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Original Article

Terminal Deoxynucleotidyl Transferase Expression in Acute Myelogenous Leukemia and Myelodysplasia as Determined by Flow Cytometry

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Pages 319-331 | Accepted 05 Sep 1999, Published online: 01 Jul 2009

References

  • McCaffrey R., Smoler D. F., Baltimore D. Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic lymphoma leukemia. Proc Natl Acad Sci USA 1973; 70: 521–525
  • Bradstock K. F., Hoffbrand A. V., Gainshaguru K., Llewellin P., Patterson K., Wonke B., Prentice A. G., Bennet M., Pizzolo G., Bollum F. J., Janossy G. Terminal deoxynucleotidyl transferase expression in acute nonlymphoid leukemia: analysis of immunofluorescence. Br J Haematol 1981; 47: 133–143
  • Folds J. D., Bollum F. J., Dean L., Chan J., Stass S. A. Simultaneous evaluation for terminal deoxynucleotidyl transferase and myelo-peroxidase in leukemia. Am J Haematol 1982; 12: 391–396, 1982
  • Jani P., Verbi W., Greaves M. F., Bevan D., Bollum F. J. Terminal deoxynucleotidyl transferase in acute myeloid leukemia. Leuk Res 1983; 7: 17–29
  • Drexler H. G., Menon M., Minowada J. Incidence of TdT positivity in cases of leukemia and lymphoma. Acta Haematol 1986; 75: 12–17
  • Drexler H. G., Sperling C., Ludwig W-D. Terminal deoxynucleotidyl transferase (TdT) expression in acute myeloid leukemia. Leukemia 1993; 7: 1142–1150
  • Paietta E., Bettelheim P., Schwarzmeimer J. D., Lutz D., Majdic O., Knapp W. Distinct lymphoblastic and myeloblastic populations in TdT positive acute myeloblastic leukemia: Evidence by double fluorescence staining. Leuk Res 1983; 7: 301–307
  • Loftin K. C., Reuben J. M., Dalton W., Hersh E. M., Sujansky D. Terminal transferase in leukemias by flow cytometry. Diagn Immunol 1986; 4: 165–169
  • Hirata M., Okamoto Y. Enumeration of terminal deoxynucleotidyl transferase positive cells in leukemia/lymphoma by flow cytometry. Leuk Res 1987; 11: 509–518
  • Adriaansen H. J., Van Dongan J. J.M., Kappers-Klunne M. C., Hahlen K., Van't Veer M. B., Wijdeneds-de Bresser J. H.F.M., Holdrinet A. C. J. M., Harthoorn-Lasthuizen E. J., Abels J., Hoojikaas H. Terminal deoxynucleotidyl transferase positive subpopulations occur in the majority of ANLL: implications for the detection of minimal disease. Leukemia 1990; 4: 404–410
  • Gucalp R., Paietta E., Weiberg V., Papenhausen P., Dutcher J., Wiernik P. Terminal transferase expression in acute myeloid leukemia: biology and prognosis. Br J Haematol 1991; 77: 48–54
  • Paietta E., Van Ness B., Bennett J., Racevskis J., Gucalp R., Cassileth P., Wiernik P. H. Lymphoid lineage-associated features in acute myeloid leukemia: phenotypic and genotypic correlations. Br J Haematol 1992; 182: 324–331
  • Paietta E., Racevskis J., Bennett J. M., Wiernik P. H. Differential expression of terminal transferase (TdT) in acute lymphocytic leukemia expressing myeloid antigens and TdT positive acute myeloid leukemia as compared to myeloid negative acute lymphoblastic leukemia. Br J Haemalo, I 1993; 84: 16–422
  • Paietta E., Meenan B., Heavey C., Thomas D. Detection of terminal transferase in acute myeloid leukemia by flow cytometry. Cytometry 1994; 16: 256–261
  • Horvatinovich J. M., Sparks S. D., Borowitz M. J. Detection of terminal deoxynucleotidyl transferase by flow cytometry: a three-color method. Cytometry (Communications in Clinical Cytometry.) 1994; 18: 228–230
  • Farahat N., Lens D., Motilla R., Matutes E., Catovsky D. Differential expression in acute leukemia by flow cytometry: a quantitative study. Leukemia 1995; 9: 583–587
  • Del Poeta G., Venditti A., Aronica G., Bruno A., Stasi R., Cox M. C., Adorno G., Buccisano R., Tamburini A., Masi M., Papa G., Amadori S. Determination of terminal transferase (TdT) by flow cytometry in de novo acute myeloid leukemia (AML). Cytometry suppl 1996; 8: 78, (abstract)
  • Lo Coco F., Lopez M., Pasqualetti D., Montefusco E., Caffola A., Monarca B., Sgadari C., De Rossi G. Terminal transferase positive acute myeloid leukemia: immunophenotypic characterization and response to induction therapy. Hematol Onto 1989; 7: 167–174
  • Benedetto P., Mertelsman R., Szatrowski, Andreef M., Arlin G. Z., Kempin S., Clarkson B. Prognostic significance of transferase activity in acute nonlymphoblastic leukemia. J Clin Onco 1986; 4: 489–495
  • Lee E. J., Yang J., Leavitt R. D., Testa J. R., Civin C. I., Forrest A., Schiffer C. A. The significance of CD34 and TdT determinations in patients with untreated de novoacuXs myeloid leukemia. Leukemia 1992; 6: 1203–1209
  • Swirsky D. M., Greaves M. F., Gray R. G., Rees J. K. Terminal transferase and HLA-DR expression appear unrelated to prognosis of acute myeloid leukemia. Br J Haemato 1988; 70: 193–198
  • Preti H. A., Huh Y., O'Brien S., Andreef M., Pierce S., Keating M., Kantarjian H. M. Myeloid markers in adult acute lymphocytic leukemia correlations with patient and disease characteristics and with prognosis. Cancer 1995; 76: 1567–1570
  • Trujillo J. M., Cork A., Ahearn M., Youness E. L., McCredie K. B. Hematologic and cytologic characterization of the 8/21 translocation acute granulocytic leukemia. Blood 1979; 53: 695–706
  • Kantarjian H. M., Hirsch-Ginsgerg C., Yee G., Huh Y., Freireich E. J., Stass S. Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy. Blood 1990; 76: 808–813
  • Schemper M., Smith T. L. A note on quantifying follow-up in studies of failure time. Control Clin Trials 1996; 17: 343–346
  • Schachner J., Kantarjian H., Dalton W., McCredie K., Keating M., Freireich E. Cytogenetic association and prognostic significance of bone marrow blast cell terminal transferase in patients with myeloblastic leukemia. Leukemia 1988; 2: 667–671
  • Adriaansen H. J., Van Dongen J. J.M., Hooikaas H., Hahlen K., Van't Veer M. B., Lowenberg B., Hagenmeijer A. Translocation (6;9) may be associated with a specific TdT-positive immunological phenotype in ANLL. Leukemia 1988; 2: 136–140
  • Desiderio S. V., Yancopoulos G. D., Paskind M., Thomas E., Boss M. A., Landau N., Alt F. W., Baltimore D. Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxytransferase in B-cells. Nature 1984; 311: 752–755
  • Kunkel T. A., Gopinathan K. P., Dube D. K., Snow E. T., Loeb L. A. Rearrangement of DNA mediated by terminal transferase. Proc Natl Acad Sci 1986; 83: 1867–1871
  • Landau N. R., Schatz D. G., Rosa M., Baltimore D. Increased frequency of N-region insertion in a murine pre B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol Cell Biol 1987; 7: 3237–3243
  • Seremetis S. V., Pelicci P-G., Tabilio A., Ubbriaco A., Grig-Nani F., Cuttner J., Winchester R. J., Knowlesll D. M., Dalla-Favera R. High frequency of clonal immunoglobulin or T cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxyribonucleotidyl transferase. J Exp Med 1987; 165: 1703–1712
  • Foa R., Casorati G., Giubellino M. C., Basso G., Schiro R., Pizzolo G., Lauria F., Lefranc M., Rabbitts T. H., Migone N. Rearrangement of immunoglobulin and T cell receptor β and γ genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia. J Exp Med 1987; 165: 879–890
  • Davey G., Bradstock K. F., Kefford R. K., Wishart Y., Kabral A., Grimsley P. Hughes WG. Lack of correlation between immunoglobulin and T cell receptor gene rearrangement and TdT expression in acute myeloid leukemia. Leuk Res 1990; 14: 77–83
  • Adriaasen H. J., Soeting P. W. C., Wolvers-Tettero I. L. M., Van Dongen J. M. Immunoglobulin and T-cell receptor gene rearrangements in acute non-lymphocytic leukemias, analysis of 54 cases and a review of literature. Leukemia 1991; 5: 744–751
  • McCurley T., Greer J. P., Glick A. D. Terminal deoxynucleotidyl transferase (TdT) in acute nonlymphocytic leukemia. Am J Clin Pathol 1988; 90: 421–430

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