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Letter

Trisomy 8 in Philadelphia chromosome negative cell preceding the evolution of a Philadelphia chromosome positive clone with the same additional change during imatinib treatment: revisiting the role of genetic instability in chronic myeloid leukemia

, , , , , , , & show all
Pages 497-498 | Received 04 Jul 2011, Accepted 14 Aug 2011, Published online: 29 Sep 2011

References

  • Cortes JE, Talpaz M, Giles F, . Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood 2003;101: 3794–3800.
  • O'Dwyer ME, Mauro MJ, Blasdel C, . Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate. Blood 2004;103:451–455.
  • Baccarani M, Cortes J, Pane F, . Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009;27:6041–6051.
  • Deininger MW, Cortes J, Paquette R, . The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in Philadelphia chromosome-negative cells. Cancer 2007;110:1509–1519.
  • Jabbour E, Kantarjian HM, Abruzzo LV, . Chromosomal abnormalities in Philadelphia chromosome negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 2007;110:2991–2995.
  • Feldman E, Najfeld V, Schuster M, . The emergence of Ph-, trisomy -8 + cells in patients with chronic myeloid leukemia treated with imatinib mesylate. Exp Hematol 2003;31:702–707.
  • Zaccaria A, Valenti AM, Donti E, . Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia. Haematologica 2007;92:564–565.
  • Baldazzi C, Luatti S, Marzocchi G, . Emergence of clonal chromosomal abnormalities in Philadelphia negative hematopoiesis in chronic myeloid leukemia patients treated with nilotinib after failure of imatinib therapy. Leuk Res 2009;33:e218–e220.
  • De Melo VA, Milojkovic D, Khorashad JS, . Philadelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia. Blood 2007;110:3086–3087.
  • Fabarius A, Haferlach C, Muller MC, . Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukaemia patients after imatinib failure. Haematologica 2007;92:834–837.
  • Verma D, Kantarjian H, Shan J, . Survival outcome for clonal evolution in chronic myeloid leukaemia patients on second generation tyrosine kinase inhibitor therapy. Cancer 2010;116:2673–2681.
  • Kantarjian H, Shah NP, Hochhaus A, . Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010;362:2260–2270.
  • Saglio G, Kim DW, Issaragrisil S, . Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;362:2251–2259.

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