Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells

References

• Pepper C, Lin TT, Pratt G, . Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood 2008;112:3807–3817.
   PubMed Web of Science ®Google Scholar
• Kitada S, Andersen J, Akar S, . Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood 1998;91:3379–3389.
   PubMed Web of Science ®Google Scholar
• Zhou P, Qian L, Kozopas KM, Craig RW. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood 1997;89:630–643.
   PubMed Web of Science ®Google Scholar
• Pepper C, Thomas A, Hoy T, Cotter F, Bentley P. Antisense-mediated suppression of Bcl-2 highlights its pivotal role in failed apoptosis in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999;107: 611–615.
   PubMed Web of Science ®Google Scholar
• O’Brien SM, Cunningham CC, Golenkov AK, Turkina AG, Novick SC, Rai KR. Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J Clin Oncol 2005;23:7697–7702.
   PubMed Web of Science ®Google Scholar
• Muchmore SW, Sattler M, Liang H, . X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 1996;381:335–341.
   PubMed Web of Science ®Google Scholar
• Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 2003;46:4259–4264.
   PubMed Web of Science ®Google Scholar
• Zhai D, Jin C, Satterthwait AC, Reed JC. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ 2006;13:1419–1421.
   PubMed Web of Science ®Google Scholar
• Becattini B, Kitada S, Leone M, . Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Chem Biol 2004;11:389–395.
   PubMed Web of Science ®Google Scholar
• Balakrishnan K, Wierda WG, Keating MJ, Gandhi V. Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008;112:1971–1980.
   PubMed Web of Science ®Google Scholar
• Zhan Y, Jia G, Wu D, Xu Y, Xu L. Design and synthesis of a gossypol derivative with improved antitumor activities. Arch Pharm (Weinheim) 2009;342:223–229.
   PubMed Web of Science ®Google Scholar
• Mohammad RM YD, Chen B, Aboukameel A, Chen J, Nikolovska-Coleska Z, Al-Katib A and Wang S. ApoG2, a potent, non-toxic small-molecule inhibitor of Bcl-2 family: a preclinical trial in lymphoma. Proc Am Assoc Cancer Res 2006;47: Abstract 1335.
   Google Scholar
• Arnold AA, Aboukameel A, Chen J, . Preclinical studies of apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model. Mol Cancer 2008;7:20.
   PubMed Web of Science ®Google Scholar
• Sun Y, Wu J, Aboukameel A, . Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther 2008;7:1418–1426.
   PubMedGoogle Scholar
• Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ, . Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334–336.
   PubMed Web of Science ®Google Scholar
• Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 2002;277:14127–14134.
   PubMed Web of Science ®Google Scholar
• Choi S, Singh SV. Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. Cancer Res 2005;65:2035–2043.
   PubMed Web of Science ®Google Scholar
• Balakrishnan K, Burger JA, Wierda WG, Gandhi V. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009;113:149–153.
   PubMed Web of Science ®Google Scholar
• Zhai D, Jin C, Huang Z, Satterthwait AC, Reed JC. Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. J Biol Chem 2008;283:9580–9586.
   PubMed Web of Science ®Google Scholar
• Lee EF, Czabotar PE, van Delft MF, . A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol 2008;180:341–355.
   PubMed Web of Science ®Google Scholar
• Stewart ML, Fire E, Keating AE, Walensky LD. The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat Chem Biol 2010;6:595–601.
   PubMed Web of Science ®Google Scholar
• Doi K, Li R, Sung SS, . Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem 2012;287:10224–10235.
   PubMed Web of Science ®Google Scholar