaptein R, Folkers GE. 2009. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension. Biochemistry 48:4431–4439.
  • Wu SM, Kuo WC, Hwu WL, Hwa KY, Mantovani R, Lee YM. 2004. RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. Mol Pharmacol 66:1317–1324.
  • Wu T, Zhang X, Huang X, Yang Y, Hua X. 2010. Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. J Biol Chem 285:18291–18300.
  • Xing Y, Fikes JD, Guarente L. 1993. Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. EMBO J 12:4647–4655.
  • Xing Y, Zhang S, Olesen JT, Rich A, Guarente L. 1994. Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short alpha-helix in HAP2. Proc Natl Acad Sci USA 91:3009–3013.
  • Yamada K, Osawa H, Granner DK. 1999a. Identification of proteins that interact with NF-YA. FEBS Lett 460:41–45.
  • Yamada K, Printz RL, Osawa H, Granner DK. 1999b. Human ZHX1: Cloning, chromosomal location, and interaction with transcription factor NF-Y. Biochem Biophys Res Commun 261:614–621.
  • Yamada K, Tanaka T, Miyamoto K, Noguchi T. 2000. Sp family members and nuclear factor-Y cooperatively stimulate transcription from the rat pyruvate kinase M gene distal promoter region via their direct interactions. J Biol Chem 275:18129–18137.
  • Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. 2004. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem 136:343–350.
  • Yamanaka K, Mizuarai S, Eguchi T, Itadani H, Hirai H, Kotani H. 2009. Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers. Genomics 94:219–227.
  • Yamanaka T, Miyazaki H, Oyama F, Kurosawa M, Washizu C, Doi H, Nukina N. 2008. Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor. EMBO J 27:827–839.
  • Yan S, Tso J. 2004. Temperature may influence and regulate NF-YB expression in toad oocyte. Biochem Biophys Res Commun 313:802–811.
  • Yang J, Huang J, Chatterjee TK, Twait E, Fisher RA. 2010. A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. J Biol Chem 285:29760–29769.
  • Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H. 2006. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell 23:377–387.
  • Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K. 2010. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun 78:468–476.
  • Yoon HS, Yang VW. 2004. Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem 279:5035–5041.
  • Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. 2000. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 20:6755–6767.
  • Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. 2001. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. Mol Cell Biol 21:1239–1248.
  • Yoshioka Y, Suyari O, Yamada M, Ohno K, Hayashi Y, Yamaguchi M. 2007. Complex interference in the eye developmental pathway by Drosophila NF-YA. Genesis 45:21–31.
  • Yoshioka Y, Suyari O, Yamaguchi M. 2008. Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development. Genes Cells 13:117–130.
  • Yun J, Chae HD, Choi TS, Kim EH, Bang YJ, Chung J, Choi KS, Mantovani R, Shin DY. 2003. Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway. J Biol Chem 278:36966–36972.
  • Zemzoumi K, Frontini M, Bellorini M, Mantovani R. 1999. NF-Y histone fold alpha1 helices help impart CCAAT specificity. J Mol Biol 286:327–337.
  • Zhang X, Wharton W, Yuan Z, Tsai SC, Olashaw N, Seto E. 2004. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol 24:5106–5118.
  • Zhou Y, Lee AS. 1998. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J Natl Cancer Inst 90:381–388.
  • Zhou Z, Lin IJ, Darst RP, Bungert J. 2009. Maneuver at the transcription start site: Mot1p and NC2 navigate TFIID/TBP to specific core promoter elements. Epigenetics 4:1–4.
  • Zhu H, Gao W, Jiang H, Jin QH, Shi YF, Tsim KW, Zhang XJ. 2007a. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Int J Biochem Cell Biol 39:93–108.
  • Zhu H, Gao W, Shi YF, Zhang XJ. 2007b. The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Biochim Biophys Acta 1770:1475–1482.
  • Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG. 2003. NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4. Blood 102:2420–2427.
  • Zhu J, Zhang Y, Joe GJ, Pompetti R, Emerson SG. 2005. NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal. Proc Natl Acad Sci USA 102:11728–11733.
  • Zhu QS, Qian B, Levy D. 2004. CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y. J Biol Chem 279:29902–29910.
  • Zhu XS, Linhoff MW, Li G, Chin KC, Maity SN, Ting JP. 2000. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol Cell Biol 20:6051–6061.
  • Zhu Z, Shendure J, Church GM. 2005. Discovering functional transcription-factor combinations in the human cell cycle. Genome Res 15:848–855.
  • Zika E, Greer SF, Zhu XS, Ting JP. 2003. Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol Cell Biol 23:3091–3102.
  • Zumbrun SD, Hoffman B, Liebermann DA. 2009. Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli. J Cell Biochem 108:1220–1231.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.