127
Views
28
CrossRef citations to date
0
Altmetric
Original Article

Bone Marrow Features and Clinical Findings in Chronic Myeloid Leukemia - A Comparative, Multicenter, Immunohistological and Morphometric Study on 614 Patients

, , , , , , , , , , , , , & show all
Pages 295-308 | Accepted 10 Jul 1999, Published online: 01 Jul 2009

References

  • Kantarjian H. M., Deisseroth A. S., Kurzrock R., Estrov Z., Talpaz M. Chronic myelogenous leukemia: a concise update. Blood 1993; 82: 691–703
  • Dickstein J. I., Vardiman J. W. Hematopathologic findings in the myeloproliferative disorders. Semin. Oncol. 1995; 22: 355–373
  • Cervantes F., Rozman C. A multivariate analysis of prognostic factors in chronic myeloid leukemia. Blood 1982; 60: 1298–1304
  • Kantarjian H. M., Smith T. L., McCredie K. B., Keating M. J., Walters R. S., Talpaz M., Hester J. P., Bligham G., Gehan E., Freireich E. J. Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival. Blood 1985; 66: 1326–1335
  • Sokal J. E., Baccarani M., Russo D., Tura S. Staging and prognosis in chronic myelogenous leukemia. Semin. Hematol 1988; 25: 49–61
  • Cortes J., Kantarjian H. M., Giralt S., Talpaz M. Natural history and staging of chronic myelogenous leukaemia. Bailliere's Clin. Haematol. 1997; 10: 277–290
  • Burkhardt R., Bartl R., Jaeger K., Frisch B., Kettner G., Mahl G., Sund M. Chronic myeloproliferative disorders (CMPD). Pathol. Res. Pract. 1984; 179: 131–86
  • Lorand-Metze I., Vasallo J., Souza C. A. Histological and cytological heterogeneity of bone marrow in Philadelphia-positive chronic myelogenous leukaemia at diagnosis. Br. J. Haematol. 1987; 67: 45–49
  • Georgii A., Vykoupil K. F., Buhr T., Choritz H., Döhler U., Kaloutsi V., Werner M. Chronic myeloproliferative disorders in bone marrow biopsies. Pathol. Res. Pract. 1990; 186: 3–27
  • Thiele J., Fischer R. Megakaryocytopoiesis in haematological disorders: Diagnostic features of bone marrow biopsies. An overview. Virchows Archiv A Pathol. Anat. 1991; 418: 87–97
  • Nafe R., Georgii A., Kaloutsi V., Fritsch R. S., Choritz H. Planimetric analysis of megakaryocytes in the four main groups of chronic myeloproliferative disorders. Virchows Archiv B Cell Pathol 1991; 61: 111–116
  • Thiele J., Titius B. R., Kopsidis C., Fischer R. Atypical micromegakaryocytes, promegakaryoblasts and megakaryoblasts. A critical evaluation by immunohis-tochemistry and morphometry of bone marrow trephines in chronic myeloid leukemia and myelodysplastic syndromes. Virchows Archiv B Cell Pathol. 1992; 62: 275–282
  • Buhr T., Choritz H., Georgii A. The impact of megakaryocyte proliferation for the evolution of myelofibrosis. Histological follow-up study in 186 patients with chronic myeloid leukemia. Virchows Archiv A Pathol. Anat. 1992; 420: 473–478
  • Bartl R., Frisch B., Wilmanns W. Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD). Eur. J. Haematol. 1993; 50: 41–52
  • Dickstein J. I., Vardiman J. W. Issues in the pathology and diagnosis of the chronic myeloproliferative disorders and the myelodysplastic syndromes. Am. J. Clin. Pathol 1993; 99: 513–25
  • Gralnick H. R., Harbor J., Vogel C. Myelofibrosis in chronic granulocytic leukemia. Blood 1971; 37: 152–162
  • Clough V., Geary C. G., Hashimi K., Davson G., Knowlson T. Myelofibrosis in chronic granulocytic leukaemia. Br. J. Haematol 1979; 42: 515–526
  • Lazzarino M., Morra E., Castello A., Inverardi D., Coci A., Pagnuco G., Magrini U., Zei G., Bernasconi C. Myelofibrosis in chronic granulocytic leukemia. Clinical pathologic correlations and prognostic significance. Br. J. Haematol 1986; 64: 227–240
  • Dekmezian R., Kantarjian H. M., Keating M., Talpaz M., McCredie K. B., Freireich E. J. The relevance of reticulin stain-measured fibrosis at diagnosis in chronic myelogenous leukemia. Cancer 1987; 57: 1739–1743
  • Thiele J., Kvasnicka H. M., Titius B. R., Parpert U., Nebel R., Zankovich R., Dienemann D., Stein H., Diehl V., Fischer R. Histological features of prognostic significance in CML - an immunohistochemical and morphomet-ric study (multivariate regression analysis) on trephine biopsies of the bone marrow. Ann. Hematol. 1993; 66: 261–302
  • Thiele J., Kvasnicka H. M., Niederle N., Kloke O., Schmidt M., Lienhard H., Zirbes T., Meuter R. B., Leder L. D., Fischer R. Clinical and histological features retain their prognostic impact under interferon therapy of CML: a pilot study. Am. J. Hematol. 1995; 50: 30–39
  • Adams D. O., Hamilton T. A. The cell biology of macrophage activation. Ann. Rev. Immunol 1984; 2: 283–318
  • Terui T., Niitsu Y., Mahara K., Fujisaki Y., Urushizaki Y., Kohogo Y., Watanabe N., Ogura M., Saito O. The production of transforming growth factor-6 in acute megakaryoblastic leukemia and its possible implication in myelofibrosis. Blood 1990; 75: 1540–1548
  • Reilly J. T., Barnett D., Dolan G., Forrest P., Eastham J., Smith A. Characterization of an acute microme-gakaryocytic leukemia: evidence for the pathogenesis of myelofibrosis. Br. J. Haematol 1993; 83: 58–62
  • Rameshwar P., Denny T. N., Stein D., Gascén P. Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines. J. Immu-nol 1994; 153: 2819–2830
  • Kimura A., Katoh O., Hyodo H., Kuramoto A., Satow Y. Platelet derived growth factor expression, myelofibrosis and chronic myelogenous leukemia. Leukemia Lymphoma 1995; 18: 237–242
  • Martyre M. C. TGF-P and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders. Leukemia Lymphoma 1995; 20: 39–44
  • Hayhoe F. G.J., Flemans R. J., Cowling D. C. Acquired lipidosis of marrow macrophages. Birefringent blue crystals and Gaucher-like cells, sea-blue histiocytes, and grey-geen crystals. J. Clin Pathol 1979; 32: 420–428
  • Buesche G., Majewski H., Schlué J., Delventhal S., Baer-Henney S., Vykoupil K. F., Georgii A. Frequency of Pseudo-Gaucher cells in diagnostic bone marrow biopsies from patients with Ph-positive chronic myeloid leukaemia. Virchows Archiv 1997; 430: 139–148
  • Albrecht M. Ergebnissse von Langzeitbeobachtun-gen bei Patienten mit chronisch myeloischer Leukamie. Leukamie, H. Gross, J. van de Loo. Springer Verlag, Heidelberg 1972; 399–404
  • Kelsey P. R., Geary C. G. Sea-blue histocytes and Gaucher cells in bone marrow of patients with myeloid leukaemia. J. Clin. Pathol 1988; 41: 960–962
  • Schaefer H. E. How to fix, decalcify and stain paraffin embedded bone marrow biopsies. Pathology of the bone marrow, K Lennert, K Huebner. G. Fischer, Stuttgart, New York 1984; 6–9
  • Gatter K. C., Cordell J. L., Turley H., Heryet A., Kieffer N., Anstee D. J., Mason D. Y. The immunohistologi-cal detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathol. 1988; 13: 256–267
  • Falini B., Flenghi L., Pileri S., Gambacorta M., Bigerna B., Duerkop H., Eitelbach E., Thiele J., Pacini R., Cava-Liere A., Martelli M., Cardelli N., Sabatini E., Poggi S., Stein H. PG-M1. A new monoclonal antibody directed against a fixative-resistant epitope on the macroph-age-restricted form of the CD68 molecule. Am. J. Pathol 1993; 142: 1359–1372
  • Tabor D. R., Larry C. H., Jacobs R. F. Differential induction of macrophage GSIB4-binding activity. J. Leukocyte. Biol 1989; 45: 452–457
  • Warfel A. H., Zucker-Franklin D. Specific ligation of surface a-D-galactosyl epitopes markedly affects the quantity of four major proteins secreted by macrophages. J. Leukocyte. Biol. 1992; 52: 80–84
  • Baldus S. E., Thiele J., Park Y. O., Charles A., Mross C., Hanisch F. G., Zirbes T. K., Wickenhauser C., Fischer R. Carbohydrate and peptide antigens in macrophage populations derived from human bone marrow and milk: an immunomorphological and immunohistochemical analysis. Histochem. J. 1995; 27: 630–638
  • Kaplan E. L., Meier P. Nonparametric estimation from incomplete observations. J. Am. Statist. Ass. 1958; 53: 457–481
  • Sokal J. E., Cox E. B., Baccarani M., Tura S., Gomez G. A., Robertson J. D., Tso C. Y., Braun T. J., Clarkson B. D., Cervantes F., Rozman C. the Italian Cooperative CML Study Group. Prognostic discrimination in “good-risk” chronic granulocytic leukemia. Blood 1984; 63: 789–799
  • Kantarjian H., Keating M. J., Smith T. L., Talpaz M., McCredie K. B. Proposal for a simple synthesis prognostic staging system in chronic myelogenous leukemia. Am J. Med. 1990; 88: 1–8
  • Hasford J., Ansari H., Pfirrmann M., Hehlmann R. the German CML Study Group. Analysis and validation of prognostic factors for CML. Bone Marrow Transplant 1996; 17: 49–54
  • Hehlmann R., Ansari H., Hasford J., Heimpel H., Hoss-Feld D. K., Kolb H. J., Loftier H., Pralle H., Queisser W., Reiter A., Hochhaus A. the German CML-Study Group. Comparative analysis of the impact of risk profile and of drug therapy on survival in CML using Sokal's index and a new score. Br. J. Haematol. 1997; 97: 76–85
  • Hasford J., Pfirrmann M., Hehlmann R., Allan N. C., Baccarani M., Kluin-Nelemanns J. C., Alimena G., Steegmann J. L., Ansare H. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J. Natl. Cancer. Inst. 1998; 90: 850–858
  • Savage D. G., Szydlo R. M., Goldman J. M. Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period. Br. J. Haematol. 1997; 96: 111–116
  • O'Brian S., Kantarjian H., Shtalrid M., Blick M., Beran M., Talpaz M. Lack of breakpoint cluster region rearrangement in marrow fibroblasts of patients with Philidelphia chromosome-positive chronic myelogenous leukemia. Hematol. Pathol. 1988; 2: 25–29
  • Bhatia R., McGlave P. M., Dewald G. W., Blaza B. R., Verfaillie C. M. Abnormal function of the bone marrow microinvironment in chronic myelogenous leukemia: role of malignant stromal macrophages. Blood 1991; 85: 3636–3645
  • Bhatia R., Verfaille C. M. The effect of interferon-a on beta-1-integrin mediated adhesion and growth regulation in chronic myelogenous leukemia. Leukemia Lymphoma 1998; 28: 241–254
  • Cervantes F., Rozman C., Piera C., Fernandez M. R. Decreased bone marrow iron in chronic myelogenous leukemia: a consistent finding not reflecting iron deficiency. Blut 1986; 53: 305–308
  • Sokal J. E., Sheerin K. A. Decreased stainable marrow iron in chronic granulocytic leukemia. Am. J. Med. 1986; 81: 395–399
  • Maddox D. E., Shibata S., Goldstein I. J. Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin. Proc. Natl. Acad. Sci. USA. 1982; 79: 166–170
  • Irimura T., North S. M., Nicolson G. L. Glycoprotein profiles of macrophages at different stages of activation as revealed by lectin binding after electrophoretic separation. Eur. J. Immunol. 1987; 17: 73–78
  • Obinata M., Okuyama R., Matsuda K. I., Koguma M., Yanai N. Regulation of myeloid and lymphoid development of hematopoietic stem cells by bone marrow stromal cells. Leukemia Lymphoma 1998; 29: 61–69
  • Osterholz J., Dowding C., Gou A. P., Siczkowski M., Goldman J. M. Interferon-α alters the distribution of CFU-GM between the adrerent and non-adherent compartments in long-term cultures of chronic myeloid leukemia marrow. Exp. Hematol. 1991; 19: 326–331
  • Dowding C., Gou A. P., Osterholz J., Siczkowski M., Goldman J., Gordon M. Interferon-α overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells. Blood 1991; 78: 499–505
  • Golde D. W., Burgaleta C., Sparkes R. S., Cline M. J. The Philadelphia chromosome in human macrophages. Blood 1977; 49: 367–370
  • Thiele J., Schmitz B., Fuchs R., Kvasnicka H. M., Loren-Zen J., Fischer R. Detection of the bcr/abl gene in bone marrow macrophages in CML and alterations during interferon therapy - a fluorescence in situ hybridization study on trephine biopsies. J. Pathol. 1998; 186: 331–335
  • Welborn J. L., Lewis J. P. Correlation of marrow iron pattern with disease status of chronic myelogenous leukemia. Leukemia Lymphoma 1993; 10: 469–475
  • Spiers A. S.D. Clinical manifestations of chronic granulocytic leukemia. Semin. Oncol. 1995; 22: 380–395
  • Thiele J., Hoefer M., Kvasnicka H. M., Bertsch H. P., Zank-Ovich R., Fischer R. Erythropoiesis in CML -immunohistomorphometric quantification, PCNA-reactivity, and influence on survival. Hematol., Pathol. 1993; 1: 239–249
  • Rozman C., Cervantes F., Feliu R. Is the histological classification of chronic granulocytic leukaemia justified from the clinical point of view?. Eur. J. Haematol. 1989; 42: 150–154
  • Cervantes F., Rozman C., Feliu E. Prognostic evaluation of initial bone marrow histopathological features in chronic granulocytic leukemia. Acta. Haemat. 1989; 82: 12–15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.