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Original Articles: Clinical

Total body irradiation plus cyclophosphamide versus busulphan with cyclophosphamide as conditioning regimen for patients with leukemia undergoing allogeneic stem cell transplantation: a meta-analysis

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Pages 50-60 | Received 08 Jul 2009, Accepted 14 Oct 2009, Published online: 07 Jan 2010

References

  • Basara N, Schulze A, Wedding U, et al Early related or unrelated haematopoietic cell transplantation results in higher overall survival and leukaemia-free survival compared with conventional chemotherapy in high-risk acute myeloid leukaemia patients in first complete remission. Leukemia 2009;23:635–640.
  • Sorror ML, Maris MB, Storer B, et al Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning: influence of pretransplantation comorbidities. Blood 2004;104:961–968.
  • Fefer A, Einstein AB, Thomas ED, et al Bone-marrow transplantation for hematologic neoplasia in 16 patients with identical twins. N Engl J Med 1974;290:1389–1393.
  • Tutschka PJ, Copelan EA, Klein JP. Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 1987;70:1382138–1382138.
  • Santos GW, Tutschka PJ, Brookmeyer R, et al Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 1983;309:1347–1353.
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560.
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21:1539–1558.
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in Meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–634.
  • Bax L, Yu LM, Ikeda N, Tsuruta H, Moons KGM. MIX: comprehensive free software for meta-analysis of causal research data. Version 1.7. http://mix-for-meta-analysis.info, July 01, 2009.
  • Wingard JR, Plotnick LP, Freemer CS, et al Growth in children after bone marrow transplantation:busulfan plus cyclophosphamide versus cyclophosphamide plus total body irradiation. Blood 1992;79:1068–1073.
  • Blaise D, Maraninchi D, Archimbaud E, et al Allogeneic bone marrow transplantation for acute myeloid leukemia in first remission: a randomized trial of a busulfan-Cytoxan versus Cytoxan-total body irradiation as preparative regimen: a report from the Group d'Etudes de la Greffe de Moelle Osseuse. Blood 1992;79:2578–2582.
  • Clift RA, Buckner CD, Thomas ED, et al Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide. Blood 1994;84:2036–2043.
  • Michel G, Gluckman E, Esperou-Bourdeau H, et al Allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: impact of conditioning regimen without total-body irradiation – a report from the Société Française de Greffe de Moelle. J Clin Oncol 1994;12:1217–1222.
  • Devergie A, Blaise D, Attal M, et al Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: a randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: a report from the French Society of Bone Marrow Graft (SFGM). Blood 1995;85:2263–2268.
  • Ringdén O, Labopin M, Tura S, et al A comparison of busulphan versus total body irradiation combined with cyclophosphamide as conditioning for autograft or allograft bone marrow transplantation in patients with acute leukaemia. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Br J Haematol 1996;93:637–645.
  • Michel G, Socie’ G, Gebhard F, et al Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukaemia in first complete remission: the impact of conditioning regimen without total-body irradiation – a report from the Société Francaise de Greffe de Moelle. J Clin Oncol 1997;15:2238–2246.
  • Ringden O, Remberger M, Ruutu T, et al Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. Blood 1999;93:2196–2201.
  • Granados E, de La Cámara R, Madero L, et al Hematopoietic cell transplantation in acute lymphoblastic leukemia: better long term event-free survival with conditioning regimens containing total body irradiation. Haematologica 2000;85:1060–1067.
  • Davies SM, Ramsay NK, Klein JP, et al Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia. J Clin Oncol 2000;18:340–347.
  • Kröger N, Zabelina T, Krüger W, et al Comparison of total body irradiation vs. busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients. Bone Marrow Transplant 2001;27:349–354.
  • Kim I, Park S, Kim BK, et al Allogeneic bone marrow transplantation for chronic myeloid leukemia: a retrospective study of busulfan-cytoxan versus total body irradiation-cytoxan as preparative regimen in Koreans. Clin Transplant 2001;15:167–172.
  • Litzow MR, Pérez WS, Klein JP, et al Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission. Br J Haematol 2002;119:1115–1124.
  • Holmström G, Borgström B, Calissendorff B. Cataract in children after bone marrow transplantation: relation to conditioning regimen. Acta Ophthalmol Scand 2002;80:211–215.
  • Bunin N, Aplenc R, Kamani N, Shaw K, Cnaan A, Simms S. Randomized trial of busulfan vs. total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium study. Bone Marrow Transplant 2003;32:543–548.
  • Zhang GC, Zheng D, Guan XX, et al Comparison of two conditioning regimens in treatment of leukemia by allogeneic hematopoietic stem cell transplantation. Chin J Cancer 2003;22:620–623.
  • Lähteenmäki PM, Chakrabarti S, Cornish JM, Oakhill AH. Outcome of single fraction total body irradiation-conditioned stem cell transplantation in younger children with malignant disease: comparison with a busulphan-cyclophosphamide regimen. Acta Oncol 2004;43:196–203.
  • Smedler AC, Winiarski J. Neuropsychological outcome in very young hematopoietic SCT recipients in relation to pretransplant conditioning. Bone Marrow Transplant 2008;42:515–522.
  • Hopewell JW. Radiation injury to the central nervous system. Med Pediatr Oncol 1998; 30(Suppl 1): 1–9.
  • Cohen A, Rovelli A, Bakker B, et al Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the working party for late effects-EBMT. Blood 1999;93:4109–4115.
  • Mehta J, Powles RL, Mitchell P, Rege K, De Lord C, Treleaven J. Graft failure after bone marrow transplantation from unrelated donors using busulfan and cyclophosphamide for conditioning. Bone Marrow Transplant 1994;13:583–587.
  • Slattery JT, Sanders JE, Buckner CD, et al Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant 1995;16:31–42.
  • Ljungman P, Hassan M, Békássy AN, Ringdén O, Oberg G. High busulfan concentrations are associated with increased transplant-related mortality in allogeneic bone marrow transplant patients. Bone Marrow Transplant 1997;20:909–913.
  • Bakker B, Oostdijk W, Geskus RB, Stokvis-Brantsma WH, Vossen JM, Wit JM. Patterns of growth and body proportions after total-body irradiation and hematopoietic stem cell transplantation during childhood. Pediatr Res 2006;59:259–264.
  • Kupst MJ, Penati B, Debban B, et al Cognitive and psychosocial functioning of pediatric hematopoietic stem cell transplant patients: a prospective longitudinal study. Bone Marrow Transplant 2002;30:609–617.
  • Hartman AR, Williams SF, Dillon JJ. Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs. total body irradiation: a meta-analysis. Bone Marrow Transplant 1998;22:439–443.

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